Category: pyrazoles-derivatives

Kelly, Niamh R.’s team published research in Tetrahedron Letters in 52 | CAS: 19959-71-8

Tetrahedron Letters published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Recommanded Product: 4-(1H-Pyrazol-4-yl)pyridine.

Kelly, Niamh R. published the artcileA simple and environmentally benign synthesis of polypyridine-polycarboxylic acids, Recommanded Product: 4-(1H-Pyrazol-4-yl)pyridine, the publication is Tetrahedron Letters (2011), 52(9), 995-998, database is CAplus.

An oxidation method using dilute nitric acid solutions under solvothermal conditions has been developed to synthesize a series of polypyridine-polycarboxylic acids. It has been successfully applied to a range of Me substituted polypyridines including sym. and asym. 2,2′-bipyridines; 2,2′:6′,2”-terpyridines and; 2,2′:6′,2”:6”,2”’-tetra-pyridines and yields crystalline polypyridine-polycarboxylic acids in a single step. Simple product recovery through filtration yields a recyclable filtrate. More forcing conditions led to demethylation of the polypyridine ligand most probably via decarboxylation. This simple approach avoids potentially harmful metal-based oxidants and negates any issues associated with the disposal of their resultant (hazardous) waste.

Tetrahedron Letters published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Recommanded Product: 4-(1H-Pyrazol-4-yl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Chen, Yantao’s team published research in Synthesis in 47 | CAS: 930-36-9

Synthesis published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Name: 1-Methylpyrazole.

Chen, Yantao published the artcileSynthesis of Enantiomerically Pure 2-Heteroaromatic-Substituted 1,2-Amino Alcohols from Chiral tert-Butanesulfinyl Aldimines, Name: 1-Methylpyrazole, the publication is Synthesis (2015), 47(5), 679-691, database is CAplus.

Nine R/S pairs of 2-heteroaromatic-substituted 1,2-amino alcs. were synthesized through 1,2-nucleophilic addition between chiral N-(tert-butylsulfinyl)imines and heteroaromatic carbanions. In most cases, the RS-isomer of N-(tert-butylsulfinyl)imines afforded the (R)-amino alc. from deprotection of the major diastereomer, and (S/S)-imines afforded the (S)-product. In general, this procedure allows for the preparation of a variety of enantiomeric pairs of 2-heteroaromatic-substituted 1,2-amino alcs. on a practical scale (>10 g) in two steps in good yields. Aldimines were prepared from [S(S)]-2-methyl-2-propanesulfinamide and [S(R)]-2-methyl-2-propanesulfinamide. The synthesis of the target compounds was achieved by a reaction of , [S(S)]-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethylidene]-2-methyl-2-propanesulfinamide (chiral auxiliary, tert-butanesulfinyl aldimine) and [S(R)]-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethylidene]-2-methyl-2-propanesulfinamide (chiral auxiliary) with 5-bromo-2-methoxypyridine, 3-bromo-1-methyl-1H-pyrazole, 1-methyl-1H-imidazole, 2-chloro-1-methyl-1H-imidazole, 4-bromo-2-methoxypyridine, pyrazine, 1-methyl-1H-pyrazole, 1,4-dimethyl-1H-pyrazole, 1-methyl-1H-1,2,4-triazole. Key intermediates included [S(S)]-N-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(1-methyl-1H-1,2,4-triazol-5-yl)ethyl]-2-methyl-2-propanesulfinamide and a diastereomer, [S(R)]-N-[(1S)-2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-(1-methyl-1H-1,2,4-triazol-5-yl)ethyl]-2-methyl-2-propanesulfinamide. Chiral β-(amino)alkanol derivatives included β-amino-1-methyl-1H-1,2,4-triazole-5-ethanol and (βS)-β-amino-6-methoxy-3-pyridineethanol, (βR)-β-amino-1-methyl-1H-imidazole-1-ethanol, (βS)-β-amino-1-pyrazineethanol, (βR)-β-amino-1-pyrazineethanol.

Synthesis published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C4H6N2, Name: 1-Methylpyrazole.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Vernier, William F.’s team published research in Tetrahedron Letters in 58 | CAS: 930-36-9

Tetrahedron Letters published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C15H12O8, Computed Properties of 930-36-9.

Vernier, William F. published the artcileRegioselective palladium-catalyzed C-H arylation of 4-alkoxy and 4-thioalkyl pyrazoles, Computed Properties of 930-36-9, the publication is Tetrahedron Letters (2017), 58(49), 4587-4590, database is CAplus.

Alkoxy- and alkylthiopyrazoles such as 4-benzyloxy-1-methylpyrazole underwent regioselective arylation with aryl and heteroaryl bromides in the presence of Pd(OAc)2 and either SPhos or QPhos in 1,4-dioxane at 70-90 °C to yield arylpyrazoles such as I and an arylimidazole in 19-88% yields; 1-methylpyrazole, 4-chloro-1-methylpyrazole, 1-phenyl-4-pyrazolecarboxaldehyde, and 1-methylimidazole also underwent arylation under similar conditions but required higher temperatures Bromoaralkyl pyrazolyl ethers and thioethers such as 4-(2-bromobenzyloxy)-1-methylpyrazole underwent intramol. arylation to yield fused pyrazoles such as pyrazoloisobenzopyran II in 34-93% yields.

Tetrahedron Letters published new progress about 930-36-9. 930-36-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole, name is 1-Methylpyrazole, and the molecular formula is C15H12O8, Computed Properties of 930-36-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Kearns, Hayleigh’s team published research in Analytical Chemistry (Washington, DC, United States) in 89 | CAS: 19959-71-8

Analytical Chemistry (Washington, DC, United States) published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Synthetic Route of 19959-71-8.

Kearns, Hayleigh published the artcileSERS Detection of Multiple Antimicrobial-Resistant Pathogens Using Nanosensors, Synthetic Route of 19959-71-8, the publication is Analytical Chemistry (Washington, DC, United States) (2017), 89(23), 12666-12673, database is CAplus and MEDLINE.

Successful pathogen detection is crucial for public health as the threat of infectious disease is dramatically increasing globally due to bacteria developing resistance to many antimicrobial drugs. The increase in bacterial infections has led to urgent demands for simpler, faster, and more reliable detection methods to be developed allowing the most appropriate therapy to be provided. Surface enhanced Raman scattering (SERS) is an anal. technique which has gained a great deal of interest for biosensing due to its sensitivity, selectivity, and multiplexing capabilities. A new bionanosensor has been developed for the isolation and detection of multiple bacterial pathogens via magnetic separation and SERS. This novel assay format involves using lectin functionalized magnetic nanoparticles for capture and isolation of bacteria from the sample matrix followed by specifically detecting bacterial pathogens using SERS active nanoparticles functionalized with antibodies which are strain specific. Therefore, the sample is captured using a “magnetic plug” and interrogated with a laser allowing simple and fast optical detection. Three bacterial pathogens (Escherichia coli, Salmonella typhimurium, and methicillin-resistant Staphylococcus aureus) were successfully isolated and detected, with the lowest concentration for each of the strains detected at just 101 colony forming units per mL (CFU/mL). In addition to single pathogen detection, a mixture of all three bacterial strains was isolated and identified within the same sample matrix using SERS with the triplex detection also being confirmed using principal component anal. Herein, this multiplexed bionanosensor is capable of providing rapid and sensitive discrimination of bacterial pathogens both individually, and within a multiplex system, offering opportunities for future point of care devices and advancements in biomedical applications.

Analytical Chemistry (Washington, DC, United States) published new progress about 19959-71-8. 19959-71-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Pyridine, name is 4-(1H-Pyrazol-4-yl)pyridine, and the molecular formula is C8H7N3, Synthetic Route of 19959-71-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Mustafa, Ahmed et al. published their research in Canadian Journal of Chemistry in 1963 | CAS: 17355-75-8

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Behavior of the hetero ring in γ-phenyl-Δβ,γ-butenolide derivatives toward hydrazines. Acid rearrangement of 4-phenylhydrazono-2-phenyloxazolin-5-one was written by Mustafa, Ahmed;Khattab, Samir A.;Asker, Wafia. And the article was included in Canadian Journal of Chemistry in 1963.Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

The substituted pyridazinones 3-phenyl- and 1,3-diphenyl-5-benzylidene-1,4,5,6-tetrahydropyridazin-6-one have been prepared from α-phenacylcinnamic acid hydrazide and α-phenacylcinnamic acid phenylhydrazone, resp. The dipyridazinone (I) was prepared from the dilactone (II). Rearrangement of 4-phenylhydrazono-2-phenyloxazolin-5-one (III) now has been found to proceed also in the presence of acidic reagents. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Application In Synthesis of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Persson, Tobias et al. published their research in Organic Letters in 2006 | CAS: 17355-75-8

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.COA of Formula: C18H16N2O2

Synthesis of N-Methoxy-N-methyl-β-enaminoketoesters: New Synthetic Precursors for the Regioselective Synthesis of Heterocyclic Compounds was written by Persson, Tobias;Nielsen, John. And the article was included in Organic Letters in 2006.COA of Formula: C18H16N2O2 The following contents are mentioned in the article:

Weinreb amides react with the lithium or sodium acetylide of Et propynoate in a hitherto unexplored acyl substitution-conjugate addition sequence to furnish (E)-N-methoxy-N-methyl-β-enaminoketoesters. This approach provides a diverse entry to densely functionalized heterocyclic compounds, including pyrazoles through regioselective cyclocondensations with hydrazines in a microwave-assisted reaction. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8COA of Formula: C18H16N2O2).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.COA of Formula: C18H16N2O2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Chen, Miao-Miao et al. published their research in Chinese Chemical Letters in 2019 | CAS: 17355-75-8

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.SDS of cas: 17355-75-8

Palladium-catalyzed late-stage mono-aroylation of the fully substituted pyrazoles via aromatic C-H bond activation was written by Chen, Miao-Miao;Shao, Ling-Yan;Lun, Li-Jun;Wu, Yu-Liang;Fu, Xiao-Pan;Ji, Ya-Fei. And the article was included in Chinese Chemical Letters in 2019.SDS of cas: 17355-75-8 The following contents are mentioned in the article:

The palladium-catalyzed late-stage aroylation of 4-methyl-1,5-diaryl-1H-pyrazole-3-carboxylates has been developed via direct and exclusive mono-Csp2-H bond activation with broad substrate scope and good functional group tolerance. A dual-core dimeric palladacycle is confirmed by X-ray single crystal crystallog., and probably serves as an active species in the catalytic cycle. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8SDS of cas: 17355-75-8).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.SDS of cas: 17355-75-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Miki, Yasuyoshi et al. published their research in Heterocycles in 1996 | CAS: 141032-72-6

Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application of 141032-72-6

Synthesis of 1-isopropylamino-3-(pyrazolo[1,5-a]pyridyloxy)-2-propanols was written by Miki, Yasuyoshi;Tasaka, Junko;Uemura, Kyoko;Miyazeki, Kunihiro;Yamada, Jun. And the article was included in Heterocycles in 1996.Application of 141032-72-6 The following contents are mentioned in the article:

Treatment of the 4-hydroxypyrazolo[1,5-a]pyridine with glycidyl tosylate in the presence of base, followed by reaction with isopropylamine gave 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-4-yloxy)-2-propanol. In a similar manner, 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-6- and 1-isopropylamino-3-(pyrazolo[1,5-a]pyrid-3-yloxy)-2-propanol were also prepared This study involved multiple reactions and reactants, such as Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6Application of 141032-72-6).

Pyrazolo[1,5-a]pyridin-4-ol (cas: 141032-72-6) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of both electronegative nitrogen atoms in the pyrazole ring reduces the electron density of the C3- and C5-positions leaving electron density of C4-position unaltered. Thus the C4-position is vulnerable to electrophilic attack. The C3 electrophilic-position may undergo deprotonation in the presence of a strong base leading to ring opening.Application of 141032-72-6

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Sun, Aixue et al. published their research in Tetrahedron Letters in 2014 | CAS: 17355-75-8

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

A new efficient synthesis of pyrazoles from hydrazonoyl halides and β-oxo-phosphonates was written by Sun, Aixue;Ye, Jia-Hai;Yu, Haitao;Zhang, Wenchao;Wang, Xiaolong. And the article was included in Tetrahedron Letters in 2014.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate The following contents are mentioned in the article:

A new practical and efficient synthesis of 1,3,5-trisubstituted pyrazoles was developed by reacting of hydrazonoyl halides with β-oxo-phosphonates under mild conditions in good yields with excellent regioselectivity. This process employs an addition-elimination sequence. Wide scope, functional group compatibility was established. This study involved multiple reactions and reactants, such as Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate).

Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate (cas: 17355-75-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Safety of Ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Korbukh, I. A. et al. published their research in Zhurnal Organicheskoi Khimii in 1973 | CAS: 49834-67-5

1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 49834-67-5

Glycosides of pyrazole and condensed pyrazole heterocycles. II. Synthesis of pyrazolo-[3,4-b]pyridine glycosides was written by Korbukh, I. A.;Blanko, F. F.;Preobrazhenskaya, M. N.;Dorn, H.;Kondakova, N. G.;Sukhova, T. I.;Kostyuchenko, N. P.. And the article was included in Zhurnal Organicheskoi Khimii in 1973.Product Details of 49834-67-5 The following contents are mentioned in the article:

β-D-Ribofuranosylpyrazolo[3,4-b]pyridines (I; R1 = Cl, H2NNH, Me2N, H2N, MeS) were obtained by condensation of the appropriate pyrazolo[3,4-b]pyridines with acyl derivatives of saccharides, followed by deacylation and appropriate substitution reactions. Addnl. 1-β-D-glucopyranosyl-4-chloropyrazolo[3,4-b]pyridine was prepared This study involved multiple reactions and reactants, such as 1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5Product Details of 49834-67-5).

1H-Pyrazolo[3,4-b]pyridin-4-ol (cas: 49834-67-5) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Product Details of 49834-67-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics