Category: pyrazoles-derivatives

Electric Literature of 14521-80-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14521-80-3 as follows.

To a solution of 3-bromo-1H-pyrazole (10 g, 68.0 mmol) in H2SO4 (50 mL) was added HNO3 (10.7 g, 170 mmol) at 0-10 C. Then, the mixture was stirred at 80 C. for 2 hours. On completion, the mixture was cooled to 25 C. Then, the mixture was poured into ice/water (300 mL), then extracted with EA (3¡Á150 mL). The combined organic layer was washed with sat. aq. NaHCO3 (100 mL) and brine (100 mL), dried over Na2SO4, and filtered. The filtrate was concentrated in vacuo to give the title compound (11.2 g, 85% yield) as yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 8.94 (s, 1H).

According to the analysis of related databases, 14521-80-3, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1H-Pyrazole-4-carbonitrile

To a solution of I-R15 (200 mg) in anhydrous THF (20 mL) was added lH-pyrazole-4- carbonitrile (90.9 mg, 1.0 mmol) and K2C03 (134 mg, 1.0 mmol) at 25C under N2. The mixture was stirred at 65C for 12 h. The reaction mixture was poured into ice-water (30 mL). The aqueous phase was extracted with EtOAc (2 x 50 mL). The combined organic phase was washed with saturated brine (2 x 50 mL), dried over anhydrous Na2S04, filtered and concentrated. The residue was purified by flash column (30-40% of EtOAc in PE) to give I-R16 (130 mg, 63%) as an oil. (2182) 1H NMR (400 MHz, CDCl3) dH 7.88 (s, 1H), 7.82 (s, 1H), 6.65 (s, 1H), 5.39-5.30 (m, 2H), 2.43 (dd, J= 6.0, 18.4 Hz, 1H), 2.16-2.07 (m, 1H), 2.00 (s, 1H), 1.97-1.49 (m, 7H), 1.43-0.99 (m, 17H), 0.96 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31108-57-3, its application will become more common.

Some common heterocyclic compound, 217073-76-2, name is 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C11H9FN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 217073-76-2

General procedure: To a solution of II (1-2 eq.) in dry DMF, dioxane or dichloromethane, particularly dry DMF (dimethylformamide) (3-10 ml) were added IV (1 mmol). HBTU (2-(lH-Benzotriazole-l-yl)- 1,1,3,3-Tetramethyluroniurn hexafluorophosphate) (1 -1.4 eq.), DIPEA (N,N- Diisopropylethylamine) (1-5 eq.) or triethylamine (5 eq.), particularly DIPEA, and optionally DMAP (4-Dimethylaminopyridine ) (0.1 eq.) were also added to the reaction mixture. The reaction temperature was usually in the range of from rt to 85 C, particularly rt. The reaction was usually allowed to process overnight (which as used herein specifies a duration of approximately between 12 and 24 h, depending on the reaction velocity). After completion of the reactions, the reaction solution was subjected to one or more after- treatments including: A) Extraction with organic solvents: The residue obtained from the reaction was dissolved in an organic solvent (such as ethyl acetate or dichloromethane) and was washed at least once with an aqueous 5% NaHC03, aqueous 5% citric acid and water. The organic layer was dried over magnesium sulfate and concentrated in vacuo. B) Chromatography: The crude product obtained from the reaction was purified by column chromatography on a silica gel flash column, by preparative TLC (thin layer chromatography) or preparative HPLC (high pressure liquid chromatography) with a defined eluent proportion. After completion of the reaction, the crude product was purified by siliga gel flash column chromatography (CHCl3/EtOH = 80:1 + 1 drop of HOAc). C) Recrystallization: The crude product was crystallized from ethanol (with activated carbon). D) Precipitation: After completion of the reaction, the reaction mixture was diluted with water, hexane or an aqueous Na2C03-solution and/or was poured into ice water and the formed precipitate was filtered off. E) Washing: The obtained solid (e.g. obtained by filtration) was washed with water, aqueous HC1 or Na2C03-solution and/or organic solvents. F) Suspending, followed by filtration: The crude product was suspended in Et20 (diethyether), filtered off and dried. G) Neutralization and recovery: After completion of the reaction, the solvent was evaporated in vacuo, water was added and the precipitate was formed. An aqueous 3% ammonia solution, or alternatively a sodium hydrogen carbonate solution was added to the suspension till pH = 8. After 30 min of stirring the precipitate was filtered off or the dissolved product was extracted

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 217073-76-2, its application will become more common.

Some common heterocyclic compound, 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 180207-57-2

A mixture ofthionyl chloride (6.318 g, 53.55 mmol) and 2-(1H-pyrazol-4-yl)ethan-1-ol (2.0 g, 17.85 mmol) washeated to 70″C for 15 minutes. The reaction mixture was concentrated under reduced pressure, the residuewas triturated with ethanol/diethyl ether to the title compound (2.3 g, 98%) as an off-white solid.LC-MS (method 6): Rt = 1.61 min; m/z = 131.06 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 180207-57-2, its application will become more common.

Synthetic Route of 67-51-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67-51-6 as follows.

General procedure: NaH (60mmol) was added to the solution of 3,5-dimethylpyrazole or 3,5-diisopropylpyrazole (50mmol) in THF (40ml) at room temperature. The resulting mixture was stirred for 1h, and then CH3I (50mmol) was added. After the reaction mixture was continuously stirred overnight at room temperature, water (100ml) was added slowly. The solution was extracted with ethyl acetate (3¡Á50ml). The organic layers were combined, washed with saturated brine and dried over anhydrous MgSO4. The solvent was removed in vacuo to give the expected products. (0012) 1,3,5-Trimethylpyrazole, yield: 46%. 1H NMR: delta 2.18 (s, 3H), 2.19 (s, 3H) (CH3), 3.67 (s, 3H, NCH3), 5.76 (s, 1H, H4 of pyrazole) ppm. 13C NMR: delta 11.0, 13.4 (CH3), 35.6 (NCH3), 104.8 (C4 of pyrazole), 139.0, 147.0 (C3 and C5 of pyrazole) ppm.

According to the analysis of related databases, 67-51-6, the application of this compound in the production field has become more and more popular.

Electric Literature of 5932-27-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A 50 mL of flask was charged with 2.62 g of 3-fluorobenzenebromide (15 mmol), 1.40 g of ethyl 1-H-pyrazole-3-carboxylate (10 mmol), 400 mg of CuI (2.0 mmol), 4.5 g of K2CO3 (3.3 mmol) and 0.9 mL of trans-N,N’-dimethylcyclohexayldiamine (2.0 mmol). The resulting mixture was stirred at 140¡ã C. for 3 h. After the mixture was cooled down to room temperature, it was diluted with 200 mL EtOAc and then was washed with water (2*50 mL), and brine (2*50 mL). The organics were dried over MgSO4 and concentrated under reduced pressure. The residue was purified via flash column chromatography on silica gel (0-25percent EtOAc in hexanes) to give the desired product (1.17 g, 50percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Related Products of 2458-26-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2458-26-6, name is 3-Phenyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of ethyl2-chloronicotinate (2 g, 10.78 mmol) and 3-phenyl-1H-pyrazo1e (2.33 g, 16.16 mmol) in DMF (30 mL) was added K2C03 (4.47 g, 32.33 mmol)and Kl (1.79 g, 10.78 mmol). The mixture was stirred at 130 oc for 16h. The reaction wasfiltered, the filtrate was added I-hO (100 mL), extracted with EA (30 mL x2), the organicphase was washed with brine ( l 00 mL ), filtered, and concentrated. The residue was purifiedby flash silica gel chromatography (ISCO; 40 g SepaFlash Silica Flash Column, Eluent of15(% Ethyl acetate/Petroleum ethergradient 40 mUmin). Compound 113A (1 g, yield:28.5%) was obtained as a white solid. 1H NMR (400MHz, CDCh) 8 8.49 (dd, J = 1.7, 4.6Hz, lH), 8.42 (d, J”‘ 2.4 Hz, 1H), 7.94 (dd, J ‘” 1.7, 7.6 Hz, lH), 7.89- 7.78 (m, 2H), 7.40 (t,J “‘ 7.3 Hz, 2H), 7.33 (br d, J ‘” 7.3 Hz, H-I), 7.29 – 7.23 (m, HI), 6.79 (d, J “‘ 2.7 Hz, HI),4.45- 4.25 (m, 2H), 1.14 (t, J = 7.2 Hz, 3H). MS (ESl) m/z (M+Ht294.1.

The chemical industry reduces the impact on the environment during synthesis 3-Phenyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 309740-49-6 as follows. category: pyrazoles-derivatives

Compound 7: 10% wt. Pd/C (0.15 g, 0.14 mmol) was added to a solution containing 6 (0.26 g, 1.4 mmol) in 10 mL of methanol. The mixture was stirred under a hydrogen atmosphere at ambient temperature. After 3 hours, the reaction mixture was filtered thru a plug of Celite. The resulting filtrate was concentrated under reduced pressure to afford 7 (0.20 g, 91%), ES (+) MS m/e=156 (M+1).

According to the analysis of related databases, 309740-49-6, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 131797-35-8, name is 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131797-35-8, Safety of 5-Chloro-3-(trifluoromethyl)-1H-pyrazole

To a solution of 2-chloro-7-(chloromethyl)-N-ethyl-5-oxo-5H-[l,3]thiazolo[3,2-a]pyrimidine- 3-carboxamide (2 g, 6.53 mmol) in acetonitrile (10 mL) was added 5-chloro-3-(trifluoromethyl)-lH- pyrazole (872 mg, 5.11 mmol), potassium iodide (542 mg, 3.26 mmol), and potassium carbonate (1.8 g, 13 mmol). The resulting mixture was stirred for 1 h at 80 C and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/petroleum ether (1/1) to afford of 2-chloro-7-[[5-chloro-3-(trifluoromethyl)-lH-pyrazol-l-yl]methyl]-N-ethyl-5-oxo-5H- [l,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (1.1 g, 38%) as a yellow solid. LCMS (ESI): M+H + = 441.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Chloro-3-(trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.

Synthetic Route of 5334-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Complex NiL2*4H2O was synthesized in the reaction on the warm ethanolic solutions of Ni(CH3COO)2 and 4-nitro-3-pyrazolecarboxylic acid ligand (L) mixed in molar ratio 1:2. After 6 h, the microcrystalline product was filtered off and washed with ethanol.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Nitro-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.