Category: pyrazoles-derivatives

3920-50-1, name is Pyrazole-3-carboxaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Pyrazole-3-carboxaldehyde

The compound (53.8 mg) obtained in Example 1-4 was dissolved in methanol (0.8 ml). Then, the solution was added with trimethyl orthoformate (50 mul), acetic acid (50 mul), and pyrazol-3-carboxaldehyde (manufactured by Merck, Inc.) (24.9 mg) and stirred at room temperature for 10 minutes. Subsequently, sodium cyanoborohydride (24.4 mg) was added, followed by stirring overnight at room temperature. The solvent was distilled off under reduced pressure and then the residue was dissolved in chloroform, followed by washing with 1 mol/l sodium hydroxide and saturated saline solution and drying with anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure. Then, the residue was then purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (26.1 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=466[M+H]+1H-NMR(500MHz,DMSO-d6) :delta=0.88(6H,t,J=7.3Hz),1.53-1.69(8H,m),2.95(4H,brs),3.05(2H,brs),3.25-3.40(2H,m),3.55(2H,s),3.58(2H,s),3.62(2H,s),6.27(1H,s),7.04( 2H,s),7.50(2H,d,J=8.2Hz),7.81(2H,d,J=8.2Hz),8.51(1H,t,J=5.5H z).

The synthetic route of 3920-50-1 has been constantly updated, and we look forward to future research findings.

Application of 16034-46-1, These common heterocyclic compound, 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of tert-butyl [2-(3-methoxybenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate (1.0 g, 2.99 mmol) obtained in Example 219-D) in ethanol (9 mL) was added dropwise concentrated hydrochloric acid (2.3 mL) at room temperature, and the mixture was stirred at 50C for 1.5 hr. The reaction mixture was cooled to 0C, neutralized with 8M aqueous sodium hydroxide solution, adjusted to pH 10-11 with saturated aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The obtained residue was dissolved in DMA (20 mL), and 1-methyl-1H-pyrazole-5-carboxylic acid (453 mg, 3.59 mmol), HATU (1.37 g, 3.59 mmol) and DIEA (0.247 mL, 1.50 mmol) were added at room temperature. The reaction mixture was stirred at 60C for 2 hr, water and 0.1N hydrochloric acid were added and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent: hexane-ethyl acetate (13:7-1:4)] and basic silica gel column chromatography [eluent: hexane-ethyl acetate (3:2-3:7)], and crystallized from ethyl acetate-hexane to give the title compound (545 mg) as colorless crystals (yield 53%). MS (ESI+): [M+H]+ 343. 1H NMR (300 MHz, DMSO-d6) delta 2.30 (3H, s), 3.74 (3H, s), 4.04 (3H, s), 4.17 (2H, s), 6.80-6.94 (3H, m), 7.06 (1H, d, J = 2.3 Hz), 7.22-7.30 (1H, m), 7.53 (1H, d, J = 2.3 Hz), 10.47 (1H, s).

Statistics shows that 1-Methyl-1H-pyrazole-5-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 16034-46-1.

Adding a certain compound to certain chemical reactions, such as: 852443-61-9, name is 3-(Trifluoromethyl)-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 852443-61-9, Recommanded Product: 3-(Trifluoromethyl)-1H-pyrazol-5-amine

To a stirred solution of 3-amino-6-bromo-5-trifluoromethyl-pyrazine-2-carboxylic acid (Intermediate 2) (100 mg, 0.350 mmol) in dry NMP (2 ml) was added NEt3 (0.097 ml, 0.699 mmol) followed by 3-(trifluoromethyl)-1 H-pyrazol-5-amine (48.0 mg, 0.318 mmol). The mixture was stirred at RT for 5 minutes, before treating with HATU (133 mg, 0.350 mmol). The resulting orange solution was stirred at RT for 10 minutes and then partitioned between EtOAc (50 ml) and 1 M NaOH (30 ml). The organic portion was separated and washed with 1 M NaOH (20 ml), water (20 ml), dried (MgS04) and concentrated in vacuo. Purification of the crude residue by chromatography on silica eluting with /’so-hexane/EtOAc (gradient of 0 to 50 % EtOAc) afforded the title compound as a yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, A new synthetic method of this compound is introduced below., SDS of cas: 368870-03-5

The 9-cyclopentyl-2,6-dichloro-9H-purine (4.70 mmol) was dissolved in a mixture of n-propanol (15.0 ml) and N,N-diisopropyl-N-ethylamine (9.40 mmol) and to the solution 1 -[4-(1H-pyrazol-1 -yl)]phenylmethanamine (1.44 mmol) was added. The reaction mixture was heated in a sealedtube under an argon atmosphere at 100C. for 1.5 hour. Afier cooling to room temperature the resulting solid precipitate was suspended in ethanol (20 ml) and the precipitate was filtered off and washed with ice-cooled ethanol (20 ml). The crude product was dried at 80 C. for 2 hours and finally crystallized from ethanol. Yield: 72%, m.p.: 165-167 C. Elemental analysis: Calcd. for C2QH,9C1N60 (394.86): C, 60.84; H, 4.85; N, 21.28. Found: C, 60.56; H, 4.92; N, 21.48. HPLC-MS (ESI+): 394.3 (97.6%). ?H NMR (DMSO-d5):1. 61-1.71 (m, 2H), 1.80-1.98 (m, 4H), 2.09-2.18 (m, 2H), 4.66 (d, J=5.25, 2H, CH2), 4.77 (qui, J=7.05, 1H, CH), 6.51 (t, J=2.16, 1H,ArH), 7.45 (d, J=8.37, 2H,ArH), 7.71 (d, J=2.16, 1H, ArH), 7.77 (d, J=8.37, 2H, ArH), 8.27 (s, 1H, CH), 8.43 (d, J=2.16, 1H, ArH), 8.86 (t, J=5.25, 1H, NH)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 92933-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The aqueous solution of Eu(NO3)3.6H2O (1mmol) was treated with threefold excess of ethanolic solution of HIPA (3mmol) and the resulting mixture was thoroughly mixed on magnetic stirrer. The aqueous solution of NaOH was added drop wise to adjust the pH of mixture by 6-7. After constant stirring of 3 hr, off white precipitates of C1 binary complex were appeared which were isolated by vacuum filtration, washed with ethanol and water respectively, and then dried in desiccators.[19] Similarly, ternary complexes C2-C5 were synthesized by adding ethanolic solution of dmbipy, dipy, dmph and phen (1mmol) respectively, to the reaction mixture of europium(III) nitrate (1mmol) and ligand HIPA (3mmol) prior to adjustment of pH of the solution. Binary complex of gadolinium ion with ligand HIPA [Gd(IPA)3.2H2O] is synthesized by similar method as of C1 to calculate the triplet state of ligand. The synthetic routes of ligand HIPA and europium (III) complexes C1-C5 are shown in Fig. 1

The synthetic route of 5-Isopropyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.

Electric Literature of 37622-90-5, A common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, molecular formula is C6H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of ethyl 1H-pyrazole-4-carboxylate (5.4 g, 38.5 mmol) in t-butanol (20 mL) was added conc. H2SO4 (4 mL, 73.5 mmol) at 15 oC. The mixture was stirred at 100 oC for 14 hours. The reaction was quenched with water (30 mL) and extracted with ethyl acetate (40 mL x3). The organic phase was washed with 2M NaOH (20 mL x2) and the aqueous was acidified with conc. HCl to pH~2 and extracted with ethyl acetate (30 mL x5). The combined organic phases were dried over anhydrous Na2SO4, filtered and concentrated to afford 1-(tert-butyl)-1H- pyrazole-4-carboxylic acid as a white solid.1H NMR (400 MHz, DMSO-d6) delta 12.17 (br, 1 H); 8.24 (s, 1 H); 7.81 (s, 1 H); 1.52 (s, 9 H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 180207-57-2, A common heterocyclic compound, 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, molecular formula is C5H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

SM (0.9 g, 8.03 mmol, 1.0 eq) was added to SOCl2 (3.82 g, 32.11 mmol).Stir at 70 C for 30 minutes.The reaction solution is concentrated and dried to obtainMC18-157-2 (1.0 g, yield 95%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, category: pyrazoles-derivatives

A mixture of (S)-6-chloro-Lambda/-(l-(4-fluorophenyl)ethyl)-3-nitropyridin-2-aniine (Method 19; 1.74 g, 5.88 mmol), S-cyclopropyl-lH-pyrazol-S-amine (0.91 g, 7.36 mmol), and DIEA (1.28 ml, 7.36 mmol) in W-BuOH (10 ml) was heated in a sealed tube at 160 C for 60 hours. The solvent was removed under reduced pressure and the residue was purified by chromatography (hexane: EtOAc = 1 : 1) to give the title compound as a yellow solid (1.35 g, 60%). NMR (400 MHz) 12.15 (s, IH), 10.43 (br, IH), 9.19 (br, IH), 8.12 (d, J= 9.2 Hz, IH), 7.45 (m, 2H), 7.17 (m, 2H), 6.25 (br, IH), 6.14 (br, IH), 5.45 (m, IH), 1.87 (m, IH), 1.60 (d, J= 6.8 Hz, 3H), 0.95 (m, 2H)5 0.65 (m, 2H). MS: Calcd.: 382; Found: [M+H]+ 383.

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Electric Literature of 118430-73-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 118430-73-2 as follows.

To 1.0 g (6.53 mmol) of 5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine in 10 mL of CH2Cl2 is added 1.37 g (7.17 mmol) of 4-isocyanate-benzoic acid ethyl ester, and the mixture is stirred at 23C for 3 hr. The white solid is filtered and triturated with methylene chloride and then with diethyl ether. The solids are air-dried 1 hr to obtain the title product (2.07 g, 6.01 mmol, 92 % yield, ES+(m/z) 345 [M+H]).

According to the analysis of related databases, 118430-73-2, the application of this compound in the production field has become more and more popular.

10010-93-2, name is 3-Methyl-5-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Methyl-5-(trifluoromethyl)-1H-pyrazole

An oven dried resealable Schlenk tube was charged with 5-bromopyridin-2-amine (400 mg, 2.24 mmol), 5-methyl-3-(trifluoromethyl)-1H-pyrazole (340 mg, 2.24 mmol), potassium phosphate (972 mg, 4.49 mmol) and 7 ml dioxane were added. The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon, and copper(I) iodide (65 mg, 0.34 mmol) and N,N’-dimethylcyclohexane-1,2-diamine (55 mul, 0.34 mmol) were added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and placed in an oil bath at 130 C overnight. The mixture was cooled and was filtered through a plug of Celite. The filtered was concentrated under reduced pressure and the brown crude was purified by flash chromatography (0% to 50%, hexane-ethyl acetate) to give 476 mg (88% yield) of the title compound. LRMS (m/z): 343 (M+1)+.

The synthetic route of 10010-93-2 has been constantly updated, and we look forward to future research findings.