Category: pyrazoles-derivatives

Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of triphenylphosphine (59.3 mg, 0.226 mmol) and 1,3, [5-TRIMETHYL-LH-] pyrazole-4-carboxylic acid (SALOR) (26.8 mg, 0.174 mmol) in dichloromethane was cooled to [0 oC AND N-CHLOROSUCCINIMIDE] added. The mixture was stirred at [0 oC] for 0.5 h then ambient temperature for an additional 0.5 h. [3-CYCLOPROPYLMETHYL-8- [4-] (ETHYL-AMINO)-BENZYL]-1-(2-FLUOROBENZYL)-3,] 7-dihydro-purine-2,6-dione (93.4 mg, 0.209 mmol) was added followed by triethylamine (30.2 mg, 0.226 mmol) and 4- dimethylaminopyridine (a few crystals). The reaction was left to stir at ambient temperature overnight before washing with 1M aqueous hydrochloric acid, saturated aqueous sodium bicarbonate, drying the organic extract (sodium sulfate) and concentrating in vacuo. Purification by chromatography using silica eluted with 5: 9 methanol/dichloromethane gave the product as a colorless solid (83.5 mg, 69%).

Statistics shows that 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 1125-29-7.

Related Products of 92933-47-6, A common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, molecular formula is C7H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate (7a)To a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (2.5 g, 16.2 mmol) [commercially available from Alfa Aesar, Ward Hill, MA, USA] in MeOH (25 mL) was added cone, sulfuric acid (1 mL) and refluxed for 12h. The reaction mixture was cooled and the solvent was removed under reduced pressure. The crude mass was purified by flash column chromatography using 1:9 MeOH in CHCl3 to yield compound 7a (2.6 g). 1H NMR (400 MHz, CDCl3): delta 6.64 (s, 1H), 4.39 (q, J=8.00 Hz, 2H), 3.06-3.01 (m, 1H), 1.39 (t, J=8.00 Hz, 3H), 1.31 (d, J=8.00 Hz, 6H). Molecular Formula: C9H14N2O2, LCMS purity: 96%; Expected: 182.1 ; Observed: 183 (M+1).

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4054-67-5, name is 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 3,3′,5,5′-Tetramethyl-1H,1’H-4,4′-bipyrazole

General procedure: A mixture of Ag2O (11.6 mg, 0.05 mmol), bpz (19 mg, 0.1 mmol), maleic acid (11.6 mg, 0.1 mmol), 5 mL H2O, and 0.15 mL pyridine was heated to 90 C for 8 h in a 25 mL Teflon-lined reaction vessel, kept at 90 C for 50 h, then slowly cooled to 30 C in 10 h. The pH values of the system were 6.06 and 6.10 before and after the hydrothermal reaction, respectively. Colorless block crystals of 1 were isolated by filtration, washed with H2O, and dried in air.

According to the analysis of related databases, 4054-67-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 103286-54-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103286-54-0, name is 3-Chloro-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 5-chloro-1H-pyrazol-4-amine, HCl (2 g, 12.99 mmol) and cesium carbonate (8.89 g, 27.3 mmol) in DMF (13 mL) was added 3,5-difluoropyridine (1.794 g, 15.58 mmol) and the mixture heated at 70 C. for 12 h. The mixture was cooled to room temperature and filtered. The solids were washed with copious amount of ethyl acetate. The filtrates was washed with brine, dried over anhydrous MgSO4 and concentrated in vacuo to give a brown solid. This solid was dissolved in ethyl acetate and the resulting solution was saturated with hexanes to precipitate 3-chloro-1-(5-fluoropyridin-3-yl)-1H-pyrazol-4-amine (2.31 g, 10.32 mmol, 79%) as a brown solid: 1H NMR (400 MHz, DMSO-d6) delta 8.89-8.82 (m, 1H), 8.45 (d, J=2.5 Hz, 1H), 8.07 (d, J=10.4 Hz, 1H), 7.94 (s, 1H), 4.51 (s, 2H); EIMS (m/z) 213 ([M+1]+).

The chemical industry reduces the impact on the environment during synthesis 3-Chloro-1H-pyrazol-4-amine. I believe this compound will play a more active role in future production and life.

Electric Literature of 29097-00-5,Some common heterocyclic compound, 29097-00-5, name is Methyl 3-amino-1H-pyrazole-4-carboxylate, molecular formula is C5H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of aminoazole 1c-e (1 mmol), acetoacetamide 2a,b,d (1 mmol), and aromatic aldehyde 3b,d-g (1 mmol) in 10 mL of ethanol was ultrasonicated at room temperature for 90 min in a round-bottom flask equipped with a condenser. The reaction mixture was allowed to stand up to 12 h at room temperature and then was filtered out to give the solid compounds 6a-e, which were washed with ethanol and air dried. Reaction products were obtained in high purity and did not require further purification by recrystallization.

The synthetic route of 29097-00-5 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3920-50-1, name is Pyrazole-3-carboxaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Pyrazole-3-carboxaldehyde

General procedure: A mixture of 1H-imidazole-2-carbaldehyde 40 (200 mg, 2.08 mmol), potassium carbonate (0.8630 g, 6.24 mmol) and 3-(bromomethyl)-1,1′-biphenyl 38 (0.7716 g, 3.12 mmol) in acetonitrile (10 mL) was stirred overnight at room temperature, then the solvent was removed, diluted with water, and extracted with ethyl acetate (3 x 30 mL). The combined organic phases were washed with brine, dried with Na2SO4, filtered, concentrated and purified by silica gel chromatography to afford 44 as a pale yellow solid (527 mg, 97%).

According to the analysis of related databases, 3920-50-1, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., Quality Control of 1H-Pyrazole-4-carbaldehyde

To a stirred solution of iFi-pyrazole-4carbaldehyde (1.00 g, 10.41 mmoi) in MeOH (20 mL) was added acetic acid (0.60 mL, 10.41 mrnol), Intermediate 74 (2.59 g, 12.49 mmol) andthe reaction mixture was stirred at ambient temperature for 20 miii. Then NaCNI3H4 (1 .96 g,3 1.2 mmol) was added and stirring was continued at ambient temperature for 14 h. The reaction mixture was distilled under reduced pressure and basified with saturated sodium bicarbonate solution (50 mL). To the resulting aqueous mixture was added BOC2O (2.34 ml, 10.09 mniol) and stirred at ambient temperature for 2. h. The reaction mixture was diluted with water (20 mL) and extracted with 5percent mnethanoi:DCM (3 x 30 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (Redisep-24 g, 4percent MeOHJCHCI3), to obtainintermediate 721 (095 g, 24.29percent). ?HNMR (300 MHz, DMSO-d6) 8 ppm 1.23 1.46 (in, 9 H)1.57 (s, I H) 2.26 (hr. s., 3 H) 308 – 3.26 (in, I H) 4.21 4.32 (m, 2 H) 5.07 – 5.19 (in, I H) 5.37(s, 2 H) 5.59 -5.71 (m, I H) 7.31 – 7.42 (m, I H) 7.69 (s, 3 H) 12.58- 12.73 (m, I H). LCMS(Method?H;): retention time 1.29 mm. [M-Hj 388.0.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 41680-34-6,Some common heterocyclic compound, 41680-34-6, name is 3-Amino-1H-pyrazole-4-carboxylic acid, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled (0 C.) solution of 3-diethoxymethyl-2-ethoxy-tetrahydro-furan (prepared accordingly to WO2005/095317) (350 mg, 1.61 mmol) in dichloromethane (2 mL) was added an aqueous solution of hydrochloric acid (6 M, 2 mL) followed by 5-amino-1H-pyrazole-4-carboxylic acid (250 mg, 1.97 mmol) and the resulting mixture was gradually heated at 70 C. for 1 hour. The organic solvent evaporated while heating and the solid formed was collected by filtration of the aqueous layer to give 50 mg of 5-amino-1H-pyrazole-4-carboxylic acid residual. The filtrate was repeatedly triturated with diethyl ether, decanted and lyophilized to give 6-(2-hydroxy-ethyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid.

The synthetic route of 41680-34-6 has been constantly updated, and we look forward to future research findings.

Application of 60061-60-1, The chemical industry reduces the impact on the environment during synthesis 60061-60-1, name is 4-Bromo-3-isopropyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Part B – 4-Bromo-3-isopropyl-N,N,alpha-trimethylpyrazole-1-acetamide Sodium hydride (2.4 g., 0.06 mole) (57% oily dispersion) was washed with dry toluene (50 ml.) and then suspended in dry toluene (50 ml.). 4-Bromo-3-isopropylpyrazole (5.7 g., 0.03 mole) in toluene (10 ml.) was added drop by drop to the sodium hydride suspension, the mixture heated to reflux, and then treated dropwise with a solution of 2-chloro-N,N-dimethylpropionamide (8.1 g., 0.06 mole). Heating was continued for 4 hours, the mixture cooled, and treated with toluene (60 ml.) and water (40 ml.). The toluene layer was washed with water, (2 * 60 ml.), dried (magnesium sulfate) and the solvent removed under reduced pressure. The resulting oil was distilled to yield 4-bromo-3-isopropyl-N,N,alpha-trimethylpyrazole-1-acetamide (5.7 g., 67%) with a boiling point of 99 to 101 C. at 0.03 mm Hg. On standing, the oil solidified to give crystals having a melting point at 63 to 65 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-isopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 285984-25-0, Recommanded Product: 285984-25-0

General procedure: A solution of compounds 10a-d or compounds 17a-d (1.0 mmol) in dichloromethane (10 mL) was slowly added to a stirred solution of triphosgene (109 mg, 0.36 mmol) in dichloromethane (50 mL) over a period of 30 min using a syringe. After stirring for a further 30 min, a solution of compound 25a-r (0.6 mmol) and triethylamine (0.4 mL, 2.77 mmol) in dichloromethane (10 mL) was added in one portion. The reaction mixture was stirred for 2 h at room temperature. After completion of the reaction, the reaction was poured into water (50 mL) and extracted three times with dichloromethane. The organic layer was washed with water (5 mL), sat. NaCl solution (5 mL), anddried over Na2SO4. After evaporation of solvent under vacuum, the residue was purified by silica gel chromatography to give the desired chromanylurea or 2H-chromenyl urea compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.