Category: pyrazoles-derivatives

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, A new synthetic method of this compound is introduced below., Product Details of 3524-32-1

(a) A mixture of 2-iodobenzoic acid (14.9 g, 0.06 mol), 5-amino-1,3-dimethylpyrazole (6.7 g, 0.06 mol), DMF (125 ml), Cu(OAc)2 (0,4 g) and K2CO3 (8.28 g, 0.06 mol) is refluxed overnight. The reaction mixture is poured into ice water (500 ml) and then is acidified with acetic acid to a pH of about 5. The solid that forms is collected by filtration, washed with water (100 ml) and dried. The solid is dissolved in hot CHCl3 (300 ml), filtered, dried over MgSO4 and evaporated to about 20 ml. Hexane (50 ml) is added, and then the product is collected by filtration, washed with hexane (30 ml) and dried to afford 6.2 g of N-(1,3-dimethyl-pyrazol-5-yl)anthranilic acid, m.p. 210-211 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 2075-45-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2075-45-8 name is 4-Bromo-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Bromo-1-(1-ethoxyethyl)-1H-pyrazole (11-II-a)To a solution of 4-bromo-1H-pyrazole (3 g, 20.4 mmol), ethyl vinyl ether (1.76 g, 24.5 mmol) in DCM (30 mL) was added HCl (4M in dioxane, 0.16 mL), and the reaction mixture was stirred for 3 h at RT. After completion of the reaction (monitored by TLC), the reaction was neutralized with saturated NaHCO3 solution and extracted with DCM (3×100 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo to afford 11-II-a (4.46 g, 89%) as colorless liquid; TLC: 30% EtOAc/Hexane (Rf: 0.7); 1H-NMR (CDCl3, 200 MHz): delta 7.60 (s, 1H), 7.46 (s, 1H), 5.46 (q, J=6.0 Hz, 1H), 3.55-3.25 (m, 2H), 1.63 (d, J=6.0 Hz, 3H), 1.15 (t, J=7.2 Hz, 3H); Mass: 221 [M++2].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1H-pyrazole, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1226781-82-3, name is tert-Butyl 2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 1226781-82-3

Trifluoroacetic acid (2.6 mL, 35 · 0 mmol) was cooled to 0 C., Compound 3 (598 mg, 1.83 mmol), Compound 1 (500 mg, 1.74 mmol) were added, and the reaction was 0 C. to 2 C. 1h. To the above reaction solution, N,N-dimethylacetamide (7.1 mL, 76.3 mmol), triethylamine (2.4 mL, 17.3 mmol) was slowly added, and the internal temperature was controlled not to exceed 15C. ; The reaction solution was cooled to 0 C, sodium triacetoxyborohydride (516 · 3mg, 2.43mmol) was added, and the reaction was carried out at 0 ~ 2 C for 5h; finally, the pH was adjusted to 9 with ammonia water, filtered, and the filtrate was filled with water ( (60 mL), extracted three times with ethyl acetate (30 mL of cesium 3), and the organic phases were combined and dried over anhydrous sodium sulfate. The solvent was evaporated to dryness under reduced pressure, and the residue was separated and purified by silica gel column (dichloromethane: methanol (volume ratio)). = 20:1), product 5 (white solid, 436 mg, 1.1 mmol, yield: 63%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 5334-39-4, These common heterocyclic compound, 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of PPh3 (20.64 g, 78.68 mmol) in THF (30 rnL) was added DIAD ( 15.91 g, 78.68 mmol, 15.30 mL), 3 -methyl -4-nitro- lH-pyrazole (5 g, 39.34 mmol) and oxetan-3-ol (2.91 g, 39.34 mmol) at 0C. Then the mixture was stirred at 25C for 12 h. The mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (S1Q2, PE:EtOAc = 50: 1 to 5 : 1). The mixture of 3-methy]-4-nitro-l -(oxetan-3-yl)pyrazole and 5 -methyl -4-nitro- 1 -(oxetan-3-yl)pyrazole was obtained as a yellow solid. To a solution of Pd/C (3 g, 10% purity) in MeOH (lOmL) was added 3 -methyl -4-nitro- l-(oxetan-3- yl)pyrazole and 5-methyl-4-nitro-l-(oxetan-3-yl)pyrazole (5 g, 37,3 mmol), then the mixture was stirred at 25C under (15 psi) for 2 h. The reaction was filtered and the filtrate was concentrated under reduced pressure to give 3 -methyl- l-(oxetan-3-yl)pyrazol-4-amine and 5-methyl- l-(oxetan-3-yl)-pyrazol- -I -am ine as a dark brown oil.

Statistics shows that 3-Methyl-4-nitro-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 5334-39-4.

5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 5334-39-4

To a solution of 3-methyl-4-nitro-lH-pyrazole (1 -1, 398 nig, 3.13 mmol) in DMF (10 niL) was added NaH (125 mg, 3.13 mmol, 60% purity) at 0 C, then the reaction was stirred at 20 C for 1 h. Then, (3-methyl- 5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3-a]pyridin-6-yl) methanesulfonate (604 mg, 2.61 mmol, 70% purity) in DMF (4 mL) was added to the solution at 20 C. Then, the mixture was stirred at 80 C for 12 h. The reaction solution was added with NH4Q solution (20 ml,), extracted with DCM:MeOH (20 mL chi 3, ratio=3: l). The organic layers were combined, dried over Na2S04, filtered and concentrated under reduced pressure. The crude product was purified by prep-TLC (DCM:MeOH = 5: 1) to give a mixture of 3-niethy3~6~(3-methyi-4~nitro^ and 3- methyl-6-(5~methyl-4-nitro-pyra^ as a yellow gum. LCMS: RT 0.925 min, m/z = 263.1 | M – H j ‘ . NMR (400 MHz, CDC13): delta 8.25 (s, 0.6 H), 8.13 (s, 0.3 H), 4.68 – 4.81 (m, 1 H), 4.14 – 4.42 (m, 2 H), 3.02 – 3.31 (m, 2 H), 2.77 (s, 1 H), 2.55 (s, 2 H), 2.44 – 2.53 (m, 4 H), 2.43 (s, 1 1H 1).To a mixture of 3-methyl-6-(3-methyl-4-nitro-pyrazol-l-yl)-5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3-aJpyri and 3-me1hyl-6-(5-methyl-4-nitro-pyrazol-l-yl)-5,6,7,8-tetrahydro-[l ,2,4]triazolo[4,3-a]pyridm (100 mg, 381.29 muetaiotaomicron) in Me OH (10 mL) was added Pd/C (10%, 50 mg) under N2. The suspension was degassed and purged with H2 for 3 times. The mixture was stirred under H2 ( 15 psi) at 20 C for 5 h. The reaction solution was filtered through a pad of celite, the filtrate was concentrated under reduced pressure to give a crude 5 -methyl- 1 -(3 -methyl-5 ,6,7,8 -tetrahydro- j 1 ,2,4 jtriazolo [4,3 -a]pyridin-6-yl)pyrazol-4-amine and 3 – m.ethyi~-(3-ni6thyl~5,6,7,8~tetrahy LCMS: RT0.173 min, m/z = 233.1 [M+H]+.

The synthetic route of 5334-39-4 has been constantly updated, and we look forward to future research findings.

Reference of 16461-94-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

3-Amino-4-bromopyrazole (5 g, 30.9 mmol) and 4-methoxybenzyl chloride (21 g, 134 mmol, 4.3 equiv.) werecombined in anhydrous DMF (25 mL) and added dropwise to a stirred suspension of sodium hydride (60% dispersionin mineral oil, 6.25 g, 156 mmol, 5 equiv.) in anhydrous DMF (50 mL). The presuming suspension was stirred 2 days atroom temperature. Water (300 mL) was added slowly and the resulting mixture was extracted with ether (4 x 350 mL).The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated underreduced pressure. The crude product was dissolved in dichloromethane and purified by silica gel chromatography using a gradient from 10% to 20% ethyl acetate-hexanes. The product, a white solid, is obtained as a 60:40 mixture of the 1-benzylated-1 H product and the 2-benzylated-2H product (14.96 g total, 93% yield). The compound from Preparative Example 100-C (10 g, 19.15 mmol) and 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (11.95 g, 57.42 mmol, 3.0 equiv.) were combined in 120 mL dimethoxyethane. 2M sodiumcarbonate solution (30 mL, 60 mmol, 3.1 equiv.) was added followed by tetrakis(triphenylphosphine) palladium(0) (2.36g, 2.04 mmol, 0.11 equiv.). The mixture was stirred 16 hours at 90 C. After cooling to room temperature, water (200mL) and brine (50 mL) were added and the mixture was extracted with ethyl acetate (2 x 200 mL). The extracts werecombined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Thecrude product was dissolved in dichloromethane and purified by silica gel chromatography using a gradient from 33%to 66% ethyl acetate-hexanes. The 1-benzylated-1 H product (Rf = 0.27 in 66% ethyl acetate-hexanes) elutes first,followed by the 2-benzylated-2H-product (Rf= 0.19 in 66% ethyl acetate-hexanes). The product is obtained as a yellowsolid (5.60 g total, 56% yield) with an isomeric ratio of 62:38.

The synthetic route of 4-Bromo-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1001020-14-9, name is 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001020-14-9, SDS of cas: 1001020-14-9

b) 2-(3-(4-Formyl-3-(trifluoromethyl)-1 H-pyrazol-1-yl)propanamido)-N-methyl-4, 5,6,7- tetrahydrobenzo[b]thiophene-3-carboxamide3-(Trifluoromethyl)-1 H-pyrazole-4-carbaldehyde (437 mg, 2.66 mmol) and 2-(3- chloropropanamido)-N-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (801 mg, 2.66 mmol) were dissolved in DMF (15 ml_). Potassium carbonate (368 mg, 2.66 mmol) was added followed by potassium iodide (10 mg, 0.06 mmol). The reaction mixture was left to stand for 7 days. Water was added and the reaction mixture extracted into EtOAc (x 3). The EtOAc layers were combined and washed with water (x 5), brine, dried over MgSO4, filtered and the solvent removed in vacuo to give desired product as a yellow solid (970 mg, 2.26 mmol, 85 %). MS (ESI) : m/z 429.3 [M + H]+ .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Trifluoromethyl)-1H-pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 143426-52-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

E) methyl 5- (4- ( lH-pyrazol-l-yl ) benzyl) -3-fluoro-2-hydroxy-4- methylbenzoate Tetrakis (triphenylphosphine) palladium ( 0 ) (0.40 g) was added to a mixture of methyl 3-fluoro-2-hydroxy-4-methyl-5- (4,4,5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl ) benzoate (2.13 g) , 1- (4- (chloromethyl) phenyl) -lH-pyrazole (1.3.2 g) , sodium carbonate (1.46 g) , DME (30.0 mL) and water (10.0 mL) under argon atmosphere, and the mixture was stirred overnight at 80C. The reaction mixture was allowed to be cooled to room temperature, water was added thereto, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.33 g) . MS: [M+H]+ 341.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, A new synthetic method of this compound is introduced below., Computed Properties of C4H6N2O

General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 288-13-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-13-1, name is 1H-Pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Complex 2 (0.05 mmol) was added to a 5 mL of a sealed tube containing the aryl iodide or bromide (0.5 mmol), 1H-pyrazole (0.75 mmol), NaOH (1 mmol), and DMSO (1 mL). The mixture was stirred at 100 C for 12 h. After being cooled to room temperature, the mixture was quenched with 10 mL H2O and extracted with EtOAc(3 × 20 mL). The combined EtOAc extracts were dried with anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure.The residue was purified by flash column chromatography on silicagel with PE/EtOAc (from 10:1 to 5:1) as the eluent to afford the pure products. All N-aryl pyrazoles reported here are known products and were characterised by 1H NMR, and GC-MS.

The synthetic route of 1H-Pyrazole has been constantly updated, and we look forward to future research findings.