Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1226781-82-3, name is tert-Butyl 2-(methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 1226781-82-3
Trifluoroacetic acid (2.6 mL, 35 · 0 mmol) was cooled to 0 C., Compound 3 (598 mg, 1.83 mmol), Compound 1 (500 mg, 1.74 mmol) were added, and the reaction was 0 C. to 2 C. 1h. To the above reaction solution, N,N-dimethylacetamide (7.1 mL, 76.3 mmol), triethylamine (2.4 mL, 17.3 mmol) was slowly added, and the internal temperature was controlled not to exceed 15C. ; The reaction solution was cooled to 0 C, sodium triacetoxyborohydride (516 · 3mg, 2.43mmol) was added, and the reaction was carried out at 0 ~ 2 C for 5h; finally, the pH was adjusted to 9 with ammonia water, filtered, and the filtrate was filled with water ( (60 mL), extracted three times with ethyl acetate (30 mL of cesium 3), and the organic phases were combined and dried over anhydrous sodium sulfate. The solvent was evaporated to dryness under reduced pressure, and the residue was separated and purified by silica gel column (dichloromethane: methanol (volume ratio)). = 20:1), product 5 (white solid, 436 mg, 1.1 mmol, yield: 63%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.