Category: pyrazoles-derivatives

Electric Literature of 285984-25-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Preparation 17 l-(5-te^-Butyl-2-p-tolyl-2ff-pyrazol-3-ylVcarbamic acid 2.2.2-trichloro-ethyl ester To a solution of 5-te^-butyl-2-^-tolyl-2F-pyrazol-3-ylamine (Regan et al. J. Med. Chem. 2002, 45,2994-3008, 400 g, 1.74 mol) in THF (8L) add a saturated solution of sodium carbonate (2.4 L) and cool the mixture to 0 0C. Then add 2, 2, 2-trichloroethyl chloroformate (406.77 g, 1.92 mol) dropwise and stir mixture at 0 0C for 2 hours. Extract the reaction mixture with ethyl acetate (3 x 6.5L), dry over anhydrous magnesium sulfate and evaporate the solvent. Dissolve the solid in a minimum amount of ethyl acetate and add an excess of hexanes to precipitate the solid. Collect the solid by filtration and dry to obtain the title compound as an off white solid (586 g, 83% yield). (ES+): m/z 406.1 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Related Products of 25016-12-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-12-0, name is 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3′-chloro-3,4,5,6-tetrahydro-2H-[l,2′]bipyrazinyl (3 g, 15.1 mmol, 1 eq) and l,3-dimethyl-lH-pyrazole-4-carbaldehyde (2.0 g, 16.6 mmol, 1.1 eq) in DCE (75 mL) add sodium triacetoxyborohydride (4.8 g, 22.6 mmol, 1.5 eq) and stir at room temperature over the weekend. Add 2 N sodium hydroxide (100 mL), separate the layers, extract the aqueous layer twice with DCM (75 mL), dry (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 0: 100 to 10:90 –65-methanol:DCM). Combine only the fractions which contain the main component and concentrate to give the title preparation as a viscous yellow oil (2.14 g, 46%). Combine all other fractions which contain main component plus impurities, concentrate then repeat the chromatography step to recover further material (1.6 g, 35%, total yield 81%). MS (ES): m/z = 307.1 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2075-46-9 as follows. name: 4-Nitro-1H-pyrazole

Dissolving 5.0 g of 4-nitropyrazole in 160 mL of ethanol, and then adding 0.8 g of 10 wt% Pd/C to the above solution; Hydrogen was introduced into the reaction solution and allowed to react overnight at room temperature; after the TLC detection reaction was completed, the insoluble matter was filtered off with diatomaceous earth; Evaporation of the ethanol solvent gave pure intermediate 2 as a red solid 3.6 g.

According to the analysis of related databases, 2075-46-9, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35277-02-2 as follows. Application In Synthesis of 4-Fluoro-1H-pyrazole

In a 100mL single mouth bottle,Add 5-acetyl-2-bromopyridine (1i) (4.00 g, 20 mmol),4-fluoropyrazole (1j) (2.06 g, 24 mmol) and 50 mL of DMF,Reaction at 110 C for 7 hours,The reaction was detected by TLC until the starting point disappeared. After lowering the temperature to room temperature, it was poured into ice water to precipitate a yellow solid, which was washed with a large amount of water, filtered, and dried to obtain 3.31 g of a light yellow solid (1k) with a yield of 81%.

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H8N2

3,5-dimethyl-1 H-pyrazole (100 mg, 1.04 mmol) was dissolved in 1.0 mL of TFA. N-iodosuccinimide (234 mg, 1.04 mmol) was added in one portion. The reaction was strirred at rt for 1 h. LCMS showed clean reaction. Water and EtOAc were added and the phases were separated. The organic phase was washed with a aqueous saturated solution of sodium sulfite and was dried over sodium sulfate, filtered and concentrated. Afforded 230 mg of crude product (1.04 mmol, 99%) as a white solid.

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1260243-04-6,Some common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, molecular formula is C6H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3.1) Ethyl 5-amino-1H-pyrazole-4-carboxylate (15.5 g, 0.1 mol) obtained in step 1)And p-fluorophenyl-4,4,4-trifluorobutanedione (23.4 g, 0.1 mol) obtained in step 2) were placed in a vessel;3.2) After dissolving the mixture in the vessel with 50 mL of glacial acetic acid,To obtain a mixture E,The container was placed under an electric heating condition,Heating up to 115°C ;3.3) The mixture E was heated to reflux,After 7 hours,Cooling, standing, precipitation of yellow – green needle – like solid;The solid was filtered, washed, dried,To give ethyl 5- (4-fluorophenyl) -7-trifluoromethylpyrazolo [1,5-a] pyrimidine-3-carboxylate;The article used for the washing process is cold glacial acetic acid.The mass of the obtained product 5- (4-fluorophenyl) -7-trifluoromethylpyrazolo [1,5-a] pyrimidine-3-carboxylate was 27.05 g.Yield: 76.63percent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 5-amino-1H-pyrazole-4-carboxylate, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 104599-36-2, name is 3,5-Dibromo-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Formula: C3HBr2N3O2

0.369 mol of sodium acetate was introduced into a solution of 0.184 mol of dibromonitropyrazole in 250 ml of N-methylpyrrolidone in a 500 ml three-necked flask, and the reaction medium was brought to 80 C. 0.369 mol of 3-bromopropanol was added dropwise at this temperature. This temperature was maintained for 5 hours. After cooling to room temperature, the medium was poured onto ice with stirring. The 3-(3,5-dibromo-4-nitro-1H-pyrazol-1-yl)propan-1-ol (compound 1) precipitated. It was filtered off by suction, dried, and obtained in a yield of 75%. The mass of the expected compound C6H7Br2N3O3 was detected by mass spectrometry. The NMR analyses (1H 400 MHz and 13C 100.61 MHz DMSO d6) were in accordance with the expected structure.

According to the analysis of related databases, 104599-36-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 37622-90-5,Some common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of LAH (45.2 mL, 45.2 mmol, 1M in THF) in a flame-dried flask was added a solution of ethyl 1H-pyrazole-4-carboxylate (3.17 g, 22.6 mmol) in THF (20 mL) dropwise at 0 C. The reaction mixture was gradually warmed to rt and stirred overnight. The reaction mixture was cooled in an ice bath, and carefully quenched by sequential dropwise addition of 1.36 mL H2O, and 10 mL of 1M NaOH, followed by 20 min of stirring. Solid MgSO4 was added, the ice bath was removed, and stirring was continued for 30 min at rt. Solids were removed by filtration through Celite® and washed with THF, then MeOH. The combined filtrate was evaporated to give (1H- pyrazol-4-yl)methanol (1.75 g, 78.9percent), as a white solid.1H NMR (500MHz, DMSO-d6) delta 12.58 (br. s., 1H), 7.58 (s, 1H), 7.40 (s, 1H), 4.74 (t, J=5.5 Hz, 1H), 4.37 (d, J=5.2 Hz, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-pyrazolecarboxylate, its application will become more common.

Electric Literature of 1621-91-6, These common heterocyclic compound, 1621-91-6, name is 1H-Pyrazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Scheme 33–Route to Preferred Groups 49 [4,3-d] ring fusion Nitration of pyrazole-3-carboxylic acid followed by reduction gives 4-aminopyrazole-3-carboxylic acid.

The synthetic route of 1621-91-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 31037-02-2,Some common heterocyclic compound, 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3.1 : 5-Amino-1 -methyl- 1 H-pyrazole-4-carboxylic acid5-Amino-1-methyl-1 H-pyrazole-4-carboxylic acid ethyl ester (16.4 g, 97 mmol) is heated to reflux in 97 ml of 2 M sodium hydroxide solution and 100 ml of ethanol. After complete saponification, the mixture is acidified to pH 5 with 6 M HCI solution, and the formed precipitate is isolated by filtration. The product is dried at the high vacuum pump and the title compound is isolated as a white solid. HPLC: tR = 4.65 min; MS-ES+: (M+H)+ = 142 ; TLC*: Rf = 0.24.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, its application will become more common.