Category: pyrazoles-derivatives

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67-51-6, name is 3,5-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Product Details of 67-51-6

3,5-Dimethyl-1H-pyrazole, 78.5 g (0.818 mol), was dissolved in 700 mL of water heated to 70C, and 517 g (3.271 mol) of potassium permanganate was added to the hot solution, maintaining the temperature no higher than 90C. The mixture was cooled to room temperature, the precipitate of MnO2 was filtered off and washed with water, and the filtrate was acidified with aqueous HCl to pH 2 and left overnight. The precipitate was filtered off and washed with water. Yield 41.75 g (33%), white crystals, mp 257-258C. 1H NMR spectrum: delta 7.07 ppm, s (1H, 4-H). 5-Methyl-1H-pyrazole-3-carboxylic acid (2). The aqueous filtrate obtained after separation of diacid 1, was neutralized to pH 5-6, and the precipitate of 2 was filtered off and washed with water. Yield 18.1 g (18%), white crystals, mp 210-211C. 1H NMR spectrum, delta, ppm: 2.25 s (3H, CH3), 6.42 s (1H, 4-H).

The synthetic route of 67-51-6 has been constantly updated, and we look forward to future research findings.

Related Products of 42027-81-6, The chemical industry reduces the impact on the environment during synthesis 42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, I believe this compound will play a more active role in future production and life.

[0215j A solution of 2-(4-nitro-1H-pyrazol-1-yl)ethanol (2.00 g, 12.73 mmol), 3,4- dihydro-2H-pyran (1.60 g, 19.10 mmol) and p-toluenesulfonic acid (87 mg, 0.51 mmol) in THF (20 mL) was stirred at room temperature for 2 h. Then the mixture was diluted with EtOAc (150 mL), washed with sat. aqueous sodium carbonate (50 mL) and water 60 mL. The organic phase was dried (Na2SO4), filtered and concentrated to give crude product 4-nitro- 1 -(2-((tetrahydro- 2H-pyran-2-yl)oxy)ethyl)-1H-pyrazole as colorless oil (2.00 g, yield: 67%). ESI-MS (M+H) :242.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 930-36-9, name is 1-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 930-36-9

Adding 5.92 g (20 mmol) of FeBr3 to a solution of 8.2 g (100 mmol) of 1-methylpyrazole dissolved in 100 mL of methyl tert-butyl ether at 0 ;Under stirring, 32 g (200 mmol) of Br2 was added dropwise.Stir at room temperature,The end of the reaction was followed by TLC.After confirming the reaction,Filter the system,The filtrate is poured into the water.Use Na2S2O3 solution in sequence,Water washing,Liquid separation.The obtained organic phase was dried over anhydrous magnesium sulfate.The solvent was evaporated under reduced pressure,Got 14.5g(yield: 90.5%, purity 98%)5-bromo-1-methylpyrazole.

The synthetic route of 1-Methylpyrazole has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89501-90-6, name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H5ClN2O2S

To a 50 mL flask was added 1-methyl-1H-pyrazole-3-sulfonyl chloride (1.12g, 6.22 mmol), ethyl (4aS,6S)-6-[(2,4-dimethoxyphenyl)methylaminoj -1 -(4-fluorophenyl)-5 ,6,7,8-tetrahydro-4H- benzo[flindazole-4a-carboxylate (lila) (1.57g, 3.11 mmol), DCM (8 mL), and triethylamine (1.73 mL, 12.45 mmol) successively. After the reaction was stirred at 40C for 5 h, it was directly concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (Si02, 40%-65% EtOAc/hexanes, gradient elution) to provide ethyl (4aS,6S) -6-[(2,4-dimethoxyphenyl)methyl-( 1- methylpyrazol-3 -yl)sulfonyl-aminoj -1 -(4-fluorophenyl)-5 ,6,7, 8-tetrahydro-4H-benzo [flindazole-4a- carboxylate (ilib) (1.86g, 92% yield) as a yellow solid. m/z(ESI, +ve ion) = 650.3 [M+Hj.

According to the analysis of related databases, 89501-90-6, the application of this compound in the production field has become more and more popular.

34605-66-8, name is 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C10H13N3

At -78 C, to a solution of 3-(2,5-di methyl- 1 /7-pyrrol- 1 -yl)- 1 -methyl- 1 /7-pyrazolc (step 1 intermediate) (2.0 g, 11.4 mmol) was added n-butyl lithium (1.6 M, 10.55 mL, 16.8 mmol) and the mixture was continued to stir at -78 C for 30 min. The mixture was stirred for 2 h at 0 C and added acetone (1.28 mL, 17.5 mmol) to the solution. The mixture was stirred at RT for 3 h. The mixture was quenched with water and extracted with ethyl acetate. The organic phase was washed with brine and dried over anhydrous sodium sulfate. The solution was filtered, concentrated and the residue obtained was purified by column chromatography to yield 1.0 g of the desired compound. NMR (400 MHz, DMSO-de) d 1.54 (s, 6H), 2.04 (s, 6H), 3.98 (s, 3H), 5.42 (s, 1H), 5.73 (s, 2H), 6.10 (s, 1H).

The synthetic route of 34605-66-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 1280210-79-8,Some common heterocyclic compound, 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, molecular formula is C10H15N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A vial was charged with (3R,3aR,6R,6aR)-6-[5-(4-bromophenyl)-6-chloro-1-(2-trimethylsilylethoxymethyl)imidazo[4,5-b]pyridin-2-yl]oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-ol (501.8 mg, 0.861 mmol), tert-butyl 4,6-dihydro-2H-pyrrolo[3,4-c]pyrazole-5-carboxylate (240.3 mg, 1.148 mmol), tripotassium phosphate (581.6 mg, 2.74 mmol), and copper (I) iodide (37.2 mg, 0.195 mmol). The vial was evacuated (3¡Á) and backfilled with nitrogen. Trans-N,N?-dimethylcyclohexane-1,2-diamine (55 mul, 0.348 mmol) and dioxane (1.7 ml) were added to the vial to give a hazy suspension that was heated to 100 C. for 24 h. The reaction mixture was cooled to room temperature and partitioned between EtOAc (100 ml) and water (100 ml). The aqueous layer was extracted with EtOAc (2¡Á50 ml). The organic layers were combined, washed with brine (1¡Á30 ml), dried over MgSO4, filtered, and evaporated under reduced pressure to give a pale green residue. Flash chromatography of the residue utilizing a 40 g silica RediSep Rf column and employing a 0-100% EtOAc/hexane gradient afforded a mixture of the two pyrazole linked regioisomers as a pale amber foam. LC-MS: calculated for C34H43ClN6O7Si 710.27 observed m/e: 711.29 (M+H)+ (Rt 1.30/2 min)

The synthetic route of 1280210-79-8 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16034-46-1 as follows. name: 1-Methyl-1H-pyrazole-5-carboxylic acid

To a solution of 1-methyl-1H-pyrazole-5-carboxylic acid (46.6 mg, 0.37 mmol, 1.3 equiv) in DMF (1 ml) were added HATU (140 mg, 0.37 mmol, 1.3 equiv), DIEA (147 mg, 1.14 mmol, 4.0 equiv), and 7-(5-ethyl-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2H-1-benzopyran-4- amine hydrochloride (80 mg, 0.28 mmol, 1.0 equiv). The mixture was stirred overnight and purified by Prep-HPLC with the following conditions: (2-AnalyseHPLC- SHIMADZU(HPLC-10)): Column, XBridge Prep C18 OBD Column, 5 mum,19*150mm; mobile phase, water (10MMOL/L NH4HCO3) and ACN (34.0% ACN up to 47.0% in 8 min); Detector, UV 220nm. This purification resulted in 170 mg (90%) of N-[6-(5-ethyl-1,2,4- oxadiazol-3-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-methyl-1H-pyrazole-4-carboxamide as a white solid. LRMS (ES) m/z 354 (M+H).

According to the analysis of related databases, 16034-46-1, the application of this compound in the production field has become more and more popular.

Synthetic Route of 706819-66-1, These common heterocyclic compound, 706819-66-1, name is 2-Bromo-1-(1-methyl-1H-pyrazol-4-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 2-bromo-1-phenylethan-1-one (11a, 5.0 g, 25.12 mmol) and 2-chloropyridin-4-ol (3.9 g, 30.11 mmol) in acetone (75 mL) was added K2CO3 (5.2 g, 37.62 mmol). The reaction mixture was stirred overnight at room temperature. After completion, the mixture was poured into water and extracted with ethyl acetate. The organic layers were combined and then dried with anhydrous sodium sulfate. After removal of the solvent, the residue was purified by a silica gel column chromatography to afford title compound 12a (5.5 g, 88%).

The synthetic route of 706819-66-1 has been constantly updated, and we look forward to future research findings.

Reference of 138786-86-4, These common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of methyl 4-nitro-1H-pyrazole-3-carboxylate obtained in Reference Example 18 (2.0 g, 11.7 mmol), methyl iodide (2.0 g, 14.0 mmol), potassium carbonate (1.62 g, 11.7 mmol) and acetone (60 mL) was stirred at 30C for 5 hr. The mixture was diluted with water, and extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate 4:1 – 1:1) to give the title compound, methyl 1-methyl-4-nitro-1-pyrazole-3-carboxylate (Rf value 0.43) (0.95 g, yield 44%) and the title compound, methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate (Rf value 0.71) (0.61 g, yield 28%). Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate 1H-NMR (CDCl3):delta 3.99(3H, s), 4.01(3H, s), 8.13(1H, s). Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate 1H-NMR (CDCl3):delta 4.02(3H, s), 4.03(3H, s), 8.01 (1H, s).

Statistics shows that Methyl 4-nitro-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 138786-86-4.

Related Products of 3398-16-1, These common heterocyclic compound, 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 924-Bromo-3,5-dimeth l-1 -(methylthiomethyl)-l H-pyrazoleTo a solution of 4-bromo-3,5-dimethyl-1 H-pyrazole (2.1 Og, 14.3mmol) in acetone (20 ml_) was added K2CO3 (2.37g, 17.1 mmol) followed by chloromethyl methyl sulfide (1.3 ml_, 5.7mmol). The light yellow suspension was stirred at room temperature for 96 hr. At this time the reaction was thick with white precipitate. The reaction mixture was stripped off volatiles, diluted with methylene chloride and filtered. The filtrate was concentrated under reduced pressure to give the title compound as a light yellow oil which was used without further purification.

Statistics shows that 4-Bromo-3,5-dimethylpyrazole is playing an increasingly important role. we look forward to future research findings about 3398-16-1.