Synthetic Route of 706819-66-1, These common heterocyclic compound, 706819-66-1, name is 2-Bromo-1-(1-methyl-1H-pyrazol-4-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 2-bromo-1-phenylethan-1-one (11a, 5.0 g, 25.12 mmol) and 2-chloropyridin-4-ol (3.9 g, 30.11 mmol) in acetone (75 mL) was added K2CO3 (5.2 g, 37.62 mmol). The reaction mixture was stirred overnight at room temperature. After completion, the mixture was poured into water and extracted with ethyl acetate. The organic layers were combined and then dried with anhydrous sodium sulfate. After removal of the solvent, the residue was purified by a silica gel column chromatography to afford title compound 12a (5.5 g, 88%).
The synthetic route of 706819-66-1 has been constantly updated, and we look forward to future research findings.