Tag: M.W=200-250

Forsyth, Craig M. published the artcileN,N-Dialkyl-N’-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part IX. Novel Triazolo-Fused Thiatriazoles and Pyrazolo-Fused Oxathiazines, Safety of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Australian Journal of Chemistry (2010), 63(5), 785-791, database is CAplus.

[1,2,4]Triazolo[1,2-b][1,2,3,5]thiatriazole derivatives were obtained by a reaction of N,N-dialkyl-N’-chlorosulfonyl chloroformamidine derivatives with 4-substituted urazoles in a selective 1,2-NN-dinucleophilic mode of action. A reaction of the above-mentioned N,N-dialkyl-N’-chlorosulfonyl chloroformamidine derivatives with N¹-substituted 5-pyrazolones afforded pyrazolo[4,3-e][1,4,3]oxathiazine derivatives by a selective 1,3-CCO dinucleophilic substitution. [1,2,4]Triazolo[1,2-b][1,2,3,5]thiatriazole derivatives and pyrazolo[4,3-e][1,4,3]oxathiazine derivatives were the only products isolated from the resp. reactions and both represent new ring systems.

Australian Journal of Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Safety of 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Audubert, Clement published the artcileBatch and Continuous-Flow One-Pot Processes using Amine Diazotization to Produce Silylated Diazo Reagents, Category: pyrazoles-derivatives, the publication is Angewandte Chemie, International Edition (2017), 56(22), 6294-6297, database is CAplus and MEDLINE.

A novel synthesis of trimethylsilyldiazomethane (TMSCHN₂) by diazotization of trimethylsilylmethylamine (TMSCH₂NH₂) is reported using batch and continuous flow syntheses. The latter affords a daily production of 275 g (2.4 mol) of TMSCHN₂. Other silylated methylamines were also successfully reacted under the developed reaction conditions to furnish various silicon-bearing diazomethane reagents. The applicability of the process is highlighted by disclosure of batch and continuous flow one-pot esterification and 1,3-dipolar cycloaddition processes. Furthermore, the high-yielding esterification of carboxylic acids with silylated and substituted methylamines in continuous flow is disclosed. Finally, work-up and purification procedures are reported for the preparation of a 2-MeTHF solution of TMSCHN₂, which can be used in rhodium-catalyzed methylenation and homologation reactions.

Angewandte Chemie, International Edition published new progress about 1297537-37-1. 1297537-37-1 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Chloride,Nitrile,Benzene, name is 2-Chloro-4-(1H-pyrazol-5-yl)benzonitrile, and the molecular formula is C10H6ClN3, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Du, Hai-Tang published the artcileSynthesis of 5-chloro-3-methyl-1-phenyl-N-[4-(trifluoromethyl)phenyl]thioxomethyl]-1H-pyrazole-4-carboxamide and 5-chloro-3-methyl-1-phenyl-N-[2,6-dichloro-4-(trifluoromethyl)phenyl]thioxomethyl]-1H-pyrazole-4-carboxamide derivatives and determination of their activity as agrochemical fungicides, Synthetic Route of 14580-22-4, the publication is Youji Huaxue (2008), 28(2), 356-360, database is CAplus.

A series of the title compounds was prepared in order to search for pesticides with high biol. activity and low toxicity. Their structures were characterized by IR, ¹H NMR spectra and elemental anal. A preliminary bioassay indicated that some compounds had fungicidal activity.

Youji Huaxue published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Synthetic Route of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Trivedi, A. R. published the artcileA facile synthesis of pyrazolo[3,4-d]pyrimidines, Product Details of C10H9ClN2O, the publication is Indian Journal of Heterocyclic Chemistry (2008), 17(4), 385-386, database is CAplus.

A new series of the pyrazolo[3,4-d]pyrimidines were prepared by one-pot reaction of 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde, 1-(aryl)-3-methyl-1H-pyrazol-5-(4H)-ones and thiourea. Compounds were evaluated for their antimicrobial activity. Some of the compounds showed interesting antimicrobial activity as compared to the standard drugs.

Indian Journal of Heterocyclic Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C8H5F3N4, Product Details of C10H9ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Hack, Daniel published the artcileAsymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis, Application In Synthesis of 14580-22-4, the publication is Angewandte Chemie, International Edition (2016), 55(5), 1797-1800, database is CAplus and MEDLINE.

A stereoselective one-pot synthesis of spiropyrazolones, e.g., I, through an organocatalytic asym. Michael addition and a formal Conia-ene reaction has been developed. Depending on the nitroalkene, the 5-exo-dig-cyclization could be achieved by silver-catalyzed alkyne activation or by oxidation of the intermediate enolate. The mechanistic pathways have been investigated using computational chem. and mechanistic experiments

Angewandte Chemie, International Edition published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Application In Synthesis of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Keyume, Ablajan published the artcileConvenient DABCO-catalyzed one-pot synthesis of multi-substituted pyrano[2,3-c]pyrazole dicarboxylates, Name: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, the publication is Tetrahedron (2014), 70(26), 3976-3980, database is CAplus.

An efficient and simple one-pot synthesis was developed for preparation of functionalized multi-substituted 2,4-dihydro-pyrano[2,3-c]pyrazole dicarboxylates from β-keto esters, hydrazine, di-Me acetylenedicarboxylate and malononitrile in EtOH. This four-component one-pot reaction carried out in the presence of DABCO catalyst showed advantages over a one-pot three-component method in its simple procedure, high yield and low toxicity. The structures of the compounds were established on the basis of the spectroscopic data and confirmed by single crystal x-ray diffraction anal. of Me 6-amino-5-cyano-4-methoxycarbonylmethyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole dicarboxylate.

Tetrahedron published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Name: 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Duffy, Kevin J. published the artcileHydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis, Quality Control of 14580-22-4, the publication is Journal of Medicinal Chemistry (2001), 44(22), 3730-3745, database is CAplus and MEDLINE.

High-throughput screening for the induction of a luciferase reporter gene in a thrombopoietin (TPO)-responsive cell line resulted in the identification of 4-diazo-3-hydroxy-1-naphthalenesulfonic acids as TPO mimics. Modification of the core structure and adjustment of unwanted functionality resulted in the development of (5-oxo-1,5-dihydropyrazol-4-ylidene)hydrazines which exhibited efficacies equivalent to those of TPO in several cell-based assays designed to measure thrombopoietic activity. Furthermore, these compounds elicited biochem. responses in TPO-receptor-expressing cells similar to those in TPO itself, including kinase activation and protein phosphorylation. Potencies for the best compounds were high for such low mol. weight compounds (MW < 500) with EC₅₀ values in the region of 1-20 nM.

Journal of Medicinal Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Quality Control of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Kaiser, Thomas M. published the artcileProspective evaluation and success of a machine learning hit-to-lead drug development program against phosphatidylinositol 3-kinase α, SDS of cas: 1416437-27-8, the publication is ARKIVOC (Gainesville, FL, United States) (2021), 25-43, database is CAplus.

A cheminformatics protocol which dramatically increases quality candidate identification and should reduce attrition rate of compounds entering clinic, increasing cost-effectiveness of drug development is described. All N-(5-(3-aryl)(imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamides I [Ar = pyrimidin-2-yl, pyrazolo[1,5-a]pyrimidin-6-yl, 2-(dimethylamino)pyrimidin-5-yl, 5-ethyl-1,2,4-oxadiazol-3-yl, 2-methoxypyrimidin-5-yl] synthesized from protocol were found to have low nanomolar activity against oncol. target phosphatidylinositol 3-kinase α. Therefore it was proposed that this protocol could be used as a tool for reducing synthetic burden required for hit-to-lead optimization.

ARKIVOC (Gainesville, FL, United States) published new progress about 1416437-27-8. 1416437-27-8 belongs to pyrazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronate Esters,Boronic acid and ester, name is 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrimidine, and the molecular formula is C12H16BN3O2, SDS of cas: 1416437-27-8.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Mehta, K. H. published the artcileSynthesis of new heterocyclic pyrazoline and isoxazoline compounds and their antibacterial activity, SDS of cas: 14580-22-4, the publication is Chemistry: An Indian Journal (2003), 1(1), 38-41, database is CAplus.

1-(2-Chlorophenyl)-3-methyl-5-pyrazolone was condensed with different aromatic aldehydes RC₆H₄CHO (R = 2-MeO, 3-NO₂, 3-OH-4-MeO, etc.) to yield arylidine derivatives I in 61-72% yield. I were further reacted with phenylhydrazine or hydroxylamine hydrochloride to yield 3-methyl-1,4,5-triphenylpyrazolo[3,4-c]pyrazole II (X = N-Ph) (63-70%) and 4-methyl-3,6-diphenylpyrazolo[3,4-c]isoxazole II (X = O) (62-72%) derivatives, resp. The prepared compounds showed antibacterial activity against S. aureus E. coli.

Chemistry: An Indian Journal published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, SDS of cas: 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Bhavsar, R. A. published the artcileSynthesis of some trisazo pyrazolone acid dyes and their application on wool and nylon, Computed Properties of 14580-22-4, the publication is Asian Journal of Chemistry (1998), 10(4), 1061-1062, database is CAplus.

Monoazo pyrazolone dyes are very common but trisazo pyrazolone dyes with an arylazo group in position-4 and a second arylazo group at position-4 of the Ph nucleus and a third arylazo group at position-7 of the naphthyl nucleus of H- or γ-acid are not available. In the preparation of the title dyes, an aryldiazonium chloride is coupled in alk. medium with 1-phenyl-3-methyl-5-pyrazolone or 1-(2-chlorophenyl)-3-methyl-5-pyrazolone and the second arylazo group in position-4 of the 1-Ph group is introduced in acidic medium and the third arylazo group in position-7 of the 4-naphthyl group of H- or γ-acid is applied in alk. medium. Light fastness on wool was 4-5 to 5-6 and 3-4 to 5-6 on polyamide. Wash fastness was 3-4 to 4-5 on wool and 2-3 to 3-4 on polyamide.

Asian Journal of Chemistry published new progress about 14580-22-4. 14580-22-4 belongs to pyrazoles-derivatives, auxiliary class Organic Pigment, name is 1-(2-Chlorophenyl)-3-methyl-5-pyrazolone, and the molecular formula is C10H9ClN2O, Computed Properties of 14580-22-4.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics