Tag: M.W:200-300

Some common heterocyclic compound, 1150271-23-0, name is tert-Butyl 4-bromo-1H-pyrazole-1-carboxylate, molecular formula is C8H11BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1150271-23-0

Add 1-Boc-4-bromopyrazole (24.7 g, 0.1 mol), bis(pinacolato)diboron (25.4 g, 0.1 mol) and catalyst [1,1′-bis (diphenylphosphino) ferrocene ] Palladium dichloride (0.74 g, 0.001 mol), potassium acetate (19.6 g, 0.2 mol), 200 ml of ethanol were added to the reaction bottle, and after removing the oxygen under reduced pressure, the nitrogen was heated to reflux, and the reaction was held for 16 hours. After monitoring the reaction of the raw materials, the filtrate was filtered. The filtrate was distilled off ethanol under reduced pressure. The residue was extracted with petroleum ether and purified to obtain 24.2 g of 1-Boc-4-pyrazoleboronic acid pinacol ester with a yield of 82.3%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1150271-23-0, its application will become more common.

Some common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Iodo-1-methyl-1H-pyrazole

General procedure: 4-Iodo-1-methyl-1H-pyrazole 1 (101 mg, 0.5 mmol) and phenylboronic 2 (59 mg, 0.5 mmol) were dissolved in DME (3 mL) and H2O (1.2 mL) in a microwave vial under a nitrogen atmosphere. Pd(PPh3)4 (2 mmol%, 11.6 mg) and Cs2CO3 (407.3 mg, 1.25 mmol) were added, and the reaction mixture was irradiated in a microwave apparatus at 90 C for 5-12 min. After the reaction mixture was cooled to ambient temperature, the product was concentrated, and the crude mixture was purified by silica gel column chromatography using petroleum ether/acetone as eluent to give the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 39806-90-1, its application will become more common.

Related Products of 51516-70-2,Some common heterocyclic compound, 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7FN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The experimental procedure was similar to synthesis of analogs1(aei). 5-amino-1-aryl-1H-pyrazole-4-carbonitriles 4(aei)(0.001 mol) were reacted with 2.0 mL of 1,3-diaminopropane andcarbon disulfide (0.004 mol). The temperaturewas 85-95oC and thereaction time was 14-16 hours. The reaction mixture was pouredinto cold water, the precipitate was filtered out and washed withcold water. The reactions were accompanied by means of TLC anddichloromethane as eluent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Safety of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile

Under nitrogen protection,5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (1.0 g, 3.6 mmol),Ethyl 2-(1-benzylpiperidin-4-ylidene)acetate (1.1 g, 4.3 mmol)A mixture of K2CO3 (745 mg, 5.4 mmol) in DMF (20 mL) was heated to 80[deg.] C. and stirred for 16 hours.Then, the reaction was quenched with water (20 mL), extracted with EA (20 mL¡Á3), the organic phases were combined, dried over Na 2 SO 4 , concentrated, and purified on a tannin extract column, eluting with 30percent EA in PE.A yellow solid product was obtained (950 mg, 54.9percent).

The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.

Electric Literature of 155377-19-8, The chemical industry reduces the impact on the environment during synthesis 155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

Ethyl 3-(trifluoromethyl)-1H-pyrazole-4-carboxylate (1.50 g, 7.21 mmol) was dissolved in dry THF (50 mL) and the resulting solution cooled to -78 oC. To the resulting solution was added, 2 M solution of LAH (6.01 mL, 14.41 mmol) in THF over 30 min by keeping the temperature <10 C. The reaction mixture was allowed to come to ambient temperature, stirred for 4 h and was cooled again with to -10 oC. The reaction was quenched with the addition of 1:1 THF:water (50 mL) mixture with cooling (maintaining the temperature <20 C), followed by 5M HCl to neutralise to pH 6. The reaction mixture was diluted with EtOAc (100 mL), stirred for 30 min and left to settle for 1 h. The resulting solid was removed by filtration through Celite and washed with EtOAc. The filtered organic layer was washed with brine, dried over MgSO4 and evaporated under reduced pressure. The crude product was triturated with ether (2 x 25 mL) to obtain Intermediate 89A (0.60 g, 50.10%).1H NMR (400 MHz, DMSO-d6) delta ppm 4.44 (s, 2 H), 5.02 (s, 1 H), 7.83 (s, 1 H), 13.73 (br. s., 1 H). LCMS (Method-H): retention time 0.54 min, [M- H] 165.0. In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Application of 84547-86-4, A common heterocyclic compound, 84547-86-4, name is 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H5BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step D: Preparation of (4-Bromo-l-methyl-lH-pyrazoI-3-yl)-{4-[2-(2,4-difluoro- phenyl)-ethyl]-piperazin-l-yl}-methanone (Compound 84).In a heavy-walled sealed tube, 4-bromo-l -methyl- lH-pyrazole-3-carboxylic acid (0.0194 g, 0.0583 mmol), l-(2,4-difluorophenethyl)piperazine (0.0145 g, 0.0641 mmol), 0-(7- azabenzotriazol-l-yO-N^/V^/V^/V-tetramethyluronium hexafluorophosphate (0.0244 g, 0.0641 mmol), and triethylamine (0.0162 mL, 0.117 mmol) were combined in TEtaF (0.5 mL). The reaction mixture was heated at 100 0C for 10 min under microwave irradiation. The reaction mixture was concentrated and then purified by RP-EtaPLC. The best fractions were lyophilized to afford the TFA salt of the title compound (0.015 g) as a yellow solid. 1H NuMR (DMS0-<4 400 MHz) delta 2.90-3.80 (m, 10H), 3.87 (s, 3H), 4.18-4.40 (bs, IH), 4.45-4.69 (bs, IH), 7.07-7.16 (m, IH), 7.23-7.33 (m, IH), 7.39-7.47 (m, IH), 8.09 (s, IH). Exact mass calculated for C17H19BrF2N4O: 412.1; Found: LCMS m/z (%) = 413.1 (M+HT 79Br, 100%), 415.1 (M+H+ 81Br, 98%). The synthetic route of 84547-86-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 59340-27-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59340-27-1, Application In Synthesis of 1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride

Example 1 4-(3,4-Dichlorophenoxy)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine 4-(3,4-Dichlorophenoxy)piperidine hydrochloride (143 mg, 0.508 mmol) (prepared as described for 4-(4-chloro-3-fluorophenoxy)piperidine hydrochloride (Intermediate 10) using 3,4-dichlorophenol) and triethylamine (142 muL, 1.16 mmol) in dichloromethane (10 mL) was treated with 1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride (106 mg, 0.508 mmol). The reaction was stirred for 2 hours at room temperature. The crude reaction was washed with 1N hydrochloric acid, filtered through a phase separation cartridge and concentrated in vacuo. The crude product was purified by silica column chromatography eluting with petrol/ethyl acetate to give the title compound. (160 mg, 76%) 1H NMR (400 MHz, DMSO-d6) delta ppm 1.62-1.75 (m, 2H) 2.00-2.15 (m, 2H) 2.30 (s, 3H) 2.45 (s, 3H) 2.78-2.86 (m, 2H) 3.34-3.42 (m, 2H) 3.75 (s, 3H) 4.45-4.54 (m, 1H) 6.95-6.98 (m, 1H) 7.28 (s, 1H) 7.24 (m, 1H) MS ES+: 419.

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Reference of 398495-65-3, The chemical industry reduces the impact on the environment during synthesis 398495-65-3, name is 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate, I believe this compound will play a more active role in future production and life.

To a mixture of 3-amino-4,6-dihydro-pyrrolo[3,4-c]pyrazole-l,5-dicarboxylic acid 5- tert-butyl ester 1-ethyl ester (244 mg, 0.75 mmol), dry tetrahydrofuran (30 mL) and N,N-diisopropylethylamine (0.75 mL, 4.4 mmol) was added 3-[(tetrahydro-pyran-4-yl)- (2,2,2-trifluoro-acetyl)-amino]-isonicotinoyl chloride (1.1 mmol). The mixture was stirred at 45C for Ih, then evaporated to dryness, diluted with dichloromethane (100 mL), washed with saturated sodium hydrogenocarbonate (100 mL), dried over sodium sulfate and avaporated to dryness affording the crude title compound that was used as such for the next step

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-tert-Butyl 1-ethyl 3-aminopyrrolo[3,4-c]pyrazole-1,5(4H,6H)-dicarboxylate, other downstream synthetic routes, hurry up and to see.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C4H5IN2

A suspension of tert-butyl (3S)-3-methyl-5-oxo-piperazine-1 -carboxylate (see Example 73, step b) (280 mg, 1.31 mmol) and 3-iodo-1-methyl-1 H-pyrazole (326 mg, 1.57 mmol) in dioxane (10 ml) was prepared and argon was bubbled for 10 minutes. K3P04 (610 mg, 2.87 mmo), copper (I) iodide (25 mg, 131 pmol) and N,N’-dimethylethylenediamine (28.1 muIota, 261 pmol) were added. The mixture was heated to 120 C for 20 h. The mixture was filtered, the soiids washed twice with ethyl acetate and the filtrate was evaporated. The residue was purified by flash chromatography (EtOAc in heptane 20% to 100%) to afford the title compound (287 mg, 75%) as a light yellow solid. (1042) MS (ESI, m/z): 295.2 [(M+H)+].

The synthetic route of 92525-10-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 100784-27-8, name is Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 3-chloro-1-methyl-5-sulfamoyl-1H-pyrazole-4-carboxylate

To a mixture of 3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide (7.0 g), 5.3 g anhydrous potassium carbonate and 50 ml of dry acetone, 2.8 g of n-butyl isocyanate was added at room temperature. The mixture was refluxed for 3 hours. (0092) After refluxing, acetone was evaporated under reduced pressure and the residue was dissolved in ice-water. After separation of a trace of water insolubles, the filtrate was acidified with hydrochloric acid and the crystals formed were filtered, washed with water and dried to obtain 5.2 g N-(n-butylcarbamoyl)-3-chloro-4-methoxycarbonyl-1-methylpyrazole-5-sulfonamide.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.