Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Safety of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile
Under nitrogen protection,5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (1.0 g, 3.6 mmol),Ethyl 2-(1-benzylpiperidin-4-ylidene)acetate (1.1 g, 4.3 mmol)A mixture of K2CO3 (745 mg, 5.4 mmol) in DMF (20 mL) was heated to 80[deg.] C. and stirred for 16 hours.Then, the reaction was quenched with water (20 mL), extracted with EA (20 mL¡Á3), the organic phases were combined, dried over Na 2 SO 4 , concentrated, and purified on a tannin extract column, eluting with 30percent EA in PE.A yellow solid product was obtained (950 mg, 54.9percent).
The synthetic route of 330792-70-6 has been constantly updated, and we look forward to future research findings.