Tag: M.W:200-300

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20055-01-0 as follows. COA of Formula: C4H10N4O4S

To a solution of (2S)-2- [ (BENZYLOXYCARBONYL) AMINO]-6- [ (TERT- butoxycarbonyl) amino] hexanoic acid (19.02 g) and triethylamine (5.56 g) in tetrahydrofuran (200 ml) was added methyl chloroformate (4.21 ml), followed by stirring under ice-cooling for 30 minutes. To the reaction mixture was added a solution of 1-METHYL-LH- pyrazole-4,5-diamine sulfate (15.75 g) and triethylamine (15.2 g) in water (50 ml) at the same temperature. The mixture was stirred at room temperature for 30 minutes. To the reaction mixture was added chloroform (300 ml), and the layers were separated. The organic layer was washed successively with 10% aqueous citric acid solution, brine and saturated aqueous sodium hydrogencarbonate solution. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give a crude product of 1- benzyl 5-tert-butyl (lS)- {l- [ (5-amino-l-methyl-lH- pyrazol-4-yl) CARBAMOYL] PENTAMETHYLENE} biscarbamate as an oil. The crude product was used directly in the next step without further purification. To a solution of the crude product of 1-benzyl 5- tert-butyl (LS)-{1-[(5-AMINO-1-METHYL-LH-PYRAZOL-4- yl) CARBAMOYL] PENTAMETHYLENE} BISCARBAMATE IN. methanol (350 ml) was treated with 10% palladium on carbon (2.0 g) under a hydrogen atmosphere at room temperature for 6 days. After the catalyst was filtered off, the filtrate was concentrated in vacuo. The residue was triturated with ethyl acetate and dried in vacuo to give tert-butyl (5S)-5-amino-6- [ (5-amino-l-methyl-lH-pyrazol-4- yl) amino] -6-oxohexylcarbamate (12.1 g) as a solid. H-NMR (DMSO-D6) 6 1. 24-1. 40 (4H, m), 1. 36 (9H, s), 1. 70- 1.77 (2H, m), 2.88-2. 91 (2H, m), 3.51 (3H, s), 3.80-3. 82 (1H, m), 5.15 (2H, s), 6.77 (1H, br), 7.27 (1H, s), 10.05 (1H, br)

According to the analysis of related databases, 20055-01-0, the application of this compound in the production field has become more and more popular.

Application of 39806-90-1,Some common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-iodo-l-methyl-lH-pyrazole (23.31 mg, 0.112 mmol) in anhydrous DMSO (5 ml) was added intermediate 19.6-1 (20 mg, 0.075 mmol), (Irans)-N 1.N2-dimethylcycloheane- 1, 2-diamine (2.125 mg, 0.015 mmol), potassium phosphate (47.6 mg, 0.224 mmol) and Cul (1.423 mg, 7.47 pmol). The resulting mixture was stirred at 90C under N2 protection for 12 hours. After filtration and concentration, the crude product was purified by pre-HPLC (TFA) to give example 19.7-1, (R,R or S,S)-5-chloro-6-(3-fluoro-l-methylpiperidin-4-yl)-l-(l-methyl-lH-pyrazol-4-yl)- lH-indazole, TFA salt. MS (ESI) m/z calc?d for C17H20CIFN5 [M+H]+ 348, found 348. NMR (400 MHz, CD3OD) d 8.12-8.25 (m, 2H), 7.96 (s, 1H), 7.88 (br s, 1H), 7.67 (s, 1H), 7.63-7.67 (m, 1H), 5.22-5.48 (m, 1H), 5.22-5.48 (m, 1H), 4.00 (s, 3H), 3.92 (br s, 1H), 3.82 (m, 1H), 3.60 (br s, 1H), 3.16-3.30 (m, 2H), 3.03 (s, 3H), 2.27 (br s, 1H), 2.02-2.20 (m, 1H). LRRK2 IC50 3.9 nM.

The synthetic route of 39806-90-1 has been constantly updated, and we look forward to future research findings.

Related Products of 16078-71-0, The chemical industry reduces the impact on the environment during synthesis 16078-71-0, name is Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

In the with the condensation tube, thermometer of 250 ml three-neck bottle in, adding […] ethyl acetate (62.1 mmol), phenyl hydrazine (93.2 mmol), ethanol (50 ml), heated to 80 C, reaction 24 h, TLC detection after the reaction, to the room temperature, the solvent is distilled under reduced pressure, the remaining solid without purification directly dissolved in absolute ethanol (200 ml), 80% hydrazine hydrate solution (100 mmol) is slowly added in the reaction solution, heating to reflux 2 hours, TLC detection reaction is over, the system to the room temperature, filtered, washing the solid with ethanol, dry and obtain the product, a white solid, yield 70.5%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34091-51-5, name is 5-Iodo-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

1) 1-Methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole A mixture of 5-iodo-1-methyl-1H-pyrazole (8.00 g), 1-ethynyl-4-(trifluoromethyl)benzene (6.54 g), copper(I) iodide (110 mg), bis(triphenylphosphine)palladium(II) dichloride (1.35 g), triphenylphosphine (504 mg), triethylamine (8.00 mL) and dimethylformamide (70 mL) was stirred at 75 C. for 2 hours. Thereafter, the reaction solution was added to water, and the obtained mixture was then extracted with ethyl acetate. The organic layer was successively washed with water and a saturated saline, and was then dried over anhydrous magnesium sulfate, followed by vacuum concentration. The residue was purified by column chromatography (silica gel cartridge, hexane:ethyl acetate=85:15 to 75:25), so as to obtain the title compound (7.74 g) in the form of a yellow solid. 1H NMR (200 MHz, CHLOROFORM-d) delta ppm 4.01 (s, 3H) 6.53 (d, J=2.20 Hz, 1H) 7.49 (d, J=2.20 Hz, 1H) 7.64 (s, 4H); MS (ESI pos.) m/z 251 [M+H]+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 34091-51-5.

Electric Literature of 83-10-3,Some common heterocyclic compound, 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, molecular formula is C12H12N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 3) N-(4-((2-aminopyridin-4-yl)oxy)phenyl)-L5-dimethyl-3-oxo-2-phenyl-2,3- dihydro-lH-pyrazole-4-carboxamide [0210] To a mixture of 4-(4-aminophenoxy)pyridin-2-amine (101 mg, 0.5 mmol) and l,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-lH-pyrazole-4-carboxylic acid (118 mg, 0.51 mmol) in DCM (5 mL) was added EDCI (115 mg, 0.6 mmol) and EtaOmicronAlphaTau (13.6 mg, 0.1 mmol). The reaction was stirred at 45 C for 3 hours, and then quenched with water (20 mL). The organic phase was separated and concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/CH3OH (v/v) = 20 /l) to give the title compound as a light grey solid (110 mg, 49.2%). MS (ESI, pos. ion) m/z: 416.4 [M+H]+; FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, DMSO-i): delta (ppm) 2.71 (s, 3H), 3.36 (s, 3H), 5.80-5.81 (d, J= 2.16 Hz, 1H), 5.92 (s, 2H), 6.12-6.14 (dd, J= 2.24 Hz, 5.8 Hz, 1H), 7.08-7.10 (m, 2H), 7.42- 7.45 (m, 2H), 7.51-7.53 (m, 1H), 7.57-7.61 (m, 2H), 7.65-7.67 (m, 2H), 7.77-7.79 (d, J = 5.8 Hz, 1H).

The synthetic route of 83-10-3 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1227611-94-0 as follows. Product Details of 1227611-94-0

Intermediate 28: 4-Iodo-1 -(1 -oxa-spiro[2.5]oct-6-yI)-1 H -pyrazole 2-Methyl-propan-2-ol potassium (466 mg; 4.15 mmol; 1.2 eq.) was added in one portion to a solution of 4-(4-Iodo-pyrazol-1-yI)-cyclohexanone (1.02 g; 3.50 mmol; 1.0 eq.) and trimethylsulfoxonium chloride (531 mg; 4.13 mmol; 1.2 eq.) in DMSO (50 mL). The reaction mixture was stirred at RT for 16 h. It was then poured into EtOAc . Organicphase was separated and washed with brine (three times), dried over magnesium sulfate, filtered and concentrated to give the title compound a white solid (813 mg, 76%).1H NMR (300 MHz, DMSO) oe8.01 (d, J = 0.5 Hz, 1H), 7.52 (d, J = 0.5 Hz, 1H), 4.41 -4.26(m, 1H), 2.66 (s, 2H), 2.13- 1.85 (m, 6H), 1.34- 1.21 (m, 2H). MS(ESI+): 305.1.

According to the analysis of related databases, 1227611-94-0, the application of this compound in the production field has become more and more popular.

Synthetic Route of 179692-08-1,Some common heterocyclic compound, 179692-08-1, name is Ethyl 4-iodo-1H-pyrazole-5-carboxylate, molecular formula is C6H7IN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a small vial was added the nitrogen-containing nucleophile (1 eq.), arylboronic acid (1.5 eq.), copper(II) acetate monohydrate (0.3 eq.) in N,N-dimethylformamide (2 mL/mmol) and pyridine (3.0 eq.). The reaction was stirred under an oxygen atmosphere at 90 C for 6 hours. The reaction was then cooled to room temperature and diluted with a saturated aqueous sodium bicarbonate solution, and the aqueous phase was extracted with 3 times with dichloromethane. The organic phases were combined, washed with brine, dried with sodium sulfate and concentrated under vacuum. The crude material was purified by flash chromatography.Similar to the procedure as described in General Procedure C, ethyl 4-iodo-lH- pyrazole-3-carboxylate was reacted with 3-bromophenylboronic acid to give the title compound (1.6g, 83%) as a white solid. LC-MS (ES, m/z): 421 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-iodo-1H-pyrazole-5-carboxylate, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 51516-70-2, name is 5-Amino-1-(4-fluorophenyl)-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 51516-70-2

General procedure: (General method). Amixture of the appropriate aminonitrile 1 (3.0 mmol) and1,3-dicarbonyl compound (3.0 mmol) in anhydrous toluene(12 ml) was refluxed for 1 h in a flask equipped with aDean-Stark trap. Tin(IV) chloride (3.0 g, 11.5 mmol) wasadded to the reaction mixture, and refluxing was continuedfor additional 5-6 h. A resinous precipitate was formed,andthe colorless toluene layer was decanted. The residualsolvent was removed on a rotary evaporator, the obtainedglassy solids were dissolved in boiling dioxane, cooled, thenpoured into a solution of Na23 (4.0 g) in water (70 ml).The precipitate that formed was filtered off, washed withwater, dried, and recrystallized from a 5:1 mixture of2-PrOH-DMF.

The synthetic route of 51516-70-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18048-64-1, HPLC of Formula: C12H14N2O

Take 11.5g82.4%) of 3′-amino-2′-hydroxybiphenyl-3-formic acid(VI) obtained in step ( 2), (6.8 g, 82.4%) 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazol-3-one (VII) was added, condensation and cyclization reactions took place, and then Ethanolamine was added under the action of hydrogen to produce the synthesis reaction of Eltrombopag (IX); The 3′-amino-2′ hydroxybiphenyl-3-formic acid and 2-(3,4-dimethylphenyl)-1,2-dihydro-5-methyl-3H-pyrazole- 3-one(VII) in step (3), reacted in a mixed solution of sodium nitrate and sodium bicarbonate.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1222174-92-6, name is Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1222174-92-6, Recommanded Product: Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate

A solution of intermediate 2a (515 mg), 2,5-dimethoxyphenylboronic acid (642 mg) and Pd(dppf)Cl2.CH2Cl2 (105 mg) in a mixture of THF (15 mL) and sodium carbonate solution (2 M, 3 mL) was heated in a microwave (Biotage) to 100 C. for 1.5 h. The mixture was chilled, the layers separated and the aqueous layer was extracted with EtOAc. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified by chromatography (Interchim cartridge 50SiHP/25 g, Cy/EtOAc) to yield the desired compound (77% yield). [0349] LC-MS (Method 2): m/z [M+H]+=277.1 (MW calc.=276.29); Rt=0.62 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.