M.W:200-300 | Page 83 of 103 | pyrazoles-derivatives

Simple exploration of 73387-46-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Bromophenyl)-1H-pyrazole, and friends who are interested can also refer to it.

Reference of 73387-46-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73387-46-9 name is 3-(4-Bromophenyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0001228] A mixture of 3-(4-bromophenyl)-lH-pyrazole (1.0 g, 4.5 mmol), cyclopropylboronic acid (0.8 g, 9 mmol), Cu(OAc)2 (1.6 g, 9 mmol), Na2C03 (0.9 g, 9 mmol), bipyridine (1.4 g, 9 mmol), and 4 A molecular sieve powder (5 g) in 1,2- dichloroethane (20 mL) was stirred at 30 C for 72 h. After filtration, the mixture was diluted with dichloromethane (50 mL), washed with water (30 mL x 2) and brine (50 mL), dried over anhydrous sodium sulfate, and concentrated to give a crude compound. The crude product was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 0% to 10% v/v) to afford Compound 349A.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Bromophenyl)-1H-pyrazole, and friends who are interested can also refer to it.

Application of 285984-25-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, its application will become more common.

Synthetic Route of 285984-25-0,Some common heterocyclic compound, 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, molecular formula is C14H19N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of compounds 10a-d or compounds 17a-d (1.0 mmol) in dichloromethane (10 mL) was slowly added to a stirred solution of triphosgene (109 mg, 0.36 mmol) in dichloromethane (50 mL) over a period of 30 min using a syringe. After stirring for a further 30 min, a solution of compound 25a-r (0.6 mmol) and triethylamine (0.4 mL, 2.77 mmol) in dichloromethane (10 mL) was added in one portion. The reaction mixture was stirred for 2 h at room temperature. After completion of the reaction, the reaction was poured into water (50 mL) and extracted three times with dichloromethane. The organic layer was washed with water (5 mL), sat. NaCl solution (5 mL), anddried over Na2SO4. After evaporation of solvent under vacuum, the residue was purified by silica gel chromatography to give the desired chromanylurea or 2H-chromenyl urea compounds.

Introduction of a new synthetic route about 1216152-26-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 1216152-26-9, name is 4-Bromo-1-(cyclopropylmethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1216152-26-9, SDS of cas: 1216152-26-9

To a degassed (N2 bubbling) solution of the compound of Intermediate Example 9(a) (0.15 g, 0.75 mmol) in 1,4-dioxane (10 ml) were added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (0.23 g, 0.9 mmol, 1.2 eq.), Pd(dppf)Cl2 (0.12 g, 0.15 mmol, 0.2 eq.) and potassium acetate (0.25 g, 2.55 mmol, 3.4 eq.). using the procedure of Intermediate Example 1(b). The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica gel, 30% ethyl acetate in hexane) to give the product in 81% yield (0.15 g). LC-MS (ESI): Calculated mass: 248.13; Observed mass: 249.2 [(M+H]+ (rt: 1.58 min).

Application of 3528-45-8

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.

Related Products of 3528-45-8, A common heterocyclic compound, 3528-45-8, name is 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine, molecular formula is C11H13N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-[l-(2,3-dimethyl-phenyl)-lH-tetrazol-5-yl]-propionic acid (49 mg, 0.20 mmol, 1.0 eq.) and 2-(4-methoxy-benzyl)-2H-pyrazol-3-ylamine (40 mg, 0.20 mmol, 1.0 eq.) in DMF (1.2 mL), lambda/-(3-dimethylaminopropyl)-lambdaf-ethylcarbodiimide hydrochloride (57 mg, 0.30 mmol, 1.5 eq.) and 4-dimethylaminopyridine (36 mg, 0.30 mmol, 1.5 eq.) were added in sequence. The mixture was stirred at r.t. for 18 hours. The mixture was purified by prep. etaPLC and evaporated to afford the title compound. LC-MS (B): tR = 0.85 min; [M+eta]+ = 432.12.

The synthetic route of 3528-45-8 has been constantly updated, and we look forward to future research findings.

Sources of common compounds: 1246549-62-1

According to the analysis of related databases, 1246549-62-1, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1246549-62-1, name is 7-Bromo-3-chloroquinoline, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 7-Bromo-3-chloroquinoline

3-Chloro-7-bromo-quinoline (10 g, 41.2 mmol) was dissolved in dichloromethane (150 mL). Then m-CPBA (7.83 g, 45.3 mmol) was added in portions. The mixture was stirred at 35 C for 16 hours. The mixture was poured into a saturated Na2S03 aqueous solution. The mixture was extracted by CH2CI2. Then the mixture was washed by a saturated Na2S03 aqueous solution (50 mL x2) and a saturated NaHC03 aqueous solution (50 mL x2). The organic was dried over anhydrous Na2S04 and concentrated. The white solid was precipitated and filtered to give intermediate 180 (10 g, 78.8 % yield) as a yellow solid.

According to the analysis of related databases, 1246549-62-1, the application of this compound in the production field has become more and more popular.

Continuously updated synthesis method about 139399-67-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromoquinolin-8-amine, and friends who are interested can also refer to it.

Application of 139399-67-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 139399-67-0 name is 3-Bromoquinolin-8-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

8-Amino-3-bromoquinoline (4) (0.3 g, 1.3 mmol) was dissolved in 10 mL of 70% sulfuric acid and placed in a Q-Tube (Sigma Aldrich). The tube was sealed and heated with stirring at 22000 for 3 days. After cooling to ambient temperature, the reaction solution was brought to pH 8 by addition of NH4OH (16 M), followed by extraction with ethyl acetate (4 x 25 mL). The organic phases were combined, dried over Na2504, filtered, and evaporated todryness. The crude product was purified by column chromatography on silica gel (7 g) using3:1 dichloromethane/hexane as the eluent. Fractions containing the product were combinedand evaporated to dryness to give 5 as a white solid 0.184 g (34% yield, mp 99-101 00, litmp 111.5-1 12.5 00) 1H NMR (400 MHz, ODd3) O 8.77 (1H, d, J= 2.0 Hz), 8.32 (1H, d, J=2.0 Hz), 7.99 (1H, 5), 7.48 (1H, t, J= 8.0 Hz), 7.18 (1H, dd, J= 23.2 Hz, J= 9.6 Hz). LCMSfound 225.90, [M+2H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromoquinolin-8-amine, and friends who are interested can also refer to it.

Continuously updated synthesis method about 68236-20-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, and friends who are interested can also refer to it.

Related Products of 68236-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Anhydrous DMF (1 mL) and Et3N (0.56 mL, 4.00 mmol, 4equiv), previously degassed with bubbling argon for 10 min, were added to a flask containing the appropriate chlorinated quinoline(1.00 mmol, 1 equiv), [PdCl2(PPh3)2] (35.1 mg, 0.050 mmol, 0.05equiv), and CuI (9.5 mg, 0.050 mmol, 0.05 equiv) under an argon atmosphere.Finally, the appropriate alkyne derivative (1.20 mmol, 1.2equiv) was added dropwise to the mixture, which was then stirred over night at r.t. After completion of the reaction (attested by TLCanalysis), the mixture was filtered through a short pad of silica and Celite and eluted with EtOAc. The crude was concentrated under reduced pressure and purified by column chromatography (silica gel, various solvent mixtures).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, and friends who are interested can also refer to it.

Brief introduction of 68236-20-4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.

Related Products of 68236-20-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68236-20-4, name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde belongs to quinolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step-c Synthesis of 7-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde A suspension of 2-chloro-7-methoxyquinoline-3-carbaldehyde (8.0 g, 36.2 mmol) in 70% acetic acid (370 mL) was heated to 110 C. for 16 h. Upon cooling the reaction mixture to room temperature and poured into crushed ice;solid was filtered off and washed with water, dried under reduced pressure for overnight to give title compound as pale yellow solid (5.6 g, 76%). 1H NMR (400 MHz, DMSO-d6) delta 12.07 (s, 1H), 10.18 (s, 1H), 8.43 (s, 1H), 7.84 (d, J=8.9 Hz, 1H), 6.89 (dd, J=2.5 Hz, 8.8 Hz, 1H), 6.82 (d, J=1.9 Hz, 1H), 3.86 (s, 3H); LC-MS: m/z 204.1 (M+1)+.

Continuously updated synthesis method about 75090-52-7

The synthetic route of 7-Bromo-4-chloroquinoline has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 75090-52-7, name is 7-Bromo-4-chloroquinoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H5BrClN

17 A solution of 4-chloro-7-bromoquinoline 17-A (1 g, 4.1 mmol) (see Scheme 1 : general preparation of quinolines), hexamethyidistannane 17-B (1.35 g, 4.1 mmol) and [(C6H5)P]4Pd (237 mg) in 1,4-dioxane (10 ml) was heated to 105-110 C for 2 hours. The solution was cooled to room temperature. Column chromatography (hexane/EtOAc 5: 1) gave 4-chloro-7- (trimethylstannyl) quinoline 17-C (1.26 g, 94%).

The synthetic route of 7-Bromo-4-chloroquinoline has been constantly updated, and we look forward to future research findings.

Extended knowledge of 99465-09-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Bromoquinolin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Related Products of 99465-09-5, The chemical industry reduces the impact on the environment during synthesis 99465-09-5, name is 5-Bromoquinolin-2(1H)-one, I believe this compound will play a more active role in future production and life.

delta: 1.50-1.65(2H, m), 1.75-1.95(2H, m), 2.39-2.45(2H, m), 2.65-2.85(4H, m), 3.00-3.20(2H, m), 3.50-3.70(1H, m), 7.07(2H, s), 10.05(1H, s) mp 209-212 C. The above 5-bromocarbostyril was dissolved in 1 ml of hydrogen chloride-methanol solution, and mixture was refluxed for 1 hr. The reaction mixture was concentrated and purified by a silica gel column chromatography to give 24 mg of 5-bromo-6-(4-hydroxypiperidino)-3,4-dihydrocarbostyril.