Category: 68236-20-4

Related Products of 68236-20-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68236-20-4 name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Anhydrous DMF (1 mL) and Et3N (0.56 mL, 4.00 mmol, 4equiv), previously degassed with bubbling argon for 10 min, were added to a flask containing the appropriate chlorinated quinoline(1.00 mmol, 1 equiv), [PdCl2(PPh3)2] (35.1 mg, 0.050 mmol, 0.05equiv), and CuI (9.5 mg, 0.050 mmol, 0.05 equiv) under an argon atmosphere.Finally, the appropriate alkyne derivative (1.20 mmol, 1.2equiv) was added dropwise to the mixture, which was then stirred over night at r.t. After completion of the reaction (attested by TLCanalysis), the mixture was filtered through a short pad of silica and Celite and eluted with EtOAc. The crude was concentrated under reduced pressure and purified by column chromatography (silica gel, various solvent mixtures).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, and friends who are interested can also refer to it.

Related Products of 68236-20-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 68236-20-4, name is 2-Chloro-7-methoxyquinoline-3-carbaldehyde belongs to quinolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step-c Synthesis of 7-methoxy-2-oxo-1,2-dihydroquinoline-3-carbaldehyde A suspension of 2-chloro-7-methoxyquinoline-3-carbaldehyde (8.0 g, 36.2 mmol) in 70% acetic acid (370 mL) was heated to 110 C. for 16 h. Upon cooling the reaction mixture to room temperature and poured into crushed ice;solid was filtered off and washed with water, dried under reduced pressure for overnight to give title compound as pale yellow solid (5.6 g, 76%). 1H NMR (400 MHz, DMSO-d6) delta 12.07 (s, 1H), 10.18 (s, 1H), 8.43 (s, 1H), 7.84 (d, J=8.9 Hz, 1H), 6.89 (dd, J=2.5 Hz, 8.8 Hz, 1H), 6.82 (d, J=1.9 Hz, 1H), 3.86 (s, 3H); LC-MS: m/z 204.1 (M+1)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-7-methoxyquinoline-3-carbaldehyde, other downstream synthetic routes, hurry up and to see.