Tag: M.W:200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73387-46-9, name is 3-(4-Bromophenyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C9H7BrN2

To a heated (80 0C) solution of 3-(4-bromophenyl)-lH-pyrazole (1.0 g, 4.5 mmol) and trifluoroacetic acid (0.02 mL, 0.23 mmol) in toluene (5 mL) was added 3,4-dihydro- 2H-pyran (0.43 mL, 4.7 mol) over 1 hour. The reaction mixture was stirred for an additional hour and was then concentrated and dried to provide 3-(4-bromophenyl)-l-(tetrahydro-2H- pyran-2-yl)-lH-pyrazole (1.3 g, 94% yield). MS (EI) for Ci4H15BrN2O: 308 (MH+).

According to the analysis of related databases, 73387-46-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19968-17-3, name is 4-Bromo-3-(trifluoromethyl)-1H-pyrazole, A new synthetic method of this compound is introduced below., COA of Formula: C4H2BrF3N2

To a solution of 4-bromo-3- (trifluoromethyl) -1H-pyrazole (1.01 g, 4.7 mmol) in DMF (40 mL)2- (bromineMethyl) pyridine hydrobromide (1.76 g, 6.96 mmol), Cs2CO3 (5.3 g, 16 mmol) and KI (0.4 g, 2 mmol)100 for 10h. The reaction mixture was concentrated under reduced pressure to remove DMF, extracted with water (40 mL) and extracted with methylene chloride (50 mL ¡Á 3), and then the organicThe phases were dried over anhydrous Na2SO4. The concentrated crude product was isolated by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 1 /1) to give 1.2 g of a yellow oil, yield: 83%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, A new synthetic method of this compound is introduced below., Formula: C10H15N3O2

3 -(Bromomethyl)- 1,1 -difluoro-cyclobutane (505 mg, 2.73 mmol) was added dropwisc over 15 mm, to a mixture of tert-butyl 4,6-dihydro-2H-pyrrolo[3,4- c]pyrazole-5-carboxylate (560 mg, 2.67 mmol), cesium carbonate (1.39 g, 4.28 mmol) and DMF (5 mL) at 0 C. The reaction mixture was allowed to warm to ambient temperature and stirred for 18 h. The solvent was concentrated and the material was partitioned betweenwater (50 mL) and EtOAc. The aqueous layer was washed with EtOAc (2 x 30 mL). The combined organic layers were washed with brine, dried (MgSO4), and the solvent was concentrated. Purification (FCC, Si02 using ether) provided the title compound (344 mg, 41%). ?H NMR (300 MHz, CDC13) 3 = 7.10 (d, J = 10.0 Hz, 1H), 4.50 -4.37 (m, 4H), 4.18 (d, J = 5.5 Hz, 2H), 2.78-2.56 (m, 3H), 2.47-2.25 (m, 2H), 1.50 (s, 9H); [M+H] = 314.26.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 1280210-79-8,Some common heterocyclic compound, 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, molecular formula is C10H15N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

INTERMEDIATE 8; Step A: fert-Butyl 2- { 2-(trimethylsilyl)ethoxy1methyI } -2 , 6-dihvdropwrol o [3 A- c1pyrazole-5(4HVcarboxylateTo a stirred solution of tert~buty 2,6-dihydropyrrolo[3f4~c]pyrazole-5(4H)- carboxylate (20 g, 96 mmol) in DMF (200 mL) at 0 C was added sodium hydride (4.21 g, 105 mmol). After stirring for 1 h at RT, 2-trimethylsilylethoxymethyl chloride (SEM-C1) (4.65 mL, 26.3 mmol) was added. The resulting mixture was stirred at RT overnight. The mixture was quenched with saturated NH4OH, and the solvents were removed. The residue was diluted with ethyl acetate (500 mL), washed with water, brine, dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography on a silica gel Biotage 65i column, eluting with 0 to 20% ethyl acetate in hexanes to give the title compound as a colorless gum. LC-MS: 340.1 (M+H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 30169-25-6, name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, A new synthetic method of this compound is introduced below., Quality Control of 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

The synthesis and basic properties of the investigated compounds were described earlier in a previously published articles [27,34], except from molecule Tz2Pyr2 which was prepared by a standard procedure [23], stirring 1eq. of TzPyr2 with 1 eq. of piperazine in acetonitrile at 60, cool down after one hour and filtering off the pure product. The NMR of Tz2Pyr2 is provided in the ESI section. In all measurements, a solution of an investigated compound was prepared in a 0.1 M tetrabutylammonium tetrafluoroborate (Bu4NBF4; Sigma Aldrich 98%)/dichloromethane (Sigma Aldrich 99.9%) supporting electrolyte. Electrochemical analysis was performed for the solutions using a concentration of 2 mM of corresponding s-tetrazine derivative in supporting electrolyte, while for the spectroelectrochemical investigations a1 mM concentration was used.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 141573-95-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Preparation Example V.13-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acidA mixture of ethyl 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylate (1.4 g, 52 mmol) and aqueous sodium hydroxide solution (10% strength, 3.1 g, 8 mmol) was stirred at 60 C. for 2 h. The reaction mixture was cooled to room temperature, and the pH was then adjusted to 1 using concentrated hydrochloric acid. The reaction mixture was cooled further to 0 C., resulting in the precipitation of a solid. The precipitated solid was filtered off, washed with cyclohexane and dried under reduced pressure. This gave 3-difluoromethyl-1-methyl-1H-pyrazol-4-ylcarboxylic acid as a solid (amount: 0.8 g; yield: 87%). 1H-NMR (DMSO-d6): delta=3.9 (s, 2H), 7.2 (t, 1H), 8.35 ppm (s, 1H).

The chemical industry reduces the impact on the environment during synthesis Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1191616-45-1, name is 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 1191616-45-1

Compound 6c (1.5g, 5.0mmol), 4-(4-bromophenyl)-1-methyl-1H-pyrazole (1.2g, 5.0mmol), catalyst Pd(dba) 2 (144mg, 0.25mmol) , Tri-tert-butylphosphine (101mg, 0.5mmol), sodium tert-butoxide (576mg, 6.0mmol) were dissolved in toluene (50ml), heated to 100 and stirred for 12 hours, TLC detection reaction, direct concentration column chromatography separation 1.6 g of off-white solid was obtained with a yield of 69.3%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 34091-51-5, name is 5-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34091-51-5, SDS of cas: 34091-51-5

Example 41 N-[(2-Chloro-3,4-difluorophenyl)methyl]-3-methyl-1 -(1 -methyl-1 H- pyrazol-5-yl)-2-oxo-4-imidazolidinecarboxamide (E41) (in a form obtainable or prepared from (4S)-2-oxo-3-{[(phenylmethyl)oxy]carbonyl}-4-imidazolidinecarboxylic acid); To a stirred mixture of N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-2-oxo-4- imidazolidinecarboxamide (60.7 mg, 0.2 mmol) (prepared as described in Example 28), 5-iodo-1-methyl-1 H-pyrazole (41.6 mg, 0.2 mmol) in 1 ,4-dioxane (4 ml) was added potassium phosphate (212 mg, 1 mmol), copper (I) iodide (38.1 mg, 0.2 mmol) and trans-N,N-dimethylcyclohexane-1 ,2-diamine (0.032 ml, 0.2 mmol) and the mixture was heated at reflux under argon for 1 h. The mixture was cooled to room temperature and partitioned between saturated sodium hydrogen carbonate solution and dichloromethane. The organic extracts were separated, washed with water and brine, dried and evaporated. The residue was purified by mass-directed automated HPLC to give N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1 H- pyrazol-5-yl)-2-oxo-4-imidazolidinecarboxamide (18 mg, 23%). LC/MS [M+H]+ = 384, retention time = 2.22 minutes.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Iodo-1-methyl-1H-pyrazole, and friends who are interested can also refer to it.

Electric Literature of 6647-97-8, These common heterocyclic compound, 6647-97-8, name is 4-Iodo-1,3-dimethyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To iodopyrazole (1 mmol) dissolved in THF (10 mL), Fuajasite (250 mg) was added. Nitric acid (d 1.52 g/cm3, 10 mL) was added slowly and the mixture was stirred at room temperature for required time. The catalyst was recovered by filtration and the filtrate was extracted repeatedly with dichloromethane. The solvent was removed under vacuum to obtain nitropyrazole.

The synthetic route of 6647-97-8 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 398491-59-3, name is tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate

To the product from Step A (133 mg) in dichloromethane (3 mL) at 0 0C was added N,N- dnsopropylethylamine (0 21 mL) followed by benzyl chloroformate (0 1 mL) The reaction mixture was stirred at 0 0C for 90 mm, then diluted with dichloromethane (10 mL) and poured into saturated aqueous sodium bicarbonate solution The layers were separated and the aqueous phase extracted with dichloromethane (3×10 mL). The combined organic phases were d?ed over anhydrous sodium sulfate, filtered and evaporated in vacuo The residue was purified on a Biotage Horizon system (silica gel, 0 to 80% ethyl acetate/hexanes gradient) to give the title compound LC/MS 359 3 (M+l)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 398491-59-3.