Tag: M.W:200-300

Adding a certain compound to certain chemical reactions, such as: 73387-46-9, name is 3-(4-Bromophenyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73387-46-9, Recommanded Product: 3-(4-Bromophenyl)-1H-pyrazole

(2) 3-(4-bromophenyl)-1-methylpyrazole and 5-(4-bromophenyl)-1-methylpyrazole Sodium hydride (0.43 g, 17.9 mmol) was added slowly to a solution of 3-(4-bromophenyl)-1H-pyrazole (1.0 g, 4.48 mmol) in 50 ml of THF under N2. The mixture was stirred for 1 h, then iodomethane (1.27 g, 8.97 mmol) was added to the suspension. The mixture was stirred at 23 for 2 h. Water (20 mL) was added and extracted with EtAc (50 mL¡Á3). The combined organic phase was washed with brine, dried, concentrated and purified by column chromatography to give 1.0 g of colorless liquid (mixture) (yield: 90%). LC-MS (Method B): m/z 237 (M+H) RT=1.62 min/2.5 min

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(4-Bromophenyl)-1H-pyrazole, and friends who are interested can also refer to it.

These common heterocyclic compound, 1202993-11-0, name is 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

-Chloro-3-(difluoromethyl)-l-methyl-lH-pyrazole-4-carbonyl chloride (Example lie)(lib) (l ie)3.2 g of 5-chloro-3-(difluoromethyl)-l-methyl-lH-pyrazole-4-carboxylic acid and 44.3 mL of thionyl chloride were heated under reflux for 5 h. After cooling, the reaction mixture was concentrated under reduced pressure, giving 3.5 g of 5-chloro-3-(difluoromethyl)-l-methyl-lH-pyrazole-4-carbonyl chloride as a yellow oil. NMR (400 MHz, CHC13- 6) delta ppm : 3.97 (s, 3H); 7.00 (t, J= 52.01 Hz, 1 H);IR (TQ): 1759 and 1725 cnT (C=0);

The synthetic route of 5-Chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference of 139308-52-4,Some common heterocyclic compound, 139308-52-4, name is Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H9BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0941] to a solution of compound 163c (2.6 g, 11.16 mmol) in MeOH (10 ml) and H2O (10 ml) was added LiOH.H2O (2.34 g, 55.80 mmol). The mixture was stirred at 25 C for 12h. The reaction mixture was concentrated and added 20 ml of water and the mixture was extracted with mtbe (20 ml x 2), the aqueous layer was acidified by in HCl to ph ~ 2-3 at 0 C, and extracted with EtOAc (30 ml x 2), the organic phase was dried over Na2SO4 and concentrated to give a residue. Compound 163f (2.2 g, yield: 96.16%) was obtained as a gray solid, which was used for next step directly. 1H NMR (400mhz, DMSO-d6) delta 12.55 (br s, 1h), 8.24 (s, 1h), 3.81 (s, 3h).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate, its application will become more common.

Electric Literature of 88095-61-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 88095-61-8, name is 1-Benzyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 1145-01-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 3,5-diphenylpyrazole (1) (0.0927 g, 0.42 mmol) and Selectfluor (0.34 g, 0.97 mmol) in non-dried, stock-grade acetonitrile (1.5 mL) was heated at 80 C (oil bath temp) in an open atmosphere for 2 h and 20 min (140 min) and then cooled. Water was added to the dark yellow solution followed by extraction with EtOAc. The organic layers were combined and dried over Na2SO4 and filtered. The filtrate was evaporated onto silica gel and subjected to flash chromatography on silica gel using 10:1 hexanes/EtOAc as eluent to give first difluoropyrazole 2 (0.031 g, 29%) and then hydrated difluoropyrazole 3 (0.077 g, 67%) as yellow solids.

The synthetic route of 3,5-Diphenyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Application of 89607-15-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89607-15-8, name is 3-Bromo-1-methyl-4-nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 3-bromo-1-methyl-4-nitro-pyrazole (3.80 g, 18.4 mmol), (5-methoxycarbonyl-3-pyridyl)boronic acid (4.67 g, 25.8 mmol, CAS871329-53-2), Pd(dppf)Cl2.CH2Cl2 (800 mg, 979 umol) and NaHCO3 (3.10 g, 36.8 mmol) in dioxane (50 mL) and H2O (10 mL) was stirred at 80 C. under N2 for 2 hours. On completion, the mixture was cooled to 25 C. The mixture was diluted with water (100 mL), then extracted with EA (3¡Á80 mL). The combined organic layer was washed with brine (50 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography on silica gel (PE:EA=5:1-DCM:EA=2:1) to give the title compound (2.95 g, 61% yield) as light yellow solid. 1H NMR (400 MHz, CDCl3) delta 9.29 (s, 1H), 9.12 (s, 1H), 8.68 (s, 1H), 8.31 (s, 1H), 4.05 (s, 3H), 4.00 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-1-methyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179692-08-1, name is Ethyl 4-iodo-1H-pyrazole-5-carboxylate, A new synthetic method of this compound is introduced below., Formula: C6H7IN2O2

60% sodium hydride (99 mg) was added to a solution of the compound 0215-2 (0.50 g) and iodomethane (0.23 mL) in tetrahydrofuran (2.0 mL) at 0C, and the mixture was stirred at room temperature for 0.5 hours. To the reaction solution, a saturated aqueous ammonium chloride solution was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine and then dried over sodium sulfate. The solvent was removed under reduced pressure and the obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain a compound 0215-2 (0.37 g) as a colorless oily substance. – Synthesis of Compound 0219 – (Synthesis of Compound 0219-1) The same method as in Example 215 except for using (2-(trimethylsilyl)ethoxy)methyl chloride instead of iodomethane used for the synthesis of the compound 0215-2 in Example 215 was used to obtain a compound 0219-1 (0.273 g) as a position isomer mixture (colorless oily substance).

The synthetic route of 179692-08-1 has been constantly updated, and we look forward to future research findings.

Electric Literature of 37687-24-4, A common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, molecular formula is C9H12N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 41; (5R, 6E&Z)-7-oxo-6- (4H, 10H-pyrazolo [5, 1-c] [1, 4] benzoxazepin-2-ylmethylene)-4- thia-1-azabicyclo [3. 2. 0] hept-2-ene-2-carboxylic acid, sodium salt Step 1: Preparation of 1-(2-fluorobenzyl)-1H-pyrazole-3,5-dicarboxylate 2-fluorobenzyl bromide (2.0 ml, 16.58 mmol) was added to a mixture of diethyl 3,5- pyrazoledicarboxylate (3.01 g, 14.18 mmol), Cs2CO3 (5.57 g, 17.1 mmol), and acetonitrile (140 ml) under N2. Heated to 60C for two hours and then cooled to room temperature. Filtered and concentrated the reaction solution. Added water (-200mL) to the resulting residue and extracted with EtOAc. Washed organics with water and brine. Dried organics over sodium sulfate and filtered and concentrated. Obtained diethyl 1- (2- fluorobenzyl)-1 H-pyrazole-3, 5-dicarboxylate (light-yellow oil) in quantitative yield.

The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.

Application of 149739-65-1, The chemical industry reduces the impact on the environment during synthesis 149739-65-1, name is 3-(3-Bromophenyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Synthesis of intermediate compound 4[00107] In a 300 ml eggplant-type flask, 7.00 g (31.4 mmol) of compound 3, 3.30 g (34.5 mmol) of sodium tert-butoxide, and 100 ml of DMF were placed. Then, 2.15 ml (34.5 mmol) of idomethane was added dropwise to the resultant mixture, followed by stirring at room temperature for 24 hours. The loss of the raw materials and production of a new compound were confirmed by TLC (Thin Layer Chromatography) . The reaction solution was concentrated, and an organic phase was recovered by three times of separation with toluene/water. The organic phase was dried over magnesium sulfate,concentrated, and then purified by silica gel columnchromatography (developing solvent toluene : heptane : ethyl acetate = 10:10:1). A target substance was concentrated to produce 5.21 g (22.0 mmol) of compound 4 (yield 70.0%).Nine protons were attributed by 1H-NMR (CDC13: 7.95 (s, 1H) , 7.71 ppm (d, 1H) , 7.42-7.39 ppm (m, 2H) , 7.26 ppm (t, 1H) , 6.53 ppm (d, 1H) , 3.96 ppm (s, 3H) ) . A peak was observed at m/z = 236 in GS-MS (gas chromatography direct-coupled to mass spectrometry) to confirm the target compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(3-Bromophenyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, molecular formula is C14H19N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C14H19N3

To a solution of 3-tert-butyl-l-p-tolyl-lH-pyrazol-5-amine (102.9 g, 448.9 mmol) in EtOAc (1 L) at 10.9 0C was added a NaOH solution (2.5 M5 269 mL), and the biphasic reaction mixture warmed to 15.9 and then stabilized. Phenyl chloroformate (98.4 g, 156.5 mmol) was added in one portion and the temperature rose to 25.5 and then stabilized. The ice bath was removed and the reaction was monitored by HPLC. After 1 hour an additional 25 mL of 2.5 M NaOH was added. The reaction mixture was stirred overnight, and then diluted with EtOAc (200 mL). The organic layer was washed with brine (1 L)5 dried over Na2SO4 (200 g) and concentrated to about 400 to 500 mL of EtOAc. The concentrated solution was warmed to 60 0C. After the solids had dissolved, heptane (2 L) was slowly added, during which solids formed. After stirring for 30 minutes the solid was collected via filtration and the cake was washed with 400-500 mL of heptane. The cake was dried in a vacuum oven at ambient temperature to yield 156.9 g (95.0%) of the title compound. 1H NMR (400 MHz3 CDCl3) delta 7.39 – 7.31 (m, 6H), 7.26-7.225 (m, 2H), 7.13 (br s, 2H)5 6.96 (br s. IH), 6.47 (br s, IH), 2.42 (s, 3H), 1.34 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 285984-25-0, its application will become more common.