Tag: 100-200

An improved synthesis of 3,6-diamino-1,2,4,5-tetrazine. I was written by Coburn, Michael D.;Ott, Donald G.. And the article was included in Journal of Heterocyclic Chemistry in 1990.Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide This article mentions the following:

Treatment of 1,3-diaminoguanidine monohydrochloride with 2,4-pentanedione in alcs. under carefully controlled conditions gave the tetrazine monohydrochloride I in 45-50% yields along with 3,5-dimethyl-1H-pyrazole and its hydrochloride. Oxidation of I with sodium perborate produced 3,6-diamino-1,2,4,5-tetrazine (II) in quant. yield. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Safety of 3,5-Dimethyl-1H-pyrazole-1-carboxamide

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Penta- and dinuclear carboxylate nickel(II) complexes with pyrazole-based ligands: Syntheses, magnetic properties and DFT calculations was written by Nikiforov, Alexey A.;Dubrov, Evgenii N.;Blinou, Daniil O.;Gurzhiy, Vladislav V.;Selyutin, Artem A.;Klyukin, Ilya N.;Zhdanov, Andrey P.;Minkovich, Alexander E.;Panina, Natalia S.;Eremin, Alexei V.. And the article was included in Polyhedron in 2021.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine This article mentions the following:

<<One pot>> reactions of pyrazole-based ligands Hdmpz and PyPz with in situ formed carboxylate precursors led to the formation of mono- and di-aqua-bridged binuclear compounds, as well as pentanuclear hydroxo-bridged compound: [Ni₂(μ-OH₂)(μ-O₂CC(CH₃)₃)₂(O₂CC(CH₃)₃)₂(PyPz)₂] (1), [Ni₅(μ₃-OH)₂(μ-O₂CPh)₈(PyPz)₄]^.4.73MeCN (2), [Ni₂(μ-OH₂)(μ-O₂CPh)₂(O₂CPh)₂(Hdmpz)₄] (3), [Ni₂(μ-OH₂)₂(μ-O₂CPh)(O₂CPh)₂(Hdmpz)₄](O₂CPh)•2.5H₂O (4) (Hdmpz = 3,5-dimethylpyrazole, PyPz = 2-(5-Methyl-1H-pyrazol-3-yl)pyridine). Compounds were characterized by structural and spectral methods, thermogravimetric anal. and magnetic measurements were also performed. It was noted, that structural motif of forming compounds are determined by the structure of carboxylate precursors formed in situ and properties of N-ligands. Comparison of magnetic measurements data, structural data, and DFT calculations allows us to conclude that in the case of investigated compounds the equilibrium between spin isomers with different multiplicities, close energy values and close geometrical structure (no data) can be realized. In the experiment, the researchers used many compounds, for example, 2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine).

2-(5-Methyl-1H-pyrazol-3-yl)pyridine (cas: 19959-77-4) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazoles are commonly used scaffold molecules in drug discovery projects. The use of pyrazole derivatives is based on their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, sedative, muscle relaxant, neuroleptic, anticonvulsant, monoamine oxidase inhibitory, antidiabetic and antibacterial activities.Application In Synthesis of 2-(5-Methyl-1H-pyrazol-3-yl)pyridine

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis and fungitoxicity of derivatives of thiopyrazolone and their oxidation products was written by Devi, S.;Mitra, P.;Mishra, S. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1983.Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one This article mentions the following:

On treatment with P₂S₅, pyrazolones afford thiopyrazolones which on condensation with 4-monobromo- and dibromopyrazolones in 1:1 and 1:2 ratio, resp., yield mixed bis and tris derivatives, i.e. I and II. The bis compounds of thiopyrazolone were also prepared These compounds with their oxidized derivatives were assayed for antifungal activity against Pyricularia oryzae and Helminthosporium oryzae. Some of the compounds show a very good fungicidal activity and are compared with standard com. fungicides. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthesis of quinazolone and its derivatives as potential fungicides was written by Das, N. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1979.Computed Properties of C4H5BrN2O This article mentions the following:

Condensation of 4-bromo-2-pyrazolin-5-one with 2-mercapto-3-aryl-4-quinazolones afforded quinazolones I (R = aryl,R¹ = H, Ph). They are fungitoxic against the rice blast pathogen Pyricularia oryzae and brown leaf spot pathogen Helminthosporium oryzae. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Computed Properties of C4H5BrN2O).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles and pyrimidines have diverse biological and pharmacological activities. There are a number of antimicrobial compounds containing pyrazole moiety as the core unit. Pyrazofurin is important antimicrobial drug and 2-methylpyrimidine-4-ylamine derivatives I and II were found to be effective inhibitors of Escherichia coli PDHc-E1 with antibacterial and antifungal activity.Computed Properties of C4H5BrN2O

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The pyrolytic rearrangement of 1-alkynoyl-3-methylpyrazoles: synthesis of pyrazolo[1,5-a]pyridin-5-ols and related compounds was written by Brown, Roger F. C.;Eastwood, Frank W.;Fallon, Gary D.;Lee, Swee Choo;McGeary, Ross P.. And the article was included in Australian Journal of Chemistry in 1994.COA of Formula: C5H7ClN2 This article mentions the following:

Flash vacuum pyrolysis of 1-(2-alkynoyl)-3-methylpyrazoles (e.g., I; R = H, Me, Ph) at 650°/0.03 mm forms pyrazolo[1,5-a]pyridin-5-ols (e.g., II), often in high yield, which may bear substituents at C2, C3 or C7. In the absence of a 3-Me group in the precursor, N-ethynylpyrazoles are formed in low yield. The formation of both types of product is interpreted as involving 3-(N-pyrazolyl)propadienones formed by N1 → N2 migration of the N-alkynoyl group with inversion of the three-carbon chain. The fused-ring structure of 2-methylpyrazolo[1,5-a]pyridin-5-ol was established by x-ray crystallog. of the O-benzoyl derivative In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8COA of Formula: C5H7ClN2).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole has two ring nitrogen atoms in which N1 is pyrrolic and N2 is pyridine-like. The N1 nitrogen is not reactive but is deprotonated in the presence of a base-forming anion. Protonation of pyrazole in strong acid leads to pyrazolium cations, which undergo electrophilic substitution preferentially at C3 rather than C4. The pyrazole anion is not reactive toward nucleophiles but is mostly reactive to electrophiles.COA of Formula: C5H7ClN2

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

One-pot, procedure for the preparation of some thiazino[2,3-b]quinoxaline derivatives was written by Bakavoli, Mehdi;Eshghi, Hossein;Azizollahi, Hamid;Saberi, Sattar;Bazrafshan, Faezeh. And the article was included in Journal of Chemical Research in 2014.SDS of cas: 51395-52-9 This article mentions the following:

An efficient and convenient synthesis of new thiazino[2,3-b]quinoxaline derivatives I (R = CH₃, C₆H₅, 4-MeC₆H₄, etc.) has been developed by employing a one-pot cyclocondensation of several α-haloketones and 3-aminoquinoxaline-2-thiol in acetic acid. A similar reaction with 4-bromo-3-methyl-4,5-dihydro-1H-5-pyrazolone gave a new heterocyclic system, 3-methyl-1,4-dihydropyrazolo[4′,3′:5,6][1,4]thiazino[2,3-b]quinoxaline. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9SDS of cas: 51395-52-9).

4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazoles, a five-membered heterocycle containing two adjacent nitrogen atoms, are the core structures found in a number of molecules that possess a wide range of pharmaceutical and agricultural activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.SDS of cas: 51395-52-9

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Transition metal azolates from metallocenes. Part 1: Dimetallic and trimetallic cyclopentadienylnickel pyrazolates, synthesis and structural studies was written by Rettig, Steven J.;Storr, Alan;Summers, David A.;Thompson, Robert C.;Trotter, James. And the article was included in Canadian Journal of Chemistry in 1997.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole This article mentions the following:

The reactions of nickelocene with pyrazoles in benzene solution gave either dimeric compounds, [CpNi(μ-pz)]₂, (room temperature conditions) or trimetallic complexes, [CpNi(μ-pz)₂]₂Ni, (elevated temperature conditions). Both dimeric and trimetallic species were obtained as red crystalline materials and x-ray structural studies are reported for representative samples of each type. Structural features are interpreted and compared with similar, previously reported, Ni pyrazolate structures. Crystals of [CpNi(3,5-diMepz)]₂ (C₂₀H₂₄N₄Ni₂), are orthorhombic, a 15.204(1), b 17.967(2), c 6.9786(9) Å, Z = 4, space group Ama2; those of [CpNi(4-NO₂-3,5-diMepz)]₂ (C₂₀H₂₂N₆Ni₂O₂), are orthorhombic, a 17.145(3), b 17.738(1), c 7.006(1) Å, Z = 4, space group P2₁2₁2₁; those of [CpNi(3,5-F₆diMepz)]₂ (C₂₀H₁₂F₁₂N₄Ni₂), are orthorhombic, a 18.7134(8), b 15.619(2), c 7.7263(9) Å, Z = 4, space group Pnma; those of [CpNi(3,5-diMepz)₂]₂Ni (C₃₀H₃₈N₈Ni₃), are triclinic, a 10.078(2), b 16.134(2), c 9.992(1) Å, α 91.586(10), β 111.050(9), γ 86.95(1)°, Z = 2, space group P1; and those of [CpNi(4-Cl-3,5-diMepz)₂]₂Ni (C₃₀H₃₄Cl₄N₈Ni₃), are monoclinic, a 10.2201(7), b 16.174(1), c 10.7207(9) Å, β 108.193(5)°, Z = 2, space group P2₁la. The structures were solved by direct (dimetallic species) or Patterson (trimetallic complexes) methods and were refined by full-matrix least-squares procedures to R = 0.035, 0.032, 0.058, 0.032, and 0.033 (R_w = 0.021, 0.026, 0.053, 0.028, and 0.032) for 1157, 1894, 1642, 4499, and 2113 reflections with I ≥ 3σ(F²), resp. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Recommanded Product: 4-Chloro-3,5-dimethyl-1H-pyrazole

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

The Reactivity Trends in Electrochemical Chlorination and Bromination of N-Substituted and N-Unsubstituted Pyrazoles* was written by Lyalin, B. V.;Petrosyan, V. A.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2014.Application of 15953-73-8 This article mentions the following:

The authors’ study of electrochem. chlorination and bromination of pyrazoles decorated with electron-withdrawing and electron-donating groups showed that the product yield and composition depended on the substitution at the N-1 atom. The authors showed for the 1st time the significant differences in halogenation reactivity patterns of N-unsubstituted and N-alkylpyrazoles. In the experiment, the researchers used many compounds, for example, 4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8Application of 15953-73-8).

4-Chloro-3,5-dimethyl-1H-pyrazole (cas: 15953-73-8) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Application of 15953-73-8

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Chemiluminescence vs. Kjeldahl determination of nitrogen in oil shale retort waters and organonitrogen compounds was written by Jones, Bonnie M.;Daughton, Christian G.. And the article was included in Analytical Chemistry in 1985.Reference of 934-48-5 This article mentions the following:

The applicability of combustion/chemiluminescent N determination to determining N in oil shale wastewaters and various representative chem. classes was demonstrated. Only azoxy compounds and those containing the pyrazole nucleus were not amenable to anal. The majority of 56 compounds tested yielded 90-110% of their theor. N content; enhanced recovery was found for N oxide salts. For 12 oil shale wastewaters, combustion/chemiluminescence gave total N values (1100-28,800 mg/L) that did not differ statistically (P > 0.10) from those obtained by the time-consuming wet-chem. Kjeldahl method. The relative standard deviations for 10 replicates of each wastewater were less than 3.5%. No matrix or solvent effects were found. In the experiment, the researchers used many compounds, for example, 3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5Reference of 934-48-5).

3,5-Dimethyl-1H-pyrazole-1-carboxamide (cas: 934-48-5) belongs to pyrazole derivatives. As is the case with imidazoles, the pyrazole ring offers many opportunities to create new multiring systems that incorporate this heterocycle. Pyrazole rings have been used as core components of several leading non-steroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. It has also been found to be useful as a bifunctional ligand for metal catalysis.Reference of 934-48-5

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

A simple and catalyst free one pot access to the pyrazolone fused 2,8-dioxabicyclo[3.3.1]nonanes was written by Bingi, Chiranjeevi;Emmadi, Narender Reddy;Chennapuram, Madhu;Nanubolu, Jagadeesh Babu;Atmakur, Krishnaiah. And the article was included in RSC Advances in 2014.Reference of 401-73-0 This article mentions the following:

A series of novel aryl and heteroaryl fused 2,8-dioxabicyclo[3.3.1]nonanes I (R = 4-Cl, 4-MeO, 4-Br, etc.; R¹ = C₆H₅, 2-BrC₆H₄, 4-CNC₆H₄, etc.; R² = H, Ph) was accomplished by one pot, catalyst free reaction of 2-hydroxy chalcones with 3-trifluoromethyl substituted pyrazolones in xylene at reflux temperature The role of the trifluoromethyl functional group in formation of I was confirmed by comparative studies with 3-Me substituted pyrazolones and the outcome is presented. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0Reference of 401-73-0).

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one (cas: 401-73-0) belongs to pyrazole derivatives. The strategies for the synthesis of pyrazoles generally can be applied for the construction of indazoles. Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns.Reference of 401-73-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics