Synthesis and fungitoxicity of derivatives of thiopyrazolone and their oxidation products was written by Devi, S.;Mitra, P.;Mishra, S. B.;Mittra, A. S.. And the article was included in Journal of the Indian Chemical Society in 1983.Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one This article mentions the following:
On treatment with P2S5, pyrazolones afford thiopyrazolones which on condensation with 4-monobromo- and dibromopyrazolones in 1:1 and 1:2 ratio, resp., yield mixed bis and tris derivatives, i.e. I and II. The bis compounds of thiopyrazolone were also prepared These compounds with their oxidized derivatives were assayed for antifungal activity against Pyricularia oryzae and Helminthosporium oryzae. Some of the compounds show a very good fungicidal activity and are compared with standard com. fungicides. In the experiment, the researchers used many compounds, for example, 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one).
4-Bromo-3-methyl-1H-pyrazol-5(4H)-one (cas: 51395-52-9) belongs to pyrazole derivatives. Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. Pyrazole the presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Quality Control of 4-Bromo-3-methyl-1H-pyrazol-5(4H)-one
Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics