Tag: M.W:200-300

Electric Literature of 13808-65-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13808-65-6 name is 4-Bromo-3-phenyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0164] In a microwave tube was placed ethyl 2-bromothiazole-4-carboxylate (1058 mg, 4.48 mmol), 3-bromo-4-phenyl-1H-pyrrole (995 mg, 4.48 mmol), and K2C03 (929 mg, 6.72 mmol). The tube was sealed and DMSO (4 ml) was added. The mixture was heated at 120C for 4 h. The mixture was poured into vigorously stirred H20 (100 mL), and the solid was filtered, triturated with H20, and dried. The solid was re-dissolved in EtOAc and filtered. Some undissolved material was the hydrolized acid. The filtrate was concentrated and triturated with ca. 3% EtOAc/hexane to give ethyl 2-(4-bromo-3-phenyl- 1H-pyrazol- 1- yl)thiazole-4-carboxylate (1329 mg, 3.51 mmol, 78% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-3-phenyl-1H-pyrazole, and friends who are interested can also refer to it.

Electric Literature of 84547-84-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84547-84-2 name is 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 22 (20 g) was dissolved in 100 mL of concentrated sulfuric acid.33 mL of concentrated nitric acid was slowly added dropwise in an ice water bath.After reacting for 16 h at room temperature, TLC showed a large amount of substrate remaining.After heating to 50 ¡ã C for 16 h, the substrate substantially disappeared.After cooling, the reaction solution was slowly added dropwise to 1 L of ice water.Extract with ethyl acetate and wash the organic phase several times with water until pH = 7.After concentration, column chromatography gave yellowSolid 23 (15 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.

Related Products of 10250-64-3,Some common heterocyclic compound, 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, molecular formula is C11H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2. 1 -Methyl-3 -phenyl-N- [( 1 -pyridin-3 -ylcyclohexyl)methyl] – 1 H-pyrazole-5 – carboxamide; A solution of DMC in DCM (1.2 mL, 0.1 M, 1.2 eq.) is added to a solution of 2- methyl-5-phenyl-2H-pyrazole-3-carboxylic acid (20 mg, 0.1 mmol, 1.0 equ.), (1 -pyridin-3 -yl- cyclohexyl)-methylamine (19 mg, 0.1 mmol, 1.0 eq.) and TEA (33 muL, 0.24 mmol, 2. 4 eq.) in DCM (1.0 mL) at RT. After standing overnight at RT, the reaction mixture is purified by PTLC (EtOAc/etaexanes/TEA 50/50/1) to give the title compound. LC/MS (M+l) = 375.16; RT = 1.38 min. *IC50.

The synthetic route of 10250-64-3 has been constantly updated, and we look forward to future research findings.

51516-67-7, name is 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 51516-67-7

General procedure: To a stirred solution of the intermediate compounds 1a-1d (1 mmol) and triethylamine (2 mmol) in DMF (12 mL) medium, a mixture of EDCI (1 mmol) and HOBt (1mmol) was added and the reaction mixture was stirred at room temperature for 30 min, then a mixture of compounds 2a-2d (1 mmol) and DMF (5 mL) was added, the reaction was stirred at room temperature. And the reaction progress was monitored by TLC. After completion of the reaction, the product was added into chloroform, then extracted from chloroform with water, and washed successively with 0.2 mol/L hydrochloric acid, water,2 mol/L sodium hydroxide, water, saturated sodium chloride, then dried, concentrated and purified by preparative thin layer chromatography (PE:EA = 8:1) followed by recrystallization from ethanol.

The synthetic route of 51516-67-7 has been constantly updated, and we look forward to future research findings.

Related Products of 285984-25-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 285984-25-0, name is 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of CDI (91 mg, 0.56 mmol) in DCM (1.0 mL) was added Intermediate A1 (129 mg, 0.563 mmol) and the reaction mixture maintained at RT for 2 hr. A portion of this solution (500 pL, 0.28 mmol) was added to a solution of Intermediate B16 (80 mg, 0.19 mmol) in THF (2.0 mL) and the reaction mixture kept at RT for 3 hr and then quenched with the addition of MeOH (2.0 mL). The resulting mixture was evaporated in vacuo and the residue was purified by flash column chromatography (Si02, 12 g, 0-100% [10% MeOH in EtOAc] in isohexane, gradient elution) to afford methyl 5-((4-((4-(3-(3-(ierf-butyl)-1-(p-tolyl)-1 H-pyrazol- 5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-1 /-/-indazole-3-carboxylate as a pale tan solid (77 mg, 57 %); Rl 2.50 min (Method 2, acidic); m/z 680 (M-H)”, (ES”).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-amine, other downstream synthetic routes, hurry up and to see.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H12N2O4

2-fluorobenzyl bromide (2.0 ml, 16.58 mmol) was added to a mixture of diethyl 3,5-pyrazoledicarboxylate (3.01 g, 14.18 mmol), Cs2CO3 (5.57 g, 17.1 mmol), and acetonitrile (140 ml) under N2. Heated to 60 C. for two hours and then cooled to room temperature. Filtered and concentrated the reaction solution. Added water (~200 mL) to the resulting residue and extracted with EtOAc. Washed organics with water and brine. Dried organics over sodium sulfate and filtered and concentrated. Obtained diethyl 1-(2-fluorobenzyl)-1H-pyrazole-3,5-dicarboxylate (light-yellow oil) in quantitative yield.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 345637-71-0, name is 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 345637-71-0, Recommanded Product: 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid

Example 17 N-[5-({7-[(1R)-2-Hydroxy-1-methylethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}carbonyl)pyridin-3-yl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide (5-Methyl-3-trifluoromethyl-pyrazol-1-yl)acetic acid (46.8 mg, 0.225 mmol) was added to (R,S) (5-aminopyridin-3-yl){7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (66 mg, 0.173 mmol) (see Preparation 36), 1-propylphosphonic acid cyclic anhydride (0.31 mL, 0.519 mmol) and DIPEA (0.09 mL, 0.606 mmol) in THF (5 mL). The mixture was heated at reflux for 48 hours, evaporated in vacuo and partitioned between saturated aqueous sodium bicarbonate (5 mL) and ethyl acetate (5 mL). The organic phase was dried over sodium sulfate, evaporated in vacuo and the residue was purified by column chromatography on silica gel (gradient of EtOAc:Hexane 85:15) to afford the intermediate as an off white solid in 53% yield, 52 mg. 10% Hydrochloric acid in 1,4-dioxane (0.4 mL) was added to the intermediate (52 mg, 0.091 mmol) in THF (2 mL) and the mixture was stirred at room temperature for 1.5 hours. The mixture was evaporated in vacuo and triturated with pentane:diethyl ether (3:1, 1 mL) to afford the title compound as an off white solid in 94% yield, 42 mg. 1H NMR (400 MHz, DMSO) delta: 1.49 (d, 3H), 2.32 (d, 3H), 3.56 (m, 1H), 5.00 (m, 1H), 5.20 (s, 2H), 6.56 (s, 1H), 8.45 (s, 1H), 8.54 (s, 1H), 8.79 (s, 1H), 9.02 (s, 2H), 9.48 (s, 1H), 11.05 (s, 1H); LCMS (system 4): Rt=2.86 min; m/z 488 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid, other downstream synthetic routes, hurry up and to see.

Application of 141573-95-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141573-95-7 as follows.

To a solution of 2.93 g (14.3 mmol, 1.00 eq) DFMMP and 3.00 g (17.3 mmol, 1.20 eq) 2-(bi(cyclopropan)-2-yl)benzenamine in 20 mL dry dioxane, 10.0 ml (72.2 mmol, 5.40 eq) triethylamine was added, followed by 7.20 g (57.1 mmol, 4.00 eq) A1C13 which was added in one portion. After stirring the reaction mixture for 1 h, it was cooled with ice and quenched with water. The aqueous phase was extracted twice with ethyl acetate, the combined organic layers were washed with water and brine, dried over Na2S04 and the solvent removed under reduced pressure. The crude product was purified by column chromatography (MTBEJ to yield (4.1 g, 85 %) Sedaxane. HPLC: t, = 10.9 min + 11.4 min (trans +cis 62:38); HPLC/MS: tr = 12.7 min [M+H]+ 332; tr = 13.3 min [M+H]+ 332; NMR (500 MHz, CDC13) delta (ppm) = 8.46 (s, br, 0.35H), 8.08 (s, br, 0.65H), 8.26 (d, 3J = 8.2 Hz, 0.35H), 8.07 (d, 3J = 8.1 Hz, 0.65H), 7.98 (d, 3J = 6.3 Hz, 1H), 7.27-7.20 (m, 1H), 7.09-7.04 (m, 2H), 7.02-6.80 (m, 1H), 3.95 (s, 1H), 3.94 (s, 2H), 1.98-1.93 (m, 0.35H), 1.66-1.62 (m, 0.65H), 1.17-1.13 (m, 0.65H), 1.07-1.02 (m, 0.35H), 0.97-0.87 (m, 1H), 0.80-077 (m, 1H), 0.71-0.67 (m, 0.65H), 0.42-0.38 (m, 1.35H), 0.30-0.25 (m. 0.35H), 0.21-0.11 (m, 1.65H), 0.07-0.01 (m, 1H).

According to the analysis of related databases, 141573-95-7, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 37687-24-4, SDS of cas: 37687-24-4

A solution of aminoacetaldehyde dimethyl acetal (0.23 mL, 2.12 mmol). in THF (dry) was cooled at 0C and a solution of trimethylaluminium (1.06 mL, 2.12 mmol) was added drop wise to the cold reaction mixture under nitrogen. The reaction mixture was allowed to warm to room temperature over 15 minutes. The reaction mixture was cooled again to 0C and treated with a solution of diethyl pyrazole-3,5-dicarboxylate 2a (300 mg, 1.41 mmol) in THF (dry) under nitrogen over a period of 15-20 minutes. The resulting reaction mixture was warmed to room temperature and stirred for 2 h. The excess trimethylaluminium was quenched by addition of methanol carefully; when the effervescence was ceased, it was filtered and washed with excess of 10% MeOH in DCM (25 mL). The filtrate was collected and evaporated under reduced pressure to dryness. The resulting crude material was purified by column chromatography (Silica gel 100-200 mesh size, 4% MeOH in DCM) to give compound 10 (285 mg, 50%). MS (ES+) m/z: 272. 1H NMR (DMSO-d6): delta 14.15-14.56 (s, 1H), 8.14-8.87 (m, 1H), 7.10-7.51 (m, 1H), 4.50 (t, J=5.40 Hz, 1H), 4.30 (q, J=7.03 Hz, 2H), 3.34-3.37 (m, 2H), 3.28 (s, 6H), 1.31 (t, J=7.03 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Synthetic Route of 39806-90-1,Some common heterocyclic compound, 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Dissolve 4-iodo-1-methyl-1H-pyrazole (1.37g, 6.59mmol) in THF (40mL), then add cuprous iodide (75mg, 0.198mmol) andBistriphenylphosphine palladium dichloride (140mg, 0.198mmol), replacing nitrogen three times, under nitrogen protection, slowly add diethylamine (7.5mL, 72.5mmol) and trimethylsilylacetylene (1.9mL, 13.2mmol, 0.69 g / mL).The reaction was stirred at room temperature for 20h.After the reaction was completed, saturated brine (100 mL) was added, extracted with ethyl acetate (50 mL ¡Á 3), the organic phases were combined, dried over anhydrous sodium sulfate, and the solvent was concentrated.Separation and purification by silica gel column chromatography (PE / EtOAc (v / v) = 20/1) to obtain 684 mg of light yellow liquid, yield: 58.2%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Iodo-1-methyl-1H-pyrazole, its application will become more common.