Tag: M.W:200-300

Application of 1280210-79-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1280210-79-8, name is tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

INTERMEDIATE 6; 2-(2-Hydroxy-2-methylpropyl -2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-5-ium trifluoroacetate saltTo a stirred solution of tert-butyl 2,6-dihydropyrrolo[3 ,4-c]pyrazole-5(4H)-carboxyIate(35 g, 167 mmol) in DMF (500 mL) at 0 C under N2 was added sodium hexamethyldisilazide in THF (351 mL, 351 mmol) and the mixture was stirred at 0 C for 30 min. Isobutylene oxide (74.3 mL, 836 mmol) was then slowly added. The solution was stirred at 0C for 0.5 h and then stirred at room temperature for 1 h. The solution was heated to 80C for 100 min in a microwave oven, cooled to room temperature and evapoarted under vacuum. The residue was purified by column chromatography on silica gel, eluting with a gradient of 0% to 6% CH2Cl2 MeOH (containing 1 % NH4OH) to give a mixture of two regioisomers. The mixture of tworegioisomers A and B was resolved by chromatography on a ChiralPak AD-H column eluting with 4-40% MeOH/C02 to give isomer A as the faster eluting isomer and isomer B as the slower eluting isomer. NMR (500 MHz, CD3OD) for isomer B: 67.42 (d, 1 H); 4.42 (s, 2H); 4. 1 (s, 2H); 4.07 (s, 2H); 1.51 (d, 9H); 1.16 (s, 6H). LC-MS: 226.27 (M+l-56).The desired isomer B was treated with 1 :1 TFA/C?C12 for 1 h to give the title compound. NMR (500 MHz, CD3OD): 57.55 (s, 1H); 4.43 (s, 2H); 4.39 (s, 2H); 4.10 (s, 2H);1.17 (s, 6H). LC-MS: 182.31 (M+l).

The synthetic route of tert-Butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate has been constantly updated, and we look forward to future research findings.

Application of 37687-24-4, These common heterocyclic compound, 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Crude 2-chloro- 1 -(1 -(4-methoxybenzyl)- 1 H-pyrazol-4-yl)ethanone (7.1 g, 21 mmol) was dissolved in acetonitrile (100 mL). Diethyl 1H-pyrazole-3,5-dicarboxylate (4.6 g, 21 mmol) was added, followed by K2C03 (5.9 g, 43 mmol), and the reaction mixture was stirred at 45 C for 1 hour. The reaction mixture was cooled to ambient temperature, diluted with EtOAc, filtered and concentrated. The residue was purified over silica gel to afford diethyl 1 -(2- (1 -(4-methoxybenzyl)- 1 H-pyrazol-4-yl)-2-oxoethyl)- 1 H-pyrazole-3 ,5-dicarboxylate (8.7 g, 20 mmol, 92 % yield) as a white solid.

The synthetic route of 37687-24-4 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 92525-10-5, A common heterocyclic compound, 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole, molecular formula is C4H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A) To a solution of 4-((benzyloxy)methyl)pyrrolidin-2-one (836 mg), 3-iodo-1-methyl-1H-pyrazole (856 mg), copper(I) iodide (80 mg) and tripotassium phosphate (1.7 g) in cyclopentyl methyl ether (20 mL) was added N1,N2-dimethylethane-1,2-diamine (87 muL). The reaction mixture was stirred at 120 C. for 22 hr, and diluted with ethyl acetate, and saturated aqueous ammonium chloride solution was added thereto. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.1 g). MS (ESI+): [M+H]+286.3.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 10250-63-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10250-63-2, name is Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Production Example 197c) 0.12 g of ethyl 1-methyl-3-phenyl-1H-5-pyrazolecarboxylate was dissolved in 5 ml ethanol. 1 ml of 5N aqueous sodium hydroxide solution was added thereto, followed by heating under reflux for 1 hour. The reaction solution was ice-cooled, neutralized with 2N hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated, to give 0.11 g of 1-methyl-3-phenyl-1H-5-pyrazolecarboxylic acid. 1H-NMR(CDCl3) delta: 4.22(s, 3H) 7.22(s, 1H) 7.33(t, J=8.0Hz, 1H) 7.40(t, J=8.0Hz, 2H) 8.80(d, J=8.0Hz, 2H)

The synthetic route of Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 51516-67-7, name is 5-Amino-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H7ClN4

Example 9: Synthesis of 4-imino-l-phenyl-5-(2,3,6-trifluorophenyl)-4,5-dihydro-lH- pyrazolor3,4-dlpyrimidine-6(7H)-thione (A575 (33)):Synthesis of 4-imino-l-phenyl-5-(2,3,6-trifluorophenyl)-4,5-dihydro-lH-pyrazolor3,4- dlpyrimidine-6(7H)-thione (A575 (33)). A mixture of 5-amino-l -phenyl- lH-pyrazole-4 carbonitrile (218 mg, 1 mmol) and l,3,4-trifluoro-2-isothiocyanatobenzene (189 mg, 1 mmol) was refluxed for 2h,and then cooled. Intermediate was precipitated spontaneously and were collected as pure products (M+l)+ = 408 (325 mg, white solid, 80%). Then using the same procedure as that of A348 (13) to synthesis compound (A575 (33)) (M+l)+ = 498.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51516-67-7, its application will become more common.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20055-01-0, name is 1-Methyl-1H-pyrazole-4,5-diamine sulfate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C4H10N4O4S

A solution of 4, 5-DIAMINO-1-METHYLPYRAZOLE sulfate (158 g) in water (1.1 L) was neutralized to pH 6.9 with 4N aqueous sodium hydroxide solution, and dioxane (474 ml) was added to this solution. To the resulting mixture was added dropwise phenyl chloroformate (124 g) maintaining pH of the mixture at 6.9 with 4N aqueous sodium hydroxide solution at a temperature below 10C. The reaction mixture was stirred for 1 hour. The precipitated solid was collected by filtration and dried to give 5-AMINO-1-METHYL-4-PHENOXYCARBONYLAMINOPYRAZOLE (155 G). 1H-NMR (DMSO-d6) 8 3.52 (3H, s), 5.00 (2H, brs), 7.10-7. 50 (6H, m), 8.93 (1H, brs)

According to the analysis of related databases, 20055-01-0, the application of this compound in the production field has become more and more popular.

106368-32-5, name is 5-Amino-1-(4-(methylsulfonyl)phenyl)-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5-Amino-1-(4-(methylsulfonyl)phenyl)-1H-pyrazole-4-carbonitrile

A MIXTURE OF 5-AMINO-1- (4-METHANESULFONYL-PHENYL)-LH-PYRAZOLE-4-CARBONITRILE (540 mg), formic acid (10 mL) and 1 mL H2O was refluxed overnight at 102’C. After cooling to room temperature, a white precipitate was observed. The mixture was diluted with H20 (10 mL), filtered through a funnel and washed thoroughly with H20, CH30H, and diethyl ether. The white solid was collected and dried under vacuum to give a crude product (300 mg, 50% YIELD). H NMR (DMSO-D6, 4. 00 MHZ) 5 3. 26 (s, 3H), 8. 12 (d, 2H), 8. 29 (s, 1H), 8. 42 (d, 2H), 8. 44 (d, 1H), 12. 61 (s, 1H). LCMS : calculated C12HoN403S 290. 05, observed 291. 2 (MH+).

The synthetic route of 106368-32-5 has been constantly updated, and we look forward to future research findings.

Application of 30169-25-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30169-25-6 name is 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 1 (20.5g, 76mmol) in acetonitrile (228ml) was added 80% hydrazine hydrate (4.7g, 76mmol) dropwise at 0C. A red precipitate formed immediately. The mixture was allowed to stir for 30min at ambient temperature, filtered, washed with toluene and dried to give 10.2g of pure material. The mother liquid was concentrated under reduced pressure and the residue treated with toluene, filtered and dried to give an additional 3.3g of pure material for a combined yield of 87.3% of a red solid. mp 135-137C; IR numax (KBr)/cm-1: 3336, 3225, 2929, 1652, 1568, 1481, 1165, 1074; 1H NMR (400MHz, DMSO-d6) delta: 9.75(s, 1H,NH), 6.17(s, 1H, CH), 4.60(s, 2H, NH2), 2.37(s, 3H, CH3), 2.21(s, 3H, CH3); 13CNMR(100MHz, DMSO-d6) delta: 162.9, 157.0, 149.9, 141.2, 108.3, 13.2, 12.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine, and friends who are interested can also refer to it.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 149739-65-1 as follows. Application In Synthesis of 3-(3-Bromophenyl)-1H-pyrazole

Into 300 ml round-bottomed flask, 7.00 g (31.4 mmol) compound 3, 3.30 g (34.5 mmol) sodium tert-butoxide , and 100 ml DMF were placed. Thereto, 2.15 ml (34.5 mmol) of iodomethane was added dropwise and the mixture was stirred for 24 hours at room temperature. Elimination of the raw materials and generation of a new compound were confirmed by thin layer chromatography (TLC). The reaction solution was concentrated and separated three times with toluene/water to recover the organic phase. The organic phase was dried over magnesium sulfate, concentrated, and purified by silica gel column chromatography (developing solvent:toluene: heptane: ethyl acetate = 10:10:1). The target substance was concentrated to obtain 5.21 g (22.0 mmol) of compound 4 (yield: 70.0%). Nine protons were assigned by 1H- NMR (CDCl3:7.95 (s, 1H) , 7.71 ppm (d, 1H) , 7.42-7.39 ppm (m, 2H), 7.26 ppm (t, 1H) , 6.53 ppm (d, 1H) , 3.96 ppm (s, 3H) ) . When analyzed with a gas chromatograph-mass spectrometer (GS-MS), a peak was observed at m/z = 236. The product was confirmed to be the target substance.

According to the analysis of related databases, 149739-65-1, the application of this compound in the production field has become more and more popular.

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 83-07-8, Name is 4-Aminoantipyrine, SMILES is O=C1N(C2=CC=CC=C2)N(C)C(C)=C1N, belongs to pyrazoles-derivatives compound. In a document, author is Dai Hong, introduce the new discover, Recommanded Product: 83-07-8.

Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit

In search of new pyrazole amide derivatives with wonderful bioactivities, fifteen novel pyrazole amide compounds were designed and synthesized by introducing substituted oxazole unit into pyrazole amide skeleton based on the lead compound tebufenpyrad. The structures of the title compounds were confirmed by H-1 NMR, C-13 NMR and elemental analysis. The preliminary bioassay data exhibited that most of target compounds had more than 90% insecticidal activities against Oriental armyworm at the concentration of 500 mu g/mL. At the concentration of 500 mu g/mL, one compound displayed 100% mortality rate against Aphis medicaginis. In addition, two compounds showed 30% insecticidal activity against Tetranychus cinnabarinus at the concentration of 500 mu g/mL.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 83-07-8 is helpful to your research. Recommanded Product: 83-07-8.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics