Tag: M.W=250-300

Wu, Xiren published the artcileSynthesis, characterization and antibacterial activity of taurine PMBP schiff base and their metal complexes, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Guangdong Weiliang Yuansu Kexue (2013), 20(4), 18-22, database is CAplus.

Objective: Synthesis of novel taurine schiff base and its metal complexes, and study on the antibacterial activities. Method: The schiff base is dissolved in absolute Me alc., and mixed with four kinds of Zn(II), Co(II), Ni(II), Cu(II) metal acetate sep. After heating under reflux, filtration and drying, we get the target compounds The element anal., IR spectra and molar conductance were used to analyze the structure and composition of the schiff base and its Zn(II), Co(II), Ni(II), Cu(II) complexes. The drilling method is used to examine the complexes antibacterial activities. Result: Four kinds of complexes M(L)(H₂O)_2∼3 belong to 1:1 non-electrolyte. The primary biol. activity assay showed that all products exhibited medium to high antibacterial activities against E. coli and Streptococcus pneumoniae, among which the Cu(II) and Co(II) complexes of the schiff base gave the strongest activity which is better than that of the schiff base. Conclusion: The preparation of the taurine-PMBP metal complex provides new content for the coordination chem. Good antibacterial activity provides the basis for its application in medicine.

Guangdong Weiliang Yuansu Kexue published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C6H8O4, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, Alexander N. published the artcileAdsorption of lanthanides and scandium ions by silica sol-gel material doped with novel bifunctional ionic liquid, trioctylmethylammonium 1-phenyl-3-methyl-4-benzoyl-5-onate, Computed Properties of 4551-69-3, the publication is Journal of Environmental Chemical Engineering (2016), 4(4_Part_A), 3788-3796, database is CAplus.

Sol-gel processed silica doped with a novel bifunctional ionic liquid, trioctylmethylammonium 1-phenyl-3-methyl-4-benzoylpyrazol-5-onate ([A336]⁺[L]^–), was prepared and used as a sorbent for recovery and separation of scandium and lanthanides from nitric acid solutions The effect of HNO₃ concentration in the aqueous phase on the adsorption of microquantities of Sc, Y, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb and Lu is considered. A significant synergistic effect was observed for scandium and lanthanide adsorption from aqueous solutions Sc(III) is sorbed from aqueous solutions much better than lanthanides(III) and separation of Sc(III) from lanthanides(III) can be achieved by simple adjusting acidity of the aqueous phase. The efficiency of lanthanide(III) adsorption from low-concentration HNO₃ solutions increases with an increasing at. number The process of lanthanide(III) adsorption is exothermic, spontaneous and follows a pseudo-second-order kinetic model. The potentialities of the doped silica material for the preconcentration of lanthanides(III) and Sc(III) from nitrate solutions are demonstrated.

Journal of Environmental Chemical Engineering published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C10H20O2, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, Alexander Nikolaevich published the artcileSynergistic solvent extraction of lanthanides(III) with mixtures of 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone and phosphoryl-containing podands, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Acta Chimica Slovenica (2020), 67(1), 246-252, database is CAplus and MEDLINE.

The solvent extraction of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu from weak acidic chloride solutions into an organic phase containing 4-benzoyl-3-methyl-1-phenyl-5-pyrazolone (HP) and phosphoryl-containing podands (L) has been studied. A considerable synergistic effect was observed in the presence of neutral ligands L in the organic phase containing HP. The stoichiometry of the Ln(III) extracted species was determined by slope anal. and the equilibrium constants were calculated It was found that the lanthanide(III) ions are extracted with mixtures of HP and neutral ligands in toluene from weak acidic solutions as LnLP3 complexes.

Acta Chimica Slovenica published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C10H20O2, Recommanded Product: 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Willson, Timothy M. published the artcileBone targeted drugs. 2. Synthesis of estrogens with hydroxyapatite affinity, COA of Formula: C11H16N2O5, the publication is Bioorganic & Medicinal Chemistry Letters (1996), 6(9), 1047-1050, database is CAplus.

The utility of the bone targeting 4-carboxy-3-hydroxy-1,2pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Pyrazoles I (n = 1, 4) demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays.

Bioorganic & Medicinal Chemistry Letters published new progress about 178424-17-4. 178424-17-4 belongs to pyrazoles-derivatives, auxiliary class Pyrazoles, name is 1-(tert-Butyl) 4-ethyl 3-oxo-2,3-dihydro-1H-pyrazole-1,4-dicarboxylate, and the molecular formula is C8H8O3, COA of Formula: C11H16N2O5.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Waterson, Alex G. published the artcileDiphenylpyrazoles as replication protein A inhibitors, Synthetic Route of 13599-22-9, the publication is ACS Medicinal Chemistry Letters (2015), 6(2), 140-145, database is CAplus and MEDLINE.

Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N). Here the authors describe the optimization of a diphenylpyrazole carboxylic acid series of inhibitors of these RPA-protein interactions. The authors evaluated substituents on the aromatic rings as well as the type and geometry of the linkers used to combine fragments, ultimately leading to submicromolar inhibitors of RPA70N protein-protein interactions.

ACS Medicinal Chemistry Letters published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C7H7BN2O2, Synthetic Route of 13599-22-9.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Dehbi, Ouarda published the artcileBis(4-benzoyl-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-olato-κ²O,O’)(methanol-κO)dioxidouranium(VI) methanol monosolvate, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, the publication is Acta Crystallographica, Section E: Structure Reports Online (2012), 68(4), m457-m458, database is CAplus and MEDLINE.

In the title compound, [U(C₁₇H₁₃N₂O₂)₂O₂(MeOH)]·MeOH, the U^VI ion is coordinated by seven O atoms in a distorted pentagonal-bipyramidal geometry with two 3-methyl-1-phenyl-4-benzoyl-4,5-dihydro-1H-pyrazol-5-olate groups with two O atoms in a bidentate chelating coordination mode and by three O atoms, one of which is from a MeOH ligand. The crystal packing can be described by alternating layers of complex mols. along the a axis. The structure is stabilized by O-H···N and O-H···O H bonding and van der Waals interactions. Crystallog. data and at. coordinates are given.

Acta Crystallographica, Section E: Structure Reports Online published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Safety of 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Gowri, M. published the artcileCrystal Structure and Characterization of Novel Schiff Base: (Z)-4-(((2-hydroxy phenyl)amino)(phenyl)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, SDS of cas: 4551-69-3, the publication is Molecular Crystals and Liquid Crystals (2012), 569(1), 151-161, database is CAplus.

The crystal structure of (Z)-4-(((2-hydroxy phenyl)amino)(phenyl)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one was investigated. Weak interactions including intermol. forces, metal-ion coordination, electrostatic forces, van der Waals interactions, and donor-acceptor interactions were responsible for the organized entities of higher complexity. Single crystal X-ray diffraction (XRD) showed that the compound crystallized in the triclinic crystal system with space group P1̅ with a = 7.1822(3) , b = 11.0015(4), c = 13.6353(5) A; α = 111.715(10)°, β = 92.255 (2)°, γ = 106.002 (2)°, and Z = 2. FTIR, UV-Vis, ¹H NMR, and CHN were employed to characterize the crystal. Thermal stability and the weak interactions among the neutral entities were also investigated.

Molecular Crystals and Liquid Crystals published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, SDS of cas: 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Pahontu, Elena published the artcileSynthesis, characterization, crystal structure and antiproliferative activity studies of Cu(II), Ni(II) and Co(II) complexes with 4-benzoyl-5-pyrazolones derived compounds, Category: pyrazoles-derivatives, the publication is Journal of Organometallic Chemistry (2017), 44-55, database is CAplus.

Eleven new Cu(II), Ni(II), and Co(II) complexes (1–11) with thiosemicarbazones 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone-4-R thiosemicarbazone (R = CH₃,C₆H₅, C₅H₅N) (HL^1-3) were synthesized. The ligands was characterized by FT- IR, ¹H NMR, ¹³C NMR spectroscopy and x-ray diffraction. All the complexes were characterized by UV-visible and FTIR spectroscopy, molar conductivity, magnetic susceptibility measurements and elemental anal. The Cu (II) complexes were studied by EPR spectroscopy. Also, the crystal structures of copper and nickel complexes 1, 3, 6 and 7 were determined by single-crystal x-ray diffraction anal. The Cu atom exhibits a distorted square-planar coordination environment in the complex 1 provided by one mol. of deprotonated ligand and one chloride anion, while in the complex 6 show a distorted square-pyramidal coordination geometry. In the complexes 3 and 7, the Ni atom exhibits a slightly distorted octahedral O₂N₂S₂ coordination provided by two mols. of tridentate deprotonated ligand. The in vitro antiproliferative activity of the ligands and metal complexes was screened on human leukemia HL-60 cells. It was noticed a significant inhibition of growth of malignant cells HL-60 in the case Cu complexes 2 and 5 with IC₅₀ values of 0.24 μM and 0.36 μM, resp.

Journal of Organometallic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileSynergistic Solvent Extraction of Lanthanides(III) with Mixtures of 4-benzoyl-3-methyl-1-phenylpyrazol-5-one and Some Novel Carbamoyl- and Phosphorylmethoxymethylphosphine Oxides, Application In Synthesis of 4551-69-3, the publication is Solvent Extraction and Ion Exchange (2014), 32(5), 492-507, database is CAplus.

The solvent extraction of La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, and Y from weak acidic hydrochloric acid solutions into an organic phase containing 4-benzoyl-3-methyl-1-phenylpyrazol-5-one (HP) and neutral tridentate organophosphorus ligands R₂P(O)CH₂OCH₂C(O)NBu₂ R = Bu (I), R = Ph (II) and R₂P(O)CH₂OCH₂P(O)R¹₂ R = R¹ = Bu (III); R = Bu, R¹ = Ph (IV); R = R¹ = Ph(V) has been studied. A considerable synergistic effect was observed in the presence of HP in the organic phase containing tetraoctyldiglycolamide (TODGA) and neutral organophosphorus ligands . A successive replacement of C(O)NAlk₂ groups in the diglycolamide extractant mol. by P(O)Ph₂ groups leads to an increase in the extraction efficiency of Ln(III) ions when toluene was used as diluent. Phosphoryl-containing podand possess a higher extraction efficiency towards Ln(III) ions than TODGA. The extraction equilibrium was investigated and the equilibrium constants were calculated It was found that the lanthanide(III) ions are extracted as LnLP₃ and LnL₂P₃ complexes with mixtures of HP and I in toluene from weak acidic solutions

Solvent Extraction and Ion Exchange published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C3H5BN2O2, Application In Synthesis of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Turanov, A. N. published the artcileExtraction of Rare Earth Elements(III) with Mixtures of Some New Tridentate Carbamoylmethylphosphine Oxides and 4-Benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one from Hydrochloric Acid Solutions, Computed Properties of 4551-69-3, the publication is Russian Journal of General Chemistry (2021), 91(3), 383-388, database is CAplus.

Extraction of rare earths(III) from hydrochloric acid solutions with mixtures of new tridentate carbamoylmethylphosphine oxides Ph₂P(O)CH₂CON(R)CH₂CH₂P(O)Ph₂ (R = Me, Bu, Oct) and 4-benzoyl-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one in organic solvents has been studied. The observed strong synergistic effect has been attributed to the formation of hydrophobic mixed-ligand rare earth complexes in the organic phase. Stoichiometry of the extractable complexes has been determined, and extraction constants have been calculated The effect of organic solvent and composition of the aqueous phase on the extraction efficiency has been analyzed.

Russian Journal of General Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C19H15NO3, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics