Tag: M.W=100-150

Witiak, Donald T.; Lu, Matthias C. published the artcile< Product ratio analysis of the reaction of methyl cis- and trans-β-(acetylthio)acrylates with diazomethane>, Recommanded Product: Methyl 1-Methylpyrazole-3-carboxylate, the main research area is pyrazoles from acetylthioacrylates diazomethanation; acetylthioacrylates diazomethanation pyrazoles from; diazomethanation acetylthioacrylates pyrazoles from.

The relative yield of Me cis-β-(methylmercapto)acrylate 1-methyl-5-carbomethoxypyrazole 3-carbomethoxypyrazole and 1-methyl-3-carbomethoxypyrazole when Me cis- or trans-β-(acetylthio)acrylate undergoes reaction with excess CH2N2 in ether, was determined by means of gas-liquid partition chromatog. The analysis shows product formation to be dependent upon the stereochemistry of the starting Me β-(acetylthio)acrylate. Competing reaction pathways are proposed to account for the different yields of products. 25 references.

Journal of Organic Chemistry published new progress about 17827-61-1. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Recommanded Product: Methyl 1-Methylpyrazole-3-carboxylate.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Schantl, J. G. published the artcile< Product class 19: azomethine imines>, Reference of 17827-61-1, the main research area is review azomethine imine preparation organic synthesis.

A review. Methods for preparing azomethine imines and their application to organic synthesis.

Science of Synthesis published new progress about Imines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (azomethine). 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Reference of 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zhang, Juan; Li, Xianfeng; Wei, Haimei; Li, Yangfeng; Zhang, Gong; Li, Yizhou published the artcile< Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries>, Application of C7H11N3, the main research area is aryl amine DNA encoded aldehyde cyclization; encoded DNA tetrazole preparation alkene cycloaddition; DNA encoded pyrazoline preparation.

Herein, a sequential DNA-encoded synthesis strategy for polysubstituted pyrazoline heterocycles, which fuses a broad panel of aldehydes, aryl amines, and alkenes as building blocks was reported. Furthermore, mock library synthesis and selection demonstrated the ability of the method to produce DNA-encoded focused libraries with highly functionalized pyrazoline cores.

Organic Letters published new progress about 1,3-Dipolar cycloaddition reaction. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Application of C7H11N3.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zhou, You; Wang, Li-Sheng; Lei, Shuang-Gui; Gao, Yun-Xiang; Ma, Jin-Tian; Yu, Zhi-Cheng; Wu, Yan-Dong; Wu, An-Xin published the artcile< I2-Promoted site-selective C-C bond cleavage of aryl methyl ketones as C1 synthons for constructing 5-acyl-1H-pyrazolo[3,4-b]pyridines>, Recommanded Product: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, the main research area is aryl methyl ketone aminopyrazole enaminone iodine cleavage cyclization; pyrazolopyridine regioselective preparation.

A novel iodine promoted [1 + 3 + 2] cleavage cyclization reaction for the synthesis of 1H-pyrazolo[3,4-b]pyridines from aryl Me ketones, 5-aminopyrazoles and enaminones was established. This transition metal-free catalysis method has simple reaction conditions and good substrate compatibility, and was demonstrated in the transformation of alkyl and natural mol.-derived enaminones. Mechanistic studies showed that two cyclization pathways affording different key intermediates were involved, but affording the same target product after site-selective cleavage of the unstrained C-C bond of the acyl group.

Organic Chemistry Frontiers published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Recommanded Product: 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Castellanos, Maria Luisa; Llinas, Montserrat; Bruix, Marta; De Mendoza, Javier; Martin, M. Rosario published the artcile< NN'-linked biazoles. Part 4. Nucleophilic substitution in quaternary salts of NN'-linked biazoles and related systems>, SDS of cas: 17827-61-1, the main research area is nucleophile substitution biazolyl cation azolylpyridinium; pyridinium azolyl substitution nucleophile.

Some di- and monocationic N,N’-linked biazoles and quaternized 1-(N-azolyl)pyridinium ions were prepared and their reactions with nucleophiles were studied. Although the pyrrolyl nucleus is a poor leaving group in these reactions, in other cases nucleophilic attack readily occurs at an azolyl C, with subsequent elimination of the N substituent. E.g., reaction of dication I with NaCN in H2O at room temperature for 18 h gave 80% 2-cyano-1-methylbenzimidazole and 7% 1-methylbenzimidazol-2-one.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Hydrolysis kinetics. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, SDS of cas: 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Morgentin, Remy; Barlaam, Bernard; Foote, Kevin; Hassall, Lorraine; Hawkins, Janet; Jones, Clifford D.; Le Griffon, Antoine; Peru, Aurelien; Ple, Patrick published the artcile< Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives>, Electric Literature of 118430-74-3, the main research area is aminoarylpyridine preparation coupling palladium; pyridine aminoaryl preparation coupling palladium; Buchwald Hartwig regioselective nucleophilic substitution bisaminoarylpyridine preparation.

We have developed two different approaches in parallel to rapidly access 2,4-bis(aminoaryl)pyridine compounds, e.g., I, from a common starting material. The C-4/C-2 approach uses palladium-mediated coupling reactions to sequentially functionalize C-4 and then C-2. An alternative C-2/C-4 route uses a regioselective SNAr reaction to first substitute at C-2 then subsequently at C-4 by a palladium-mediated reaction. Both approaches have been used successfully to provide a range of 2,4-bis(aminoaryl)pyridine compounds

Synthetic Communications published new progress about Buchwald-Hartwig reaction. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Electric Literature of 118430-74-3.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Perrocheau, Jacques; Carrie, Robert; Fleury, Jean-Pierre published the artcile< Thermal and photochemical evolution of triazolines obtained by addition of diazo compounds to methyl esters of oximino-malonodinitriles, oximino-cyanoacetates and oximino-malonates>, HPLC of Formula: 17827-61-1, the main research area is thermolysis triazoline; photolysis triazoline; triazoline thermolysis photolysis; aziridine.

Thermolysis of 1,2,3-triazolines I [R = Ts, COC6H4Z-4, Ac; R1 = H, Me, Ph, (MeO)2CH] leads to the corresponding aziridines only when X = Y = CO2Me, and then with a very low yield. However, photolysis or evolution in the presence of trifluoroacetic acid gives good results when carried out at sufficiently low temperature The thermolysis study of I shows a new route to 1,2,3-triazoline decomposition that has not yet been mentioned in the literature. The easy elimination of the p-toluenesulfonate or benzoate group explains this particular behavior.

Canadian Journal of Chemistry published new progress about Photolysis. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, HPLC of Formula: 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Broom, N. J. P.; Elder, J. S.; Hannan, P. C. T.; Pons, J. E.; O’Hanlon, P. J.; Walker, G.; Wilson, J.; Woodall, P. published the artcile< The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocycle-substituted oxazole derivatives>, Electric Literature of 17827-61-1, the main research area is pseudomonic acid heterocycle oxazole derivative preparation; bactericide heterocycle oxazole derivative preparation.

Semisynthetic analogs of pseudomonic acid A were prepd containing a heterocycle-substituted oxazole. Derivatives in which the heterocycle was thiophene, furan, pyridine, or isoxazole showed good antibacterial potency and were further evaluated in vivo. Both pharmacokinetic parameters and oral activity against an exptl. i.p. sepsis were superior to results obtained from previously described pseudomonic acid A derivatives

Journal of Antibiotics published new progress about 17827-61-1. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, Electric Literature of 17827-61-1.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Auwers, K. v.; Breyhan, Th. published the artcile< Further observations on alkylation and acylation of pyrazoles>, COA of Formula: C6H8N2O2, the main research area is .

3(5)- Methyl-5(3)-chloropyrazole with MeBr (8 hrs. at 100) gives 100% of the 1,3-di-Me derivative; CH2N2 gives largely the 1,3-di-Me derivative with some of the 1,5-isomer; the Na salt with Mel gives 100% of the 1,5-isomer. 3(5)- Phenylpyrazole (I) with MeBr (1 day at 100°) gives principally 1-methyl-3-phenylpyrazole, with some of the 5-Ph isomer; the Na salt with MeI yields 100% of the 5-Ph isomer. Excess ClCO2Me gives 1-carbomethoxy-3-phenylpyrazole (II), m. 76°. The Na derivative of BzCH:CHOH and MeO2CNHNH2 in dilute Et4OH give a nearly quant. yield of the carbomethoxyhydrazone of benzoylacetaldehyde, m. 152°; POCl3 in CHCl3 yields the 5-Ph isomer of II, m. 63-4°, with some II. I and SO2Cl2 give 4-chloro-5(3)- phenylpyrazole (III), b11 193°, m. 102°. 1-Methyl-4- chloro-3-phenylpyrazole (IV), pale brown, b9 163-5°; 5-Ph isomer (V), b12 153-6°. III and MeI with Na give about equal quantities of IV and V; Me2SO, in NaOH also give a mixture of the 2 isomers; MeBr gives essentially IV; CH2N2 reacts only slightly with III. II and SO2Cl2 give the 4-Cl derivative (VI), m. 89-90°; the 5-Ph isomer, m. 113-15°. III and ClCO2Me give VI. 3(5)-Methyl-5(3)-phenylpyrazole and MeBr (8 hrs. at 100°) give principally 1,5- dimethyl-3-phenylpyrazole, with some of the isomer; the Na salt with MeI gives the same products. 1-Carbomethoxy-3-phenyl-5-methylpyrazole, m. 74-5°; it is unchanged after heating with MeBr at 100° for 1 day; 4-Cl derivative, m. 107°. The carbomethoxyhydrazone of benzoylacetone, pale yellow, m. 121-2°; POCl3 gives 1-carbomethoxy-3-methyl-5-phenylpyrazole, m. 58-9°; 4-Cl derivative, m. 97°. Me pyrazole-3(5)-carboxylate, m. 139-40°; both MeBr and CH2N2 give principally Me 1-methylpyrazole-5-carboxylate, b9 73°, with a little of the 1,3-isomer, bg 120°. Me 5(3)-methylpyrazole-3(5)-carboxylate and CH2N2 give principally the 1,3-di-Me derivative, with some 1,5-isomer; the Et ester behaved similarly; there was no reaction with MeBr; MeI gives the almost pure 1,5-di- Me derivative; the Na salt with MeI gives principally the 1,3- isomer; EtI gives the 1-ethyl-5-methyl derivative; the salt with AcCl in C6H6 yields the 1-Ac derivative, m. 68.5-9.5°, and with ClCO2Me in Et2O the 1-MeO2C derivative Me 3(5)-phenylpyrazole-5(3)-carboxylate does not react with MeBr; with Mel it yields Me 1-methyl-3-phenylpyrazole 5-carboxylate; the Na salt and Mel in C6H6 give the same compound; the free ester or the Na salt and ClCO2Me yield a N-carbomethoxy derivative, m. 95°; the Et ester also does not react with EtBr; the Na salt and EtI give Et 1-ethyl-3- phenylpyrazole-5-carboxylate; the Na salt does not react with AcCl. 3(5)-Phenylpyrazole-5(3)-carboxylic acid (VII) and ClCO22Me give a N-carbomethoxy derivative, m. 126- 6.5°; with Cl the CO2Me group is split off. The 4-Cl derivative of VII m. 258-61°; it does not yield a CO2Me derivative

Journal fuer Praktische Chemie (Leipzig) published new progress about Acylation. 17827-61-1 belongs to class pyrazoles-derivatives, and the molecular formula is C6H8N2O2, COA of Formula: C6H8N2O2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Zhao, Yujun; Zhou, Bing; Bai, Longchuan; Liu, Liu; Yang, Chao-Yie; Meagher, Jennifer L.; Stuckey, Jeanne A.; McEachern, Donna; Przybranowski, Sally; Wang, Mi; Ran, Xu; Aguilar, Angelo; Hu, Yang; Kampf, Jeff W.; Li, Xiaoqin; Zhao, Ting; Li, Siwei; Wen, Bo; Sun, Duxin; Wang, Shaomeng published the artcile< Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor>, Synthetic Route of 118430-74-3, the main research area is pyrazole pyrimido indole preparation bromodomain inhibitor cancer.

We report the structure-based discovery of CF53 (28) as a highly potent and orally active inhibitor of bromodomain and extra-terminal (BET) proteins. By the incorporation of a NH-pyrazole group into the 9H-pyrimido[4,5-b]indole core, we identified a series of compounds that bind to BRD4 BD1 protein with Ki values of <1 nM and achieve low nanomolar potencies in the cell growth inhibition of leukemia and breast cancer cells. The most-promising compound, CF53, possesses excellent oral pharmacokinetic properties and achieves significant antitumor activity in both triple-neg. breast cancer and acute leukemia xenograft models in mice. Determination of the co-crystal structure of CF53 with the BRD4 BD1 protein provides a structural basis for its high binding affinity to BET proteins. CF53 is very selective over non-BET bromodomain-containing proteins. These data establish CF53 as a potent, selective, and orally active BET inhibitor, which warrants further evaluation for advanced preclin. development. Journal of Medicinal Chemistry published new progress about Antitumor agents. 118430-74-3 belongs to class pyrazoles-derivatives, and the molecular formula is C7H11N3, Synthetic Route of 118430-74-3.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics