Tag: M.W:100-200

A common heterocyclic compound, 3469-69-0, name is 4-Iodopyrazole, molecular formula is C3H3IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 3469-69-0.

To a solution of 4-iodo-1H-pyrazole (2.0 g, 10.31 mmol) in tetrahydrofuran (20 mL) was added sodium hydride (619 mg, 15.47 mmol) at 0 C. The resulting white suspension was stirred at 0 C for 2 hours. 2-(chloromethoxyethyl)trimethyl silane (SEM-Cl, 90% purity, 2.101 g, 2.230 mL, 11.34 mmol) was added dropwise at 0 C. The suspension was then allowed to warm up to room temperature and stirred for 16 hours. The reaction was quenched with water (0.5 mL), and concentrated to ~5 mL at reduced pressure. The mixture was then partitioned between EtOAc (50 mL) and saturated NaHCC solution (30 mL). The organic layer was separated, washed with brine (20 ml_), dried (Na2S04) and concentrated at reduced pressure. The residue was purified by Biotage Isolera chromatography [SNAP Cartridge KP-Sil 50 g; eluting with a gradient of eluents; 0-20% EtOAc in heptane] to give the title compound (3.27 g, 91% yield) as a colourless oil. 1H NMR (500 MHz, chloroform-d) delta [ppm] 7.62 (s, 1 H), 7.54 (s, 1 H), 5.40 (s, 2H), 3.59 – 3.51 (m, 2H), 0.94 – 0.85 (m, 2H), -0.02 (s, 9H). LCMS (Analytical Method A): Rt = 1.36 mins; MS (ESIPos) m/z = 324.9 (M+H)

The synthetic route of 4-Iodopyrazole has been constantly updated, and we look forward to future research findings.

26621-44-3, Name is 3-Nitro-1H-pyrazole, 26621-44-3, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

Into a 250-mL round-bottom flask was placed a solution of 3-nitro-lH-pyrazole (10 g, 88.4 mmol) in DMF (100 mL). This was followed by the addition of NaH (60% wt, 3.9 g, 97.5 mmol) in portions at 0C. The resulting solution was stirred for 0.5 h at 0C. This was followed by the addition of 2-bromopropane (14.1 g, 114.6 mmol) dropwise with stirring at 0C in 10 min. The resulting solution was stirred for 16 h at RT and then was quenched by the addition of 100 mL of water. The resulting solution was extracted with 3×100 mL of ethyl acetate. The organic layers were combined and dried over anhydrous Na2S04, then concentrated under vacuum. The residue was applied onto a silica gel column and eluted with a gradient of ethyl acetate/petroleum ether (1 :5 to 1 :3). This resulted in 11.8 g (86%) of the title compound as yellow oil. MS-ESI: 156.1 (M+l).

Statistics shows that 3-Nitro-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 26621-44-3.

175137-46-9, These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The compound of example 33 (4.92 mmol) was reacted with 5-cyclopropyl-1H-pyrazol-3-amine(5.91 mmol) in presence of DMF (4.92 mmol), ethanol (148 mmol), sodium iodide (4.92 mmol)and triethylamine (24.62 mmol). The reaction mixture was stirred at a temperature of 100 C for 2 days. The DMF and excess triethylamine was evaporated followed by addition of water and ethyl acetate. The organic layer was separated and concentrated for purification using column chromatography (silica gel, 0.5 % methanol dichloromethane) to obtain the title compound.Yield: 70.1 %; ?H NMR (DMSO-d6, 300 MHz): oe 12.14 (s, 1H), 9.00 (s, 1H), 6.23(s, 1H), 2.59 (bs, 2H), 2.50 (d, 1=9.9Hz, 2H), 1.90 (m, 1H), 1.73 (bs, 4H), 0.93 (d, 1=6.6Hz, 2H), 0.69 (m, 2H); MS (ES+): mlz 418.3 (M+1).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 175137-46-9.

82560-12-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82560-12-1, name is 3-Amino-5-tert-butylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A solution of [2-(6-bromo-pyridin-2-yloxy)-ethyl]-dimethyl-amine(WO2003/082278, 500 mg, 2.00 mmol), 3-tert-butyl-lH-pyrazole-5-amine (341 mg, 2.50 mmol) and trans-N,N’-dimethyl-cyclohexane-diamine (58.0 mg,0.40 mmol) was formed in toluene (5 mL). Potassium carbonate (592 mg, 4.30mmol) was added and the mixture degassed by bubbling N2 through it.Copper(I) iodide (39.0 mg, 0.20 mmol) was added and the mixture was sealedin a microwave vial and heated using microwave irradiation at 150C for 2 h.The resulting mixture was partitioned between EtOAc/Water and extractedwith EtOAc. The combined organics were dried over Na SO4, filtered andevaporated. Purification by FCC, eluting with a gradient of 0-10% [2M NH3/MeOH] in DCM, gave the crude title compound (428 mg, 69%) as a brown oil.

The synthetic route of 82560-12-1 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 139756-02-8

General procedure: To a solution of 2-aminobenzamide (1.470 mmol, 1.0 eq.) was added to a solution of Terminal Alkyne (1.470 mmol, 1.0 eq.), Tosyl Azide, (1.470 mmol, 1.0eq.), CuI (0.147 mmol, 0.1 eq.), triethylamine (2.941 mmol, 2.0 eq.), in acetonitrile (10 ml) under N2 atmosphere. The mixture was stirred at room temperature for 12 h. After completion of the reaction (as indicated by TLC) the reaction mixture was poured into water (25 mL) and extracted with ethyl acetate (2×25 mL), dried over Na2SO4, concentrated under vacuum to get crude compound which was purified by column chromatography using a mixture of petroleum ether: ethyl acetate to give the desired product as a white solid.

The synthetic route of 139756-02-8 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5932-27-4

1H-pyrazole-3-carboxylic acid ethyl ester (13.0g, 93 mmol) was dissolved in dimethylformamide (200ml). Potassium carbonate (32g, 232 mmol) was added to the solution, followed by 4-chloro-2- (bromomethyl) phenyl phenylmethyl ether (29g, 93 mmol) and the reaction mixture stirred overnight at room temperature under argon. Water and ethyl acetate were added and the layers separated. The aqueous phase was re-extracted with ethyl acetate. The organic phases were combined and washed with water followed by brine. The extracts were dried (Na2SO4) and evaporated. The residue was purified by on a biotage (15-25percent ethyl acetate: hexane) to yield the title compounds. 1- ( {5-chloro-2- [ (phenylmethyl) oxy] phenyl} methyl)-1H-pyrazole-3-carboxylic acid ethyl ester: (13. 90g, 40percent). t = 3.40, no ion observed.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5932-27-4, its application will become more common.

The chemical industry reduces the impact on the environment during synthesis 5744-51-4, name is Ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life. 5744-51-4

LAH (1.05 M in THF, 15.0 kg, 17.4 mol) was gradually added to a stirring solution of ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate (5.33 kg, 31 .7 mol) in THF (10.7 L) over 1.5 h at 4- 23 C, followed by THF (1.0 L). After 30 min, the solution was cooled to 15 C, then, while continuing to cool, a solution of water (0.66 L, 37 mol) in THF (1.9 L) was gradually added over 20 min. Aq. NaOH (15 wt%, 0.66 L, 2.8 mol) was then added over a few min, followed by water (2.0 L). The resulting slurry was stirred for 20 min at 4-1 1 C then filtered under suction. The collected solids were washed four times with THF (10.7 L per wash) to give (1 ,5-dimethyl-1 H- pyrazol-3-yl)methanol as a solution in the collected filtrates. (0239

The chemical industry reduces the impact on the environment during synthesis 5744-51-4. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112758-40-4, name is 3-Methyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., 112758-40-4

3. 3-Methyl-1-(3-(tetrahydrofuran-2-yl)pyridin-2-yl)-1H-pyrazole-4-carbaldehyde; To a screw-cap test tube containing 2-fluoro-3-(tetrahydrofuran-2-yl)pyridine (148 mg, 0.88 mmol) in dimethylformamide (2.2 mL) are added 3-methyl-1H-pyrazole-4-carbaldehyde (81 mg, 0.74 mmol) and potassium carbonate (152 mg, 1.1 mmol). The reaction tube is quickly sealed (caution: build-up of pressure possible; use a safety shield) and stirred in a preheated oil bath at 110 C. for 18 h with the aid of a magnetic stirrer. The mixture is diluted with water and extracted with ethyl acetate. The organic layer is separated, dried over magnesium sulfate, filtered and the solvent evaporated in vacuo. The resulting residue is purified by silica gel using normal phase Isco chromatography eluting with hexane: acetone (gradient from 5 to 20% in acetone) to give 116 mg of the title compound. MS (m/z): 258 (M+1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

5334-43-0, These common heterocyclic compound, 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Equimolar portionsof the intermediate compounds 1 (1 mmol) and the intermediatecompounds 3 (1 mmol) were dissolved in approximately 8 mL ofethanol. The reaction solution was allowed to stir at 80 8C for 2 huntil the reaction was complete. The reaction was monitored byTLC. Mostly, a precipitate formed and was then collected by suctionfiltration.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5334-43-0.

A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 402-61-9.

[(VIVO)(C5H5N2O2)2H2O]2H2O (2) VO(acac)2 (0.0265 g,0.1 mmol) and 5-pyrazol-1H-pyrazol-3-carboxylic acid (0.025 g,0.2 mmol) were mixed and stirred for 3 h in a solution of 95%methanol (8 mL) at room temperature. After two days, purplecrystals of complex were obtained. Yield (based on V): 0.036 g,48.78%. Anal. Calc. For C10H16N4O8V: C, 32.35; H, 4.3; N, 15.09.Found: C, 32.35; H, 4.28; N, 15.05.

The synthetic route of 5-Methyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.