82560-12-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82560-12-1, name is 3-Amino-5-tert-butylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A solution of [2-(6-bromo-pyridin-2-yloxy)-ethyl]-dimethyl-amine(WO2003/082278, 500 mg, 2.00 mmol), 3-tert-butyl-lH-pyrazole-5-amine (341 mg, 2.50 mmol) and trans-N,N’-dimethyl-cyclohexane-diamine (58.0 mg,0.40 mmol) was formed in toluene (5 mL). Potassium carbonate (592 mg, 4.30mmol) was added and the mixture degassed by bubbling N2 through it.Copper(I) iodide (39.0 mg, 0.20 mmol) was added and the mixture was sealedin a microwave vial and heated using microwave irradiation at 150C for 2 h.The resulting mixture was partitioned between EtOAc/Water and extractedwith EtOAc. The combined organics were dried over Na SO4, filtered andevaporated. Purification by FCC, eluting with a gradient of 0-10% [2M NH3/MeOH] in DCM, gave the crude title compound (428 mg, 69%) as a brown oil.
The synthetic route of 82560-12-1 has been constantly updated, and we look forward to future research findings.