Sources of common compounds: 3524-32-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1,3-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.

Electric Literature of 3524-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: In a 50 mL single-mouth flask,Salicylaldehyde (1 mmol) was added in sequence,Ethyl cyanoacetate (1 mmol) and 3-methyl-1-phenyl-5-aminopyrazole (1 mmol),Triethylamine (0.1 mmol) and ethanol (8 mL),The reaction was stirred under reflux for 8 h.After the reaction is over,Cool to room temperature.Rotate the solvent under reduced pressure,Get a rough product,The crude product was recrystallized from 95% ethanol.5-amino-1-methyl-3-phenylcoumarin[4,3-d]pyrazolo[3,4-b]pyridine-6(3H)-one (Ia):Yield 63%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1,3-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.

Research on new synthetic routes about 42027-81-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Related Products of 42027-81-6, The chemical industry reduces the impact on the environment during synthesis 42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, I believe this compound will play a more active role in future production and life.

[0215j A solution of 2-(4-nitro-1H-pyrazol-1-yl)ethanol (2.00 g, 12.73 mmol), 3,4- dihydro-2H-pyran (1.60 g, 19.10 mmol) and p-toluenesulfonic acid (87 mg, 0.51 mmol) in THF (20 mL) was stirred at room temperature for 2 h. Then the mixture was diluted with EtOAc (150 mL), washed with sat. aqueous sodium carbonate (50 mL) and water 60 mL. The organic phase was dried (Na2SO4), filtered and concentrated to give crude product 4-nitro- 1 -(2-((tetrahydro- 2H-pyran-2-yl)oxy)ethyl)-1H-pyrazole as colorless oil (2.00 g, yield: 67%). ESI-MS (M+H) :242.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Sources of common compounds: 89501-90-6

According to the analysis of related databases, 89501-90-6, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89501-90-6, name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C4H5ClN2O2S

To a 50 mL flask was added 1-methyl-1H-pyrazole-3-sulfonyl chloride (1.12g, 6.22 mmol), ethyl (4aS,6S)-6-[(2,4-dimethoxyphenyl)methylaminoj -1 -(4-fluorophenyl)-5 ,6,7,8-tetrahydro-4H- benzo[flindazole-4a-carboxylate (lila) (1.57g, 3.11 mmol), DCM (8 mL), and triethylamine (1.73 mL, 12.45 mmol) successively. After the reaction was stirred at 40C for 5 h, it was directly concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (Si02, 40%-65% EtOAc/hexanes, gradient elution) to provide ethyl (4aS,6S) -6-[(2,4-dimethoxyphenyl)methyl-( 1- methylpyrazol-3 -yl)sulfonyl-aminoj -1 -(4-fluorophenyl)-5 ,6,7, 8-tetrahydro-4H-benzo [flindazole-4a- carboxylate (ilib) (1.86g, 92% yield) as a yellow solid. m/z(ESI, +ve ion) = 650.3 [M+Hj.

According to the analysis of related databases, 89501-90-6, the application of this compound in the production field has become more and more popular.

The important role of 34605-66-8

The synthetic route of 34605-66-8 has been constantly updated, and we look forward to future research findings.

34605-66-8, name is 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C10H13N3

At -78 C, to a solution of 3-(2,5-di methyl- 1 /7-pyrrol- 1 -yl)- 1 -methyl- 1 /7-pyrazolc (step 1 intermediate) (2.0 g, 11.4 mmol) was added n-butyl lithium (1.6 M, 10.55 mL, 16.8 mmol) and the mixture was continued to stir at -78 C for 30 min. The mixture was stirred for 2 h at 0 C and added acetone (1.28 mL, 17.5 mmol) to the solution. The mixture was stirred at RT for 3 h. The mixture was quenched with water and extracted with ethyl acetate. The organic phase was washed with brine and dried over anhydrous sodium sulfate. The solution was filtered, concentrated and the residue obtained was purified by column chromatography to yield 1.0 g of the desired compound. NMR (400 MHz, DMSO-de) d 1.54 (s, 6H), 2.04 (s, 6H), 3.98 (s, 3H), 5.42 (s, 1H), 5.73 (s, 2H), 6.10 (s, 1H).

The synthetic route of 34605-66-8 has been constantly updated, and we look forward to future research findings.

New learning discoveries about 16034-46-1

According to the analysis of related databases, 16034-46-1, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16034-46-1 as follows. name: 1-Methyl-1H-pyrazole-5-carboxylic acid

To a solution of 1-methyl-1H-pyrazole-5-carboxylic acid (46.6 mg, 0.37 mmol, 1.3 equiv) in DMF (1 ml) were added HATU (140 mg, 0.37 mmol, 1.3 equiv), DIEA (147 mg, 1.14 mmol, 4.0 equiv), and 7-(5-ethyl-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2H-1-benzopyran-4- amine hydrochloride (80 mg, 0.28 mmol, 1.0 equiv). The mixture was stirred overnight and purified by Prep-HPLC with the following conditions: (2-AnalyseHPLC- SHIMADZU(HPLC-10)): Column, XBridge Prep C18 OBD Column, 5 mum,19*150mm; mobile phase, water (10MMOL/L NH4HCO3) and ACN (34.0% ACN up to 47.0% in 8 min); Detector, UV 220nm. This purification resulted in 170 mg (90%) of N-[6-(5-ethyl-1,2,4- oxadiazol-3-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-methyl-1H-pyrazole-4-carboxamide as a white solid. LRMS (ES) m/z 354 (M+H).

According to the analysis of related databases, 16034-46-1, the application of this compound in the production field has become more and more popular.

Discovery of 138786-86-4

Statistics shows that Methyl 4-nitro-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 138786-86-4.

Reference of 138786-86-4, These common heterocyclic compound, 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of methyl 4-nitro-1H-pyrazole-3-carboxylate obtained in Reference Example 18 (2.0 g, 11.7 mmol), methyl iodide (2.0 g, 14.0 mmol), potassium carbonate (1.62 g, 11.7 mmol) and acetone (60 mL) was stirred at 30C for 5 hr. The mixture was diluted with water, and extracted with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane-ethyl acetate 4:1 – 1:1) to give the title compound, methyl 1-methyl-4-nitro-1-pyrazole-3-carboxylate (Rf value 0.43) (0.95 g, yield 44%) and the title compound, methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate (Rf value 0.71) (0.61 g, yield 28%). Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate 1H-NMR (CDCl3):delta 3.99(3H, s), 4.01(3H, s), 8.13(1H, s). Methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate 1H-NMR (CDCl3):delta 4.02(3H, s), 4.03(3H, s), 8.01 (1H, s).

Statistics shows that Methyl 4-nitro-1H-pyrazole-3-carboxylate is playing an increasingly important role. we look forward to future research findings about 138786-86-4.

New downstream synthetic route of 3398-16-1

Statistics shows that 4-Bromo-3,5-dimethylpyrazole is playing an increasingly important role. we look forward to future research findings about 3398-16-1.

Related Products of 3398-16-1, These common heterocyclic compound, 3398-16-1, name is 4-Bromo-3,5-dimethylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

PREPARATION 924-Bromo-3,5-dimeth l-1 -(methylthiomethyl)-l H-pyrazoleTo a solution of 4-bromo-3,5-dimethyl-1 H-pyrazole (2.1 Og, 14.3mmol) in acetone (20 ml_) was added K2CO3 (2.37g, 17.1 mmol) followed by chloromethyl methyl sulfide (1.3 ml_, 5.7mmol). The light yellow suspension was stirred at room temperature for 96 hr. At this time the reaction was thick with white precipitate. The reaction mixture was stripped off volatiles, diluted with methylene chloride and filtered. The filtrate was concentrated under reduced pressure to give the title compound as a light yellow oil which was used without further purification.

Statistics shows that 4-Bromo-3,5-dimethylpyrazole is playing an increasingly important role. we look forward to future research findings about 3398-16-1.

Discovery of 5334-40-7

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Nitro-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 5334-40-7, The chemical industry reduces the impact on the environment during synthesis 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.

A stirred solution of S-83 (1.00 g, 6.36 mmol) in THF (10 mL) taken in a round- bottom flask was charged with Et3N (1.3 mL, 9.55 mmol) and DPPA (2.62 g, 9.55 mmol) at room temperature. The reaction mixture was stirred for 6 h at room temperature under nitrogen atmosphere. At this time, t-butanol (10 mL) was added and refluxed for 6 h under nitrogen atmosphere. When TLC showed complete consumption of starting material, the reaction mixture was diluted with the water (10 mL) and extracted with EtOAc (2 ¡Á 10 mL). The combined organic layers were washed with water (10 mL). The organic layers were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel using 0? 50percent EtOAc in hexanes as eluent to afford S-91 (0.20 g, 14percent, AMRI lot IN-SKY-C-110) as an off-white solid. The compound was characterized by UPLC analysis. MS-UPLC (MM) m/z 127.2 [M? ]-

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Nitro-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

The origin of a common compound about 5334-40-7

According to the analysis of related databases, 5334-40-7, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5334-40-7 as follows. SDS of cas: 5334-40-7

Reference Example 1 Methyl 4-nitro-1H-pyrazole-3-carboxylate Acetyl chloride (9 mL) was added dropwise to methanol (90 mL), 4-nitro-1H-pyrazole-3-carboxylic acid (9.00 g, 57.3 mmol) was added to the mixture. The mixture was stirred at room temperature for 16 hr, and concentrated under reduced pressure. Methanol was added to the residue, and the mixture was concentrated under reduced pressure, the operation was twice repeated. The residue was diluted with methanol and ethyl acetate. 5% sodium hydrogencarbonate aqueous solution was added, and the pH was adjusted to 8-9. The mixture was extracted with ethyl acetate. The extract was washed with water, brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (9.83 g, yield 100%). 1H-NMR (DMSO-d6, 200 MHz): delta 3.98 (3H, s), 8.28 (1H, s).

According to the analysis of related databases, 5334-40-7, the application of this compound in the production field has become more and more popular.

New learning discoveries about 943541-20-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, its application will become more common.

Reference of 943541-20-6,Some common heterocyclic compound, 943541-20-6, name is 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, molecular formula is C8H7ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 13: A route to prepare compound (I)6-{difluoror6-(1-methvl-1 H-pvrazol-4-vl)? ,2,41triazolor4,3-lpvridazin-3-vnmethvl>quinolineStep 1 : tert-butyl 2-f6-(1-methyl-1 H-pyrazol-4-yl)pyridazin-3-vnhvdrazinecarboxylatetert-butyl carbazate, 8,98g (67,3 mmol) and 3-chloro-6-(1-methyl-1 /-/-pyrazol-4- yl)pyridazine (11 ,9 g, 61 ,1 mmol) were mixed in 1-butanol (245 ml_). This mixture was heated till 900C and stirred at that temperature for 16h. The reaction mixture was cooled and water (250 ml_) and ethylacetate (250 mL) were added. The biphasic mixture was neutralised with sodium hydrogencarbonate till the pH is 7. Then the organic layer was separated and the water layer was extracted with ethylacetate (250 mL). The combined organic layers were washed once with water (250 mL) and evaporated. The residue was stirred in isopropylether, filtered off and dried under vacuum. Yield: 5,9 g (20,3 mmol; 33%) of the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyridazine, its application will become more common.