Tag: M.W=200-250

Osawa, Akio; Kaiho, Terumitsu; Ito, Takashi; Okada, Mamiko; Kawabata, Chikako; Yamaguchi, Kentaro; Igeta, Hiroshi published the artcile< Reactions of N-aminopyrazoles with halogenating reagents and synthesis of 1,2,3-triazines>, Product Details of C9H7BrN2, the main research area is triazine; pyrazolamine reaction halogenating agent; ring expansion aminopyrazole.

Reactions of N-aminopyrazoles with halogenating reagents (Cl2, Br2, I2, BrCl, ICl, IBr, N-chlorosuccinimide, and N-bromosuccinimide) were examined Some of these reagents preferentially leas to oxidation of the amino group to give the corresponding 1,2,3-triazines as major products, while others mainly gave either or both of 1-amino-4-halopyrazoles and 5-halo-1,2,3-triazines as the result of halogenation of the 4-position of the pyrazole ring prior to the oxidation of the amino group. In some cases, the oxidation of the amino group and the halogenation of the pyrazole ring proceeded concurrently to form not only the unhalogenated triazines but also the 1-amino-4-halopyrazines and the 5-halotriazines. Various reagents and reaction conditions were explored to utilize the reaction for the synthesis of halogenated and unhalogenated 1,2,3-triazines.

Chemical & Pharmaceutical Bulletin published new progress about Halogenation. 13808-65-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Product Details of C9H7BrN2.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Olsen, Kathryn L.; Jensen, Matthew R.; MacKay, James A. published the artcile< A mild halogenation of pyrazoles using sodium halide salts and Oxone>, Name: 4-Bromo-3-phenyl-1H-pyrazole, the main research area is pyrazole halogenation sodium halide oxone green chem.

A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided.

Tetrahedron Letters published new progress about Alkali metal halides, sodium halides Role: RGT (Reagent), RACT (Reactant or Reagent). 13808-65-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Name: 4-Bromo-3-phenyl-1H-pyrazole.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Liu, Haidong; Ge, Liang; Wang, Ding-Xing; Chen, Nan; Feng, Chao published the artcile< Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem-Difluoroalkenes>, Safety of 1-(4-Bromophenyl)-1H-pyrazole, the main research area is homoallylic trifluoromethane preparation; gem difluoroalkene photoredox coupled fluoroallylation; allylic compounds; fluorine; photochemistry; radicals; reaction mechanisms.

A novel strategy for the expedient construction of CF3-embeded tertiary/quaternary carbon centers was developed by taking advantage of photoredox catalysis. Thanks to a key step of single-electron oxidation, electron-rich gem-difluoroalkenes, which otherwise are essentially reluctant towards F-nucleophilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation, as well as functionalization, of α-CF3-substituted benzylic radical intermediates using cheap and readily available starting materials.

Angewandte Chemie, International Edition published new progress about Allylation (fluoro). 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Safety of 1-(4-Bromophenyl)-1H-pyrazole.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Poslusney, Michael S.; Melancon, Bruce J.; Gentry, Patrick R.; Sheffler, Douglas J.; Bridges, Thomas M.; Utley, Thomas J.; Daniels, J. Scott; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.; Wood, Michael R. published the artcile< Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule>, Related Products of 1046832-21-6, the main research area is spirocycle preparation SAR human rat muscarinic M1 receptor selectivity; pos allosteric modulator SAR spirocycle MLPCN probe mol.

This Letter describes the further optimization of an MLPCN probe mol. (ML137) through the introduction of 5- and 6-membered spirocycles in place of the isatin ketone. Interestingly divergent structure-activity relationships, when compared to earlier M1 PAMs, are presented. These novel spirocycles, e.g. I, possess improved efficacy relative to ML137, while also maintaining high selectivity for the human and rat muscarinic M1 receptor subtype.

Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 1046832-21-6 belongs to class pyrazoles-derivatives, and the molecular formula is C11H19BN2O2, Related Products of 1046832-21-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Tan, Yun-Xuan; Liu, Xing-Yu; Zhang, Shuo-Qing; Xie, Pei-Pei; Wang, Xin; Feng, Kai-Rui; Yang, Shao-Qian; He, Zhi-Tao; Hong, Xin; Tian, Ping; Lin, Guo-Qiang published the artcile< An unconventional trans-exo-selective cyclization of alkyne-tethered cyclohexadienones initiated by rhodium(III)-catalyzed C-H activation via insertion relay>, Computed Properties of 13788-92-6, the main research area is rhodium carbon hydrogen activation catalysis alkyne cyclohexadienone cyclization.

Different from the established trans-endo-selective cyclization of alkyne-tethered electrophiles that involve an E/Z isomerization process, herein, the authors present a novel strategy to allow trans-exo-selective arylative cyclization of 1,6-enynes. Through initiation of rhodium(III)-catalyzed C-H activation, a diverse range of N-heterocyclic directing groups, including pyridine, pyrazole, imidazo[1,2-a] pyridine, benzoxazole, benzothiazole, and purine, was feasible for the cascade transformation, exhibiting high efficiency (up to 92% yield), broad substrate scope, and excellent functional group compatibility. Moreover, the modification of natural products and pharmaceutical compounds was also demonstrated to showcase its synthetic utility. Based on d. functional theory (DFT) calculations, a key three-membered ring intermediate through the insertion relay, rather than the direct E/Z isomerization of alkenyl rhodium species, controlled the stereochem. outcome for this trans-exo-selective cyclization. The subsequent ring-opening protonation of the more favored rotamer led to exclusive trans-exo-selectivity.

CCS Chemistry published new progress about C-H bond activation. 13788-92-6 belongs to class pyrazoles-derivatives, and the molecular formula is C9H7BrN2, Computed Properties of 13788-92-6.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazoles are a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.Notable drugs containing a pyrazole ring are celecoxib (celebrex) and the anabolic steroid stanozolol. Recommanded Product: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.

Leung, Leo;Niculescu-Duvaz, Dan;Smithen, Deborah;Lopes, Filipa;Callens, Cedric;McLeary, Robert;Saturno, Grazia;Davies, Lawrence;Aljarah, Mohammed;Brown, Michael;Johnson, Louise;Zambon, Alfonso;Chambers, Tim;Menard, Delphine;Bayliss, Natasha;Knight, Ruth;Fish, Laura;Lawrence, Rae;Challinor, Mairi;Tang, HaoRan;Marais, Richard;Springer, Caroline research published 《 Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure-Activity Relationships》, the research content is summarized as follows. Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase that cross-links collagens and elastin in the extracellular matrix and is a critical mediator of tumor growth and metastatic spread. LOX is a target for cancer therapy, and thus the search for therapeutic agents against LOX has been widely sought. We report herein the medicinal chem. discovery of a series of LOX inhibitors bearing an aminomethylenethiophene (AMT) scaffold. High-throughput screening provided the initial hits. Structure-activity relationship (SAR) studies led to the discovery of AMT inhibitors with sub-micromolar half-maximal inhibitory concentrations (IC₅₀) in a LOX enzyme activity assay. Further SAR optimization yielded the orally bioavailable LOX inhibitor CCT365623 (I) with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy.

Recommanded Product: 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Formula: C10H17BN2O2.

Li, Anbang;Li, Zhongshan;Zhao, Yang;Yao, Tingting;Cheng, Jingli;Zhao, Jinhao research published 《 Design, synthesis and antifungal activity of novel pyrazole-thiophene carboxamide derivatives》, the research content is summarized as follows. Succinate dehydrogenase inhibitor is a low-toxic and high active fungicide. In order to develop novel and broad-spectrum succinate dehydrogenase inhibitor (SDHI) fungicides, thiophene was introduced into the structure of pyrazole carboxamide fungicides. Twenty four pyrazole-thiophene carboxamides were designed, synthesized and characterized by ¹H NMR, ¹³C NMR and HRMS. The crystal structure of N-(4-methoxyphenyl)-4-(1-methyl-1H-pyrazol-4-yl) thiophene-2-carboxamide (7i) was determined by X-ray diffraction. The antifungal activity of all the synthesized compounds was determined against six plant pathogenic fungi, and preliminary bioassays suggested that some compounds exhibited good antifungal activity against Rhizoctonia solani, Fusarium graminearum and Botrytis cinerea. Among them, N-(4-fluorophenethyl)-4-(1-methyl-1H-pyrazol-4-yl) thiophene-2-carboxamide (7c) exhibited the best antifungal activities against R. solani in vitro with EC₅₀ value of 11.6μmol/L, and N-(2-fluorophenyl)-4-(1-methyl-1H-pyrazol-4-yl) thiophene-2-carboxamide (7j) against F. graminearum with EC₅₀ value of 28.9μmol/L. And N-(4-chlorophenyl)-4-(1-methyl-1H-pyrazol-4-yl) thiophene-2-carboxamide (7h) showed similar inhibition abilities with thifluzamide against B. cinerea with EC₅₀ value of 21.3μmol/L. The mol. docking results showed that the high antifungal activities compounds form stronger interactions with important amino acid residues of succinate dehydrogenase.

Formula: C10H17BN2O2, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles can be selectively lithiated at different carbons and subsequently react with electrophiles depending on the substitution patterns. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. 1-Methyl-5-(trifluoromethyl)pyrazole underwent deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Synthetic Route of 761446-44-0.

Li, Jian-Yuan;Huang, Hongbing research published 《 Development of DNA-Compatible Suzuki-Miyaura Reaction in Aqueous Media》, the research content is summarized as follows. DNA-encoded chem. libraries (DELs) are a cost-effective technol. for the discovery of novel chem. probes and drug candidates. A major limiting factor in assembling productive DELs is the availability of DNA-compatible chem. reactions in aqueous media. In an effort to increase the chem. accessibility and structural diversity of small mols. displayed by DELs, the authors developed a robust Suzuki-Miyaura reaction protocol that is compatible with the DNA structures. By employing a water-soluble Pd-precatalyst, the authors developed conditions that allow efficient coupling of DNA-linked aryl halides with a wide variety of boronic acids/esters including heteroaryl boronates.

Synthetic Route of 761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazoles are synthesized by the reaction of α,β-unsaturated aldehydes with hydrazine and subsequent dehydrogenation. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Substituted pyrazoles are prepared by condensation of 1,3-diketones with hydrazine (Knorr-type reactions). For example, acetylacetone and hydrazine gives 3,5-dimethylpyrazole. HPLC of Formula: 761446-44-0.

Li, Meng-Yao;Han, Pengbo;Hu, Tian-Jiao;Wei, Dong;Zhang, Ge;Qin, Anjun;Feng, Chen-Guo;Tang, Ben Zhong;Lin, Guo-Qiang research published 《 Suzuki-Miyaura Coupling Enabled by Aryl to Vinyl 1,4-Palladium Migration》, the research content is summarized as follows. An efficient Suzuki-Miyaura coupling enabled by a controllable 1,4-palladium migration was realized to afford stereodefined multisubstituted olefins and 1,3-dienes. The reaction exhibited remarkable broad substrate scope, excellent functional-group tolerance, versatile conversion with obtained products, and easy scalability. The practicality of this method was highlighted by the aggregation-induced emission feature of the produced olefins and 1,3-dienes, as well as the capability of affording geometric isomer pairs with a marked difference on photoluminescent quantum yield values.

761446-44-0, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., HPLC of Formula: 761446-44-0

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. 761446-44-0, formula is C10H17BN2O2, Name is 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C).Pyrazole used as a ligand to prepare organometallic compounds. Category: pyrazoles-derivatives.

Jin, Fangfang;Hu, Qiyue;Fei, Hongbo;Lv, Hejun;Wang, Shenglan;Gui, Bin;Zhang, Junzhen;Tu, Wangyang;Zhang, Yun;Zhang, Lei;Wan, Hong;Zhang, Limin;Hu, Bin;Yang, Fanglong;Bai, Chang;He, Feng;Zhang, Lianshan;Tao, Weikang research published 《 Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors》, the research content is summarized as follows. In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, resp.). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenograft mouse model. The combination of compound 18 with PD-1 monoclonal antibody showed a synergistic antitumor effect. These data indicated that compound 18 as a potential cancer immunotherapy agent should warrant further investigation.

Category: pyrazoles-derivatives, 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a useful research compound. Its molecular formula is C10H17BN2O2 and its molecular weight is 208.07 g/mol. The purity is usually 95%., 761446-44-0.

Referemce:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics