Tag: M.W:100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 863548-52-1, name is (1-Methyl-1H-pyrazol-5-yl)methanamine, A new synthetic method of this compound is introduced below., SDS of cas: 863548-52-1

General procedure: To a solutionof the corresponding aldehyde (1.2 eq.; unless stated otherwise) in DMF (2 inL per 0.3 mmol of aldehyde; unless stated otherwise) was added the corresponding amine (2.5 eq.; unless stated otherwise) and the resulting solution was stirred at 25 C to form the corresponding inline. Then, the corresponding isocyano(tosyl)methyl)arene reagent (1 eq.; unless stated otherwise) and K2CO3 (1.5 eq.; unless stated otherwise*) were added and the reaction mixture was stirred at 25 C (unless stated otherwise). The reaction was stopped after the time indicated for each particular reaction. The reaction progress was monitored by TLC. (0083) A saturated aqueous solution of NH4CI (10 mL per 1 mmol of aldehyde) was added to the reaction mixture, which was then extracted with EtOAc (2 x 30 mL per 1 mmol of aldehyde). The combined organic extracts were washed with H2O (2 x 25 mL per 1 mmol of aldehyde), dried over MgSCC, filtered, and the solvent was evaporated in vacuo to provide the crude product. The residue obtained after the workup was purified using column chromatography or preparative TLC (unless stated otherwise). (0084) * note: in cases when the amine was used as HC1 salt, 4 eq. of K2CO3 were used

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4522-35-4, name is 3-Iodo-1H-pyrazole, A new synthetic method of this compound is introduced below., Recommanded Product: 3-Iodo-1H-pyrazole

A solution of 3-iodo-lH-pyrazole (500 mg, 2.6 mmol) and ethylene carbonate (238 mg, 2.70 mmol) was formed in DMF (5 mL) and heated at 150C for 3 h. The mixture was allowed to cool then evaporated under vacuum to remove the solvent. Purification of the residue by FCC eluting with a gradient of 0-100% EtOAc in cyclohexane gave crude title compound (444 mg, 72%) as a brown oil. LCMS (Method 3): Rt 2.17 min, m/z 239 [MH+].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Formula: C5H6N2O2

Example 29 To a 50 ml_ flask containing 20 ml_ of DMF was added 1 mL of oxalyi chloride siowly and stirred for 10 min at RT. 100 mg of 2-Methyi-2H-pyrazole-3-carboxyiic acid was dissolved in 2 mL of the above solution and stirred for 5 min at RT. Then 50 mg of E was dissolved in 1 mL pyridine and added to the above solution. The reaction was completed in 5 min at RT and quenched with 1 mL NH4OH. The solvent was then evaporated under vacuum and the residue dissolved in CH3CN and water and purified with prep HPLC (0% to 95% water/ Acetonitriie) to afford 29 (29mg, 46%).1H-NMR (DMSO, 300 MHz): delta 10.23 (s, 1 H), 8.54 (d, J = 3.9 Hz, 1 H), 7.77 (d, J = 6.9 Hz, 1 H)1 7.66 (s, 1 H), 7.52 (d, J = 7.8 Hz, 2H)1 7.26 (t, J = 6.6 Hz, 1 H), 7.08 (t, J = 7.8 Hz, 1 H), 6.99-6.91 (m, 3H), 6.82 (d, J = 1.2 Hz, 1 H), 4.87 (me, 1 H), 4.03 (s, 3H), 3.22-3.10 (m, 3H)1 2.83-2.80 (m, 1 H), 0.70 (m, 2H), 0.56 (m, 2H).LCMS m/z [M+Hf C28H25N5O3S requires: 512.59. Found 512.12HPLC Tr (min), purity %: 2.95, 98%

The synthetic route of 16034-46-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 174891-10-2, Quality Control of 5-Amino-1H-pyrazole-3-acetic acid

Compound 7 (96 g, 0.395 mol, 1.0 eq.) and compound 4 (83.5 g, 0.592 mol, 1.5 eq.) were suspended in 960 mL of AcOH at 18-2O0C. The suspension was heated to 100- 1020C, and stirred for 2.5 h at this temperature. The suspension was cooled down to 18-2O0C, and filtered. Filtrate cake was washed with 50 mL of AcOH, followed by 100 mL of EtOAc. Solid was collected and dried under vacuum at 5O0C (12 h) to give 136 g of compound 10 with 96.5% HPLC purity in 98.9% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1H-pyrazole-3-acetic acid, other downstream synthetic routes, hurry up and to see.

Reference of 52222-73-8,Some common heterocyclic compound, 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

For the synthesis of the intermediates 1-3.2.1 17 and 1-3.2.118 to the educt 1-3.1.2 with the appropriate amine in MeOH 0.14 eq copper(I)oxide is added (as shown in Table 15).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(Trifluoromethyl)-1H-pyrazole, its application will become more common.

These common heterocyclic compound, 110860-60-1, name is Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 110860-60-1

(6) Synthesis of alpha-type crystal form azo pigment (1)-1 20.5 mL of acetic acid is cooled with ice to an internal temperature of 10C. 16.8 g of nitrosylfulfic acid is added with keeping the internal temperature at 15C or lower, and successively 9.5 g of the intermediate (b) is added thereto by portions with keeping the internal temperature at 15C or lower. After stirring for 15 minutes at an internal temperature of 15C, the internal temperature is increased to 25C in 15 minutes. After stirring for 90 minutes at the same temperature, 0.4 g of urea is added by portions at the same temperature, followed by stirring for 15 minutes at the same temperature to obtain a diazonium salt solution. Separately, 11.6 g of the intermediate (e) is completely dissolved in 405 mL of methanol at room temperature, and then the solution is cooled with ice to an internal temperature of -3C. At the same temperature, the above-described diazonium salt solution is added thereto by portions with keeping the internal temperature at 3C or lower and, after completion of the addition, the mixture is stirred for 2 hours to obtain an azo compound reaction solution. Separately, 810 mL of water is prepared, and the azo compound reaction solution is added thereto. The resulting mixture is stirred for 30 minutes at room temperature, and crystals precipitated are collected by filtration, spray-washed with 150 mL of methanol and, further, with 100 mL of water. The thus-obtained crystals are suspended in 750 mL of water without drying, and a 8-N potassium hydroxide aqueous solution is added thereto to adjust the pH to 5.7. After stirring for 20 minutes at room temperature, resulting crystals are collected by filtration, sufficiently spray-washed with water, and then spray-washed with 80 mL of methanol to obtain a crude pigment (1-1).

The synthetic route of Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34334-96-8 as follows. Safety of 3-Methyl-5-nitro-1H-pyrazole

In a sealed tube, 2-(tributylphosphoranylidene)-acetonitrile (7.30 g, 30.25 mmol) was added to a solution of 5-Methyl-3-nitro-lH-pyrazole (2.00 g, 15.74 mmol) and 2- cyclopropylethanol (2.04 g, 23.68 mmol) in toluene (70 mL). The mixture was heated at 60 C for 19 h. After cooling down to rt, the mixture was diluted with EtOAc and water. The organic layer was decanted and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel (Irregular SiOH, 20-45 muiotaeta, 40 g, mobile phase: heptane/EtOAc, gradient from 60:40 EtOAc to 50:50). The pure fractions were combined and the solvent was evaporated until dryness to give 2.10 g of intermediate 232′ (68% yield) and 330 mg of intermediate 232 (11% yield).

According to the analysis of related databases, 34334-96-8, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151049-87-5 as follows. Quality Control of 3-Bromo-1-methyl-1H-pyrazole

To a solution of 3-bromo-1-methyl-1H-pyrazole (40 g, 248 mmol) (see the Supporting Information for the synthesis) in THF (1 L) was added dropwise a solution of t-BuLi (200 mL, 1.3 M, 260 mmol) in hexane at -90 C under N2 with stirring over 2 h. The reaction mixture was stirred at -90 C for further 0.5 h. Then a solution of (SS)-4 (58 g, 209 mmol) in THF (0.2 L) was added dropwise to the reaction mixture at -90 C. The mixture was stirred and warmed slowly to r.t. overnight. TLC showed the desired spot with Rf = 0.25 (EtOAc). Then the solution was quenched with sat. aq NH4Cl (1 L) and extracted with Et2O (3 ¡Á 0.8 L). The combined organic layers were dried (Na2SO4) concentrated. The crude product was purified by column chromatography over silica gel (PE-EtOAc, 20:1 ? 2:1) to give the title product; yield: 22.9 g (30%); brown oil; Rf = 0.25 (EtOAc).

According to the analysis of related databases, 151049-87-5, the application of this compound in the production field has become more and more popular.

Application of 1613191-73-3, The chemical industry reduces the impact on the environment during synthesis 1613191-73-3, name is Allyl 3,5-diamino-1H-pyrazole-4-carboxylate, I believe this compound will play a more active role in future production and life.

[0450] To a suspension ofallyl3,5-diamino-1H-pyrazole-4-carboxylate 3 ( 42.72 g, 234.5 mmol) in DMSO (270.8mL)/Water(270.8 mL), was added p-TsOHhydrate (46.72 g,245.6 mmol) and 3-( diisopropylamino )-2-fluoro-prop-2-enal(described in Tetrahedron Letters, 33(3), 357-60; 1992) (38.69 g, 223.3 mmol). The reaction mixture was heated to 100C. for 3 hr. during which time a solid slowly precipitated outof solution. The orange suspension was allowed to cool downto RT overnight. The solid was filtered, washed with waterand dried under vacuum to give allyl2-amino-6-fluoro-pyrazolo[1,5-a]pyrimidine-3-carboxylate 4a as a sand solid (45.05 g, 85% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Allyl 3,5-diamino-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 20154-03-4, These common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

NaH (33.08 g (19.85, 60percent), 1.5 equiv.) was added to a small amount of n-hexane and the mixture was stirred for 10 minutes. The n-hexane was decanted, dry DMF (500 mL) was added under an N2 atmosphere and the mixture was stirred. A solution of the product obtained in step b (75 g, 550 mmol) in DMF (125 mL) was added dropwise under an N2 atmosphere. A solution of 4-methoxyl benzoyl chloride (86.3 g, 550 mmol, 1 equiv.) in DMF (125 mL) was then added dropwise and the mixture was stirred for 12 h at RT and then poured into iced water (500 mL), and the mixture was extracted with EA (2.x.400 mL). The mixture was then dried over Na2SO4 and concentrated under reduced pressure, the crude product being obtained as a brown oil (125 g, 88percent yield).

Statistics shows that 3-(Trifluoromethyl)-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 20154-03-4.