Tag: M.W:100-200

Adding a certain compound to certain chemical reactions, such as: 313735-62-5, name is 4-Bromo-1-isopropylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 313735-62-5, SDS of cas: 313735-62-5

To a degassed (N2 bubbling) solution of the compound of Intermediate Example 12(a) 4-bromo-1-isopropyl-1H-pyrazole (1.5 g, 7.9 mmol) in 1,4-dioxane (30 ml) were added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (3 g, 11.84 mmol, 1.5 eq.), Pd(dppf)Cl2 (0.64 g, 0.79 mmol, 0.1 eq.) and potassium acetate (1.93 g, 19.74 mmol, 2.5 eq.) using the procedure of Intermediate Example 1(b). The solvent was distilled off to afford the product in 67% yield (1.2 g). LC-MS (ESI): Calculated mass: 236.12; Observed mass: 237.1 [M+H]+ (rt: 1.41 min).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-isopropylpyrazole, and friends who are interested can also refer to it.

Electric Literature of 176969-34-9, The chemical industry reduces the impact on the environment during synthesis 176969-34-9, name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, I believe this compound will play a more active role in future production and life.

To a solution of 600 mg of 3-difluoromethyl-1- methyl-lH-pyrazole-4-carboxylic acid [compound (III)] and a catalytic amount of N, -dimethylformamide in dichloromethane (7 mL) , 450 mg of thionyl chloride were added dropwise. The mixture was refluxed for 2h. The reaction was monitored by GC/MS . The solvent was evaporated in vacuo. The crude acid chloride obtained was used in the following step.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference of 57097-81-1, A common heterocyclic compound, 57097-81-1, name is 3-Bromo-5-methyl-1H-pyrazole, molecular formula is C4H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 3-bromo-5-methyl-1H-pyrazole (from Ark Pharm, 6.4 g, 40 mmol) in tetrahydrofuran (263 mL) at 0 C. was added sodium hydride (3.2 g, 80 mmol). After stirring for 30 min, [beta-(trimethylsilyl)ethoxy]methyl chloride (8.4 mL, 48 mmol) was added and the reaction mixture was allowed to warm to room temperature over 2 h. The reaction mixture was diluted with ethyl acetate and water. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated. The crude was purified with flash chromatography (eluting with a gradient of 0-15% ethyl acetate in hexanes) to give the desired product as colorless oil (12 g, 100%). LCMS calculated for C10H20BrN2OSi (M+H)+: m/z=291.1. Found: 291.0

The synthetic route of 57097-81-1 has been constantly updated, and we look forward to future research findings.

Related Products of 16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1. A solution of 5-amino-1H-pyrazole-4-carbonitrile (10 g, 92.51 mmol, 1.00 equiv) in formamide (80 mL) was stirred under nitrogen at 165 ¡ãC for 5 h. The reaction mixture was cooled to room temperature and the solid was collected by filtration. The filter cake was washed first with 20 mL of water then 20 mL of methanol and dried to yield 9.5 g (76percent) of 1H-pyrazolo[3,4-d]pyrimidin-4-amine as a white solid.

Statistics shows that 3-Amino-1H-pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 16617-46-2.

Reference of 89501-90-6, A common heterocyclic compound, 89501-90-6, name is 1-Methyl-1H-pyrazole-3-sulfonyl chloride, molecular formula is C4H5ClN2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of sodium sulfite (17.93g, 142.26 mmol) in H2O (100 ml) was stirred at room temperature for10 min. Sodium carbonate (23.90 g, 284.52 mmol)was added to the stirred solution.The resulting solution was stirred at 50 C for 10 minutes.cyclopropanesulfonyl chloride (20 g, 142.26 mmol) was added dropwise to thesolution and was stirred at 50 C for 2 hours. Thereaction mixture was evaporated to dryness and redissolved in EtOH (200 ml). The suspension was allowed to stir at roomtemperature for 20 min. The suspension was filtered and the filtrate evaporatedto afford a white solid, this was stirred with MeCN (50 ml) and thenfiltered to afford sodium cyclopropanesulfinicacid (13.70 g, 75 %) as a white solid. 1H NMR (400.132 MHz, DMSO d6)delta 1.38-1.31 (m, 1H), 0.27-0.24 (m,2H) and 0.08-0.03 (m, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H9N3O2

To a solution of ethyl 5-amino-lH-pyrazole-4-carboxylate (1.0 g, 6.45 mmol) in n- BuOH (1 ml) was added to ethyl 3-(2H-l,3-benzodioxol-5-yl)-3-oxopropanoate (1.83 g, 7.75 mmol and TsOH (55 mg, 0.32 mmol), and the reaction mixture was stirred for 20 h at 130C. The solid was collected by filtration and washed with methanol (3 x 10 ml) and dried in an oven under reduced pressure to afford ethyl 5- (2H-l,3-benzodioxol-5-yl)-7-oxo-4H,7H-pyrazolo[l,5-a]pyrimidine-3-carboxylate as a yellow solid (1.8 g, 85 ). LC/MS (ES, m/z): [M+H]+ 328.0 *H NMR (300 MHz, DMSO) delta 11.52 (s, 1H), 8.25 (s, 1H), 7.39 (d, /= 1.8 Hz, 1H), 7.31 – 7.35 (m, 1H), 7.12 (d, /= 8.1 Hz, 1H ), 6.23 (s, 1H), 6.16 (s, 2H), 4.28 – 4.35 (m, 2H), 1.32 – 1.37 (t, / = 7.2 Hz, 3H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1254717-53-7, name is (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: (5-(Trifluoromethyl)-1H-pyrazol-3-yl)methanamine

Step i: (3-(Trifluoromethyl)-1H-pyrazol-5-yl)methanamine (0.7 g, 4.2 mmol, 1 eq) was charged in dichloromethane (70 ml) at room temperature, then to that TEA (0.42 g, 4.2 mmol, 1 eq) was added at room temperature and stirred for 10 min and cooled to 0-5 C. (Boc)2O (0.92 g, 4.2 mmol, 1 eq) was added drop wise to reaction mixture for 30 min and maintained for 3 h at 0-5 C. Progress of the reaction was monitored by the TLC (30% Ethyl acetate/Hexane). On completion of the reaction, dichloromethane was distilled, the residue obtained was treated water (50 ml) and extracted with ethyl acetate (100 ml). The combined organic layer was dried over sodium sulphate, distilled the solvent under vacuum. The obtained crude was purified with column chromatography to yield the required product as a white colored solid (0.5 g, 44% yield).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1254717-53-7.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Computed Properties of C6H9ClN2

A solution of 7d (58 mg, 0.20 mmol, 1.0 equiv) in anhydrous DMF (0.8 mL) was treated with 60% sodium hydride (18 mg, 0.44 mmol, 2.2 equiv). After stirring at room temperature for 5 min, 5-(chloromethyl)-l,3-dimethyl-lH-pyrazole (63 mg, 0.42 mmol, 2.1 equiv) was introduced. Then the mixture was stirred at room temperature for 2 hours. The reaction was quenched with saturated aqueous NaHCO3. The resulting solution was extracted with ethyl acetate. The combined extracts were washed once with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by prep-TLC (ethyl acetate/dichloromethane/ methanol 10/10/1, 2 runs) to afford compound 30 (50 mg, 50%) as a white solid. MS 505 (MH)+, 503 (M-H)”. Purity 99% (HPLC).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 139756-02-8, name is 4-Amino-1-methyl-3-N-propyl-1H-pyrazole-5-carboxamide, molecular formula is C8H14N4O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: pyrazoles-derivatives

Preparation of 4-[2-Propoxy Benzamido]-1-Methyl-3-Propyl-5-Carbamoyl Pyrazole To a solution of 25 g of 2-propoxy benzoic acid dissolved in dichloromethane, 66 g of thionyl chloride was added and stirred for 3 hours under reflux. After reaction was completed, the solvent and excessive thionyl chloride were distilled off under reduced pressure. To the residue was added 200 ml of dichloromethane (reaction solution 1). In another container, to 24 g of 1-methyl-3-propyl-4-amino-5-carbamoyl pyrazole in dichloromethane was added 13.4 g of triethylamine and 100 mg of dimethylaminopyridine and then cooled to 0 C., to which said reaction solution 1 was slowly added while maintaining the temperature of the solution at 0 C., and then stirred for 1 hour. The reaction mixture was successively washed with water, saturated aqueous sodium bicarbonate solution and brine. The organic layer was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated under reduced pressure to obtain a crude product and then triturated with hexane to give 39 g of the title compound. 1H NMR (CDCl3): 0.91(t,3H), 1.05(t,3H), 1.62(m,2H), 1.89(m,2H), 2.52(t,2H), 4.06(s,3H), 4.18(t,2H), 5.57(br s,1H), 7.09(m,2H), 7.52(m,1H), 7.73(br s,1H), 8.26(dd,1H), 9.45(br s,1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 139756-02-8, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-pyrazole-5-carbaldehyde

B); With ligand (S)-2-piperidinyl-1,1,2-triphenylethanol and diethylzinc at -10 C In a 20 ml vial 50 mg (0.21 mmol) 2-aminoethyl-dithienyl-borinate and 9.3 mg (0.025mmol) of ligand (S)-2-piperidinyl-1,1,2-triphenylethanol (10 mol%) is placed. The vial is closed and flushed with argon. Dry toluene (2 mL) is added and the vial is placed in a cooling bath of -10 C. Diethylzinc (0.7 mL, 0.7 mmol, 2M solution in toluene) and 25 mul (0.25 mmol) 2-methyl-2H-pyrazole-3-carbaldehyde is added and the reaction mixture is stirred for at least 12 h at -10 C. Work-up is conducted as described in Example 2a affording the title compound (24 mg, 51%) in 70% ee.

The synthetic route of 27258-33-9 has been constantly updated, and we look forward to future research findings.