Tag: M.W:100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 25016-12-0, name is 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C6H8N2O

6.22. Synthesis of (S)-2-Amino-3-(4-(5-((1,3-dimethyl-1H-pyrazol-4-yl)methylamino)pyrazin-2-yl)phenyl)propanoic acid A mixture of 1,3-dimethyl-1H-pyrazole-4-carbaldehyde (142 mg, 1.145 mmol), 2-amino-5-bromopyrazine (200 mg, 1.149 mmol), borane trimethylamine complex (126 mg, 1.73mmol) and glacial acetic acid (137 mg, 2.29 mmol) in anhydrous methonol (3 ml) was stirred at room temperature overnight. The reaction mixture was then diluted with ethyl acetate, washed with water, dried over MgSO4 and filtered. The filtrate was concentrated to give 300 mg of (5-bromo-pyrazin-2-yl)-(1,3-dimethyl-1H-pyrazol-4-ylmethyl)amine as crude product, which was used for next step reaction without further purification. Crude yield: 93%.

The synthetic route of 25016-12-0 has been constantly updated, and we look forward to future research findings.

Related Products of 52222-73-8, These common heterocyclic compound, 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a nitrogen-purged glove box, a vial, equipped with a TEFLON coated magnetic stir bar, was charged with (oxybis(2,1-phenylene))bis(diphenylphosphine) (1.00 g, 1.86 mmol) and 4-trifluoromethylpyrazole (0.253 g, 1.86 mmol). Toluene (5 mL) was added, followed by mesitylcopper(I) (0.283 g, 1.55 mmol) dissolved in toluene (5 mL). The resulting yellow solution was stirred at approximately 60C for 15 hours. The mixture was cooled and filtered. The white solid was washed with toluene (5 mL) and hexanes (5 mL), and dried to afford the title compound as a white solid (0.785 g).

Statistics shows that 4-(Trifluoromethyl)-1H-pyrazole is playing an increasingly important role. we look forward to future research findings about 52222-73-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 96799-02-9, name is 5-(Furan-2-yl)-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-(Furan-2-yl)-1H-pyrazol-3-amine

EXAMPLE 7 3-[(5-Furan-2-yl-1H-pyrazol-3-ylamino)-methylene]-4-methyl-1,3-dihydro-indol-2-one The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and substituting 3-amino-5-(2-furyl)-pyrazole for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one (0.110 gms.) is reacted with 0.2065 gms. of 3-amino-5-(2-furyl)-pyrazole by refluxing in tetrahydrofuran (2.5 mL).

According to the analysis of related databases, 96799-02-9, the application of this compound in the production field has become more and more popular.

Application of 52867-42-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52867-42-2 as follows.

Reference Example 61 Production of methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate Using methyl 3-hydroxy-1-methyl-1H-pyrazole-5-carboxylate (2.34 g, 15.0 mmol), 1-bromo-2-methoxyethane (3.13 g, 22.5 mmol), potassium carbonate (4.15 g, 30.0 mmol) and N,N-dimethylformamide (15 mL), and in the same manner as in Reference Example 57, the title compound (3.03 g, yield 94%) was obtained. 1H-NMR (DMSO-d6, 300 MHz) delta 3.28 (3H, s), 3.57-3.64 (2H, m), 3.81 (3H, s), 3.93 (3H, s), 4.14-4.20 (2H, m), 6.28 (1H, s).

According to the analysis of related databases, 52867-42-2, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 25016-12-0, name is 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-12-0, Quality Control of 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde

(4) 6.3 g of 1,3-dimethyl-1H-pyrazole-4-carbaldehyde (0.052 mol) and2.9 g of ethyl isocyanate (0.026 mol)Add 30mL of water,And heated to 40 C in the air and stirred for 3 hours;After the reaction, add 50% sodium hydroxide aqueous solution to the reaction mixture and mix well.It was then extracted with dichloromethane to remove impurities;The aqueous phase was adjusted to pH = 2-3, filtered, the filter cake was washed, and the solid was collected.4.9 g of 1,3-dimethyl-1H-pyrazole-4-carboxylic acid was obtained; the purity was 99% and the yield was 79%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.

Related Products of 402-61-9, A common heterocyclic compound, 402-61-9, name is 5-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 14; 5 -Methyl- lH-pyrazole-3-carboxylic acid [2-methyl-4-(2(2S)-methyl- [1 ,3′(3 ‘ S)]bipyrrolidinyl- 1 ‘-yl)-phenyl] -amide; 2-Methyl-4-(2(2S)-methyl-[l,3′(3’S)]bipyrrolidinyl-r-yl)-phenylamine (330 mg, 1.15 mmol) was dissolved in DCM (6 mL) and DMF (2 mL), and the solution was cooled in an ice- water bath. To this solution was added powdered 5 -methyl- lH-pyrazole-3-carboxylic acid (174.6 mg, 1.38 mmol, 1.2 equiv.), N-methylmorpholine (280mg, 3 equiv.), 1- hydroxylbenzotriazole (HOBT) (0.162 g, 1.19 mmol, 1.3 equiv.), sequentially, and finally EDC HCl (0.228 g, 1.19 mmol, 1.3 equiv.). The resulting clear brown solution was stirred at r.t. overnight. TLC (10% MeOH in DCM) and LC/MS showed that the reaction was complete and the product peak (368) was detected. The reaction was quenched with saturated sodium bicarbonate aqueous solution (3 mL) and 3 mL of DCM. The two layers were separated, and the aqueous layer was extracted with DCM (5 mLx2). The combined DCM extracts were washed with sodium bicarbonate (5mL) and brine (5 mL), dried (anhydrous potassium carbonate), filtered, and concentrated in vacuo to obtain a crude product which was purified on a silica gel column (25 g of silica gel) on Analogix to obtain the title compound as a tan solid, 207 mg (49% yield).LCMS: Rx = 1.61 minutes, MS: 368 (M+H).1H NMR (300MHz, CDCl3), delta (ppm): 8.3 ((bs, IH), 7.65 (d, 9.6Hz, IH), 6.64 (s, IH), 6.43-6.39 (m, 2H), 3.52 (m, IH), 3.39 (m, IH), 3.26 (m, 2H), 3.02 (m, IH), 2.78 (m, IH), 2.53 (q,8.1Hz, IH), 2.37 (s, 3H), 2.28 (s, 3H), 2.12 (m, IH), 1.98 (m 2H), 1.78 (m, 2H), 1.51 (m, 2H).

The synthetic route of 402-61-9 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5334-40-7, category: pyrazoles-derivatives

4-(2-oxa-5-heterobicyclo[2.2.1]-heptan-5-ylmethyl)phenyl-1,2-diamine(0.85g, 3.88mmol), 4-nitro-1H-pyrrole-3-carboxylic acid (0.58g, 3.69mmol), EDCl (0.78g, 4.06mmol) and HOBt (0.55g, 4.06mmol)DMF (10 mL) was stirred at room temperature overnight. The solvent was removed under reduced pressure.AcOH (16 mL) was added to the residue and heated to reflux for 3.5 hr.The solvent was removed under reduced pressure and purified by column (dichloromethane/methanol (v/v) = 10/1).A yellow solid (0.79 g, 63percent) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Nitro-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Some common heterocyclic compound, 78703-53-4, name is 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H8N2O2

To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one hydrochloride (1.501 g, 0.611 mmol) and 1,3-dimethyl-1H-pyrazole-4-carboxylic acid (0.943 g, 0.67 mmol), and pyridine (2.23 mL, 27.52 mmol) in acetonitrile (60 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 9.10 mL, 15.29 mmol). The sealed tube was heated to 100 C. for 24 hours and precipitation was observed. After cooling, the precipates were collected by filtration washed with 1:1 cold acetonitrile/water to give a beige solid product. The resulting filtrate was partitioned between EtOAc (50 mL) and 50 mL of water. Several extraction with EtOAc (4*25 mL) were made. The combined organic layers were washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated in vacou. The residue was dried loaded onto silica and purified by silica gel column chromatography using 95:5 dichloromethane/methanol to give combined 1,3-dimethyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-1H-pyrazole-4-carboxamide (1.04 g, 46%). 1H NMR (400 MHz, DMSO-d): delta 12.16 (bs, 1H), 10.18 (s, 1H), 8.55 (s, 1H), 7.73 (bs, 1H), 7.68 (dd, 1H, J=8.0, 2.0 Hz), 7.44 (s, 1H), 6.89 (d, 1H, J=8.0 Hz), delta, 3.82 (s, 3H), 2.93 (m, 2H) 2.48 (partial masked under d-DMSO, m, 2H), 2.39 (s, 3H). MS (ESI): Calcd. for C18H17N5O2S: 367, found 368 (M+1)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 78703-53-4, its application will become more common.

Electric Literature of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a flask was added Pd(OAc)2 (22.4 mg, 0.1 mmol), (biphenyl-2- ylmethylene)bis(dimethylphosphine) (60 mg, 0.2 mmol) and sodium tert-butoxide (240 mg, 2.5 mmol). The flask was sealed and refilled with N2. To the mixture was added a solution of EPO 6-bromo-N-(4-fluorobenzyl)pyridin-2-amine (Method 19; 281 mg, 1.0 mmol) and 5- cyclopropyl-lH-pyrazol-3 -amine (123 mg, 1.0 mmol) in toluene (5 ml). The reaction mixture was heated at 110C overnight. The solvent was removed and EtOAc was added and the mixture was washed with brine and was concentrated. Semi-prep HPLC (Gilson) purification gave the title compound (6.4 mg, 2%). 1H NMR (CDCl3) delta 0.65 (m, 2H), 0.95 (m, 2H), 1.80 (m, IH), 4.43 (m, 2H), 4.91 (br s, IH), 5.60 (br s, IH), 5.80 (m, IH), 6.18 (m, IH), 6.73 (m, IH), 7.00 (m, 2H), 7.25 (m, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.

Application of 20583-33-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20583-33-9 name is 1-(1H-Pyrazol-3-yl)ethanone, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Synthesis Example 118 (0768) 3-(1,1-Difluoroethyl)-1H-pyrazole (0769) To a dichloroethane solution (6.0 mL) of 1-(1H-pyrazol-3-yl)ethanone (300 mg, 2.73 mmol) and bis(2-methoxyethyl))amino-sulfur trifluoride (1.11 mL, 5.99 mmol), one drop of ethanol was added at 0 C. and the resultant mixture was stirred at room temperature for 1 hour and 30 minutes. After completion of the reaction, the reaction solution was added dropwise to saturated sodium bicarbonate aqueous solution at 0 C. After adding dichloromethane, the resultant mixture was washed with saturated sodium chloride aqueous solution. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was purified by column chromatography (hexane/ethyl acetate=3/1) to obtain the title compound (145 mg, yield 41%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(1H-Pyrazol-3-yl)ethanone, and friends who are interested can also refer to it.