The origin of a common compound about 52222-73-8

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C4H3F3N2

55 mg of 2-[3-(ethylsulphonyl)-6-fluoropyridin-2-yl]-1-methyl-5-(trifluoromethyl)-1H-benzimidazole (0.14 mmol) were dissolved in 2 ml of acetonitrile. 29 mg (0.21 mmol) of 4-(trifluoromethyl)-1H-pyrazole and 59 mg (0.42 mmol) of potassium carbonate were added and stirred for 3 h at room temperature. The mixture was filtered, concentrated and purified by column chromatography with a cyclohexane/ethyl acetate gradient as mobile phase. log P (neutral): 4.16; MH+: 504; 1H-NMR (400 MHz, D6-DMSO) delta ppm: 9.38 (s, 1H), 8.712 (d, 1H), 8.46 (s, 1H), 8.42 (d, 1H), 8.16 (s, 1H), 7.98 (d, 1H), 7.70 (dd, 1H), 3.906 (q, 2H), 3.90 (s, 3H), 1.24 (t, 3H).

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

Continuously updated synthesis method about 112758-40-4

The synthetic route of 3-Methyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Synthetic Route of 112758-40-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112758-40-4, name is 3-Methyl-1H-pyrazole-4-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 3 -methyl- lH-pyrazole-4-carbaldehyde (1 g, 9.08 mmol) in acetonitrile (10 mL) is added potassium carbonate (1.76 g, 12.71 mmol) and 2,3- difluornitrobenzene (1.73 g, 10.90 mmol) and the mixture is stirred at room temperature overnight. Water is added and the organic phase is extracted with ethyl acetate. Organic layer is dried over sodium sulfate and the solvent evaporated under reduced pressure. The residue is purified by normal phase Isco chromatography using as eluent ethyl acetate/hexane (20-80%) to give a 62% yield of a mixture of regioisomers containing the title compound as major product that is used with no further purification. NMR is consistent with desired structure, although mixture of regiosomers is detected: NMR (MeOD): 9.98 (s, 1H), 8.65 (d, 1H, J= 1.6 Hz), 7.99-7.26 (m, 3H), 2.49 (s, 3H). A solution of 2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine] (2.1 g, 7.5 mmol) and l-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazole-4-carbaldehyde (3 g) (as major compound in a mixture of regioisomers in the pyrazole) in dichloromethane (47 mL) is stirred at room temperature for 30 minutes. Then, sodium triacetoxy borohydride (3.94g) is added and the mixture is stirred overnight at that temperature. The reaction mixture is quenched carefully with sodium bicarbonate (saturated solution) and extracted with dichloromethane. Organic layer is washed with brine, decanted and dried over sodium sulfate. Solvent is evaporated and the residue is purified by normal phase Isco chromatography using as eluant dichloromethane and isopropanol to give 2.28 g of 2-chloro-4,4-difluoro- -[[l-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4- yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine] (the compound is contaminated with the other pyrazole regioisomer in a ratio 80:20). MS (m/z): 513 (M+l). To a solution of 2-chloro-4,4-difluoro-l’-[[l-(2-fluoro-6-nitro-phenyl)-3-methyl- pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine] (2.28g, 4.46 mmol) and iron (2.5g) in ethanol (1 lmL) and water (1 lmL), a few drops of acetic acid is added. The reaction mixture is stirred at 90C for 70 min. The mixture is then filtered over celite and concentrated under vacuum. Remained solution is basified with sodium bicarbonate(saturated solution) and extracted with dichloromethane. Organic layer is decanted, dried over sodium sulfate and solvent evaporated to obtain 1.8 g of 2-[4-[(2-chloro-4,4- difluoro-spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine]- -yl)methyl]-3-methyl-pyrazol-l- yl]-3-fluoro-aniline that is used in next step without further purification (the compound is contaminated with the other pyrazole regioisomer in a ratio 80:20). MS (m/z): 483 (M+l).

The synthetic route of 3-Methyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.

Share a compound : 1134-50-5

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Adding a certain compound to certain chemical reactions, such as: 1134-50-5, name is 1-Phenyl-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1134-50-5, category: pyrazoles-derivatives

Procedure: The pyrazole is solubilized in DMF in a reactor under nitrogen and with magnetic stirring. CDI is then rapidly added in a single portion and the mixture is kept stirring for approximately 20 minutes. The amine is then rapidly added dropwise by means of a syringe. After stirring for 3 h 30 min, TLC monitoring of the reaction indicates that the starting product has completely disappeared. The reaction medium is then poured into 80 ml of an ice/water mixture. The white precipitate formed after stirring for 15 minutes is then recovered by filtration through a sintered glass filter and dried by suction. The orangey solid obtained is then taken up in 50 ml of dichloromethane, washed once with water, and dried over sodium sulfate. After filtration through sintered glass filter and evaporation under partial vacuum, 0.8 g of a yellow solid is thus obtained. The latter is chromatographed on silica (elution: 7/3 hexane/ethyl acetate) and then recrystallized from toluene. 0.80 g of a beige solid is thus recovered (yield: 56%). It is characterized in the form of a compound associated with half a molecule of water.

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Share a compound : 175137-46-9

The synthetic route of 5-Cyclopropyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5-Cyclopropyl-1H-pyrazol-3-amine

A mixture of 2,4,6-trichloropyrimidine (30 g, 163 mmol), 5-cyclopropyl-1H-pyrazol-3-ylamine (20 g, 163 mmol), diisopropylethylamine (50 mL, 300 mmol) and 1-butanol (100 mL) was heated to 80 C. for 2 h. The solvents were removed on a rotary evaporator and the residue was taken up in ethyl acetate. The organic solution was washed with water and brine and dried over magnesium sulfate. The residue was concentrated on a rotary evaporator to give the desired product (40.7 g, 92%) as a light yellow solid.

The synthetic route of 5-Cyclopropyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Some scientific research about 5334-39-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methyl-4-nitro-1H-pyrazole, its application will become more common.

Electric Literature of 5334-39-4,Some common heterocyclic compound, 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of tert-butyl 4-(3-methyl-4-nitro-lH- pyrazol-1- yl)piperidine-l- carboxylate and tert-butyl 4-(5-methyl-4-nitro-lH- pyrazol- 1 -yl)piperidine- 1- carboxylate (4.8 g, 15.5 mmol, form step 1) in MeOH (20 mL) was added 10% Pd/C (480 mg), and the resulting mixture was stirred at room temperature under hydrogen atmosphere for 4 hours. The LCMS indicated the starting materials were consumed. After filtration, the filtrate was concentrated to give a mixture of tert-butyl 4-(4-amino-3 -methyl- lH-pyrazol-1- yl) piperidine- 1 -carboxylate and tert-butyl 4-(4-amino-5 -methyl- IH-pyrazol-l-yl) piperidine- 1-carboxylate (4.1 g, Yield: 94%, isomeric ratio: around 5/3 based on HNMR) as light yellow oil. ESI-LCMS (m/z): 281.2 [M+1]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methyl-4-nitro-1H-pyrazole, its application will become more common.

The origin of a common compound about 25016-20-0

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-20-0.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O2

C2-Ocyclopropyl Boc protected amine macrocycle Am (75 mg, 0.093 mmol) is charged in a vial, then a 4 M solution of HCI in dioxane (1 ml_, 4 mmol) is added. The solution is stirred at RT for 1 .5 h, after which a precipitate forms. The solution is evaporated to dryness. 1 -methyl-1 H-pyrazole-3-carboxylic acid R2b (14.0 mg, 0.1 1 1 mmol) is dissolved in DCM (2 ml_), then TEA (51 .6 muIota_, 0.370 mmol) is added followed by TBTU (35.7 mg, 0.1 1 1 mmol). The solution is stirred for 15 mins, after which it is added to the amine hydrochloride in solution in DCM (1 ml_). The solution is stirred at RT for 16 h. The reaction is not complete so additional 1 -methyl-1 H pyrazole-3-carboxylic Acid R2b (3.5 mg, 0.028 mmol), TEA (13.0 muIota_, 0.092 mmol) followed by TBTU (8.9 mg, 0.028 mmol) are added. The solution is stirred at RT for 5 h, concentrated and then the residual is dissolved in DMSO. The resulting solution is filtered through a Millex filter and purified by prep HPLC (Sunfire column, ammonium formate and MeOH). The pure fractions are combined, concentrated, redissolved in MeCN and water, frozen and lyophilized to provide compound 1028. FIA M.S.(electrospray) : 818.4 (M+H)+ Retention time (min) = 5.5 min1H NMR (400 MHz,DMSO-d6): delta 10.80 (bs, 1 H), 8.93 (s, 1 H), 7.84 (d, 1 H, J = 8.9 Hz), 7.76 (d, 1 H, J = 2.4 Hz), 6.74-7.70 (m, 1 Hz), 7.10 (d, 1 H, J = 9.2 Hz), 6.59 (d, 1 H, J = 2.1 Hz), 6.38 (s, 1 H), 5.68-5.54 (m, 1 H), 5.47-5.40 (m, 1 H), 5.10-5.00 (m, 1 H), 4.68-4.56 (m 1 H), 4.50 (qn, 1 H, J = 3.2 Hz) 4.47-4.38 (m, 2H), 4.08-3.96 (m, 1 H), 3.89 (s, 3H), 3.88 (s, 3H), 2.66-2.58 (m, 1 H), 2.47 (s, 3H), 2.40-2.28 (m, 2H), 2.01 -1 .74 (m, 2H), 1 .64-1 .49 (m, 3H), 1 .48-1 .13 (m, 12H), 0.93-0.79 (m, 4H), 0.76- 0.69 (m, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 25016-20-0.

Continuously updated synthesis method about 3469-69-0

The synthetic route of 3469-69-0 has been constantly updated, and we look forward to future research findings.

Electric Literature of 3469-69-0,Some common heterocyclic compound, 3469-69-0, name is 4-Iodopyrazole, molecular formula is C3H3IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-Iodopyrazole (2 g, 10.311 mmol) was dissolved in DMF (50 mL), sodium hydride (1.25 g, 30.933 mmol) was added at 0 C, and the reaction was stirred for 30 min.Methyl iodide (1.3 mL, 20.622 mmol) was slowly added dropwise to the above solution, warmed to room temperature, and stirred for 22 hours.After the reaction was completed, filter, concentrate the filtrate, dilute with water, extract with ethyl acetate (80 mL ¡Á 3), collect the organic phase, dry over anhydrous sodium sulfate, filter, and concentrate the filtrate.Silica gel column chromatography was separated and purified (PE / EtOAc (v / v) = 18/1) to obtain 1.37 g of light yellow liquid, yield: 63.9%.

The synthetic route of 3469-69-0 has been constantly updated, and we look forward to future research findings.

Some tips on 51105-90-9

According to the analysis of related databases, 51105-90-9, the application of this compound in the production field has become more and more popular.

Synthetic Route of 51105-90-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51105-90-9 as follows.

Potassium carbonate (822 mg, 5.95 mmol) was added to a solution of 2-(2-(benzyloxy)ethoxy)ethyl methanesulfonate (598 mg, 2.181 mmol) and methyl 1 H-pyrazole-4-carboxylate (250 mg, 1.982 mmol) in DMF (15 mE) and heated to 60 C. for 2 days. The reaction was cooled to it, diluted with EtOAc (50 mE) and washed sequentially with water (30 mE), sat. aq. NaHCO3 (30 mE) and 20% v/v brine (30 mE). The organic layer was dried (MgSO4) and concentrated in vacuo. The crude product was purified by chromatography on silica gel (12 g column, 0-100% EtOAc/ isohexane) to afford the sub-title compound (472 mg) as a colourless oil.?H NMR (400 MHz, DMSO-d6) oe 8.33 (d, 1H),7.87 (d, 1H), 7.38-7.30 (m, 2H), 7.30-7.24 (m, 3H), 4.44 (s,2H), 4.32 (t, 2H), 3.80 (t, 2H), 3.72 (s, 3H), 3.58-3.53 (m,2H), 3.53-3.48 (m, 2H).mlz 305.1 (M+H) (ES)

According to the analysis of related databases, 51105-90-9, the application of this compound in the production field has become more and more popular.

Analyzing the synthesis route of 52222-73-8

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 52222-73-8

A mixture of compound 26 (200 mg, 0.342 mmol), 4-(trifluoromethyl)-1H-pyrazole (93 mg, 0.68 mmol), copper(I) iodide (13 mg, 0.068 mmol), 8-hydroxyquinoline (20 mg, 0.14 mmol), and potassium carbonate (95 mg, 0.68 mmol) in DMSO (2 mL) was stirred at 130 C under N2 atmosphere overnight. The mixture was quenched with saturated aqueous NH4Cl solution and the insoluble materials were removed by filtration. The filtrate was extracted with AcOEt. The organic layer was successively washed with water and brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/AcOEt = 70:30 to 30:70) and crystallized from AcOEt-iPr2O to give the title compound as a pale yellow solid (80 mg, 0.13 mmol, 37%). MS (ESI/APCI) m/z 640.3 [M+H]+. 1H NMR (300 MHz, DMSO-d6) delta 1.96-2.10 (4H, m), 3.20 (2H, t, J = 8.2 Hz), 3.83 (2H, br s), 4.40 (2H, t, J = 8.1 Hz), 7.38-7.47 (2H, m), 7.48-7.57 (2H, m), 8.28 (1H, s), 9.05 (2H, s), 9.18 (1H, s), 10.02 (1H, s). 13C NMR (101 MHz, DMSO-d6) delta 18.0, 27.5, 30.3, 48.4, 52.0, 112.8 (t, J = 16.9 Hz), 113.1-113.4 (m), 113.8 (q, J = 37.4 Hz), 120.2, 122.7 (q, J = 266.3 Hz), 124.1, 125.6, 127.5, 128.9 (q, J = 3.7 Hz), 132.6 (t, J = 13.2 Hz), 134.3, 137.3, 138.5-138.6 (m), 140.7, 149.2, 156.7, 158.9 (dd, J = 253.5, 5.5 Hz), 171.1. Mp 242-245 C. Anal. Calcd for C26H19ClF5N7O3S: C, 48.79; H, 2.99; N, 15.32. Found: C, 48.82; H, 2.92; N, 15.06.

The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.

Extended knowledge of 127107-23-7

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Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Product Details of 127107-23-7

1. 5.0 kg of l-methyl-pyrazol-4-amine hydrochloride and 9.2 kg of water were added to a flask (“Flask 1”). 2. The contents of Flask 1 were stirred at 15-25 C until dissolved. 3. 9.6 kg of tert-butyl 4-(2-chloropyrimidin-4-yl)-2-methylbenzylcarbamate, 15.6 kg of 2-butanol, and 14.6 kg of water were added to a separate flask (“Flask 2”). 4. The contents of Flask 2 were stirred at 55-65 C until a clear solution was observed. 5. The contents of Flask 1 were added to Flask 2, rinsing Flask 1 with 5 kg of water and transferring the rinse to Flask 2. 6. The contents of Flask 2 were heated to 80-90 C and were stirred at 80-90 C for at least 16 hours. 7. The contents of Flask 2 were cooled to 30-40 C. 8. 46.1 g of water was added to Flask 2 while maintaining the temperature at 30-40 C. 9. 24.2 kg of ammonium hydroxide (28-30%) was diluted with 25.7 kg of water and added to Flask 2 over at least 1 hour. 10. 5 kg of water was added to Flask 2. 11. The contents of Flask 2 were cooled to 10-20 C over at least 1 hour. 12. The contents of Flask 2 were stirred at 10-20 C for at least 1 hour. 13. The contents of Flask 2 were vacuum filtered to isolate a solid product. 14. The product was dried under vacuum at < 75 C. 15. 7.65 kg of product was obtained (90.0% yield), and MR conformed to prior assignments. If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.