Synthetic Route of 51105-90-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51105-90-9 as follows.
Potassium carbonate (822 mg, 5.95 mmol) was added to a solution of 2-(2-(benzyloxy)ethoxy)ethyl methanesulfonate (598 mg, 2.181 mmol) and methyl 1 H-pyrazole-4-carboxylate (250 mg, 1.982 mmol) in DMF (15 mE) and heated to 60 C. for 2 days. The reaction was cooled to it, diluted with EtOAc (50 mE) and washed sequentially with water (30 mE), sat. aq. NaHCO3 (30 mE) and 20% v/v brine (30 mE). The organic layer was dried (MgSO4) and concentrated in vacuo. The crude product was purified by chromatography on silica gel (12 g column, 0-100% EtOAc/ isohexane) to afford the sub-title compound (472 mg) as a colourless oil.?H NMR (400 MHz, DMSO-d6) oe 8.33 (d, 1H),7.87 (d, 1H), 7.38-7.30 (m, 2H), 7.30-7.24 (m, 3H), 4.44 (s,2H), 4.32 (t, 2H), 3.80 (t, 2H), 3.72 (s, 3H), 3.58-3.53 (m,2H), 3.53-3.48 (m, 2H).mlz 305.1 (M+H) (ES)
According to the analysis of related databases, 51105-90-9, the application of this compound in the production field has become more and more popular.