Tag: M.W:100-200

Synthetic Route of 176969-34-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176969-34-9, name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

a synthesis reaction experimental device is connected in a circulating cooling reaction pump at 0 C, and nitrogen gas is introduced in the early stage.To remove the air from the reaction flask, keep nitrogen in, and add 1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid to the round bottom flask after about 5 minutes.(LM-1-a) 0.528 g (3 mmol), 20 mL of re-distilled dichloromethane,Re-steaming DMF 0.482 mL (6 mmol),The reaction liquid was stirred and 0.316 mL (3.6 mmol) of oxalyl chloride was slowly added dropwise thereto using a dropping funnel. After 1.5h-2.5h reactionThe reaction was closed, and the insoluble material was removed by suction under reduced pressure. The filtrate was slowly added dropwise to a solution of 0.856 g (2.4 mmol) of N-(2-fluorophenyl)-2-aminocyclohexanesulfonamide and 0.6 mL with a dropping funnel. 4.32mmol) triethylamine in a mixed solution of dichloromethane, continue to be lowAfter stirring for 15 min, the reaction was changed to room temperature for about 2 h, and the reaction was monitored by TLC [V (petroleum ether): V (ethyl acetate) = 2:1].During the reaction, the reaction of the raw materials is judged according to the condition of the plate. After the reaction is completed, the reaction is stopped. AdditionalAppropriate amount of methylene chloride, the reaction solution was washed with HCl, washed with NaHCO3, washed with water, dried over anhydrous sodium sulfate, and allowed to stand for more than 8h.The crude product is purified by column chromatography, and the product is recrystallized from dichloromethane or acetone to give a white powdery solid.Pure productN-(2-Trifluoromethyl-4-chlorophenyl)-2-[1-methyl-3-difluoromethyl-4-pyrazolecarboxamido]cyclohexanesulfonamide.

The chemical industry reduces the impact on the environment during synthesis 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

Into a 100 mL round-bottom flask under inert atmosphere were placed interemediate 55.1 (200 mg, 0.54 mmol, 1.00 equiv), 2-methylpropan- 2-ol (10 mL), potassium phosphate (346 mg, 1.63 mmol, 3.00 equiv), 1-methyl-1H-pyrazol-4- amine hydrochloride (109 mg, 1.12 mmol, 1.50 equiv), and 3T generation xphos precatalyst (43 mg, 0.05 mmol, 0.10 equiv). The resulting solution was stirred overnight at room temperature. The resulting mixture was concentrated under vacuum and crude was purified using preparative HPLC to furnish 84.4 mg (36%) of compound 1-55 as a pink solid. LCMS (ES, m/z): 430 [M+H] ?H NMR (400 MHz ,CD3OD): oe 7.53 1 (s, 1H), 7.8777.913 (d, 1H), 5.1565.225 (m, 1H), 3.8503.886 (d, 3H), 3.6763.707 (t, 4H), 2.6822.725 (d, 3H), 2.5852.616 (t, 4H), 2.2892.360 (m, 3H), 2.0692.113 (d, 2H), 1.5041.596 (t, 2H), 1.5961.681 (t, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 27006-76-4, A common heterocyclic compound, 27006-76-4, name is 5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde, molecular formula is C6H7ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(3) 8.5 g of 5-chloro-1,3-dimethyl-1H-pyrazole-4-carbaldehyde (0.054 mol)Dissolved in methanol, add Pd / C (0.85g, 0.1w / w) andMgO (1.7g, 0.2w / w);The system was replaced with hydrogen three times;Under the condition of 1 atmosphere of hydrogen,Stir the reaction at 25 C for 16 hours;After the reaction was completed, the solid was removed by filtration (filter cake washing), the filtrate was concentrated under reduced pressure, dissolved in water, and extracted with ethyl acetate.The organic phase was concentrated to obtain 6.3 g of 1,3-dimethyl-1H-pyrazole-4-carbaldehyde as a pale yellow solid; purity 93%, yield 96%.

The synthetic route of 27006-76-4 has been constantly updated, and we look forward to future research findings.

Application of 112029-98-8, These common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To the solution of alcohol 4b (0.50?g, 2.67?mmol) and DMSO (0.41?g, 5.34?mmol) in ethyl acetate (5?ml) was added ?T3P (1.84?g, 6.68?mmol, 2.5?equiv, 50percent solution in ethyl acetate) at 0?¡ãC. The resulting mixture was allowed to warm to RT and stirred for 1?h. Pyrazine-2-amine 3a (0.254?g, 2.67?mmol) was added to the above mixture and stirred for 15?min, which was followed by the addition of isocyanide 1c (0.33?g, 4.01?mmol) at room temperature and stirring for 4?h. Progress of the reaction was monitored by TLC. After the reaction was complete, the reaction mixture was diluted with ethyl acetate and neutralized with aqueous sodium bicarbonate solution. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (25?mL?¡Á?2), the combined organic phases were washed with water, brine solution, dried over anhydrous sodium sulfate, and concentrated under vacuum to afford a crude product, which was purified on silica gel using ethyl acetate and petroleum ether.

Statistics shows that (1-Methyl-1H-pyrazol-4-yl)methanol is playing an increasingly important role. we look forward to future research findings about 112029-98-8.

Electric Literature of 37622-90-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of O-methyl-nu-oxide salt intermediate in AcCN (10 ml) obtained as above from 1.37 g (4.71 mmol) N-oxide m-CBA salt and dimethylsulfate (0.49 ml, 1.05 eq.) was added a solution OfNH3 in dry MeOH (7M, Aldrich, 15 ml) under cooling in an icebath. The brown mixture was stirred in a sealed vial at 70 0C overnight. After evaporation of the solvent and aq. workup as above, the crude was purified by silica gel chromatography to give a light-brown, cryst. solid. HR-MS calculated for [MH]+: 134.07127, found: 134.07150.

The synthetic route of Ethyl 4-pyrazolecarboxylate has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 5334-40-7

4-Nitropyrazole-3-carboxylic acid (7.3 g; 15.9 mmol) was added to a stirred solution of 4-amino-1-Boc- piperidine (10.2 mg; 51 mmol), EDC (10.7 g; 55.8 mmol), and HOAt (55.8 g; 19.1 mmol) in DMF (100 ml), and then stirred at room temperature overnight. The solvent was removed by evaporation under reduced pressure and the residue triturated with water (250ml). The resultant cream solid was collected by filtration, washed with water then dried under vacuum to give 13.05 g of 4-[(4-nitro-1H-pyrazole-3-carbonyl)-amino]-piperidine-1- carboxylic acid tert-butyl ester (LC/MS: Rt 2.50, [M+H]+ 340).

The synthetic route of 5334-40-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 2075-46-9,Some common heterocyclic compound, 2075-46-9, name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-nitro-lH-pyrazole (1.13 g, 10.0 mmol) and iodomethane (1.25 mL, 20.0 mmol) in DMF (12 mL), NaH (60% in mineral oil, 0.600 g, 15.0 mmol) was added. The mixture was stirred for 18 h. Water and EtOAc were added. The organic phase was separated, washed with water, dried over Na2S04, concentrated in vacuo to give l-methyl-4- nitro-lH-pyrazole as a solid (1.11 g).

The synthetic route of 2075-46-9 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 37718-11-9, These common heterocyclic compound, 37718-11-9, name is 1H-Pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a suspension of lH-pyrazole-4-carboxylic acid (50 g, 446 mmol) in 500 ml DMF was added p-toluenesulfonic acid(8.48 g, 44 mmol) and DHP (132 mL, 1561 mmol).The reaction medium turned yellow and then changed at room temperature for 20 hoursblack. The reaction mixture was poured into saturated aqueous NaHCO3 and extracted with EtOAc. The aqueous phase was added by the addition of 6M hydrochloric acid solutionTo pH = 3. The resulting precipitate was filtered off and washed with water and then dried in vacuo at 50 C to give 61.2 g of a white powder(Yield: 70%).

The synthetic route of 37718-11-9 has been constantly updated, and we look forward to future research findings.

Application of 2458-26-6,Some common heterocyclic compound, 2458-26-6, name is 3-Phenyl-1H-pyrazole, molecular formula is C9H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

At 0 C, a solution of 3-phenyl-1H-pyrazole (0.61 g, 5.3 mmol) in dry THF (10 mL) was added dropwise to a suspension of NaH (0.13 g,5.34 mmol) in dry THF (10 mL). After 15 min of stirring, a solution of 2,6-pyridine-dimethylene-ditosylate (1.20 g, 2.67 mmol) in dry THF (15 mL) was added to this solution; the mixture was stirred overnight and filtered, and the solvent was removed. The crude product was purified by column chromatography on silica gel with hexane:EA = 1:1 as eluent to afford 0.41 g (40%) of pure ligand as a white oil that solidified with time. Single crystals were obtained by slow diffusion of hexane into a concentrated solution of the ligand in THF at room temperature. 1H NMR (300 MHz, acetone-d6): 7.84(m, 2H, 4H, 5-H Pz, 2,6-H Ph), 7.65 (t, J = 7.8 Hz, 1H, 4-H Py), 7.36(t, J = 7.2 Hz, 4H, 3,5-H Ph), 7.26 (t, J = 7.5 Hz, 2H, 4-H Ph), 6.96 (d,J = 7.8 Hz, 2H, 3,5-H Py), 6.72 (d, J = 2.4 Hz, 2H, 4-H Pz), and 5.48 (s,4H, PyCH2Pz).13C NMR (75 MHz, acetone-d6): 157.9 (2C, 2,6-CPy), 152.2 (2C, 3-C Pz), 138.9 (1C, 4-C Py), 134.8 (2C, 1-C Ph), 132.9(2C, 5-C Pz), 129.3(4C, 3,5-C Ph), 128.2 (2C, 4-C Ph), 126.1 (4C, 2,6-CPh), 121.2 (2C, 3,5-C Py), 103.7 (2C, 4-C Pz), and 57.9 (2C, PyCH2Pz).

The synthetic route of 2458-26-6 has been constantly updated, and we look forward to future research findings.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5334-39-4, name is 3-Methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives

To a solution of 3-methyl-4-nitro-lH-pyrazole (3.81 g, 30.0 mmol) in DMF (20 mL) was added K2CO3 (8.28 g, 60.0 mmol) and diethyl 2-bromo-2-methylmalonate (9.10 g, 36.0 mmol). The mixture was stirred at 100 C for 20 h. The reaction mixture was then treated with H20 (500 mL), extracted with ethyl acetate (20 mL x 3). The organic layer was evaporated and the residue was purified by silica gel column chromatography eluting with petroleum ether/ethyl acetate (10/1) to afford the title compound (3.6 g, 41%) as oil. LC-MS (ESI): m z = 300 (M+H)+.

According to the analysis of related databases, 5334-39-4, the application of this compound in the production field has become more and more popular.