Tag: M.W:100-200

Extracurricular laboratory: Synthetic route of 13669-51-7

The synthetic route of 13669-51-7 has been constantly updated, and we look forward to future research findings.

Reference of 13669-51-7, These common heterocyclic compound, 13669-51-7, name is Quinolin-3-ylmethanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-(Chloromethyl)quinoline hydrochloride MDE 32004 To a solution of quinolin-3-ylmethanol MDE 32002 (0.26 g, 1.63 mmol) in dry CH2Cl2 (10 mL) at 0 C. under N2 in a 25 mL round-bottomed flask equipped with a magnetic stirrer was added dropwise SOCl2 (2.4 mL, 33.1 mmol) and the mixture was stirred for 1 h at RT. The volatiles were then removed at 40 C. under vacuum and the residue was taken up in CH2Cl2 (20 mL) before concentration back to dryness at 40 C. under vacuum (done 3 times) to give 3-(chloromethyl)quinoline hydrochloride MDE 32004 as an off-white solid (301 mg, 85% yield). MW: 214.09; Yield: 85%; Off-white solid; Mp ( C.): 192.1 1H-NMR (CD3OD, delta): 5.10 (s, 2H, CH2), 8.01-8.06 (m, 1H, ArH), 8.24-8.26 (m, 1H, ArH), 8.31 (d, 1H, J=8.4 Hz, ArH), 8.39 (d, 1H, J=8.4 Hz, ArH), 9.32 (s, 1H, ArH), 9.41-9.42 (m, 1H, ArH). 13C-NMR (CD3OD, delta): 42.3, 121.5, 130.3, 130.7, 131.9, 134.5, 136.8, 138.6, 146.5, 147.8. MS-ESI m/z (% rel. Int.): 178 ([MH]+, 35Cl, 100), 180 ([MH]+, 37Cl, 32).

The synthetic route of 13669-51-7 has been constantly updated, and we look forward to future research findings.

The important role of 37873-29-3

Statistics shows that 5,7-Dimethyl-8-hydroxyquinoline is playing an increasingly important role. we look forward to future research findings about 37873-29-3.

Synthetic Route of 37873-29-3, These common heterocyclic compound, 37873-29-3, name is 5,7-Dimethyl-8-hydroxyquinoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The zinc complexes (Zn(HPB)(Me2q) and Zn(HPB)(CNq)) were obtained by reacting 0.5 g (2.36 mM) 2-(2-hydroxyphenyl)benzoxazole (HPB) and 0.41 g (2.36 mM) 5,7-dimethyl-8-hydroxyquinoline (Me2q) or 0.403 g (2.36 mM) 2-carbonitrile-8-hydroxyquinoline with 0.52 g (2.36 mM) zinc acetate (ligands and metal) at 1:1:1 molar ratio in acetonitrile, respectively. Details ofthe synthesis process for the preparation of metal complexes can be found in our previous publication [34]. The re-crystallized materials were further purified by vacuum sublimation technique. The chelates gave orange-yellow and orange fluorescence under UV light, respectively (Scheme 1).

Statistics shows that 5,7-Dimethyl-8-hydroxyquinoline is playing an increasingly important role. we look forward to future research findings about 37873-29-3.

New downstream synthetic route of 391-77-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-6-fluoroquinoline, and friends who are interested can also refer to it.

Related Products of 391-77-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 391-77-5 name is 4-Chloro-6-fluoroquinoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a homogeneous mixture of 4-chloro-6-fluoroquinoline (500.0 mg, 2.8 mmol)inNMP (5 mL), in a sealable vial, was added 1-Boc-piperazine (750.0 mg, 4.0 mmol) followed by DIPEA (2 mL, 11.6 mmol). After the addition was complete, the vial was capped and the mixture was stirred at 120 C. After 15 hours, the reaction was cooled to room temperature then partitioned between water and Et20. The layers were separated and the aqueous layer was extracted twice more with Et20 then once with EtOAc. Theseorganic extracts were combined with the original organic layer and were washed with brine, dried (Na2SO4), filtered and concentrated in vacuo to afford the crude product as an oil. Purification by Isco chromatography afforded tert-butyl 4-(6-fluoroquinolin-4- yl)piperazine-1-carboxylate as a solid (719.3 mg; 77% yield). MS(ES): m/z = 332 [M+H]. tp. = 0.70 mm (Method A). ?H NMR (400MHz, DMSO-d6) oe 8.70 (d, J=4.9 Hz,1H), 8.04 (dd, J=9.2, 5.6 Hz, 1H), 7.76 – 7.58 (m, 2H), 7.07 (d, J=5.0 Hz, 1H), 3.71 – 3.54 (m, 4H), 3.14 – 3.01 (m, 4H), 1.44 (s, 9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Chloro-6-fluoroquinoline, and friends who are interested can also refer to it.

The important role of 391-77-5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 391-77-5, name is 4-Chloro-6-fluoroquinoline, belongs to quinolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 391-77-5, name: 4-Chloro-6-fluoroquinoline

4-Chloro-6-fluoro-quinoline (50 mg), 5,6-dimethyl-[2,2′]bipyridinyl-3-ol (55 mg), and 4-dimethylaminopyridine (101 mg) were dissolved in dimethylsulfoxide (1.5 ml), cesium carbonate (269 mg) was added to the suspension, and the mixture was stirred at 130C overnight. The reaction mixture was cooled to room temperature, and water was added thereto. The organic layer was extracted with chloroform, and the chloroform layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography with a methanol-chloroform system to give the title compound (87 mg, yield 90%). 1H-NMR (CDCl3, 400 MHz): delta 2.41 (s, 3H), 2.67 (s, 3H), 6.51 (d, J = 3.7 Hz, 1H), 7.10 (ddd, J = 1.0, 4.9, 7.6 Hz, 1H), 7.38 (s, 1H), 7.54 – 7.64 (m, 2H), 7.90 (d, J = 7.6 Hz, 1H), 7.98 (dd, J = 2.7, 9.0 Hz, 1H), 8.21 (m, 1H), 8.36 (m, 1H), 8.54 (d, J = 5.4 Hz, 1H) Mass spectrometric value (ESI-MS, m/z): 368 (M+Na)+

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The important role of 68500-37-8

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68500-37-8.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68500-37-8, name is 4-Chloro-7-methoxyquinoline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-Chloro-7-methoxyquinoline

Add 4-chloro-7-methoxyquinoline 5.0g (25.91mmol), 2-fluoro-4-nitrophenol 4.1g (25.91mmol), toluene 50mL and DIPEA 10.1g (77.73mmol) in a 100 mL single-necked flask. After 24 hours of reflux reaction, the reaction was complete by TLC.The reaction liquid was cooled to room temperature, and sand was obtained. Column chromatography gave 5.2 g of pale yellow solid, yield 64.1%

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68500-37-8.

Extended knowledge of 5334-40-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5334-40-7, Formula: C4H3N3O4

To a solution of 4-nitro-1H-pyrazole-3-carboxylic acid (1.00 g, 6.37 mmol) in DMF (20 mL) were added K2C03 (1.93 g, 14.01 mmol) and iodomethane (1.99 g, 14.01 mmol), and the mixture was stirred at rt overnight under nitrogen. Water (50 mL) was added and the mixture was extracted with EtOAc (3 x 60 mL). The combined organic layers were washed with brine (25 mL), dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluting with petroleum ether EtOAc (8: ito 1:2) to afford methyl 1- methyl-4-nitro- 1H-pyrazole-3-carboxylate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

The important role of 2075-46-9

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Reference of 2075-46-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2075-46-9, name is 4-Nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 119 This example illustrates the preparation of Compound 108 namely, 3-pyridinecarboxylic acid, 5-[(4-amino-1H-pyrazol-1-yl)carbonyl]-2-methoxy-4-(2-methylpropyl)-6-(trifluoromethyl)-, methyl ester. A solution of 4-nitropyrazole (22.62 g, 200 mmol) in THF (100 mL) was cooled to 0 C., then sodium bis(trimethylsilyl)amide (204.3 mmol) in THF solution was added dropwise. A solution of Compound 84 (70.75 g, 200 mmol) in THF (100 mL) was then added dropwise at 0 C., then the pot was stirred at 25 C. for 30 minutes. The reaction mixture was then poured into 5% hydrochloric acid and extracted with dichloromethane. The organic layer was dried with MgSO4 and the solvent removed by rotary evaporation. The residue was purified by silica gel chromatography (5% ethyl acetate: hexane) to give 70.14 g (82%) of the pyrazole amide (Compound 101).

The chemical industry reduces the impact on the environment during synthesis 4-Nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.

Brief introduction of 10199-68-5

The synthetic route of 10199-68-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 10199-68-5, A common heterocyclic compound, 10199-68-5, name is 4-Phenyl-1H-pyrazole, molecular formula is C9H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-phenyl-lH-pyrazole (775 mg, 5.38 mmol, 1.0 eq), l-iodo-3-methoxybenzene (1510 mg, 768 mu, 6.45 mmol, 1.2 eq), Cul (21 mg, 0.11 mmol, 0.02 eq) and 2C03 (1561 mg, 11.30 mmol, 2.1 eq) were added to a dry pressure tube equipped with a magnetic stir bar. Then trans- 1,2-cyclohexanediamine (123 mg, 1.08 mmol, 0.20 eq) and dioxane (12 mL) were added. The mixture was bubbled with nitrogen for 30 minutes and then the tube was sealed. The mixture was stirred in an oil bath at a temperature of 110 C for three days and then cooled to ambient temperature. The solvent was removed under reduced pressure and the residue was purified through column chromatography on silica gel using hexane and ethyl acetate (10: 1 -5 : 1 -3 : 1) as eluent to obtain the desired product, l-(3-methoxyphenyl)-4-phenyl-lH-pyrazole 8, as a colorless liquid (1.13 g in 84% yield). H NMR (DMSO-Je, 400 MHz): delta 3.84 (s, 3H), 6.87-6.90 (m, 1H), 7.25 (t, J = 12 Hz, 1H), 7.38-7.48 (m, 5H), 7.71 (d, J= 7.2 Hz, 2H), 8.20 (s, 1H), 9.01 (s, 1H).

The synthetic route of 10199-68-5 has been constantly updated, and we look forward to future research findings.

New learning discoveries about 5932-20-7

The synthetic route of 3-Bromo-4-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 5932-20-7, name is 3-Bromo-4-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 5932-20-7

To a solution of 58 (120 mg, 0.74 mmol) in dimethylformamide (DMF) (1 mL) was added NaH (40 mg, 1.6 mmol). The mixture was stirred for 0.5 h at room temperature and 2- bromo-l,3-thiazole (125 mg, 0.74 mmol) was added. The reaction mixture was stirred for 1 h at room temperature. The reaction temperature was raised to 90C and stirred overnight. The reaction was quenched with MeOH and solvent was removed in vacuo. The residue was treated with water and EtOAc. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over a2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 59 (67 mg, 37%) as a yellow solid.

The synthetic route of 3-Bromo-4-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Share a compound : 176969-34-9

The chemical industry reduces the impact on the environment during synthesis 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.

Synthetic Route of 176969-34-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176969-34-9, name is 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

3-(Difluoromethyl)-1-methyl-pyrazole-4-carboxylic acid (75 mg, 0.43 mmol) and (S)- 6-(4-(1,1,1-trifluoropropan-2-yl)-4H-1,2,4-triazol-3-yl)pyridin-2-amine (110 mg, 0.43 mmol) were dissolved in Et3N (0.60 mL, 4.3 mmol). Propylphosphonic anhydride ( 50 wt% in EtOAc, 0.44 mL) was then added and the reaction was heated at 80 C for 3 h. After this time, he reaction was cooled to rt and quenched by addition of MeOH (2 mL). The resulting solid was filtered and dried under vacuum to give the title compound (150 mg, 85%) as a white solid. 1H NMR (400 MHz, MeOD) d ppm 9.01 (s, 1H), 8.30 – 8.38 (m, 1H), 8.18 – 8.26 (m, 1H), 7.92 – 8.05 (m, 2H), 7.05 – 7.41 (m, 2H), 4.02 (s, 3H), 1.85 – 1.94 (m, 3H). MS (ESI): 416.0 [M + H]+.

The chemical industry reduces the impact on the environment during synthesis 3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.