These common heterocyclic compound, 5932-20-7, name is 3-Bromo-4-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 5932-20-7
To a solution of 58 (120 mg, 0.74 mmol) in dimethylformamide (DMF) (1 mL) was added NaH (40 mg, 1.6 mmol). The mixture was stirred for 0.5 h at room temperature and 2- bromo-l,3-thiazole (125 mg, 0.74 mmol) was added. The reaction mixture was stirred for 1 h at room temperature. The reaction temperature was raised to 90C and stirred overnight. The reaction was quenched with MeOH and solvent was removed in vacuo. The residue was treated with water and EtOAc. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over a2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 59 (67 mg, 37%) as a yellow solid.
The synthetic route of 3-Bromo-4-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.