Tag: M.W:100-200

Electric Literature of 138786-86-4, The chemical industry reduces the impact on the environment during synthesis 138786-86-4, name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, I believe this compound will play a more active role in future production and life.

Methyl 4-nitro-lH-pyrazole-3-carboxylate (5 g, 29.2 mmol),Toluenesulfonic acid (0.5 g, 2.9 mmol) was dissolved in dichloromethane (40 mL)3,4-Dihydro-2H-pyran (3.7 g, 44.0 mmol) was added dropwise at 0 C. The addition was completed, 20 C for 4 hours,Add 100mL dichloromethane and 100mL water, liquid separation, the organic phase spin dry,The residue was subjected to silica gel column chromatography (PE: EA = 10: 1) to give 5.3 g of the title product in a yield of 71.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-nitro-1H-pyrazole-3-carboxylate, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143426-52-2, name is 1-(4-(Chloromethyl)phenyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 143426-52-2

Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine-8-carboxylate (250 mg, 0.83 mmol, 1.0 eq.), 4-(1-pyrazolyl)benzyl chloride (319 mg, 1.7 mmol, 2.0 eq.), cesium carbonate (542 mg, 1.6 mmol, 2.0 eq.), Pd(dppf)Cl2.DCM (101 mg, 0.12 mmol, 0.15 eq.), THF (5.5 mL) and H2O (1 mL) were added into a microwave vial. The vial was evacuated and purged with N2 (3*). The mixture was stirred at 90 C. After 1 h, the mixture was cooled to r.t., filtered through a pad of Celite which was rinsed thoroughly with EtOAc/DCM/MeOH. The filtrate was concentrated and purified using column chromatography on silica gel (0-50% DCM/EtOAc for 15 min then 50-100% of 10% MeOH/DCM solution) to provide the title compound with some impurities. Further purification was conducted using RP-HPLC (25-60% MeCN in 0.05% NH4OH aqueous solution over 20 min). The desired fractions were concentrated to provide the title compound as a tan solid (170 mg, 62%). 1H-NMR (400 MHz, DMSO) delta 8.73 (s, 1H), 8.46 (d, J=2.4 Hz, 1H), 8.04 (d, J=1.2 Hz, 1H), 7.81-7.78 (m, 2H), 7.72 (d, J=1.7 Hz, 2H), 7.63 (d, J=1.2 Hz, 1H), 7.44-7.42 (m, 2H), 6.53 (t, J=2.1 Hz, 1H), 4.06 (s, 2H), 3.87 (s, 3H); ES-MS [M+H]+=333.2.

According to the analysis of related databases, 143426-52-2, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25016-20-0, Computed Properties of C5H6N2O2

Acid R2a (13.9 mg; 0.1 10mmol) is dissolved in DMF (2 mL) and TEA (51.2 muIota 0.367 mmol) and TBTU (34.0 mg; 0.1 10 mmol) are added and the mixture is stirred for 15 mins. The Boc de-protected macrocyclic amine hydrochloride Cf is dissolved in DMF (1.0 mL) and added to the acid solution and stirred at RT overnight. The resulting solution is filtered through a Millex filter and purified by prep HPLC (ammonium bicarbonate/MeOH). The pure fractions are combined, concentrated, frozen and lyophilized to provide compound 1003.FIA M.S.(electrospray) : 822.5/ 824.5 (M-H)- , 824.4/ 826.3 (M+H)+Retention time (min): 7.0 min1H NMR (400 MHz,DMSO-d6): delta 10.83 (s, 1 H) , 8.92 (s, 1 H), 7.86 (d, 1 H, J = 8.6 Hz), 7.79 (d, 1 H, J = 5.1 Hz), 7.75 (d, 1 H, J = 2 Hz), 7.29 (d, 1 H, J = 8.6 Hz), 6.57 (s, 1 H), 6.53 (d, 1 H, J = 2 Hz), 5.67- 5.55 (m, 1 H), 5.55- 5.44 (m, 2H), 5.12- 5.00(m, 1 H), 4.62- 4.50 (m, 2H), 4.45- 4.37 (m, 1 H), 4.05- 3.95 (m, 1 H), 3.88 (s, 3H), 2.66 (s, 3H), 2.40- 2.25 (m, 2H), 2.03- 1.87 (m, 1 H), 1.87-1.72 (m, 1 H), 1.60- 1.47(m, 3H), 1.47-1.15 (m, 19H), 0.95- 0.78 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference of 64517-88-0, A common heterocyclic compound, 64517-88-0, name is 1,3-Dimethyl-1H-pyrazol-4-amine, molecular formula is C5H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[5]; 2-(6-Chlorobenzotriazol-l-yl)-l,l,3,3-tetramethyluronium tetrafluoroborate was used in place of 2-(7-azabenzotriazol- 1 -yl)- 1 , 1 ,3,3-tetramethyluronium hexafluorophosphate(V) as the coupling agent. The product gave the following characterising data :- 1H NMR Spectrum: (DMSOd6) 2.13 (s, 3H), 3.66 (s, 2H), 3.70 (s, 3H), 3.78 (s, 3H), 6.77 (d, IH), 6.91 (m, IH), 7.06 (d, IH), 7.37 (d, IH), 7.81 (s, IH)5 8.08 (s, IH), 8.92 (s, IH), 9.44 (s, IH), 9.57 (d, IH); Mass Spectrum: M+H+ 438 and 440.

The synthetic route of 64517-88-0 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C3H3BrN2

General procedure: To a 20 ml or 40 ml viale quipped with a stir bar was added photocatalyst, nitrogen nucleophile, iodomesitylene dicarboxylate, copper salt, and ligand. Dioxane was added followed by addition of the base. The solution was sonicated for 1-3 min until it became homogeneous. Next, the solution was degassed by sparging with nitrogen for 5-10 min before sealing with Parafilm. The reaction was stirred and irradiated using two 34-W blue LED lamps (3 cm away, with cooling fan to keep the reaction at room temperature) for 1 h. The reaction mixture was removed from the light, cooled to ambient temperature, diluted with water (15 ml) and ethyl acetate (25 ml), and the aqueous layer was extracted with ethyl acetate (3 ¡Á 25 ml). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated. The residue was purified by flash chromatography on silica gel to afford the desired decarboxylative C-N coupling product. For aniline substrates, a solution of these nitrogen nucleophiles in dioxane was used; additionally, if the iodomesitylene dicarboxylate is a liquid, its solution in dioxane was used.

The synthetic route of 3-Bromo-1H-pyrazole has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1384973-12-9, name is 5-Amino-3-bromo-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1384973-12-9, Quality Control of 5-Amino-3-bromo-1H-pyrazole-4-carbonitrile

A mixture of 5-amino-3-bromo-1H-pyrazole-4-carbonitrile 7b (10 g, 53.8 mmol), 3-(toluenesulfonyloxy)pyrrolidine-1-carboxylic acid tert-butyl ester (22 g, 64.5 mmol), cesium carbonate (58 g, 107.6 mmol) and acetonitrile (250 mL) was heated to 90 C. and reacted for 4 hours, and was then cooled to room temperature, filtered and the resulting filter cake was washed with dichloromethane, the filtrates were combined and concentrated under reduced pressure, the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate=5/1), so as to obtain the title product (S)-3-(5-amino-3-bromo-4-cyano-1H-pyrazol-1-yl)pyrrolidine-1-carboxylic acid tert-butyl ester 7c (5 g, yellow oil), and the yield was 26%. MS m/z (ESI): 300/302[M+1-56]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-3-bromo-1H-pyrazole-4-carbonitrile, other downstream synthetic routes, hurry up and to see.

Application of 26621-44-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 26621-44-3, name is 3-Nitro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Example 38 (S)-3-Cyclohexyl-2-[4-(2,6-difluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-N-[1-((R)-2,3-dihydroxy-propyl)-1H-pyrazol-3-yl]-propionamide A solution of 3-nitro-1H-pyrazole (prepared as in Example 5, 3.00 g, 26.55 mmol) in N,N-dimethylformamide (15 mL) was treated with solid potassium carbonate (5.50 g, 39.82 mmol) and (S)-(-)-glycidol (3.93 g, 53.10 mmol) and placed in a sealed tube and heated at 100 C. for 1 h in an oil bath. After this time the N,N-dimethylformamide was removed in vacuo. Purification by ISCO flash chromatography (Teledyne Isco RediSep Flash Column 12 g; 0% to 10% methanol/dichloromethane) afforded (R)-3-(3-nitro-pyrazol-1-yl)-propane-1,2-diol (3.17 g, 64%) as a yellow oil: LR-ES-MS m/z calculated for C6H9N3O4 [M]+ 187, observed [M+H]+ 188.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2458-26-6, name is 3-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2458-26-6, COA of Formula: C9H8N2

A solution of 2,2,2-trifluoro-1- (2-iodo-phenyl) -ethanol (0.331 g, 1.1 mmol), 3-phenylpyrazole (0.144 g,(0.1 L), (1R, 2R) -N, N’-dimethyl-cyclohexane-1,2-diamine (0.028 g, 0.2 mmol) and toluene (10 ml) were placed in a 20 ml pressure tube at 130 C (oil bath temperature)Under heating for 12 hours. The mixture was diluted with ethyl acetate, washed with H? O (2 x 20 ml), brine and dried over sodium sulfate. RemovedSolvent The crude product was purified by ISCO column chromatography using 5-10% ethyl acetate in hexanes as solvent to giveTo a solution of 2,2,2-trifluoro-1- [2- (3-phenyl-pyrazol-1-yl) -phenyl] -ethanol (75 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 154471-65-5, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 154471-65-5, Formula: C5H5F3N2

To a stirred solution of 11.5 g (76,6 mmol) 1-methyl-3-(trifluoromethyl)-1H-pyrazole (2) in dichloromethane (100 ml) was added 8.75 ml (79.8 mmol) of methyltriflate. The solvent was removed after stirring overnight at ambient temperature. Crystallization from MTBE gave 19 g (79 %) of the ionic liquid 6 as colourless solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-3-(trifluoromethyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 1260243-04-6, A common heterocyclic compound, 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, molecular formula is C6H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of ethyl-5-amino-1H-pyrazole-4-carboxylate 1 (1.0 mmol), an appropriate aldehyde 2 (1.0 mmol) and aterminal alkyne 3 (1.0 mmol) in acetic acid (5 mL) was stirred at 25 ¡ãC for 10 min. The mixture was then stirred at 60 ¡ãC under ultrasound using a laboratory ultrasonic bath SONOREX SUPER RK 510H model producing irradiationof 35 kHz for 30 min in the presence of air. The increase of bath temperature beyond 60 ¡ãC due to the prolonged ultrasound irradiation was controlled by adding cold water time to time. After completion of the reaction the mixture was cooled to room temperature, poured into ethyl acetate (25 mL) and washed with brine solution (2 x 15 mL) followed by 10percent NaHCO3 solution (2 x 15 mL). The organiclayer was collected, dried over anhydrous Na2SO4, filteredand concentrated under low vacuum. The residue isolatedwas purified by column chromatography over silica gel using3-8percent petroleum ether-EtOAc to give the desired product.

The synthetic route of 1260243-04-6 has been constantly updated, and we look forward to future research findings.