Tag: M.W:100-200

Reference of 2644-93-1, These common heterocyclic compound, 2644-93-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

At room temperature for 6-bromo-4-chloro-2-methoxy-3 – (4 – (trifluoromethyl) benzyl) quinoline (1.37 g, 3.86 mmol, Intermediate 10: step d) comprises that the flask, THF It was added (45 mL) to obtain a colorless, homogeneous mixture.Cooling the solution to -78 Next,ndropwise -BuLi (2.5 M, 1.8 mL, 4.5 mmol in hexane).The color of the solution was reddish brown.4 minutes after, 1,3,5-trimethyl -1H-pyrazole-4-carbaldehyde (300 mg, 2.17 mmol, 3 mL of THF) was introduced to he a mixture of red-brown color over 5 min It was in turn greenish yellow.The mixture was warmed to 0 over 45 minutes and, at this time the reaction NH4was quenched with aqueous solution of Cl.The mixture was diluted further with water and extracted with EtOAc (3 ¡Á 150 mL).The combined organics were washed with brine, MgSO4dried, filtered, and concentrated to give a light orange foam.Silica gel by FCC on (2% MeOH-DCM, increased to 8% MeOH-DCM), to give the title compound as a pale yellow non-crystalline solid.

The synthetic route of 2644-93-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1151802-23-1, name is 4-Bromo-1-cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151802-23-1, Computed Properties of C6H7BrN2

A mixture of (2,6-dichlorophenyl)boronic acid (1.9 g, 10.1 mmol), 4-bromo-l- cyclopropyl-lH-pyrazole (1.7 g, 9.2 mmol), PdCl2(dppf)-CH2Cl2 adduct (0.30 g, 0.34 mmol) and Na2C03 (1.9 g, 18.4 mmol) in THF (15 mL) and water (5 mL) was degassed and then heated under microwave irradiation at 100 C for 3 hours. The reaction mixture was diluted with EtOAc, washed with saturated aqueous NH4CI and brine, dried over MgS04, filtered, and concentrated in vacuo. The residue was purified by flash chromatography on S1O2 (0-30% EtOAc/hexanes) to afford l-cyclopropyl-4-(2,6-dichlorophenyl)-lH-pyrazole (1.4 g, 5.5 mmol, 60% yield) as an oil which became solid upon standing. NMR (500 MHz, CDCh) delta 7.63 (s, 2H), 7.35-7.43 (m, 2H), 7.15 (t, J=7.98 Hz, 1H), 3.68 (tt, J=3.78, 7.36 Hz, 1H), 1.21 (dt, J=1.10, 3.03 Hz, 2H), 1.07 (dd, J=1.93, 7.15 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-cyclopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114474-28-1 as follows. Product Details of 114474-28-1

To a solution of 2,4-dichloro-6-(2-methoxyethoxy)quinazoline (273 mg, 1.00 mmol) and 4-(4-aminophenyl)pyrazole amine (159 mg, 1.00 mmol) in DMF (2 mL) in a 1- dram vial was added DIEA (258 mg, 2.00 mmol, 0.348 mL). The mixture was heated at 100 C overnight. LC-MS showed one main peak corresponding to the desired product mass. The reaction mixture was cooled to rt and poured into water. The precipitate was filtered and washed with water. The resulting yellow solid was left to dry on the filter for 2 h to give 419 mg of crude product which was used as is in the next reaction. MS (ES+) m/e 396/398 (M+H)+.

According to the analysis of related databases, 114474-28-1, the application of this compound in the production field has become more and more popular.

These common heterocyclic compound, 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H8N2O

3-(2-Methoxyethoxy)-2-methyl-4-(methylsulfonyl)benzoic acid (1 g) was dissolved in chloroform (20 mL), and oxalyl chloride (500 mg) was added. A catalytic amount of dimethylformamide was added, followed by stirring at room temperature for 3 hours. Then, the solvent was distilled off under reduced pressure. The obtained residue was dissolved in tetrahydrofuran (5 mL), and then a solution having 5-hydroxy-1 ,3-dimethylpyrazole (450 mg) dissolved in tetrahydrofuran (15 mL) was slowly added. Triethylamine (0.65 mL) was added, followed by heating and refluxing for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and poured into water, then acidified with dilute hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure. The obtained residue was dissolved in acetonitrile (20 mL), and under cooling in an ice bath, triethylamine (0.65 mL) and acetone cyanohydrin (100 mg) were added, followed by stirring at room temperature for 18 hours. The reaction solution was poured into water and washed with a small amount of ethyl acetate. Then, the aqueous layer was acidified with dilute hydrochloric acid. It was extracted with ethyl acetate, and then, the organic layer was washed with a saturated sodium chloride aqueous solution and then dried over magnesium sulfate. The solvent was distilled off 5 under reduced pressure. The obtained residue was purified by column chromatography (developing solvent: ethyl acetate) to obtain 5-hydroxy-1 ,3-dimethylpyrazol-4-yl 3-(2- methoxyethoxy)-2-methyl-4-(methylsulfonyl)phenyl ketone (500 mg, the following Compound No. 5- 2) as slightly yellow solid.

The synthetic route of 1,3-Dimethyl-1H-pyrazol-5-ol has been constantly updated, and we look forward to future research findings.

Application of 612511-81-6, These common heterocyclic compound, 612511-81-6, name is (1-Methyl-1H-pyrazol-3-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 5-bromo-2-chloro-3-nitropyridine (600 mg, 2.53 mmol) in CH3CN (12 mL) were added (1 -methyl-1 H-pyrazol-3-yl)methanamine (281 mg, 2.53 mmol) and N,N- diisopropylethylamine (0.530 mL, 3.03 mmol), and the reaction mixture was stirred at room temperature for 20 hours. The mixture was concentrated, and the resulting residue was washed with water and dried under vacuum to give the desired product (750 mg) as a pale yellow solid. LC-MS (ES) m/z = 312, 314 [M+H]+. NMR (400 MHz, CD3OD): delta 3.87 (s, 3H), 4.80 (d, J = 5.6 Hz, 2H), 6.25 (d, J = 2.3 Hz, 1 H), 7.52 (d, J = 2.3 Hz, 1 H), 8.51 (d, J = 2.3 Hz, 1 H), 8.63 (d, J = 2.3 Hz, 1 H).

The synthetic route of 612511-81-6 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, name: 5-Cyclopropyl-1H-pyrazol-3-amine

A solution of S-cyclopropyl-lH-pyrazol-S-amine (1.9g, 16.0 mmol) in CH3CN (20 ml) was added dropwise to a solution of 2,6-dichloro-5-fluoronicotinonitrile (3.0 g, 16.0 mmol) and triethylamine (2.1 g, 20.0 mmol) in CH3CN (80 ml) at 25 C. The resulting solution was heated to 82 0C for 18 hrs, and then cooled to 25 0C. The resulted precipitate was collected by filtration and washed with CH3CN (100 ml) to give the title compound (3.2 g, 73%). MS:Calcd.: 277; Found: [M+H]+ 278.

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Electric Literature of 208511-67-5,Some common heterocyclic compound, 208511-67-5, name is 4-(1H-Pyrazol-3-yl)benzoic acid, molecular formula is C10H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The following compounds were made in a parallel manner using the following procedure: Reauents were weighed into stubby tubes. Stock solutions were made for reagent addition : Dissolved 2305.8 mg Intermediate 4 in 45.75 niL DMF and DIEA(2 eq). Dissolved 3131.85 mg HATU in 75 mE DMF. To each vial containing reagent acid(0.063 mmoi) was added 0.25 ml of the HAT1 solution in DMF followed by DIEA (0.028 mL, 0.158 mrnoi). After stirring for 10 mm, 0.25 ml of the intermediate 4 solution was added and the resulting reaction mixture vials were placed in a Bohdan Miniblock XT and were agitated overnight at 400rpm.Upon completion, reaction mixtures were purified via preparative LC/MS with thefollowing conditions: Column: XBridge C18, 19 x 100 mm, 5-.tm particles; Mobile PhaseA: 5:95 acetonitrile: water with 10 ml?I ammoniumn acetate; Mobile Phase B: c.5:5 acetonitrile: water with 10 m?1 ammonium acetate; Gradient: 10-50% B over 20 minutes, then a 2-minute hold at 100% B; Flow: 20 mL/min. Fractions containing the desired product were combined and dmied via centrifugal evaporation. **Gradient varied for eachreaction depending on polarity of comnpound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(1H-Pyrazol-3-yl)benzoic acid, its application will become more common.

Synthetic Route of 139756-02-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 139756-02-8 as follows.

To a 250 ml three-mouth bottle by adding 2 – ethoxy -3 – pyridine formaldehyde 8.20 g, 1 – methyl -3 – propyl -4 – amino pyrazole -5 – carboxamide 9.6 g and isopropyl alcohol 150 ml, stir at room temperature 3 hours; adding 8.56 g anhydrous ferric trichloride, stirring which separate the reaction system access oxygen, 60 C reaction 3 hours; boil off isopropanol about 100 ml, adding 180 ml purified water, filtered, drying to obtain the solid 15.7 g. Yield: 95.1%.

According to the analysis of related databases, 139756-02-8, the application of this compound in the production field has become more and more popular.

Application of 5203-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2.5 g (0.022 mol) of 1,3-dimethyl-5-hydroxypyrazole,40 mL of tetrahydrofuran was added to a three-necked flask,9.0 g of triethylamine (0.09 mol) was added with stirring.Ice bath control temperature of 5-10 ,A solution of 6.3 g (0.022 mol) of a solution of 2-methanesulfonyl-4-trifluoromethylbenzoyl chloride in tetrahydrofuran was added dropwise,Control the reaction temperature does not exceed 15 ,Drop finished,Remove the ice bath,The reaction was stirred at room temperature for 30 min,TLC detection reaction (ethyl acetate: petroleum ether = 4: 1, GF254, UV color)After the reaction is complete,2-methyl-2-hydroxypropanenitrile (0.2 g)Stirring slowly warming to 45-50 C reaction,TLC detection reaction (ethyl acetate: petroleum ether = 2: 1, GF254, UV color)After the reaction is complete,A solution of 5.5 g (0.023 mol) of tetrahydrofuran in 4-allyl-2-methoxyphenoxyacetyl chloride was added dropwise at room temperature,Control the temperature does not exceed 35 ,Drop at room temperature stirring 8hr,Add 50 mL of water to stir the crystals. The precipitated solid was collected by filtration and washed with 30% ethanol to give the title compound (7.2 g), yield: 57.8%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dimethyl-1H-pyrazol-5-ol, other downstream synthetic routes, hurry up and to see.

Related Products of 368870-03-5,Some common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate (UIPC-II-278)(28) (60 mg, 0.26 mmol) was refluxed in triethylorthoformate(0.110 mL, 0.65 mmol) and acetic anhydride (0.10 mL, 1.05 mmol) for 24 h to yield the intermediate enol ether (29). After the reactionwas complete, the mixture was concentrated in vacuo and thendissolved in ethanol. To this was added (4-(1H-pyrazol-1-yl)phenyl)methanamine (55 mg, 0.30 mmol) and the reaction wasallowed to stir at room temperature for 2 h. The reaction wasconcentrated in vacuo and purified by flash chromatography using agradient of dichloromethane:methanol. The reaction intermediatewas then dissolved in dioxanes, sodium hydride (13 mg,0.52 mmol) was added at 0 C and the reaction was allowed to stirfor 1 h. Once complete, the reaction was concentrated in vacuo anddiluted with water and extracted thrice with 10 mL ethyl acetate.The combined organic layers were washed with brine, dried overNa2SO4, filtered and concentrated in vacuo to afford 30b in 89%yield. 30b was used for the next step without further purification.MS ESI calculate for (M H) 392.136, found 392.13. Retention time(analytical HPLC) 18.1 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(1H-Pyrazol-1-yl)phenyl)methanamine, its application will become more common.