Adding a certain compound to certain chemical reactions, such as: 1151802-23-1, name is 4-Bromo-1-cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1151802-23-1, Computed Properties of C6H7BrN2
A mixture of (2,6-dichlorophenyl)boronic acid (1.9 g, 10.1 mmol), 4-bromo-l- cyclopropyl-lH-pyrazole (1.7 g, 9.2 mmol), PdCl2(dppf)-CH2Cl2 adduct (0.30 g, 0.34 mmol) and Na2C03 (1.9 g, 18.4 mmol) in THF (15 mL) and water (5 mL) was degassed and then heated under microwave irradiation at 100 C for 3 hours. The reaction mixture was diluted with EtOAc, washed with saturated aqueous NH4CI and brine, dried over MgS04, filtered, and concentrated in vacuo. The residue was purified by flash chromatography on S1O2 (0-30% EtOAc/hexanes) to afford l-cyclopropyl-4-(2,6-dichlorophenyl)-lH-pyrazole (1.4 g, 5.5 mmol, 60% yield) as an oil which became solid upon standing. NMR (500 MHz, CDCh) delta 7.63 (s, 2H), 7.35-7.43 (m, 2H), 7.15 (t, J=7.98 Hz, 1H), 3.68 (tt, J=3.78, 7.36 Hz, 1H), 1.21 (dt, J=1.10, 3.03 Hz, 2H), 1.07 (dd, J=1.93, 7.15 Hz, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-cyclopropyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.