Tag: M.W:100-200

Electric Literature of 1260243-04-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1260243-04-6 name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of ethyl-5-amino-1H-pyrazole-4-carboxylate (20.0 g, 129 mmol), (E)-ethyl 3-ethoxyacrylate (22.4 mL, 155 mmol) and cesium carbonate (63.0 g, 193 mmol) in DMF (322 mL) was stirred at 110 C. overnight. After being cooled to 0 C., the reaction mixture was acidified with 2 N aq. HCl. A precipitated solid was collected by filtration and washed with water and EtOAc to afford ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (24.7 g, 92%) as a pale yellow solid. 1H-NMR (DMSO-d6, Varian, 400 MHz): delta 1.27 (3H, t, J=7.2 Hz), 4.80 (2H, q, J=6.8 Hz), 6.16 (1H, d, J=8.0 Hz), 8.14 (1H, s), 8.58 (1H, d, J=8.0 Hz), 11.7 (1H, br. s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 5-amino-1H-pyrazole-4-carboxylate, and friends who are interested can also refer to it.

Some common heterocyclic compound, 15802-80-9, name is 3-(tert-Butyl)pyrazole, molecular formula is C7H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 15802-80-9

Part A – 4,5-Dibromo-3-tert-butylpyrazole Following the procedure of Example 30, Part A, but substituting 3-tert-butylpyrazole for 3-ethylpyrazole, there was prepared 4,5-dibromo-3tert-butylpyrazole with a melting point at 224 to 227 C. Analysis: Calc’d. for C7 H10 Br2 N2: C, 29.81; H, 3.57; N, 9.94. Found: C, 30.06; H, 3.68; N, 10.01.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 15802-80-9, its application will become more common.

Related Products of 14521-80-3, The chemical industry reduces the impact on the environment during synthesis 14521-80-3, name is 3-Bromo-1H-pyrazole, I believe this compound will play a more active role in future production and life.

A mixture of 0.28 g of 2-(3-fluoropyridin-4-yl)-5-(trifluoromethyl)benzoxazole, 0.19 g of 3-bromopyrazole, 0.55 g of potassium carbonate and 2 ml of DMF was stirred while heating at 50C for 1.5 hours. Then, the reaction mixture was cooled to room temperature. Water was added to the reaction mixture, followed by extraction with ethyl acetate twice. The combined organic layers were washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 0.31 g of 2-[3-(3- bromopyrazole-l-yl)pyridin-4-yl]-5-(trifluoromethyl)benzoxazole (hereinafter, referred to as “active compound 59”).Active compound 591H-NMR (CDC13) 6: 8.92 (s, IH), 8.89 (d, J=5.1 Hz, IH), 8.16 (d, J=5.1 Hz, IH), 8.08-8.07 (m, IH), 7.69 (dd, J=8.8, 1.2 Hz, IH), 7.66 (d, J=2.4 Hz, IH), 7.59 (d, J=8.8 Hz, IH), 6.57 (d, J=2.4 Hz, IH)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 112029-98-8,Some common heterocyclic compound, 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol, molecular formula is C5H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 70 (160mg, 1 eq.) was dissolved in re-distilled dichloromethane, and dichlorosulfoxide (310 mul, 3 eq.) was added under ice bath. The mixture was reacted for 1 h, evaporated to remove solvent. The product was directly used in the next step without purification

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (1-Methyl-1H-pyrazol-4-yl)methanol, its application will become more common.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 143426-52-2 as follows. Recommanded Product: 1-(4-(Chloromethyl)phenyl)-1H-pyrazole

To a mixture of methyl 2-amino-3, 4-dimethyl-5- (4, 4, 5, 5- tetramethyl-1, 3, 2-dioxaborolan-2-yl) benzoate (0.69 g) , l-(4- (chloromethyl) phenyl) -lH-pyrazole (0.46 g) , 2 M aqueous sodium carbonate solution (2.26 mL) and DME (20 mL) was added (1,1- bis (diphenylphosphino) ferrocene) dichloropalladium ( II) (1707) dichloromethane adduct (0.09 g) under an argon atmosphere and the mixture was stirred at 80C overnight. The reaction mixture was dried over anhydrous sodium sulfate and (1708) concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.65 g) . (1709) MS: [M+H]+ 336.1

According to the analysis of related databases, 143426-52-2, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 26308-42-9, name is 3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 26308-42-9

To a suspension of 6-(2-amino-5-chlorothiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one (0.100 g, 0.44 mmol) and 3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid (0.074 g, 0.48 mmol), and pyridine (0.16 mL, 1.96 mmol) in acetonitrile (4 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.91 mL, 1.53 mmol). The sealed tube was heated to 50 C. for 5 days and the precipitation formed. After cooling, the precipitate was collected by filtration and washed with cold 1:1 acetonitrile/water to give 3-ethyl-1-methyl-N-(4-(2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiazol-2-yl)-1H-pyrazole-5-carboxamide (0.044 g, 26%). 1H NMR (400 MHz, DMSO-d): delta 12.64 (bs, 1H), 10.19 (s, 1H), 7.76 (m, 1H), 7.69 (dd, 1H, J=8.4, 2.0 Hz), 7.54 (s, 1H), 7.22 (s, 3H), 6.91 (d, 1H, J=8.0 Hz), 4.07 (s, 3H), 2.93 (t, 2H, J=7.2 Hz), 2.59 (m, 2H), 1.19 (t, 3H, J=7.6 Hz). MS (ESI): Calcd. for C19H19N5O2S: 381, found 382 (M+1)+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 85290-80-8,Some common heterocyclic compound, 85290-80-8, name is Ethyl 1-methyl-1H-pyrazole-4-carboxylate, molecular formula is C7H10N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of ethyl 1-methyl-1H-pyrazole-4-carboxylate (20.2 g, 131 mmol) and NaOH (6.3 g, 158 mmol) in 200 mL absolute ethanol was refluxed for 2 h and stirring was continued at RT for 18 h. After that, the solvent was removed in vacuo. The residue was dissolved in water. The aq solution was washed with ether and acidified with concentrated HCl. The solid was filtered, washed with water and air-dried to give 14.2 g of 1-methyl-1H-pyrazole-4-carboxylic acid in 86% yield.

The synthetic route of 85290-80-8 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 784193-37-9, name is 3-Bromo-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 784193-37-9, Recommanded Product: 3-Bromo-4-nitro-1H-pyrazole

To a mixture of 3-bromo-4-nitro-1H-pyrazole (6.20 g, 32.3 mmol) and K2CO3 (5.36 g, 38.7 mmol) in DMF (40 mL) was added MeI (5.50 g, 38.7 mmol) at 0 C. Then, the mixture was stirred at 25 C. for 2 hours. On completion, the mixture was diluted with water (200 mL), then extracted with EA (3¡Á80 mL). The combined organic layer was washed with brine (50 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by column chromatography over silica gel (PE:EA=20:1-3:1) to give the title compound (3.90 g, 58% yield) as light yellow solid. 1H NMR (400 MHz, CDCl3) delta 8.16 (s, 1H), 3.97 (s, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 26621-44-3, The chemical industry reduces the impact on the environment during synthesis 26621-44-3, name is 3-Nitro-1H-pyrazole, I believe this compound will play a more active role in future production and life.

[322] To a 0 C solution of 3-nitro-1H-pyrazole (1.0 g, 8.84 mmol) in NMP (10.0 mL) was added NaH (425 mg of 60 %w/w, 10.63 mmol). After 20 minutes, the mixture was warmed to room temperature and stirred a further 60 minutes. The mixture was re-cooled to 0 C and 2-fluoropyrimidine (1.0 g, 10.20 mmol) was added. The resultant mixture was heated to 80C for 16 h. The reaction mixture was poured over ice, resulting in precipitation of a solid. The product was collected by vacuum filtration, and the solids air-dried to provide 2-(3-nitro-1H-pyrazol-1-yl)pyrimidine (1.66 g, 96% yield). 1H NMR (400 MHz, DMSO-d6) delta 9.00 (d, J = 4.8 Hz, 2H), 8.91 (d, J = 2.9 Hz, 1H), 7.68 (t, J = 4.9 Hz, 1H), 7.35 (d, J = 2.8 Hz, 1H) ppm. ESI-MS m/z calc. 191.04, found 191.96 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, This compound has unique chemical properties. The synthetic route is as follows., name: tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate

2,6-Dichloropyrazine (5.0 g, 33.6 mmol), tert-butyl 3-amino-5-methyl-lH- pyrazole-1-carboxylate (6.62 g, 33.6 mmol), palladium(II) acetate (0.75 g, 3.36 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (3.88 g, 6.71 mmol), potassium carbonate (46.4 g, 336 mmol), and dioxane (224 mL) were combined and the mixture was degassed with nitrogen for 2 minutes before heating to 90C for one hour. The reaction was cooled to room temperature and filtered through Celite followed by washing with dichloromethane. The filtrate was condensed and the crude material was purified by silica gel chromatography (10-70% ethyl acetate in hexanes) to give the title compound as a white solid (6.43 g, 20.8 mmol, 62% yield); MS (ESI) MS (ESI) m/z 310.5 [M+l]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 578008-32-9.