Tag: M.W:100-200

Electric Literature of 1152582-56-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1152582-56-3 name is 2-(1-Methyl-1H-pyrazol-4-yl)acetic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(Step 4) A solution of 2-amino-2-(4-(methoxymethyl)phenyl)-N-(4-(trimethylsilyl)phenyl)acetamide (104 mg, 0.30 mmol), 2-(1-methyl-1H-pyrazol-4-yl)acetic acid (51.1 mg, 0.36 mmol), HATU (150 mg, 0.39 mmol) and DIEA (0.106 mL, 0.61 mmol) in DMF (1.5 mL) was stirred at room temperature for 10 hr. To the reaction mixture were added water and ethyl acetate, and the organic layer was separated. The organic layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 40?80% ethyl acetate/hexane), and crystallized from ethyl acetate/hexane to give the title compound (45.0 mg, 0.097 mmol, 31.9%) as white crystals. MS(API): Calculated 464.6, Found 465.1(M+H) 1H NMR(300 MHz,DMSO-d6):delta0.17-0.22(9H,m),3.31(3H,s),3.38(2H,s),3.76(3H,s),4.37(2H,s),5.63(1H ,d,J=7.9 Hz),7.24-7.34(3H,m),7.39-7.60(7H,m),8.71(1H,d,J=7. 9 Hz),10.35(1H,s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1-Methyl-1H-pyrazol-4-yl)acetic acid, and friends who are interested can also refer to it.

Synthetic Route of 26621-44-3, The chemical industry reduces the impact on the environment during synthesis 26621-44-3, name is 3-Nitro-1H-pyrazole, I believe this compound will play a more active role in future production and life.

Step B: To a stirred mixture of 3-nitro-1H-pyrazole (3.16 g, 27.9 mmol) in glacial acetic acid (20 mL) at 0 C. was added fuming nitric acid (2.6 mL, 58.69 mmol) dropwise, followed by acetic anhydride (6.6 mL, 69.87 mmol). The mixture was stirred and allowed to warm to rt over 3 h, then poured into ice water (50 mL) and stirred for 20 h. The mixture was extracted with EtOAc combined organic layers were dried over MgSO4, filtered and concentrated to dryness to afford 1,3-dinitro-1H-pyrazole (4.3 g, 97%). 1H NMR (300 MHz, DMSO-d6) delta 8.00 (br s, 1H), 6.44 (br s, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 3469-69-0, name is 4-Iodopyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3469-69-0, Recommanded Product: 3469-69-0

Diisopropylethylamine (DIEA, 1.75 ml, 10 mmol) and trimethylsilylethoxymethyl chloride (SEMCl, 1.83 ml, 10 mmol) are added, under argon, to a solution of 4-iodopyrazole (1.94 g, 10 mmol) in CH2Cl2 (100 ml). The mixture is stirred overnight at ambient temperature. The solvent is evaporated off under vacuum. The residue is taken up with a diethyl ether/water mixture. The organic phase, after drying and evaporation, gives a colourless oil which is purified by elution on silica gel with an EtOAc/CH2Cl2 (5/95) mixture. 3.02 g of product are obtained in the form of a colourless oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodopyrazole, other downstream synthetic routes, hurry up and to see.

Related Products of 16034-46-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 1 -methyl- lH-pyrazole-5-carboxylic acid (5 g, 39.7 mmol) in methanol (100 mL) was added thionyl chloride (103.2 mmol) under argon atmosphere at 0 C. The reaction mixture was stirred to room temperature over 12 h. The reaction mixture was cone, in vacuo, then diluted with water (100 mL), carefully quenched with sat’d aqueous NaHCC”3, and extracted with ethyl acetate (100 mL x 3). The combined organic phase was dried with anhydrous sodium sulphate, filtered and the filtrate was concentrated to give afford the title compound as a white solid which was used without further purification (5 g, 90 %) m/z 240.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazole-5-carboxylic acid. I believe this compound will play a more active role in future production and life.

Reference of 14521-80-3,Some common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 5. Synthesis of N-[3-({4-[2-(3-bromo-lH-pyrazol-l-yl)-l,l,l,3,3,3-hexafluoropropan~ 2-yl]-2,6-dimethylphenyl}carbamoyl)phenyl]-2-chloropyridine-3-carboxamide.; 2-(4- { [(3 – { [(2-chloropyridin-3 -yl)carbonyl]amino } phenyl)carbonyl]amino } -3 ,5 -dimethylphenyl)- 1 ,l,l,3,3,3-hexafluoro-2-yl methanesulfonate (0.10 g) and 3-bromopyridine (28 mg) were dissolved in DMF (1.5 ml), and sodium hydride (in oil, 10 mg) was added thereto under ice cooling. After stirring for 4 hours, water was added. The resulting mixture was extracted with ethyl acetate, washed with water, and dried over magnesium sulfate. After the filtration, the solvent was evaporated off under reduced pressure. The resulting residue was purified with silica gel chromatography to obtain the title compound (76 mg, 70%).1H-NMR (CDCl3) delta : 2.31(6H, s), 6.45 (IH, d), 7.16 (2H, s), 7.36-7.64 (4H, m), 7.74 (IH, d), 7.86 (IH, d), 8.14-8.22 (IH, m), 8.29 (IH, s), 8.44-8.55 (2H, m).

The synthetic route of 14521-80-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 1,5-Dimethyl-1H-pyrazol-3-amine

To a solution of 3-amino-1,5-dimethylpyrazole (0.50 g) and triethylamine (0.63 ml) in chloroform (5 ml), 2-fluoro-3-(trifluoromethyl)benzoyl chloride (0.65 ml) was added under ice cooling. The reaction solution was stirred at room temperature for 0.5 hours, washed with an aqueous 2M sodium hydroxide solution, dried over anhydrous sodium sulfate and filtrated. Thereafter, the filtrate was concentrated under vacuum. The residue obtained was washed with n-hexane to obtain a colorless solid substance of N-(1,5-dimethylpyrazol-3-yl)-2-fluoro-3-(trifluoromethyl)benzamide (1.25 g). 1H-NMR(200 MHz, CHLOROFORM-D) d ppm; 2.30 (s, 39H), 3.72 (s, 3H), 6.59 (s, 1H), 7.40 (t, J =7.5 Hz, 1H), 7.78 (t, J = 7.5 Hz, 1H), 8.34 (td, J = 7.5 Hz, 1H), 8.60-8.89. (br. s, 1H) MS (ESI)(Positive)m/z; 302 (M+H)+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

These common heterocyclic compound, 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 35691-93-1

A solution of 2-(3-chloro-5-fluorobenzyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole obtained in Reference Example 69 (330 mg, 0.85 mmol), ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate (172 mg, 1.02 mmol) and copper(II) acetate monohydrate (85 mg, 0.43 mmol) in pyridine (4.3 mL) was stirred overnight at 80C. The reaction mixture was allowed to cool to room temperature, and diluted with saturated brine and ethyl acetate. The mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate= 90:10?67:33) to give the title compound (271 mg, yield 74%). 1H-NMR (CDCl3) delta : 1.40 (3 H, t, J = 7.1 Hz), 2.54 (3 H, s), 2.57 (3 H, s), 4.35 (2 H, q, J = 7.1 Hz), 5.54 (2 H, s), 6.84 – 6.92 (1 H, m), 6.98 – 7.10 (3 H, cm), 7.33 – 7.41 (1 H, m), 7.78 (1H, dd, J = 8.8, 0.5 Hz), 8.01 (1 H, s).

The synthetic route of Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 55864-87-4, name is Ethyl 4-nitro-1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55864-87-4, Formula: C6H7N3O4

To a mixture of compound A32 (12.4 g, 66.9 mmol, 1 eq) and K2CO3 (23.1 g, 167 mmol, 2.5 eq) in MeCN (120 mL) was added Dl-1 (28.5 g, 167 mmol, 16.4 mL, 2.5 eq) and the resulting mixture was heated to 60-70C for 16 hours to afford a white mixture. TLC showed two new spots. The mixture was partitioned between EtOAc (100 mL) and H20 (100 mL). The aqueous phase was extracted with EtOAc (100 mL x 2). The combined organic extract was dried over anhydrous Na2S04, filtered and concentrated under reduced pressure to give crude product. The crude product was purified by combi flash (PE/EtOAc = 1/0 to 4/1 to 3/1) to afford compound A33 (9.5 g, 62.4% yield) as a yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Related Products of 1125-29-7, These common heterocyclic compound, 1125-29-7, name is 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A suspension of triphenylphosphine (59.3 mg, 0.226 mmol) and 1,3, [5-TRIMETHYL-LH-] pyrazole-4-carboxylic acid (SALOR) (26.8 mg, 0.174 mmol) in dichloromethane was cooled to [0 oC AND N-CHLOROSUCCINIMIDE] added. The mixture was stirred at [0 oC] for 0.5 h then ambient temperature for an additional 0.5 h. [3-CYCLOPROPYLMETHYL-8- [4-] (ETHYL-AMINO)-BENZYL]-1-(2-FLUOROBENZYL)-3,] 7-dihydro-purine-2,6-dione (93.4 mg, 0.209 mmol) was added followed by triethylamine (30.2 mg, 0.226 mmol) and 4- dimethylaminopyridine (a few crystals). The reaction was left to stir at ambient temperature overnight before washing with 1M aqueous hydrochloric acid, saturated aqueous sodium bicarbonate, drying the organic extract (sodium sulfate) and concentrating in vacuo. Purification by chromatography using silica eluted with 5: 9 methanol/dichloromethane gave the product as a colorless solid (83.5 mg, 69%).

Statistics shows that 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid is playing an increasingly important role. we look forward to future research findings about 1125-29-7.

Related Products of 92933-47-6, A common heterocyclic compound, 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, molecular formula is C7H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A Ethyl 3-isopropyl-1H-pyrazole-5-carboxylate (7a)To a solution of 3-isopropyl-1H-pyrazole-5-carboxylic acid (2.5 g, 16.2 mmol) [commercially available from Alfa Aesar, Ward Hill, MA, USA] in MeOH (25 mL) was added cone, sulfuric acid (1 mL) and refluxed for 12h. The reaction mixture was cooled and the solvent was removed under reduced pressure. The crude mass was purified by flash column chromatography using 1:9 MeOH in CHCl3 to yield compound 7a (2.6 g). 1H NMR (400 MHz, CDCl3): delta 6.64 (s, 1H), 4.39 (q, J=8.00 Hz, 2H), 3.06-3.01 (m, 1H), 1.39 (t, J=8.00 Hz, 3H), 1.31 (d, J=8.00 Hz, 6H). Molecular Formula: C9H14N2O2, LCMS purity: 96%; Expected: 182.1 ; Observed: 183 (M+1).

The synthetic route of 92933-47-6 has been constantly updated, and we look forward to future research findings.