Tag: M.W:100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 948570-75-0, name is 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 1-(2-Methoxyethyl)-4-nitro-1H-pyrazole

To a solution of l-(2-methoxyethyl)-4- nitro-pyrazole (3.0 g, 17.53 mmol) in MeOH (50 ml) was added 10 % Pd/C (300 mg) under N2. The suspension was degassed and purged with H2 several times. The mixture was stirred under a H2 atmosphere at 25 C for 3 h. The reaction mixture was filtered. The filtrate was concentrated under reduced pressure to give the title compound as a red oil (Y = 97 %). NMR (400 MHz, chloroform-rf) d ppm 7.16 (s, 1H), 7.09 (s, 1H), 4.16 (t, J= 5 Hz, 2H), 3.69 (t, J= 5 Hz, 2H), 3.32 (s, 3H), 2.93 – 2.83 (hr. s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C8H15N3

[140] To a 100 mL oven dried flask, was added 5-AMINO-3-TETT-BUTYL-1-METHYLPYRAZOLE (2.00 G, 13.1 MMOL), methyl 2-bromo-5-methoxybenzoate (2.67 g, 10.9 MMOL), cesium carbonate (4.96 g, 15.2 mmol), Pd2 (dba) 3 (337 mg, 0.33 MMOL), BINAP (338 mg, 0.54 MMOL), and toluene (35 mL). The reaction mixture was degassed, placed under an N2 atmosphere, and then stirred at 110C for 16 h. The reaction mixture was cooled to rt, and ethyl acetate (30 mL) was added. The mixture was filtered, the filter cake washed with EtOAc (10 mL), and the filtrate concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (eluent : 10 to 30% EtOAc in hexane) to give the title compound as a light yellow oil (1.34 g, 38%).’H NMR (400 MHz, CDCIG) 8 1. 28 (s, 9H), 3.63 (s, 3H), 3.78 (s, 3H), 3.94 (s, 3H), 5.97 (s, 1H), 6.82 (d, 1H), 7.10 (dd, 1 H), 7.47 (d, 1 H).

The synthetic route of 118430-73-2 has been constantly updated, and we look forward to future research findings.

Electric Literature of 41680-34-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41680-34-6, name is 3-Amino-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 5-amino-i H-pyrazole-4-carboxylic acid (1 .00 g, 7.87 mmol) and ethyl 2-formyl-3- oxopropanoate (2.0 ml, 16 mmol) in acetic acid (6.0 ml) was heated for 1 h at 1100 in a microwave reactor (Biotage Initator). Upon cooling to room temperature, the precipitate wascollected by filtration, washed with water and dried under high vacuum at SOC to give the title compound (900 mg, 48% yield).[C-MS (Method 1): R = 0.68 mm; MS (ESIpos): m/z = 236.1 [M+i]iH-NMR (400 MHz, DMSO-d6): 6 [ppm] = 12.59 (5, iH), 9.72 (d, iH), 9.13 (d, iH), 8.76 (5, 1 H), 4.41 (q, 2H), 1.38 (t, 3H).

The synthetic route of 3-Amino-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, A new synthetic method of this compound is introduced below., Computed Properties of C5H6N2O2

A mixture of 2-methyl-4-(6-(trifluoromethyl)quinolin-2-yl)aniline (10 g, 33.08 mmol, 1.00 equiv), l-methyl-lH-pyrazole-5-carboxylic acid (4.4 g, 34.89 mmol, 1.05 equiv), DIPEA (8.5 g, 65.77 mmol, 2.00 equiv) and HATU (4.4 g, 11.57 mmol, 1.50 equiv) in DMF (200 mL) was stirred overnight at room temperature. The reaction was quenched by the addition of 600 mL of water, extracted three times with 200 mL of ethyl acetate and the combined organic layers washed with 50 mL of water. Volatiles were eliminated under reduced pressure. The crude product was purified by recrystallization with methanol to afford the desired final product as a yellow solid in 76% yield. (ES, m/z): [M+H]+ 411; -NMR (DMSO-de, 300MHz, ppm): 52.40(s,3H), 54.12(s,3H), 57.12-7.13(d,lH), 57.57-7.61(m,2H), 58.00-8.04(d,lH), 58.19-8.36(m, 4H), 58.54 (s, 1H), 58.66-8.69 (d, 1H), 510.00 (s,lH).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 876343-24-7,Some common heterocyclic compound, 876343-24-7, name is 1-Ethyl-1H-pyrazol-4-amine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[3]; 2-(6-Chlorobenzotriazol-l-yl)-l,l,3,3-tetramethyluronium tetrafluoroborate was used in place of 2-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate(V) as the coupling agent. The product gave the following characterising data :- H NMR Spectrum: (DMSOd6) 1.32 (t, 3H), 3.6 (s, 2H), 3.77 (s, 3H), 4.02 (s, 3H), 4.07 (q, 2H), 6.51 (d, IH), 6.88 (m, IH), 7.03 (d, IH), 7.23 (s, IH), 7.36 (d, IH), 7.42 (s, IH), 7.88 (s, IH), 8.77 (d, IH), 9.43 (s, IH), 10.04 (s, IH); Mass Spectrum: M+H4 434.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Ethyl-1H-pyrazol-4-amine, its application will become more common.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 31037-02-2

Step 3.1 : 5-Amino-1 -methyl- 1 H-pyrazole-4-carboxylic acid5-Amino-1-methyl-1 H-pyrazole-4-carboxylic acid ethyl ester (16.4 g, 97 mmol) is heated to reflux in 97 ml of 2 M sodium hydroxide solution and 100 ml of ethanol. After complete saponification, the mixture is acidified to pH 5 with 6 M HCI solution, and the formed precipitate is isolated by filtration. The product is dried at the high vacuum pump and the title compound is isolated as a white solid. HPLC: tR = 4.65 min; MS-ES+: (M+H)+ = 142 ; TLC*: Rf = 0.24.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Related Products of 112758-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112758-40-4 name is 3-Methyl-1H-pyrazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3 -methyl- lH-pyrazole-4-carbaldehyde (1 g, 9.08 mmol) in acetonitrile (10 mL) is added potassium carbonate (1.76 g, 12.71 mmol) and 2,3- difluornitrobenzene (1.73 g, 10.90 mmol) and the mixture is stirred at room temperature overnight. Water is added and the organic phase is extracted with ethyl acetate. Organic layer is dried over sodium sulfate and the solvent evaporated under reduced pressure. The residue is purified by normal phase Isco chromatography using as eluent ethyl acetate/hexane (20-80%) to give a 62% yield of a mixture of regioisomers containing the title compound as major product that is used with no further purification. NMR is consistent with desired structure, although mixture of regiosomers is detected: NMR (MeOD): 9.98 (s, 1H), 8.65 (d, 1H, J= 1.6 Hz), 7.99-7.26 (m, 3H), 2.49 (s, 3H). A solution of 2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine] (2.1 g, 7.5 mmol) and l-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazole-4-carbaldehyde (3 g) (as major compound in a mixture of regioisomers in the pyrazole) in dichloromethane (47 mL) is stirred at room temperature for 30 minutes. Then, sodium triacetoxy borohydride (3.94g) is added and the mixture is stirred overnight at that temperature. The reaction mixture is quenched carefully with sodium bicarbonate (saturated solution) and extracted with dichloromethane. Organic layer is washed with brine, decanted and dried over sodium sulfate. Solvent is evaporated and the residue is purified by normal phase Isco chromatography using as eluant dichloromethane and isopropanol to give 2.28 g of 2-chloro-4,4-difluoro- -[[l-(2-fluoro-6-nitro-phenyl)-3-methyl-pyrazol-4- yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4′-piperidine] (the compound is contaminated with the other pyrazole regioisomer in a ratio 80:20). MS (m/z): 513 (M+l).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-1H-pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methyl-1H-pyrazole-4-carboxylic acid

EXAMPLE 2 N-(2-Thienylsulfonyl)-1-methylpyrazole-4-carboxamide 3.8 g of 1-methylpyrazole-4-carboxylic acid and 4.9 g of carbonyldiimidazole in 100 ml of 1,2-dichloroethane are heated at 55° C. for 3.5 h. 4.9 g of 2-thienylsulfonamide and 5.4 ml of triethylamine are added and then the mixture is heated at 55° C. for 13 h. After cooling, 40 ml of 10percent strength aqueous NaOH solution are added and then the pH of the aqueous phase is adjusted to 1. The precipitate is removed and dried under reduced pressure. 5.2 g of N-(2-thienylsulfonyl)-1-methylpyrazole-4-carboxamide with a melting point of 174°-180° C. are obtained (active ingredient Example No. 103).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5952-92-1.

Adding a certain compound to certain chemical reactions, such as: 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1260243-04-6, SDS of cas: 1260243-04-6

To a mixture of ethyl 3-amino-1H-pyrazole-4-carboxylate (29) (30.0 g, 193 mmol) and ethyl 3-ethoxy-2-propenoate (cis- and trans-mixture, 41.9 mL, 290 mmol) in DMF(387 mL) was added cesium carbonate (113 g, 348 mmol). Themixture was stirred at 100C for 2 h, diluted with water andthen acidified to pH ca. 5 with AcOH. The resulting solid wasfiltered by filtration, washed with water and dried to afford 30(36.4 g, 176 mmol, 91%) as a beige solid. 1H-NMR (300 MHz,DMSO-d6) delta: 1.28 (3H, t, J=7.1 Hz), 4.28 (2H, q, J=7.1 Hz),6.15 (1H, d, J=7.9 Hz), 8.13 (1H, s), 8.57 (1H, d, J=7.9 Hz),11.73 (1H, br s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Application of 5334-41-8, A common heterocyclic compound, 5334-41-8, name is 5-Amino-1-methyl-1H-pyrazole-4-carbonitrile, molecular formula is C5H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 20 2-(Azetidin-1-yl)-4-difluoromethoxybenzooxazole-7-carboxylic acid (4-cyano-2-methyl-2H-pyrazol-3-yl)-amide Starting from 2-(azetidin-1-yl)-4-difluoromethoxybenzooxazole-7-carboxylic acid 4-nitro-phenyl ester (178 mg) and 5-amino-1-methyl-1H-pyrazole-4-carbonitrile (107 mg). Purification by column chromatography on silica eluding with 3% methanol in dichloromethane followed by trituration in diethyl ether afforded the title compound as a white solid (124 mg). TLC Rf 0.31 (ethyl acetate). M.p. 247-248 C.

The synthetic route of 5334-41-8 has been constantly updated, and we look forward to future research findings.