Category: 5952-92-1

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 1-Methyl-1H-pyrazole-4-carboxylic acid

EXAMPLE 2 N-(2-Thienylsulfonyl)-1-methylpyrazole-4-carboxamide 3.8 g of 1-methylpyrazole-4-carboxylic acid and 4.9 g of carbonyldiimidazole in 100 ml of 1,2-dichloroethane are heated at 55° C. for 3.5 h. 4.9 g of 2-thienylsulfonamide and 5.4 ml of triethylamine are added and then the mixture is heated at 55° C. for 13 h. After cooling, 40 ml of 10percent strength aqueous NaOH solution are added and then the pH of the aqueous phase is adjusted to 1. The precipitate is removed and dried under reduced pressure. 5.2 g of N-(2-thienylsulfonyl)-1-methylpyrazole-4-carboxamide with a melting point of 174°-180° C. are obtained (active ingredient Example No. 103).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5952-92-1.

Adding some certain compound to certain chemical reactions, such as: 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5952-92-1. 5952-92-1

A suspension of 1 -methyl- lH-pyrazole-4-carboxy lie acid (0.25 g) in thionyl chloride (4 mL) was stirred at reflux for 30 minutes. The reaction was concentrated, the residue azeotroped with toluene and dissolved in acetonitrile (5 mL). To the cooled (0 ¡ãC) solution, a 2 M solution of (trimethylsilyl)diazomethane in hexanes (1.5 mL) was added and the mixture stirred at 0 ¡ãC for 1 hour. A solution of 33 wt. percent hydrogen bromide in acetic acid (1.0 mL) was added and the mixture stirred at room temperature for a further 80 minutes. To the reaction mixture, tert-butyl methyl ether (20 mL) was added and the resultant precipitate isolated by filtration to give the title product having the following physical properties (0.22 g). LC MS rR 1.23 minutes; MS (ES+) m/z 203 and 205 (M+H) a.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-Methyl-1H-pyrazole-4-carboxylic acid.

A common heterocyclic compound, 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C5H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5952-92-1.

A solution of 8-(4-amino-benzyl)-3-cyclopropylmethyl-1-(2-fluoro-benzyl)-3, 7- dihydro-purine-2,6-dione (50 mg, 0.12 mmol) [IN N, N DIMETHYLFORMAMIDE] at [25 oC] was treated with a solution of 1-methyl-1H-pyrazole-4-carboxylic acid (15 mg, 0.12 mmol), [O-BENZOTRIAZOL-L-YL-N, N. NN-TETRAMETHYLURONIUM] hexafluorophosphate (49.7 mg, 0. [L 3 MMOL), AND N, N-DIISOPROPYLETHYLAMINE (62, UL,] 0.36 mmol). The resulting solution was stirred at [25 oC] for 18 h. At this time, the reaction was concentrated in vacuo. The residue was dissolved in chloroform and then was washed with a IN aqueous hydrochloric acid solution [(1 X 10] mL) and a saturated aqueous sodium chloride solution [(1 X 10] mL). The organics were dried over magnesium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60,230- 400 mesh, 5: 95 methanol/dichloromethane) afforded 1-methyl-1H-pyrazole-4- carboxylic acid {4-[3-cyclopropylmethyl-1-(2-fluoro-benzyl)-2, 6-dioxo-2,3, 6,7- tetrahydro-1H-purin-8-ylmethyl]-phenyl}-amide (13.5 mg, 21.5percent) as a tan solid

The synthetic route of 1-Methyl-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 5952-92-1, name is 1-Methyl-1H-pyrazole-4-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 5952-92-1

[00263] Step A: (Trimethylsilyl)diazomethane (12.0 niL, 24 mmol, 2.0M solution in hexanes) was added dropwise via an addition funnel to a cold (O0C) solution of 1 -methyl- IH- pyrazole-4-carboxylic acid (0.59 g, 4.7 mmol) in MeOH (20 mL). The reaction mixture was stirred for 20 minutes and then concentrated. The crude product was partitioned between ethyl acetate (100 mL) and water (50 mL). The organics were dried, filtered and concentrated. The crude product was purified by flash chromatography, eluting with hexanes/ethyl acetate (4:1) to give methyl 1 -methyl- lH-pyrazole-4-carboxylate (0.50 g, 3.6 mmol, 76% yield) as a solid, m/z (APCI-pos) M+l = 141.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5952-92-1, its application will become more common.