Tag: M.W=0-100

35344-95-7, Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7.

To a stirred solution of 1H-pyrazole-4-carbaldehyde (1.00 g. 10.4 mmoi) and6-bromo-4-rnethyinicotinonitrile (2.05 g, 10.4 mrnol) in dioxane (15 mL) were added K2C03 (4.31 g, 31.2 mrnol) The resulting reaction mixture was degassed with nitrogen for 5 minutes and was added copper(1) iodide (0595 g, 3. 12 mmoi), followed by trans_N,NLdimethylcyciohexanei .2-diamine (2.59 mL, 16.4 mmoi). The resulting reaction mixture was degassed with nitrogen for an additional 5 minutes and heated at110 ¡ãC for 1 h under microwave irradiation. The reaction mixture was cooled to ambient temperature, filtered through celite and the organic layer was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep-24 g, 20-40percent EtOAc/ n-hexane) to obtain Intermediate 9 (115 g, 52.1percent) as a pale yellow solid. ?H NMR (300 MHz, DMSO?d6) oe ppm 2.62 (s, 3 H), 8.10 (s, I Fl), 8.38 (s, I H), 8.95 (s, IH), 9.37 (s, I H), 998 (s, I H). LCMS (method-i)), retention time 1.68 mi [M+Hi213.2.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.

1120-82-7, Adding a certain compound to certain chemical reactions, such as: 1120-82-7, name is (1H-Pyrazol-1-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1120-82-7.

General procedure: The target pyrazoly compounds (Scheme 2), were preparedin one step by condensation of one equivalent of (3,5-dimethyl-1H-pyrazol-1-yl) methanol ((1H-pyrazol-1-yl)methanol) with one equivalent of an appropriate amine in20 mL of acetonitrile (CH3CN) as solvent. All reactionswere carried out at reflux for 4 h. The liquid residue is driedover MgSO4, filtered and concentrated in vacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-1-yl)methanol, other downstream synthetic routes, hurry up and to see.

6126-22-3, name is 3-Amino-1H-pyrazol-5(4H)-one, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 6126-22-3

Scheme 3 (FIG. 17) is one synthetic pathway for preparing 6,6?-(4-nitro-1H-pyrazole-3,5- diyl)bis(3 -bromo-7-methylpyrazolo[ 1,5 -alpyrimidin-2( 1H)-one) (compound 8). Compound 8 differs from ANY1 by introduction of two additional methyl groups. Based on the crystal structure data, the methyl groups should be readily accommodated and may increase binding affinity. Briefly, pyrazol-3-one 1 is condensed with 2 to generate bicyclic 1,2-dihydropyrazolo[1,5-alpyrimidine 3. Selective bromination of 3 can be accomplished under free radical (shown) or direct bromination conditions to furnish 4. At this stage, a portion of ester 4 will undergo saponification to generate acid 5.Next, 5 is coupled to CH3NHOCH3 to yield the corresponding Weinreb amide, which can then be transformed to the corresponding methyl ketone 6 by reaction with the Grignard reagentmethyl magnesium bromide. Ester 4 and methyl ketone 6 are then coupled to yield a 1,3- dicarbonyl compound that is condensed with hydrazine to yield the pyrazole core in compound 7. Finally, mild nitration with copper (II) nitrate will deliver compound 8, a direct analogue of ANY 1

Statistics shows that 6126-22-3 is playing an increasingly important role. we look forward to future research findings about 3-Amino-1H-pyrazol-5(4H)-one.

1192-21-8, The chemical industry reduces the impact on the environment during synthesis 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, I believe this compound will play a more active role in future production and life.

3rd Generation BrettPhos precatalyst (11.90 mg, 0.01 mmol) was added to 1 -methyl- 1H- pyrazol-5 -amine (87 mg, 0.89 mmol), Cs2C03 (291 mg, 0.89 mmol) and (5)-2-(2-chloro-5- methylpyrimidin-4-yl)-6-methyl-7-((6-(trifluoromethyl)pyridin-2-yl)methyl)-6,7- dihydroimidazo[l,2-a]pyrazin-8(5H)-one (Intermediate 77; 130mg, 0.30 mmol) in 1,4- dioxane (5 mL) under nitrogen. The resulting mixture was stirred at 100 ¡ãC for 4 hours. The solvent was then removed under reduced pressure. The crude product was purified by flash silica chromatography, elution gradient 0 to 6percent MeOH in DCM, product containing fraction were evaporated to afford a solid. This solid was purified further by preparative HPLC (XSelect CSH Prep C18 OBD column, 5mu silica, 19 mm diameter, 150 mm length), using decreasingly polar mixtures of water (containing 0.1percent Formic acid) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford (5)-6-methyl-2-(5-methyl-2-((l-methyl-lH-pyrazol-5-yl)amino)pyrimidin-4-yl)-7-((6- (trifluoromethyl)pyridin-2-yl)methyl)-6,7-dihydroimidazo[l,2-a]pyrazin-8(5H)-one (Example 27; 100 mg, 67.5percent) as a white solid. lH NMR (300 MHz, DMSO, 23 ¡ãC) delta 1.20 (3H, d), 2.56 (3H, s), 3.70 (3H, s), 4.05-4.18 (1H, m), 4.37-4.41 (1H, m), 451-4.60 (2H, m),5.212 (1H, d), 6.30 (1H, d), 7.34 (1H, d), 7.76-7.83 (2H, m), 7.96 (1H, s), 8.06-8.11 (1H, m), 8.32 (1H, s). m/z (ES+), [M+H]+ = 498.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-5-amine. I believe this compound will play a more active role in future production and life.

288-13-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 288-13-1 name is 1H-Pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) will nitroiodobenzene 0.248g (1.0mmol), pyrazole 0.069g (1.0mmol), Cu (OAc)2¡¤H2O 0.030g (0.15mmol), 2,2- biimidazole 0.022g (0.15mmol), NaOH 0.08g (2mmol), DMSO (2mL) was added the reaction tube with a piston, it was heated to 80 deg.] C the reaction was stirred for 48 hours .(2) TLC until the reaction was complete the reaction was followed ends.After the reaction was cooled to room temperature, diluted with water, extracted with ethyl acetate 3-4 was added, and the combined organic phases were dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product.After the end of (3) to obtain the crude product was purified by column chromatography (petroleum ether / ethyl acetate elution) to give the desired product 7 (68% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole, and friends who are interested can also refer to it.

35344-95-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35344-95-7 as follows.

1-(2-Hydroxyethyl)-1H-pyrazole-4-carbaldehyde In a 30-mL sealed tube, 1H-pyrazole-4-carbaldehyde (500 mg, 5.20 mmol, 1.00 equiv), potassium carbonate (1.08 mg, 7.80 mmol, 1.50 equiv) and 2-bromoethan-1-ol (775.3 mg, 6.20 mmol, 1.19 equiv) were mixed in CH3CN (10 mL) at room temperature. The reaction mixture was then irradiated with microwave for 40 min at 150¡ã C. After the reaction was done, the reaction mixture was cooled to room temperature, filtered through a celite pad and the filtrate was concentrated under reduced pressure. The residue was purified in a silica gel column eluting with dichloromethane/methanol (1percent to 5percent gradient) to afford 1-(2-hydroxyethyl)-1H-pyrazole-4-carbaldehyde (650 mg, 89percent) as yellow solid. MS: m/z=140.8 [M+H]+

According to the analysis of related databases, 1H-Pyrazole-4-carbaldehyde, the application of this compound in the production field has become more and more popular.

1453-58-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1453-58-3, name is 3-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.

Sodium hydride (30 mg, 1.25 mmol) was added to a solution of 3-methylpyrazole (88 mg, 1.07 mmol) in dry THF (5 cm3) under an atmosphere of argon. A solution of 7-tert-butyl-2-chloro-1-azaxanthone (280 mg, 0.97 mmol) in dry THF (5 cm3) was then added to the reaction mixture, which was stirred at 65 ¡ãC for 16 h. The reaction mixture was allowed to cool to room temperature before water (~10 cm3) was added to the reaction mixture. The precipitate was collected via centrifugation and the resultant solid triturated with a minimum volume of Et2O. The solvent was decanted to yield the title compound as a white solid (290 mg, 0.87 mmol, 90percent). deltaH (CDCI3, 400 MHz) 1.39 (9H, s, tBu), 2.37 (1H, s, Me), 6.31 (1H, d, J 2.8, H2′), 7.51 (1H, d, J 8.8, H10), 7.80 (1H, dd, J 8.8; 2.8, H9), 7.99 (1H, d, J 8.4, H2), 8.27 (1H, d, J 2.8, H7), 8.51 (1H, d, J 2.8, H 1′, 8.72 (1H, d, J 8.4, H3). deltac (CDCI3, 100 MHz) 14.2 (Me), 31.6 (C14), 35.1 (C13), 109.7 (C2), 110.1 (C2′), 113.9 (C4), 118.1 (C10), 121.4 (C6), 122.7 (C7), 129.0 (C1′), 133.4 (C9), 140.1 (C3), 148.3 (C8), 153.7 (C11), 153.9 (C12), 154.0 (C3′), 160.0 (C1), 177.0 (C5). m/z (ES+) 688.9 (100percent, 2M + H), 334.3 (50percent, M + H). HRMS (ES+) 334.1551; C20H20O2N3 requires 334.1550, [M + H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

35277-02-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35277-02-2 name is 4-Fluoro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Intermediate (11): 4-fluoro-1-(4-nitrophenyl)-1H-pyrazole To a solution of 4-fluoro-1H-pyrazole (250 mg, 2.90 mmol) and potassium carbonate (803 mg, 5.81 mmol) in acetonitrile (3 mL) was added 4-fluoronitrobenzene (430 mg, 3.05 mmol). The resulting mixture was stirred at 70 C. for 2 hours. The reaction was then filtered and concentrated. Purification by column chromatography gave 4-fluoro-1-(4-nitrophenyl)-1H-pyrazole (400 mg, 67%). 1H NMR (400 MHz, CDCl3, delta): 8.34 (d, 2H), 7.91 (d, 1H), 7.81 (d, 2H), 7.67 (d, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Fluoro-1H-pyrazole, and friends who are interested can also refer to it.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, A new synthetic method of this compound is introduced below., 35344-95-7

(E)-methyl 3-(l -methyl- lH-pyrazol-4-yl)acrylateCs2C03 (1.304g, 4 mmol) was added to a solution of lH-pyrazole-4-carbaldehyde (0.192 g, 2 mmol) in dioxane (8 mL) at room temperature. Trimethylphosphonoacetate (0.364g, 0.40 mmol) was added to this suspension, followed by DMSO (2 mL). The reaction mixture was heated to 100¡ãC overnight. It was then diluted with EtOAc (40 mL), and washed with water (40 mL) and brine (20 mL). The organic layer was concentrated under vacuum. The crude was purified by silica gel column chromatography using a 0-100percent gradient of EtOAc in hexanes to provide (E)-methyl 3 -(1 -methyl- lH-pyrazol-4- yl)acrylate (0.278 g). ES+ (M+H)+ 167

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

1192-21-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows.

[00180] Step 3: To a solution of dioxane (150 mL) was added 2-chloro-4-(2- fluoropyridin-4-yl)pyrimidine (15.0 g, 72.1 mmol), 1 -methyl- lH-pyrazol-5 -amine (7.6 g, 79.3 mmol), cesium carbonate (35.3 g, 108.0 mmol), Pd2(dba)3 (6.6 g, 7.2 mmol) and xantphos (8.3 g, 14.4 mmol). The mixture was heated at 80 ¡ãC under a nitrogen atmosphere for 2 hours. TLC (PE:EtOAc = 5: 1) indicated that the starting material was consumed. The mixture was cooled to room temperature and filtered through a bed of Celite?. The filtrate was then partitioned between EtOAc (200 mL) and water (100 mL). After separation, the organic layer was washed with water, brine, dried over anhydrous MgS04, filtered, concentrated and then purified by column chromatography on silica gel (PErEtOAc = 10: 1 to about 1 : 1) to provide 4-(2-fluoropyridin-4-yl)-N-(l -methyl- lH-pyrazol-5-yl)pyrimidin-2- amine (14.5 g, 74percent) as a solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.