Tag: M.W=0-100

Synthetic Route of 35344-95-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35344-95-7 as follows.

2-((3,5-dicyano-4-ethyl-6-(piperazin-1-yl)pyridin-2-yl)thio)-2-phenylacetamide trifluoroacetic acid (synthesis described in example 176 step 2, 215 mg, 0.413 mmol) was dissolved in dichloromethane (15 mL) and DIEA (0.144 mL, 0.826 mmol). Acetic acid (0.047 mL, 0.826 mmol) was added followed by 1H-pyrazole-4-carbaldehyde (79 mg, 0.826 mmol) The reaction was stirred for 30 minutes and sodium triacetoxyborohydride (350 mg, 1.652 mmol) was added. The reaction was stirred at 25 ¡ãC for 18Hous. The DCM solution was washed with water, a solution of saturated sodium bicarbonate, and then water. The DCM solution was dried then evaporated and the resulting solid was triturated with ethyl acetate to give after filtration pure product. The solid was dried in vacuum oven overnight to afford 2-((6-(4-((1H-pyrazol-4-yl)methyl)piperazin-1-yl)-3,5- dicyano-4-ethylpyridin-2-yl)thio)-2-phenylacetamide (75 mg, 0.149 mmol, 36percent yield) LCMS m/z = 487.2 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.20 (t, J=7.60 Hz, 3 H) 2.44 (br. s., 4 H) 2.75 (d, J=7.60 Hz, 2 H) 3.44 (s, 2 H) 3.86 (d, J=4.82 Hz, 4 H) 5.52 (s, 1 H) 7.28 – 7.44 (m, 4 H) 7.46 – 7.61 (m, 5 H) 7.91 (s, 1 H).

According to the analysis of related databases, 35344-95-7, the application of this compound in the production field has become more and more popular.

Related Products of 288-13-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-13-1, name is 1H-Pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

[0158] To a solution of pyrazole (0.5 g, 7.34 mmol) in glacial acetic acid (4 mL) was added [NAOCI] (0.55 g, 7.34 mmol). The reaction mixture was left at room temperature for 18h, then neutralized with saturated [NA2CO3] solution, extracted with CH2Cl2 (2 x 25 mL), the combined organic layers evaporated, then diluted with [NAOH,] and further extracted with CH2C12 (3 X 20 mL). The organic extracts were combined, dried over [NA2S04] and evaporated to give the title compound as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 69843-13-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69843-13-6, name is 1-Methyl-1H-pyrazol-4-amine, This compound has unique chemical properties. The synthetic route is as follows.

4- amine (52 g, 0.53 mol, prepared according to Procedure B) and cyanamide (29 g, 0.69 mol) in dioxane (50 mL) then the mixture was heated to 95C overnight. The reaction was cooled to room temperature and the solvent removed in vacuo. The residue was washed with ether (100 mL) to afford l-(l-methyl-lH-pyrazol-4-yl)guanidine hydrochloride (93 g , ~ 100%) as a yellow solid which was used in the next step without further purification.

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine. I believe this compound will play a more active role in future production and life.

Adding a certain compound to certain chemical reactions, such as: 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31230-17-8, Product Details of 31230-17-8

A mixture of compound C (1.0 g, 2.94 mmol)and 3-amino-5- methylpyrazole (314 mg, 3.23 mrnol) in dirnethylfo?namide (6 ml) was treated with diisopropylethylamine (0.614 ml, 3.53 mmol) and sodium iodide (530 mg, 3.53 mmol). The mixture was stirred under nitrogen at 85 for 4 hours, cooled to room temperature and diluted with ethyl acetate. The solution was washed with water (x 4), dried over magnesium sulphate and concentrated to 5 ml to afford, upon crystallization and harvesting ofcolourless crystals, the title compound D (920 mg, 78%). 1H- NMR DMSO-d5, delta 0.80-0.87 (4H, m), 1.77-1.85 (IH, m), 1.92 (IH, s), 5.24 (IH, br s), 6.47 (IH, br s), 7.55 (2H, d), 7.70-7.80 (2H, m), 10.24 (IH, s), 10.47 (IH, s), 11.92 (IH, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Reference of 1904-31-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step 3: Preparation of 5-fluoro-N-(1-methyl-1H-pyrazol-3-yl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine To a solution of 2-chloro-5-fluoro-4-(3-nitrophenoxy)-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine (483 mg, 1.1 mmol), in 1,4-dioxane (12 mL) was added 1-methyl-1H-pyrazol-3-amine (128 mg, 1.32 mmol), Cs2CO3 (717 mg, 2.2 mmol), Xantphos (66 mg, 0.11 mmol) and Pd2(dba)3 (101 mg, 0.11 mmol). The reaction vial was flushed with nitrogen, capped, stirred and heated at 140¡ã C. in a microwave reactor for 45 min. After removing the reaction solvent, the residue was partitioned in EtOAc (120 mL) and water (20 mL). The organic layer was separated, washed with water (20 mL) and brine (10 mL), dried over Na2SO4 and evaporated. Purification via flash chromatography with a gradient of 0percent-50percent EtOAc in heptanes afforded the title compound (523 mg, 95percent yield) as a thick oil. 1H NMR (400 MHz, DMSO-d6) delta ppm 9.62 (s, 1H) 8.28-8.32 (m, 1H) 8.26 (d, J=8.06 Hz, 1H) 7.90-7.95 (m, 1H) 7.81-7.88 (m, 1H) 7.45 (br. s., 1H) 7.32 (d, J=2.27 Hz, 1H) 5.52 (s, 2H) 3.74 (s, 3H) 3.55-3.66 (m, 2H) 0.94 (t, J=8.18 Hz, 2H) 0.00 (s, 9H). m/z (APCI+) for C22H26FN7O4Si 500.1 (M+H)+.

The synthetic route of 1-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C4H7N3

1-Methyl-1H-pyrazol-5-amine (4.85 g, 49.9 mmol) and diethylethoxymethylenemalonate (10 mL, 50 mmol) were heated at110 C for 1.5 h. The ethanol by-product was removed by evaporationunder reduced pressure. Phosphoryl trichloride (12.1 mL,130 mmol) was added and the mixture was heated at 110 C for3.5 h. The mixture was cooled to room temperature and MeCN(5 mL) was added, and then the solution was further cooled downto 10 C. Water (80 mL) was added slowly maintaining the temperaturebelow 10 C and the suspension was stirred at ambient temperatureovernight. The resultant solid was collected by filtration,washed with minimum amount of water and dried under reducedpressure to afford the title compound (6.7 g, 54percent) as a white solid;1H NMR (400 MHz, DMSO-d6) d = 8.96 (s, 1H), 8.40 (s, 1H), 4.38 (q,J = 7.0 Hz, 2H), 4.10 (s, 3H), 1.36 (t, J = 7.0 Hz, 3H); 13C NMR(101 MHz, DMSO-d6) d = 163.6, 151.0, 150.7, 137.8, 132.2, 118.0,115.1, 61.5, 34.2, 14.0. LCMS (Method A, UV, ES): RT = 1.00 min,[M+H]+ = 240, 242, 97percent purity. These data were in agreement withthose reported in the literature.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1192-21-8, its application will become more common.

Related Products of 930-36-9, These common heterocyclic compound, 930-36-9, name is 1-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 1. Synthesis of 2-Methyl-2H-pyrazole-3-carbaldehyde In a dry 50 ml Vial is placed a solution of 1.642 g (20 mmol) N-Methylpyrazole in 30 ml dry THF. The mixture is cooled to -20C and while stirring 8 ml (20 mmol, 2.5M in hexane) n-BuLi-solution is slowly added. The reaction mixture is stirred for 2.5 h at -20 C. With vigorous stirring 4.7 ml (4.39g, 60 mmol) dry DMF is slowly added at -20 C and the mixture kept at this temperature for 1h. The reaction mixture is then poured into 100 ml of a 1M acetic acid / sodium acetate buffer (pH: 4.5), 50 ml MTBE is added and the organic layer is separated, washed with 50 ml sat. Na2CO3-Solution to remove excess acetic acid (extraction with ethyl acetate leads to DMF in the final product). The organic layer is separated, dried with MgSO4 and the solvent is removed by om a rotary evaporator. The crude product is purified by vacuum distillation (bp: 67 C, 21 mbar). 3 preparations which were distilled together yielded 5.969g (54 mmol, 90%) of the title compound. 1H-NMR (300 MHz, CDCl3): 4.18 (s, 3H, CH3-N), 6.91 (d, 1H, 3J=2.0 Hz, CH=C-N), 7.53 (d, 1H, 3J=2.0 Hz, CH=N), 9.87 (s, 1H, CH=O) ppm. 13C-NMR (100 MHz, CDCl3): 39.31 (CH3-N), 114.78 (CH=C-N), 138.54 (CH=N), 138.98 (CH=C-N), 179.83 (CH=O) ppm.

Statistics shows that 1-Methylpyrazole is playing an increasingly important role. we look forward to future research findings about 930-36-9.

Application of 31108-57-3,Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of II-C7 (245 mg, 0.6 mmol) and lH-pyrazole-4-carbonitrile (53.6 mg, 0.6 mmol) in acetone (5 mL) was added K2C03 (158 mg, 1.12 mmol). The reaction mixture was stirred at 20 C for 16 hrs. The reaction mixture was extracted with EtOAc (3 x 30 mL). The combined organic layer was washed with saturated brine (30 mL), dried over Na2S04, filtered and concentrated to give the product. The product was purified by flash column (0-30% of EtOAc in PE) to give II-C8 (39.5 mg, 16%) as a solid. (2671) 1H NMR (400 MHz, CDCl3) dH 7.85 (s, 1H), 7.81 (s, 1H), 4.95 (dd, J= 18.0, 44.8 Hz, 2H), 2.58 (t, J= 8.4 Hz, 1H), 2.25-2.15 (m, 1H), 2.08-1.99 (m, 1H), 1.82-1.60 (m, 9H), 1.45-1.15 (m, 13H), 1.05-0.79 (m, 7H), 0.66 (s, 3H); ELSD purity, 99%; MS ESI calcd. for (2672) C27H4ON302 [M+H]+ 438, found 438.

The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Computed Properties of C4H7N3

4,6-Dichloro-lH-pyrrolo[2,3-b]pyridine-3-carbonitrile (0.1 18g), 1-methyl-lH- pyrazo 1-3 -amine (0.027g), sodium tert-butoxide (0.269g), tris(dibenzylideneacetone)dipalladium(0) (0.026 g) and 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos, 0.035g) were added to a microwave vial, followed by dry DMF (5 mL). The reaction mixture was flushed with N2 for -lOmin, and then heated to 80 ¡ãC with microwaves for 1 h. The reaction mixture was subjected to silica-gel flash column chromatography [dichloromethane-methanol (2-3percent)]. The eluted material, obtained as a yellow solid (0.055 g, 78percent) was identified as 4-chloro-6-[(l-methyl-lH-pyrazol-3- yl)amino]-lH-pyrrolo[2,3-b]pyridine-3-carbonitrile. LC-MS (Method A) (m/z) 273 (M+H+); tR = 2.11

The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 930-36-9, name is 1-Methylpyrazole, A new synthetic method of this compound is introduced below., SDS of cas: 930-36-9

A solution of POCl3 (2.61 mL, 28 mmol) in DMF (2.16 mL, 28 mmol)was stirred at 8 C for 2 h, and the resultant viscous solution waswarmed to 80 C. To this solution was added N-methylpyrazole (1 g,12 mmol), and it was stirred at 80 C for 1 h, at 100 C for 3 h, and at115 C for 1 h. The solution was then cooled to room temperature andquenched by addition of 60 mL of ice-cold water. The reaction mixturewas stirred for 24 h and then neutralized to pH 7 using 1 N NaOH andextracted with chloroform (3¡Á30 mL). The combined organic layerwas washed with brine (30 mL) and dried over MgSO4. After filtration, the filtrate was concentrated in vacuo. The residue was purified bycolumn chromatography to afford 5 (0.68 g, 50%), Rf=0.2 Hex/EA7:3. 1H NMR (400 MHz, CDCl3) delta 9.80 (s, 1H), 7.91 (s, 1H), 7.89 (s, 1H),3.93 (s, 3H). MS (ESI) m/z 110.8 [M+H]+. HRMS calcd for C5H6N2O[M+H]+ 111.0558, found 111.0556.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.