Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, A new synthetic method of this compound is introduced below., Computed Properties of C4H7N3
4,6-Dichloro-lH-pyrrolo[2,3-b]pyridine-3-carbonitrile (0.1 18g), 1-methyl-lH- pyrazo 1-3 -amine (0.027g), sodium tert-butoxide (0.269g), tris(dibenzylideneacetone)dipalladium(0) (0.026 g) and 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos, 0.035g) were added to a microwave vial, followed by dry DMF (5 mL). The reaction mixture was flushed with N2 for -lOmin, and then heated to 80 ¡ãC with microwaves for 1 h. The reaction mixture was subjected to silica-gel flash column chromatography [dichloromethane-methanol (2-3percent)]. The eluted material, obtained as a yellow solid (0.055 g, 78percent) was identified as 4-chloro-6-[(l-methyl-lH-pyrazol-3- yl)amino]-lH-pyrrolo[2,3-b]pyridine-3-carbonitrile. LC-MS (Method A) (m/z) 273 (M+H+); tR = 2.11
The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.