Tag: M.W=0-100

Synthetic Route of 35344-95-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 35344-95-7 name is 1H-Pyrazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 2,3-diamino-1,4-naphthoquinone (1.0 mmol),appropriate aromatic aldehyde (1.0 mmol) with sodium pyrosulfitein DMF was stirred at 120 C overnight. On completion of the reactionmonitored by TLC, the solvent was evaporated and the residuewas purified by silica gel chromatography by DCM/MeOHsystem to afford the final product. If necessary, the crude productcould be recrystallized in methanol or DMSO to afford pure sample.4.1.5.1. 2-(2-Chlorophenyl)-1H-naphtho[2,3-d]imidazole-4,9-dione(T1). Pale yellow solid; yield 80percent;

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.

Application of 36650-74-5, A common heterocyclic compound, 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, molecular formula is C4H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of SB-FF (100 mg, 0.241 mmol), lH-pyrazole-3-carbonitrile (45 mg, 0.48 mmol), K2CO3 (66 mg, 0.48 mmol) and DMF (3 mL) were stirred at room temperature for 2 h. TLC showed the reaction was finished. The reaction mixture was poured into brine (10 mL) and extracted with EtOAc (10 mLx2). Combined the organic layers and dried over Na2S04, concentrated to give crude product, which was purified by silica gel column to give SB-13 (30 mg, yield: 28%) as a white solid. 1H NMR: (400 MHz, CDC13) delta 7.48 (s, 1H), 6.73 (s, 1H), 4.79-4.97 (m, 2H), 4.47-4.65 (m, 1H), 2.56-2.63 (m, 1H), 2.30-2.20 (m, 1H), 2.10-2.00 (m, 1H), 1.90-1.60 (m, 6H), 1.50-1.20 (m, 15H), 0.85-0.75 (m, 1H), 0.70 (s, 3H). LCMS: rt = 1.23 mm, m/z = 428.2 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 288-13-1, name is 1H-Pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-13-1, Recommanded Product: 288-13-1

General procedure: Complex 2 (0.05 mmol) was added to a 5 mL of a sealed tube containing the aryl iodide or bromide (0.5 mmol), 1H-pyrazole (0.75 mmol), NaOH (1 mmol), and DMSO (1 mL). The mixture was stirred at 100 C for 12 h. After being cooled to room temperature, the mixture was quenched with 10 mL H2O and extracted with EtOAc(3 ¡Á 20 mL). The combined EtOAc extracts were dried with anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure.The residue was purified by flash column chromatography on silicagel with PE/EtOAc (from 10:1 to 5:1) as the eluent to afford the pure products. All N-aryl pyrazoles reported here are known products and were characterised by 1H NMR, and GC-MS.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-Pyrazole, other downstream synthetic routes, hurry up and to see.

These common heterocyclic compound, 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: (1H-Pyrazol-4-yl)methanol

(lH-Pyrazol-4-yl)-methanol (0.55 g, 5.61 mmol) and imidazole (0.953 g, 14.00 mmol) are placed in an oven-dried flask under an atmosphere of argon. Dry DMF (2.2 mL) is added followed by tert-butyldiphenylsilyl chloride (1.85 g, 6.73 mmol). The reaction mixture is stirred at room temperature. The reaction is shown to be complete by TLC after 18 hours. The reaction mixture is partitioned between dichloromethane (50 mL) and water (50 mL). The organic layer is washed with water (20 mL) and brine (20 mL), dried over MgSO 4, filtered and the solvent is removed in vacuo. The title compound is obtained after purification by flash column chromatography (silica, ethyl acetate / isohexane 1:8). 1H nmr (CDCU 400 MHz); 7.70(m, 4H), 7.50(m, 2H), 7.40(m, 6H), 4.75(s, 2H), 1.10(s, 9H).

The synthetic route of (1H-Pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.

Application of 28466-26-4, These common heterocyclic compound, 28466-26-4, name is 4-Aminopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of (2S,3R,4R)- I -acetyl-2-cyclopropyl-3-methyl-4-((6-methylpyridin-2-yl)amino)- 1,2,3,4- tetrahydroquinoline-6-carboxylic acid (for a preparation see Example 247, 50 mg, 0.132 mmol) andHATU (90 mg, 0.198 mmol) in N,N-dimethylformamide (DMF)(1 mL)was added IH-pyrazol-4-amine (13 mg, 0.158 mmol) followed by DIPEA (0.097 mL, 0.553 mmol). The reaction mixture was stirred at rt for 90 mm, then purified directly by MDAP (HpH). The solvent was evaporated in vacuo to give the product (8 mg). LCMS (2 mm High pH): Rt = 0.88 mi [MH] = 445.

Statistics shows that 4-Aminopyrazole is playing an increasingly important role. we look forward to future research findings about 28466-26-4.

Adding a certain compound to certain chemical reactions, such as: 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1904-31-0, Safety of 1-Methyl-1H-pyrazol-3-amine

Boc2O (134.83 g, 617.79 mmol, 1 .00 Eq) was added to a solution of compound 14-1 (60.00 g, 617.79 mmol, 1 .00 Eq) and NaOH (27.18 g, 679.57 mmol, 1 .10 Eq) in THF/H2O (1 :1 ) (1200 ml_) at 25C in portions. The mixture was stirred for 4 h, extracted with EtOAc (800 ml_), dried and concentrated to give compound 14-2 (89.00 g, 451 .25 mmol, 73.04% yield) as a white solid. LCMS m/z 142[M-55]+. 1 H NMR (400MHz, CDCI3) delta ppm 8.01 (s, 1 H), 7.21 -7.20 (d, J=2Hz, 1 H), 6.44 (s, 1 H), 3.81 (s, 3H), 1 .51 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1H-Pyrazole-4-carbonitrile

To a solution of I-R15 (200 mg) in anhydrous THF (20 mL) was added lH-pyrazole-4- carbonitrile (90.9 mg, 1.0 mmol) and K2C03 (134 mg, 1.0 mmol) at 25C under N2. The mixture was stirred at 65C for 12 h. The reaction mixture was poured into ice-water (30 mL). The aqueous phase was extracted with EtOAc (2 x 50 mL). The combined organic phase was washed with saturated brine (2 x 50 mL), dried over anhydrous Na2S04, filtered and concentrated. The residue was purified by flash column (30-40% of EtOAc in PE) to give I-R16 (130 mg, 63%) as an oil. (2182) 1H NMR (400 MHz, CDCl3) dH 7.88 (s, 1H), 7.82 (s, 1H), 6.65 (s, 1H), 5.39-5.30 (m, 2H), 2.43 (dd, J= 6.0, 18.4 Hz, 1H), 2.16-2.07 (m, 1H), 2.00 (s, 1H), 1.97-1.49 (m, 7H), 1.43-0.99 (m, 17H), 0.96 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 31108-57-3, its application will become more common.

Synthetic Route of 67-51-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67-51-6 as follows.

General procedure: NaH (60mmol) was added to the solution of 3,5-dimethylpyrazole or 3,5-diisopropylpyrazole (50mmol) in THF (40ml) at room temperature. The resulting mixture was stirred for 1h, and then CH3I (50mmol) was added. After the reaction mixture was continuously stirred overnight at room temperature, water (100ml) was added slowly. The solution was extracted with ethyl acetate (3¡Á50ml). The organic layers were combined, washed with saturated brine and dried over anhydrous MgSO4. The solvent was removed in vacuo to give the expected products. (0012) 1,3,5-Trimethylpyrazole, yield: 46%. 1H NMR: delta 2.18 (s, 3H), 2.19 (s, 3H) (CH3), 3.67 (s, 3H, NCH3), 5.76 (s, 1H, H4 of pyrazole) ppm. 13C NMR: delta 11.0, 13.4 (CH3), 35.6 (NCH3), 104.8 (C4 of pyrazole), 139.0, 147.0 (C3 and C5 of pyrazole) ppm.

According to the analysis of related databases, 67-51-6, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-13-1, name is 1H-Pyrazole, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives

3.40 g (0.05 mol) of pyrazoleAnd 2.8g (0.05mol) powdered KOH were added to a 100mL three-necked flask,Add 10mLDMSO as a solvent, the mixture was stirred at 80 for 30min,Then 6.25 g (0.05 mol) of 2-bromoethanol was added (added to the flask in 30 mL intervals, three times)Continue stirring for 20 ~ 30h, cooled to room temperature,After filtration, 20 mL of chloroform was added and the solution was washed with water (5 ¡Á 20 mL)Rotary drying to give a colorless transparent liquid 1-ethylpyrazole (yield: 60 ~ 70%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 35277-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35277-02-2, name is 4-Fluoro-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

Step D: 4-fluoro-lH-pyrazole-l-carboxamidine hydrochloride (28-e) To 4-fluoro-lH-pyrazole, 28-d, (2g, 23mmol) and cyanamide (0.97g, 23mmol) in dioxane (5mL) was added 4N HC1 in dioxane (15mL). The mixture was gently refluxed with stirring for 2h under nitrogen. During the course of the reaction the product crystallizes. After cooling to room temperature, 10 mL of anhydrous ether was added and the mixture was allowed to stand for 30min. The white solid was collected by filtration, washed with anhydrous ether and dried to constant weight in vacuuo providing the product, 28-e, (3g, 80%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Fluoro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.