Tag: M.W=0-100

Related Products of 31230-17-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31230-17-8 as follows.

Example 118a 5-Bromo-1-methyl-3-(5-methyl-1H-pyrazol-3-ylamino)pyridin-2(1H)-one 118a A 100-mL single-neck round-bottomed flask equipped with a magnetic stirrer and reflux condenser was charged with 1,4-dioxane (15 mL), 5-methyl-1H-pyrazol-3-amine (1 g, 10 mmol) (1), 3,5-dibromo-1-methylpyridin-2(1H)-one (4 g, 15 mmol) (2), and cesium carbonate (6.4 g, 20 mmol). Xantphos (400 mg, 0.8 mmol) and Pd2(dba)3 (700 mg, 0.8 mmol) were added, and the reaction mixture was heated at 100¡ã C. for 5 h. After this time the reaction was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the residue was purified on flush column eluting with dichloromethane:methanol (20:1) to afford 118a (1.0 g, 35percent). MS: [M+H]+ 283.

According to the analysis of related databases, 31230-17-8, the application of this compound in the production field has become more and more popular.

Some common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 1904-31-0

A solution of 1-methyl-1H-pyrazol-3-ylamine (0.92 g, 9.5 mmol) in benzene (4.8 mL) was treated with hexane-2,5-dione (1.34 mL, 11.4 mmol) and para-toluenesulfonic acid (182 mg, 0.95 mmol) and was heated to 115 C. under Dean-Stark conditions for 4 h. After this time, the reaction was cooled to 25 C., concentrated in vacuo and dried under high vacuum overnight. The resulting residue was dissolved in methylene chloride (100 mL) and was washed with water (1¡Á150 mL), dried over sodium sulfate, filtered and concentrated in vacuo. Silica gel column chromatography (ISCO, 80 g, 1:4 ethyl acetate/hexanes) afforded 3-(2,5-dimethyl-pyrrol-1-yl)-1-methyl-1H-pyrazole (1.57 g, 94%) as a green oil; ES+-HRMS m/e calcd for C10H13N3 [M+H+] 176.1182, found 176.1182.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1904-31-0, its application will become more common.

Reference of 1904-31-0, These common heterocyclic compound, 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of benzoic acid which was obtained by hydrolysis of methyl esters 8 or 12A-E (0.22 mmol, 1.0 equiv), aminothiazole or imidazo[1,2-a]pyrazin-8-amine or aminopyrazole (0.33 mmol, 1.5 equiv), HATU (0.33 mmol, 1.5 equiv) and HOAt (0.33 mmol, 1.5 equiv) in DMF (2 mL) was added dropwise di(isopropyl)ethylamine (DIPEA) (0.12 mL, 0.67 mmol, 3 equiv). The reaction was run under microwave at 60 ¡ãC (40 W) for 30 min, and then cooled to room temperature and poured into brine. The aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over anhydrous NaSO4 and concentrated. The residue was purified by chromatography (SiO2, petroleum ether/EtOAc = 4:1-1:1) to yield corresponding amides as white or yellow powder.

The synthetic route of 1904-31-0 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 64781-79-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64781-79-9, name is 4-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.

Compound 6 (40 mmol) was dissolved in DMF (100 mL), then 4-methyl-2-aminopyrazole(44 mmol), sodium iodide (48 mmol) and diisopropylethylamine (DIPEA) (48 mmol). the solution was heated to 100 deg.] C, overnight,then cooled to room temperature, diluted with ethyl acetate (200 mL), saturated sodium bicarbonate solution (3 ¡Á 200mL), dried and reducedpressure concentrated and purified by flash chromatography on silica gel, washing wherein release agent, 0% to 4% methanol / dichloromethane to give a white-basedcolor solid 10- (sec-butyl) -5 – ((4-methyl -1H- pyrazol-3-yl) amino) -7 – oxo -2,3,7,10- tetrahydro – [1,4]dioxin [2], 3-H] quinoline-8-carboxylate, 15.09g, yield 91.5%,

The chemical industry reduces the impact on the environment during synthesis 4-Methyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.

Application of 1904-31-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1904-31-0, name is 1-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

2-Bromo-5-cyclopentyloxy-pyridine (0.97 mmol), sodium-tert.- butylate (1.4 eq.), and 1-methyl-1 H-pyrazole-3-amine (1.2 eq.) are dissolved in degassed dioxane (2 ml) and heated to 80 0C. Chloro-(di-2- norbornylphosphino)(2-dimethylaminoferrocene-1-yl)palladium (II) (3 mg) in degassed dioxane (1 ml) is added and the reaction mixture is heated for 1 hour at 150 0C in the microwave. The reaction is quenched with ethylacetate / methanol (30 ml, 9:1 ) and filtrated over celite. The solvent of the filtrate is removed in vacuo. (5-Cyclopentyloxy-pyridine-2-yl)-(1-methyl- 1 H-pyrazole-3-yl)-amine (“A25”) is obtained after reversed phase column chromatography (water / acetonitrile + 0.1 percent TFA) as a colorless powder in a yield of 29 percent; HPLC (method C): 1.55 min; LC-MS (method A): 0.97 min, 259.15 (M+H+); 1H-NMR (DMSO-Cl6, 400 MHz): delta [ppm] 10.745 (s, 1 H), 7.848 (d, 1 H, J=2.9 Hz), 7.739-7.709 (m, 2H), 7.282 (of, 1 H, J=9.6 Hz)1 6.091 (d, 1 H, J=2.3 Hz), 4.793-4.764 (m, 1 H), 3.850 (s, 3H), 1.953-1.865 (m, 2H), 1.751-1.688 (m, 4H), 1.661-1.583 {m, 2H).

The synthetic route of 1-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.

3920-50-1, name is Pyrazole-3-carboxaldehyde, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Pyrazole-3-carboxaldehyde

The compound (53.8 mg) obtained in Example 1-4 was dissolved in methanol (0.8 ml). Then, the solution was added with trimethyl orthoformate (50 mul), acetic acid (50 mul), and pyrazol-3-carboxaldehyde (manufactured by Merck, Inc.) (24.9 mg) and stirred at room temperature for 10 minutes. Subsequently, sodium cyanoborohydride (24.4 mg) was added, followed by stirring overnight at room temperature. The solvent was distilled off under reduced pressure and then the residue was dissolved in chloroform, followed by washing with 1 mol/l sodium hydroxide and saturated saline solution and drying with anhydrous sodium sulfate. After filtration, the solvent was distilled off under reduced pressure. Then, the residue was then purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (26.1 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=466[M+H]+1H-NMR(500MHz,DMSO-d6) :delta=0.88(6H,t,J=7.3Hz),1.53-1.69(8H,m),2.95(4H,brs),3.05(2H,brs),3.25-3.40(2H,m),3.55(2H,s),3.58(2H,s),3.62(2H,s),6.27(1H,s),7.04( 2H,s),7.50(2H,d,J=8.2Hz),7.81(2H,d,J=8.2Hz),8.51(1H,t,J=5.5H z).

The synthetic route of 3920-50-1 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 35344-95-7

into a 100-mL round-bottom flask, was placed a solution of tert-butyl N-[3-(methanesulfonyloxy)cyclobutyl]carbamate (2.65 g, 9.99 mmol, 1.00 eq.), 1H-pyrazole-4-carbaldehyde (1.152 g, 11.99 mmol, 1.20 eq.) and Cs2CO3 (6.52 g, 20.01 mmol, 2.00 eq.) inDMF (20 mL). The resulting solution was stirred for 4 h at room temperature. The reaction was then quenched by the addition of 100 mL of water. The resulting solution was extracted with 3×100 mL of ethyl acetate and the organic layers combined. The resulting mixture was washed with 100 mL of brine. The mixture was dried over anhydrous sodium sulfate andconcentrated under vacuum. The crude product was purified by Flash-Prep-HPLC with the following conditions (CombiFlash-1): Column, C18 silica gel; mobile phase, MeCN/H20=60:40 increasing to MeCN/H20=70:30 within 3 mm; Detector, UV 254 nm. The crude product was purified by Prep-SFC with the following conditions (prep SFC 350-2):Column: Phenomenex Lux 5u Cellulose-4 250*50mm; mobile Phase A: C02:70, Mobile PhaseB: MeQH-HPLC:30; Flow rate: 150 mL/min; 254 nm; RT1:4.53; RT2:5.36. This resulted in 712 mg (54%) of tert-butyl N-[cis-3 -(4-formyl- 1 H-pyrazol- 1 -yl)cyclobutyl]carbamate as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35344-95-7, its application will become more common.

Electric Literature of 288-13-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 288-13-1 name is 1H-Pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2a (5.Og, 73.5mmol) was added in portions to H2SO4 (35mL) while keeping the temperature below 400C, then 70% HNO3 (5.06mL, 80.6mmol) was added dropwise while maintaining the temperature below 55 0C. The mixture was then heated at 550C for 5h and cooled to 00C. The mixture was neutralized with 50% NaOH and the resulting slurry was diluted with ethyl acetate. The resulting precipitate was removed by filtration. The filtrate was separated and the organic phase was washed with water and brine, dried over MgSO4 and concentrated in vacuum. The residue was crystallized for ethanol to afford 2b (7.1g, 85.5%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole, and friends who are interested can also refer to it.

Application of 1453-58-3,Some common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, molecular formula is C4H6N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(a) 1-Benzenesulfonyl-3-methylpyrazole. A mixture of 3-methylpyrazole (5 g, 60.9 mmol), benzenesulfonyl chloride (8.55 mL, 67 mmol) and triethylamine (9.3 mL, 67 mmol) in acetonitrile was heated at reflux for 2 h, allowed to cool and concentrated. EtOAc (300 mL) was added and the solution was filtered and concentrated to provide a solid residue which was crystallised from EtOAc to give the title compound as an off-white powder (Yield:7.92 g, 58 percent).1H-NMR (DMSO-d6): delta 8.35 (d, 1 H), 7.97-7.94 (m, 2H), 7.78 (tt, 1 H), 7.66 (t, 2H),6.43 (d, 1 H), 2.17 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methylpyrazole, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35344-95-7, Formula: C4H4N2O

A solution of 3-[4-(bromomethyl)phenyl]-5-(trifluoromethyl)-1 ,2,4-oxadiazole (5.0 g, 15.5 mmol),1H-pyrazole-4-carbaldehyde (2.35 g, 23.2 mmol), and potassium carbonate (4.32 g, 30.9 mmol) in acetonitrile (62 mL) were sealed in a vial. The contents were irradiated with microwaves at 130¡ãC for 1 hour. Solids were removed by filtration, washed with ethyl acetate, and the mother liquors were concentrated under reduced pressure. The resultant residue was purified by flash chromatography oversilica gel (cyclohexane:EtOAc eluent gradient 1:0 to 0:1)to afford 362mg of the title compound as a white solid. LC/MS (Method A) retention time = 1.06 minutes, 352 (M+H). mp: 91 – 96¡ãC1H NMR (400 MHz, CDCI3)o ppm: 9.78 (s, 1H), 8.22 (d, 2H), 8.05 (s, 1H), 7.98 (s, 1H), 7.40 (d,2H), 5.40 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-Pyrazole-4-carbaldehyde, and friends who are interested can also refer to it.