Tag: M.W=0-100

Reference of 31230-17-8, The chemical industry reduces the impact on the environment during synthesis 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.

Intermediate 2; 2,,5-Dichloro-N-(5-methyl-lH-pyrazol-3-yl)pyrimidin-4-amine To a solution of 5-methyl-lH-pyrazol-3-amine (2.78 g, 27.3 mmol) in absolute EtOH (30 ml) was added triethylamine (5 ml) and 2,4,5-trichloropyrimidine (5.0 g, 27.3 mmol) and the resulting solution was aged at room temperature for 12 hours. The mixture was partitioned between EtOAc and H2O, the organic layer was washed with brine and dried. The solvents were removed under reduced pressure to give the title compound (4.1 g). LC-MS: 245 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/7753; (2009); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25222-43-9, SDS of cas: 25222-43-9

General procedure: Add acid chloride (2mmol) dropwise to (1H-pyrazol-4-yl) methanol or(1H-3,5-dimethylpyrazol-4-yl) methanol (1 mmol),4-Dimethylaminopyridine (0.2mmol) and triethylamine (2.5mmol) were dissolved in a solution of dichloromethane (30mL), and the reaction was stirred at room temperature for 12 hours, and then a saturated sodium bicarbonate solution was slowly added with sufficient stirring. Until the reaction no longer produces gas,The layers were separated, and the organic phase was washed twice with saturated sodium bicarbonate solution (20 mL each time) and once with water (20 mL). The organic phase was dried over anhydrous sodium sulfate and the solvent was removed by rotary evaporation. The residue was purified on a silica gel column of 100-200 mesh, and ethyl acetate / petroleum ether (60-90 C) (1: 5, volume ratio) was used as eluent. After removing the solvent by rotary evaporation, a pyrazole methoxide derivative having the general chemical structure I is obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (1H-Pyrazol-4-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nankai University; Tang Liangfu; Xu Yue; Yang Jiali; Xia Dongqi; (10 pag.)CN110386899; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 14521-81-4, name is 3-Fluoro-1H-pyrazole, molecular formula is C3H3FN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: pyrazoles-derivatives

(5)-N-(4-Cyano-3-(trifluoromethyl)phenyl)-3-(3-fluoro-lH-pyrazol- l-yl)-2-hydroxy-2- methylpropanamide Ci5Hi2F4N402 (1012) (0755) (0756) [00344] To a solution of 3-fluoro-pyrazole (0.20 g, 0.00232 mol) in anhydrous THF (10 mL), which was cooled in an ice water bath under an argon atmosphere, was added sodium hydride (60% dispersion in oil, 0.24 g, 0.00582 mol). After addition, the resulting mixture was stirred for 3 h. (7?)- 3-Bromo-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide (8, 0.82 g, 0.00232 mol) was added to above solution, and the resulting reaction mixture was allowed to stir overnight at RT under argon. The reaction was quenched by water, and extracted with ethyl acetate. The organic layer was washed with brine, dried with MgS04, filtered, and concentrated under vacuum. The product was purified by a silica gel column using ethyl acetate and hexanes (2: 1) as eluent to afford 0.36 g of the compound as white needles. (0757) [00345] Compound 1012 was characterized as follows: lH NMR (400 MHz, DMSO-i delta 10.39 (s, 1H, NH), 8.47 (d, = 2.0 Hz, 1H, ArH), 8.24 (dd, = 8.8 Hz, = 2.0 Hz, 1H, ArH), 8.11 (d, = 8.8 Hz, 1H, ArH), 7.55 (t, J = 3.0 Hz, 1H, Pyrazole-H), 6.29 (s, 1H, OH), 5.93-5.91 (m, 1H, Pyrazole- H), 4.34 (d, = 13.6 Hz, 1H, CH), 4.15 (d, = 13.6 Hz, 1H, CH), 1.36 (s, 3H, CH3); Mass (ESI, Positive): 357.0966 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 14521-81-4, its application will become more common.

Reference:
Patent; UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION; NARAYANAN, Ramesh; MILLER, Duane; PONNUSAMY, Thamarai; HWANG, Dong-Jin; HE, Yali; (234 pag.)WO2017/214634; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H8N2

145 Kg of 3,4-dimethylpyrazole obtained after post-treatment of reaction zone B was dissolved in 200 Kg of ethanol and 110 Kg of water.After the mixed solution is placed in the corresponding storage tank, the reaction zone C of the microchannel reactor is preheated to about 45 C, wherein the reaction CThe zone is composed of 3 microchannel reaction tablets with a liquid holding capacity of 200 mL, wherein the ethanol solution of 3,4-methylpyrazole and 174 Kg areThe amount of phosphoric acid with a fraction of 85% is 2.50 L/min and 1.02 L/min, the residence time is about 10 s, cooling, crystallization, overFiltration, drying to obtain about 281.2Kg of white powdery solid, namely 3,4-dimethylpyrazole phosphate, the yield is 95.9%, the purity is96.2% (HPLC).

The synthetic route of 2820-37-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sinochem Agricultural (Linyi) Research And Development Center Co., Ltd.; Sun Yingxiang; Wei Yanqing; Liu Xiaobo; Zhang Xixing; (17 pag.)CN109574935; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35277-02-2, name is 4-Fluoro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., name: 4-Fluoro-1H-pyrazole

7-Bromo-5 -(chloromethyl)-2,3 -dihydro- 1 -benzofuran 3 (120 mg, 0.48 mmol, 1.17 eq.), 4-fluoro-JH-pyrazole (35 mg, 0.41 mmol, leq.), K2C03 (120 mg, 0.87 mmol, 2.1 eq.) in DMF (1 mL) were stirred at rt for 18 hr. The reaction was diluted with water (8 mL) and extracted with EtOAc (10 mL X 2). The combined organics were dried over Na2SO4, and concentrated to give a residue, which was purified by chromatography (SG, hexane/DCM (1.5:1)) to yield 4 as a white solid (106 mg, 88% yield).

According to the analysis of related databases, 35277-02-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TETRA DISCOVERY PARTNERS, LLC; NUGENT, Richard A.; GURNEY, Mark; MO, Xuesheng; (92 pag.)WO2016/49595; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 288-13-1, name is 1H-Pyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C3H4N2

General procedure: Iodobenzene (1.0 mmol), imidazole (1.5 mmol), TEPA (2.0 mmol), TBAB (0.3 mmol), CuI (0.1 mmol), and 3 mL H2O were added to a 10 mL flask, which was subsequently capped with a rubber balloon. The mixture was stirred in a preheated oil bath at 125 C for 12 h. After cooling the mixture to the room temperature, 5 mL water was added and the product was extracted by ethyl acetate (10 mL¡Á3). The combined organic layer was washed by brine (15 mL), dried over anhydrous MgSO4, and evaporated under the reduced pressure. Further purification by silica gel column chromatography (6:1 petroleum ether/ethyl acetate) give the 1-phenyl-1H-imidazole.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Yang, Qichao; Wang, Yufang; Yang, Li; Zhang, Mingjie; Tetrahedron; vol. 69; 30; (2013); p. 6230 – 6233;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, A new synthetic method of this compound is introduced below., Computed Properties of C4H6N2O

General procedure: Dichloromethane (10 mL) was taken in a round-bottomed flask,into which 1.0 equivalent (1 mmol) of triethylamine and pyrazolonewere poured. The mixture was stirred for 2 min without heating. To this mixture, 1.0 equivalent of corresponding presynthesized benzylidene from malononitrile was added. Then the mixture was agitated for 25-30 min. The reaction was observed by TLC. The desired products appeared as precipitates. The precipitates were washed with water to remove the unreacted pyrazolone to obtain pure products. Melting points were recordedfor crystalline substances.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 288-13-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-13-1, name is 1H-Pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Complex 2 (0.05 mmol) was added to a 5 mL of a sealed tube containing the aryl iodide or bromide (0.5 mmol), 1H-pyrazole (0.75 mmol), NaOH (1 mmol), and DMSO (1 mL). The mixture was stirred at 100 C for 12 h. After being cooled to room temperature, the mixture was quenched with 10 mL H2O and extracted with EtOAc(3 × 20 mL). The combined EtOAc extracts were dried with anhydrous Na2SO4, filtered and the solvent was removed under reduced pressure.The residue was purified by flash column chromatography on silicagel with PE/EtOAc (from 10:1 to 5:1) as the eluent to afford the pure products. All N-aryl pyrazoles reported here are known products and were characterised by 1H NMR, and GC-MS.

The synthetic route of 1H-Pyrazole has been constantly updated, and we look forward to future research findings.

Application of 31230-17-8, The chemical industry reduces the impact on the environment during synthesis 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.

General procedure: In a one neck round bottom flask placed, taken 3-substituted-1H-pyrazol-5-amine (1eq) in dichloromethane and added 4N KOH (8eqin water). The reaction mixture was allowed to stir at room temperature followed by addition ofBocanhydride (1.2eq) in small batches. The reaction mixture was allowed to stir for 3h and reaction completion was monitored by thin layer chromatography (1:1 hexane: ethyl acetate). The reaction mixture was diluted in CH2Cl2, washed brine and dried with MgSO4. The crude product was purified using silica gel column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.

Related Products of 930-36-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 930-36-9 as follows.

To a solution of 1-methyl pyrazole (4.1 g, 50 mmole) in THF (100 mL) at 00C was added n-BuLi (2.2M in THF, 55 mmole). The reaction solution was stirred for 1 hour at RT and then cooled to -78C [J. Heterocyclic Chem. 41 , 931 (2004)]. To the reaction solution was added 2-isopropoxy-4,4,5,5-tetramethyl-1 ,3,2-dioxaborolane (12.3 mL, 60 mmole). After 15 min at -78C, the reaction was allowed to warm to 00C over 1 hour. The reaction was diluted with saturated NH4CI solution and extracted with DCM. The organic fractions were washed with H2O (2 x 100 ml_), dried over Na2SO4 and concentrated under vacuum to afford a tan solid (8.0 g, 77%) which was used without further purification. LCMS (ES) m/z 127 (M+H)+ for [RB(OH)2]; 1H NMR (CDCI3, 400 MHz) delta 7.57 (s, 1 H), 6.75 (s, 1 H), 4.16 (s, 3H), and 1.41 (s, 12H).

According to the analysis of related databases, 930-36-9, the application of this compound in the production field has become more and more popular.