Tag: M.W=250-300

Atanassova, Maria published the artcileDetermination of pK_aIL Values of Three Chelating Extractants in ILs: Consequences for the Extraction of 4f Elements, Product Details of C17H14N2O2, the publication is Journal of Solution Chemistry (2015), 44(3-4), 606-620, database is CAplus.

Aqueous-ionic liquid biphasic systems have been examined in terms of water and acid solubilities in the IL-rich phase at ambient temperature The biphasic mixtures were comprised of acids of various concentrations (H⁺; Cl^–, H⁺; NO^–₃, H⁺; ClO^–₄, mainly from 1 × 10^-2 to 1 × 10^-4 mol·dm^-3) and four ionic liquids of the imidazolium family [C₁C_ni.m.][Tf₂N] (n = 4, 6, 8 and 10). The effects of ionic medium (μ = 0.1 mol·dm^-3, by use of Na⁺; Cl^–, Na⁺; NO^–₃ or Na⁺; ClO^–₄, according to the acid investigated), the nature of the IL cation as well as the nature of the acid on the mutual solubilities of (H₂O, H⁺, [C₁C_ni.m.]⁺ and [Tf₂N]^–) entities were determined Then, three chelating compounds (HL), which belong to the β-diketone family (thenoyltrifluoroacetone (HTTA), 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one (HP) and 4-benzoyl-3-phenyl-5-isoxazolone (HPBI)), were added to [C₁C₄i.m.][Tf₂N] and subsequent determination of the H⁺ distribution between the two phases allowed the determination of their dissociation constants (pK_aIL) in the water-saturated ionic liquid phase. A very strong effect of the IL cation on the HTTA pK_aIL value was observed from n = 4 to n = 10. The influence of this phenomenon on the lanthanide extraction process is discussed.

Journal of Solution Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Product Details of C17H14N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Zheng published the artcileSelective removal of magnesium from lithium-rich brine for lithium purification by synergic solvent extraction using β-diketones and Cyanex 923, Computed Properties of 4551-69-3, the publication is AIChE Journal (2020), 66(7), e16246, database is CAplus and MEDLINE.

In the production of battery-grade and high-purity Li₂CO₃, it is essential to remove magnesium impurities. The state-of-the-art solvent extraction (SX) process using Versatic Acid 10 and D2EHPA co-extracts 3.3-5.5% lithium, while removing 86-98% magnesium. Here, we demonstrate that synergic SX systems containing a β-diketone (HPMBP, HTTA or HDBM) and Cyanex 923 are highly selective for magnesium extraction over lithium (separation factor α > 1000). The extracted magnesium and lithium complexes have the stoichiometry of [Mg·A₂·(C923)₂] and [Li·A_x·(C923)₂] (x = 1, 2), resp. (A represents deprotonated β-diketone). The three β-diketone synergic SX systems all considerably outperformed the Versatic Acid 10 system for magnesium removal from a synthetic solution containing 24 g L^-1 Li and 0.24 g L^-1 Mg. In a three-stage batch counter-current extraction, the HPMBP and Cyanex 923 synergic SX system removed 100% magnesium with only 0.6% co-extraction of lithium. This excellent Mg/Li separation is the best result reported so far.

AIChE Journal published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Computed Properties of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Zhu, Hualing published the artcileSynthesis, structure and biological activities of phenylmethylacylpyrazolinone derivatives modified with glycylglycine methyl ester, Quality Control of 4551-69-3, the publication is Youji Huaxue (2013), 33(12), 2631-2636, database is CAplus.

Four new 1-phenyl-3-methyl-4-acyl-2-pyrazolin-5-one derivatives modified with glycylglycine Me ester were synthesized and characterized by UV, ¹H NMR, ¹³C NMR, IR, elemental anal. The mol. structure of compound I was also characterized by single-crystal X-ray diffraction. The anal. results showed that new compounds existed in enamine-ketone forms. The antibacterial activity tests of the compounds at different concentrations against E. coli and Bacillus subtilis were performed using disk diffusion method. The results indicated that most compounds had weak abilities of inhibiting the growth of the two bacteria, and the inhibiting abilities of 4-aryl compounds were better. The herbicidal activity tests of the compounds against wheat and rape were performed by plate culture method. The results indicated that all compounds had the abilities of inhibiting the growth of the two plants, and the inhibiting abilities of the compounds against rape were better, especially the inhibiting abilities to the growth of rapeseed radicle almost reached completely suppressed.

Youji Huaxue published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C7H8O3, Quality Control of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Gao, Jie published the artcileCobalt complex bearing β-ketoamine ligand: syntheses, structure, catalytic behavior for styrene and methyl methacrylate polymerization, Category: pyrazoles-derivatives, the publication is Applied Organometallic Chemistry (2014), 28(8), 584-588, database is CAplus.

Cobalt complex based on β-ketoamine ligand [(Z)-4-((2,5-dimethylphenylamino) (phenyl)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one] was successfully synthesized. The produced catalyst showed satisfactory activities in the cobalt-mediated radical polymerization of styrene and Me methacrylate with the common initiator of AIBN. The resulting polymerizations have the characteristics of living radical polymerization and displayed a nearly linear correlation between the number-average mol. weight and monomer conversion. Low polydispersity was obtained for all polymerizations, and the polydispersity index decreased with the increase of conversion. These improvements facilitate the implementation of styrene and methacrylate cobalt-mediated radical polymerization, and open the door to the scale-up of the process. Copyright © 2014 John Wiley & Sons, Ltd.

Applied Organometallic Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Aghazadeh-Tabrizi, Mojgan published the artcileDiscovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors, COA of Formula: C16H12N2O2, the publication is Journal of Medicinal Chemistry (2018), 61(3), 1340-1354, database is CAplus and MEDLINE.

Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiol. processes. Beyond the possible utilization of MAGL inhibitors as anti-inflammatory, antinociceptive, and anticancer agents, their application has encountered obstacles due to the unwanted effects caused by the irreversible inhibition of this enzyme. The possible application of reversible MAGL inhibitors has only recently been explored, mainly due to the deficiency of known compounds possessing efficient reversible inhibitory activities. The authors report a new series of reversible MAGL inhibitors. Among them, compound 26 ((4-benzylpiperidin-1-yl)(5-(4-hydroxyphenyl)-1-(3-methylbenzyl)-1H-pyrazol-3-yl)methanone) showed to be a potent MAGL inhibitor (IC₅₀ = 0.51 μM, K_i = 412 nM) with a good selectivity vs. fatty acid amide hydrolase (FAAH), α/β-hydrolase domain-containing 6 (ABHD6), and 12 (ABHD12). Interestingly, this compound also possesses antiproliferative activities against two different cancer cell lines and relieves the neuropathic hypersensitivity induced in vivo by oxaliplatin.

Journal of Medicinal Chemistry published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, COA of Formula: C16H12N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Kurteva, Vanya published the artcileNMR Study on the Possible Interactions Between Imidazolium Based Ionic Liquids and Extractants Widely Applied in Solvent Extraction and Separation of f-Ions, Synthetic Route of 4551-69-3, the publication is Journal of Solution Chemistry (2015), 44(12), 2416-2430, database is CAplus.

Abstract: A detailed NMR study on the possible interactions between a series of imidazolium based ionic liquids (1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl) amide, RmimTf₂N, n = 4, 6, 8, 10), and compounds commonly applied in the solvent extraction and separation of 4f and 5f-ions as acidic chelating agents and neutral extractants is presented. The anal. techniques applied are ¹H, ¹³C, ¹⁹F and ³¹P NMR spectra and NOESY experiments Investigation of the types and strengths of the solvent-solute interactions is necessary for a better understanding of the chem. solubility, reactivity and selectivity, as ILs have a strong influence on the solvent extraction mechanism of metal ions. The goal of the scientific research is to gain insight on the role of ILs as a perspective efficient “green” medium in the solvent extraction processes. The exptl. results show that no IL-ligand interactions occurred in chloroform solution independently on the length of the imidazolium alkyl chain or on the structure and acidity of the ligand. Graphical Abstract: [InlineMediaObject not available: see fulltext.]

Journal of Solution Chemistry published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Synthetic Route of 4551-69-3.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Shcherbakov, Dmitriy published the artcileDesign and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors, Safety of 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, the publication is ACS Medicinal Chemistry Letters (2022), 13(1), 140-147, database is CAplus and MEDLINE.

For the first time, derivatives of 3,7-diazabicyclo[3.3.1]nonane (bispidine) were proposed as potential inhibitors of the SARS-CoV-2 main viral protease (3-chymotrypsin-like, 3CLpro). Based on the created pharmacophore model of the active site of the protease, a group of compounds were modeled and tested for activity against 3CLpro. The 3CLpro activity was measured using the fluorogenic substrate Dabcyl-VNSTLQSGLRK(FAM)MA; the efficiency of the proposed approach was confirmed by comparison with literature data for ebselen and disulfiram. The results of the experiments performed with bispidine compounds showed that 14 compounds exhibited activity in the concentration range 1-10μM, and 3 samples exhibited submicromolar activity. The structure-activity relationship studies showed that the mols. containing a carbonyl group in the ninth position of the bicycle exhibited the maximum activity. Based on the exptl. and theor. results obtained, further directions for the development of this topic were proposed.

ACS Medicinal Chemistry Letters published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C8H19NO2, Safety of 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Ouyang, Zhen-zhong published the artcileDetermination of trace scandium in fly ash by calcein fluorescence spectrophotometry, Category: pyrazoles-derivatives, the publication is Yejin Fenxi (2015), 35(6), 53-56, database is CAplus.

The fluorescence reaction between calcein and scandium(III) was studied. The results showed that trace scandium(III)ions could react with calcein to form complex in NH₃·H₂O-NH₄Cl buffer solution at pH8.5in presence of surfactant Triton X-100, and the fluorescence intensity of this system was enhanced significantly. The excitation wavelength and emission wavelength was 495 nm and 520 nm, resp. The content of scandium (III)in range of 0.021-1.80μg/mL exhibited good linearity to its fluorescence intensity difference(ΔF). The equation of linear regression wasΔF=3.431+2.473ρ (μg/mL)with correlation coefficient of r=0.998 1. The detection limit was 0.021μg/mL. The interference tests indicated that most common ions did not interfere with the determination after scandium in fly ash sample was extracted and separated with 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone (PMBP)-toluene. The proposed method was applied to determination of trace scandium in fly ash samples. The results were consistent with those obtained by inductively coupled plasma at. emission spectrometry (ICP-AES). The relative standard deviation(RSD, n=6)was 0.57%-1.0%. The recoveries were between 98% and 105%.

Yejin Fenxi published new progress about 4551-69-3. 4551-69-3 belongs to pyrazoles-derivatives, auxiliary class Benzenes, name is 4-Benzoyl-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, and the molecular formula is C17H14N2O2, Category: pyrazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Li, Chunpu published the artcileDesign, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors, Recommanded Product: (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid, the publication is ACS Medicinal Chemistry Letters (2015), 6(5), 507-512, database is CAplus and MEDLINE.

A series of imidazo[1,2-a]pyridine derivatives against c-Met was designed by means of bioisosteric replacement. In this study, a selective, potent c-Met inhibitor, I was identified, with IC₅₀ values of 3.9 nM against c-Met kinase and 45.0 nM against c-Met-addicted EBC-1 cell proliferation, resp. Compound I inhibited c-Met phosphorylation and downstream signaling across different oncogenic forms in c-Met overactivated cancer cells and model cells. Compound I significantly inhibited tumor growth (TGI = 75%) with good oral bioavailability (F = 29%) and no significant hERG inhibition. On the basis of systematic metabolic study, the pathway of all possible metabolites of I in liver microsomes of different species has been proposed, and a major NADPH-dependent metabolite was generated by liver microsomes. To block the metabolic site, II was designed and synthesized for further evaluation. Taken together, the imidazo[1,2-a]pyridine scaffold showed promising pharmacol. inhibition of c-Met and warrants further investigation.

ACS Medicinal Chemistry Letters published new progress about 1190875-39-8. 1190875-39-8 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Piperidine,Boronic acid and ester,Amide,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid, and the molecular formula is C13H22BN3O4, Recommanded Product: (1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-1H-pyrazol-4-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics

Lapkin, I. I. published the artcileEsters of oxo acids of acetylene series. VI. Reaction of the esters of phenylethynylglyoxalic acid with hydrazine, hydrazide, and hydroxylamine, Product Details of C16H12N2O2, the publication is Zhurnal Organicheskoi Khimii (1966), 2(11), 2075-8, database is CAplus.

cf. CA 65, 10523b. Addition of N2H4.H2O to Et phenylethynylglyoxalate in EtOH gave 75% Et 3-phenylpyrazole-5-carboxylate, m. 139.5°; similarly were prepared: Pr ester, m. 110°; iso-Pr ester, m. 164°. Addition of RNHNH2 in Et2O to the appropriate ester of phenylethynylglyoxalic acid gave the following esters of 4-arylhydrazino-4-phenyl-3-buten-2-on-1-oic acids, RNHNHCPh:CCOCO2R’ (R and R’ shown, resp.): Ph, Et, 32%, m. 83°; Ph, iso-Pr (I) 65%, m. 124.5°; p-MeC6H4, iso-Pr, 32%, m. 77°; 0-MeC6H4, iso-Pr, 55%, m. 72.5°; Bz, iso-Pr (II) 87%, m. 125.5°; 0-O2NC6H4CO, iso-Pr, 78%, m. 137°; m-O2NC6H4CO, iso-Pr, 83%, m. 181°; p-O2NC6H4CO, iso-Pr, 88%, m. 175°. II heated in AcOH 2 hrs. gave 93% 1,5-diphenylpyrazole-3-carboxylic acid iso-Pr ester, m. 86.5-7°. I heated with aqueous alc. KOH 20 min. gave 1,5-diphenylpyrazole-3-carboxylic acid. Heating iso-Pr phenylethynylglyoxalate with HONH2.HCl in aqueous EtOH gave after addition of aqueous Na2CO3 over 9 hrs. 50% iso-Pr 3-phenylisoxazole-5-carboxylate, m. 65-6°. Similarly was prepared 29% Et 3-phenylisoxazole-5-carboxylate, m. 47°. Ir spectra were reported.

Zhurnal Organicheskoi Khimii published new progress about 13599-22-9. 13599-22-9 belongs to pyrazoles-derivatives, auxiliary class Pyrazole,Carboxylic acid,Benzene, name is 1,5-Diphenyl-1H-pyrazole-3-carboxylic acid, and the molecular formula is C16H12N2O2, Product Details of C16H12N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyrazole,
Pyrazoles – an overview | ScienceDirect Topics