Tag: M.W=300-400

Synthetic Route of 162758-35-2, The chemical industry reduces the impact on the environment during synthesis 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.

Scheme 3 depicts the conversion of the carboxylic acid from Scheme 1 to its acid chloride using thionyl chloride or oxalyl chloride in dichloroethane at ambient to elevated temperatures followed by treatment with an amine such as alanine ethyl ester (A=methyl, n=0) in the presence of triethylamine to afford the amide ester (step a). Hydrolysis of the ester with lithium hydroxide in aqueous THF solution and acidification with dilute hydrochloric acid solution should yield the amide carboxylic acid (step b). This acid can be further treated with Boc anhydride (Boc2O) in THF in the presence of pyridine, followed by a solution of ammonia in THF at 0 degrees to ambient temperature to yield the carboxamido compound (step c).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JENRIN DISCOVERY; US2007/213302; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Synthetic Route of 152120-54-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

To a solution of piperidine-4-carboxylic acid trifluoroacetate salt (0.20 g, 0.82 mmol) in methanol (10 mL), triethylamine (0.20 mL, 1.6 mmol) and N,N’-bis{[(2-methyl-2-propanyl)oxy]carbonyl}-1H-pyrazole-1-carboximidamide (0.30 g, 0.98 mmol) was added and the reaction mixture stirred at room temperature for 18 h. The solvent was evaporated under reduced pressure and the resulting residue dissolved in ethyl acetate and washed with brine. The organic layer was dried and concentrated to dryness to obtain the title compound (200 mg, 76%) as a white solid. 1H NMR (400 MHz, DMSO-d6) delta 3.91 (d, 2H), 3.30 (t, 2H), 2.63-2.66 (m, 1H), 1.90-1.96 (m, 2H), 1.67-1.69 (m, 2H), 1.45 (s, 18H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; Imagawa, Akira; Kondo, Takashi; Nishiyama, Taihei; Courtney, Steve; Yarnold, Chris; Ichihara, Osamu; Flanagan, Stuart; US2015/152048; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95162-14-4, name is 4-Bromo-1-tritylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-Bromo-1-tritylpyrazole

To a 500 mL Schenk flask backfilled with N2was added 4-bromo-1-trityl-1H-pyrazole(10.0 g, 25.7 mmol) and dry THF (250 mL). The resulting suspension was cooledto -78 C under stirring. 1.6 M n-butyl lithium (20.0 mL, 32.0 mmol, 1.2equiv.) was then added dropwise, and the solution was left to stir for 30minutes before adding triisopropyl borate (7.4 mL, 32.0 mmol, 1.2 equiv.)dropwise. The resulting solution was stirred at 1 hour at -78 C and allowed toreach room temperature over 1 hour. Pinacol (3.9 g, 33.4 mmol, 1.3 equiv.) wasadded under stirring, and the solution was stirred for 30 minutes before addingglacial acetic acid (1.6 mL, 28.3 mmol, 1.1 equiv.). The suspension was stirredfor a further 30 minutes before removing the solvent in vacuo to yield awhite solid. Recrystallization was achieved by triturating the crude compoundin DCM (3 mL) and methanol (200 mL) over 1 hour. The resulting solid wascollected by filtration, washed with methanol and dried overnight at 50 C toyield 1-trityl-1H-pyrazol-4-ylboronatepinacol ester (9.1 g, 20.9 mmol, 81.4%) as a white solid. 1H NMR (500 MHz, CD2Cl2) delta = 1.28(s, 12H), 7.12 – 7.14 (m, 6H), 7.30 – 7.33 (m, 9H), 7.63 (d, J = 0.9 Hz, 1H),7.81 (d, J = 0.9 Hz,). 13CNMR (125 MHz, CD2Cl2) delta = 25.17, 79.22, 83.82, 128.25,130.72, 139.35, 143.82, 145.83. HRMS(ESI) Calcd for C28H29BN2O2 [M+H]: 437.239983;Found: 437.240521.

According to the analysis of related databases, 95162-14-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kershaw Cook, Laurence J.; Kearsey, Rachel; Lamb, Jessica V.; Pace, Edward J.; Gould, Jamie A.; Tetrahedron Letters; vol. 57; 8; (2016); p. 895 – 898;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C11H5Cl2F3N4

General procedure: A mixture of compound A (5 mmol) and corresponding benzaldehyde (5 mmol) in 10 mL ethanol was refluxed for 24 hours in a reaction flask wrapped up by silver paper. Upon the reactions completed (monitored by TLC), tawny solids were obtained through suction filtration. The precipitates were washed with ethanol (5 mLx3) and recrystallized from ethanol with 50-84% yields.

The synthetic route of 120068-79-3 has been constantly updated, and we look forward to future research findings.

Reference:
Letter; Li, Guanglong; Zhou, Cong; Zhu, Chengchun; He, Lujue; Li, Xiaoyang; Xu, Zhiping; Xu, Xiaoyong; Shao, Xusheng; Li, Zhong; Cheng, Jiagao; Letters in drug design and discovery; vol. 16; 10; (2019); p. 1175 – 1180;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Related Products of 95162-14-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 95162-14-4, name is 4-Bromo-1-tritylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.

A stirred mixture of 5.0 g (12.8 mmol) of 4-bromo-1-trityl-1H-pyrazole, 9.8 g (38.6 mmol, 3.0 eq.) of bis(pinacolato)diboron, 1.0 g (1.3 mmol, 10 mol %) of PdCl2(dppf) and 6.3 g (64.2 mmol, 5.0 eq) of potassium acetate in DMF (30 mL) was heated at 80 C. for 16 h. The resulting mixture was diluted with water, and the product was extracted with dichloromethane. The organic layer was washed with brine, dried over sodium sulfate, and purified by flash chromatography to give 5.1 g (91%) of 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-tritylpyrazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bentzien, Joerg Martin; Takahashi, Hidenori; US2008/261975; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, A new synthetic method of this compound is introduced below., Safety of tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate

Example 7 : 1 -f N’-bis ( f (2-methyl-2-propanyl)oxy]carbonyU carbamimidovfH- piperidinecarboxylic acid To a solution of piperidine-4-carboxylic acid trifluoroacetate salt (0.20 g, 0.82 mmol) in methanol (10 mL), triethylamine (0.20 mL, 1.6 mmol) and N,N’-bis{[(2- methyl-2-propanyl)oxy]carbonyI}-lH-pyrazole-l-carboximidamide (0.30 g, 0.98 mmol) was added and the reaction mixture stirred at room temperature for 18 h. The solvent was evaporated under reduced pressure and the resulting residue dissolved in ethyl acetate and washed with brine. The organic layer was dried and concentrated to dryness to obtain the title compound (200 mg, 76%) as a white solid. NMR (400 MHz, D SO-i) delta 3.91 (d, 2H), 3.30 (t, 2H), 2.63-2.66 (m, IH), 1.90- 1.96 (m, 2H), 1.67-1.69 (m, 2H), 1.45 (s, 18H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ONO PHARMACEUTICAL CO., LTD; IMAGAWA, Akira; KONDO, Takashi; NISHIYAMA, Taihei; COURTNEY, Steve; YARNOLD, Chris; ICHIHARA, Osamu; FLANAGAN, Stuart; WO2013/174937; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives

To a stirred solution of compound 2 (382 mg; 1.0 mmol) in toluene (10 ml) one drop of dimethyl formamide was added. The reaction mixture was cooled to 0 C and added thionyl chloride (140 mg:1 .2mmol) in 2ml toluene drop-wise for the period of 2 minutes at the same temperature. The reaction mixture was allowed to attain room temperature and heated at 100 C for 4 h. Excess of thionyl chloride and toluene was distilled off under reduced pressure. In another flask under nitrogen atmosphere was introduced 1- amino piperidine (100 mg; 1.0 mmol) and triethyl amine (101 mg; 1.0 mmol) in 5.0 ml dichloromethane. The flask was cooled to 0 C. To this was added a cooled solutionof acid chloride drop-wise at the same temperature. The resulting reaction mixture was allowed to attain room temperature and then it was stirred for 12 h. After completion of the reaction (monitored by TLC), the reaction mixture was diluted with water (10 ml) and organic layer was separated, washed with water (2 x 5 ml) and brine solution(5m1), dried over Na2SO4(anhydrous) and concentrated in vacuo. The residue was purified by column chromatography over silica gel (ethyl acetate/petroleumether 1:9(v/v)) afforded pure product.

The synthetic route of 162758-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; GAJBHIYE, Jayant, Maroti; WO2014/174457; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 139756-04-0, name is 1-Methyl-4-(2-propoxybenzamido)-3-propyl-1H-pyrazole-5-carboxamide, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C18H24N4O3

Step 9 3-(5-Carbamoyl-1-methyl-3-propyl-1H-pyrazol-4-ylcarbamoyl)-4-propxy-benzenesulfonyl chloride: 2-Methyl-4-(2-propoxybenzoylamino)-5-propyl-2H-pyrazole-3-carboxamide (20 g, 58.1 mmol) was added to chlorosulfonic acid (81.3 g, 698 mmol) at 0 C. and the reaction was warmed to ambient temperature and stirred for 2 hours. The reaction mixture was poured into ice water (800 g) and mechanically stirred for 1 hour to give a white solid, which was filtered and washed with water. Following standard extractive work up, the solvent was evaporated under reduced pressure to yield the title compound (8 g, 31%). 1H NMR (300 MHz, CDCl3) delta 9.19 (s, 1H), 8.97 (s, 1H), 8.19 (t, 1H, J=8.9 Hz), 7.56 (br. s, 1H), 4.35 (t, 2H, J=6.6 Hz), 4.07 (s, 3H), 2.53 (t, 2H, J=7.5 Hz), 2.06-1.94 (m, 2H), 1.78-1.60 (m, 2H), 1.18 (t, 3H, J=7.5 Hz), 0.95 (t, 3H, J=7.2 Hz); LC-MS: m/z=443.1 (M+H)+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 139756-04-0.

Reference:
Patent; AUSPEX PHARMACEUTICALS, INC.; US2008/194529; (2008); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27511-79-1, name is 3-Amino-1H-pyrazole-4-carboxamide sulfate(2:1), This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H14N8O6S

This embodiment relates to a process for synthesizing a pyrazolo [3,4-d] pyrimidine compound, which comprises the following steps:Step one, 15 g of 3-aminopyrazole-4-carboxamide hemisulfateAnd 150g of formamide (molar ratio of 1:10) was added to a 100mL three-necked round bottom flask, first with hydrochloric acid to adjust the pH to 2.6, and then warmed to 115 , and stirred at this temperature for 12h at room temperature, the reaction mixture First clear as a clear solution and then gradually precipitated a white solid, the reaction was cooled to room temperature after the reaction;Step two, the product obtained in step one was placed in the range of 7 12h,Let the product fully crystallized from formamide solution;Step three, the filter, the filtrate recovery applied, the resulting crystal crude beaker into the beater by mass than the crude product: purified water ratio of 1:14 by adding purified water, beating washing 3 hours;Step four, filtered again, the filtrate was discarded, the filter cake was washed with purified water until the eluate pH ? 6, after drying to obtain a white 4-hydroxypyrazolo [3,4-d] pyrimidine, the state is white Crystal powder, molar yield of 92.1%, purity of 99.8%

According to the analysis of related databases, 27511-79-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Titan Technology Co., Ltd.; Xie Yingbo; Zhang Qing; Zhang Hua; Xu Xiaobing; Zhang Weiyan; Luo Guiyun; (6 pag.)CN104447758; (2017); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics

Application of 50-33-9,Some common heterocyclic compound, 50-33-9, name is Phenylbutazone, molecular formula is C19H20N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3-((2R,3R)-1-(Dimethylamino)-2-methylpentan-3-yl)phenol (250 mg) was dissolved while heating in as little ethanol as possible. 4-Butyl-1 ,2-diphenylpyrazolidine-3,5- dione (Phenylbutazone, 339 mg) was dissolved in H2O/ethanol under heating. The solutions were mixed, heated to reflux for 12 hours and allowed to cool to room temperature overnight. The solvent was removed in vacuo and the residue was dried by freeze drying to obtain a white solid (589 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Phenylbutazone, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; WO2007/128412; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics